BRPI0912171B8 - composto ativador de receptor de glicocorticoide, e, composição - Google Patents

composto ativador de receptor de glicocorticoide, e, composição

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Publication number
BRPI0912171B8
BRPI0912171B8 BRPI0912171A BRPI0912171A BRPI0912171B8 BR PI0912171 B8 BRPI0912171 B8 BR PI0912171B8 BR PI0912171 A BRPI0912171 A BR PI0912171A BR PI0912171 A BRPI0912171 A BR PI0912171A BR PI0912171 B8 BRPI0912171 B8 BR PI0912171B8
Authority
BR
Brazil
Prior art keywords
glucocorticoid receptor
formula
lower alkyl
composition
group
Prior art date
Application number
BRPI0912171A
Other languages
English (en)
Inventor
Dota Atsuyoshi
Imoto Kenji
Matsuda Mamoru
Kato Masatomo
Takai Miwa
Matsuyama Takahiro
Kurose Tatsuji
Mori Toshiyuki
Hagiwara Yumi
Original Assignee
Ayumi Pharmaceutical Corp
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ayumi Pharmaceutical Corp, Santen Pharmaceutical Co Ltd filed Critical Ayumi Pharmaceutical Corp
Publication of BRPI0912171A2 publication Critical patent/BRPI0912171A2/pt
Publication of BRPI0912171A8 publication Critical patent/BRPI0912171A8/pt
Publication of BRPI0912171B1 publication Critical patent/BRPI0912171B1/pt
Publication of BRPI0912171B8 publication Critical patent/BRPI0912171B8/pt

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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  • Immunology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
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  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
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  • Transplantation (AREA)

Abstract

composição farmacêutica é divulgado um agonista do receptor de glicocorticóide composto de um composto representado pela fórmula (i) ou um sal deste; que é derivado de 2,2,4-trimetil-6-fenil-1,2-diidroquinolina tendo um grupo óxi substituído. uma nova ação farmacológica do agonista também é divulgada. na fórmula, r1 representa um grupo representado pela fórmula (2a), (3a), (4a) ou (5a); r2 representa -(co)-r8, -(co()o-r9 ou semelhante; r2-o- é substituído na posição 4 ou na posição 5 do anel a de benzeno; r3 representa um grupo alquila inferior; r4, r5, r6 ou r7 representa um átomo de halógeno, um grupo alquila inferior opcionalmente substituído ou semelhante; m, n, p ou q representam 0, 1 ou semelhante; e r8, r9 ou semelhante representam um grupo alquila inferior opcionalmente substituído, um grupo alquenila inferior ou semelhante.
BRPI0912171A 2008-05-12 2009-05-12 composto ativador de receptor de glicocorticoide, e, composição BRPI0912171B8 (pt)

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JP2008124714 2008-05-12
JP2008-127414 2008-05-12
PCT/JP2009/058801 WO2009139361A1 (ja) 2008-05-12 2009-05-12 置換オキシ基を有する２，２，４－トリメチル－６－フェニル－１，２－ジヒドロキノリン誘導体からなるグルココルチコイド受容体アゴニスト

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BRPI0912171A2 BRPI0912171A2 (pt) 2017-10-31
BRPI0912171A8 BRPI0912171A8 (pt) 2017-12-12
BRPI0912171B1 BRPI0912171B1 (pt) 2020-11-03
BRPI0912171B8 true BRPI0912171B8 (pt) 2021-05-25

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KR (1) KR20110010634A (pt)
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AU (1) AU2009247250B2 (pt)
BR (1) BRPI0912171B8 (pt)
CA (1) CA2724055C (pt)
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GE (1) GEP20146061B (pt)
MX (1) MX2010012303A (pt)
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US8008496B2 (en) 2006-11-14 2011-08-30 Santen Pharmaceutical Co., Ltd. 1,2-dihydroquinoline derivative having substituted phenylchalcogeno lower alkyl group and ester-introduced phenyl group as substituents
WO2012108455A1 (ja) * 2011-02-09 2012-08-16 参天製薬株式会社 ３－ヒドロキシ－６Ｈ－ベンゾ［ｃ］クロメン－６－オン誘導体およびその製造方法
KR20140117481A (ko) * 2012-01-20 2014-10-07 산텐 세이야꾸 가부시키가이샤 1,2-디하이드로퀴놀린 유도체 또는 그의 염의 공업적 제조 방법 및 그 제조 중간체
JP6060910B2 (ja) * 2013-03-28 2017-01-18 アイシン精機株式会社 周辺監視装置、及びプログラム
CN107922356A (zh) 2015-08-25 2018-04-17 参天制药株式会社 [4‑(1,3,3‑三甲基‑2‑氧代‑3,4‑二氢‑1h‑喹喔啉‑7‑基)苯氧基]乙基氧基化合物或其盐
EP3639854B1 (en) 2017-06-16 2026-01-07 The Doshisha Mtor-inhibitor-containing medicine for treating or preventing fuchs' endothelial corneal dystrophy
US20200121652A1 (en) 2017-06-16 2020-04-23 The Doshisha Compounds having caspase inhibitory activity, pharmaceutical agent containing said compounds and for treating or preventing corneal endothelial symptoms, disorders, or diseases, and application of said pharmaceutical agent
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JP2009298775A (ja) 2009-12-24
EP2319835A4 (en) 2011-12-28
JP5635743B2 (ja) 2014-12-03
CA2724055C (en) 2016-08-02
CN102089283B (zh) 2015-11-25
KR20110010634A (ko) 2011-02-01
US20110118260A1 (en) 2011-05-19
TWI510240B (zh) 2015-12-01
EP2319835B1 (en) 2016-04-13
CN102089283A (zh) 2011-06-08
BRPI0912171B1 (pt) 2020-11-03
MY158747A (en) 2016-11-15
CN105395550B (zh) 2018-07-17
GEP20146061B (en) 2014-03-25
MX2010012303A (es) 2011-03-30
TW200950781A (en) 2009-12-16
ES2574987T3 (es) 2016-06-23
AU2009247250A1 (en) 2009-11-19
EA019091B1 (ru) 2014-01-30
AU2009247250B2 (en) 2014-04-10
EA201071296A1 (ru) 2011-06-30
US8426406B2 (en) 2013-04-23
WO2009139361A1 (ja) 2009-11-19
CN105395550A (zh) 2016-03-16
EP2319835A1 (en) 2011-05-11
CA2724055A1 (en) 2009-11-19
UA102101C2 (ru) 2013-06-10
BRPI0912171A8 (pt) 2017-12-12
BRPI0912171A2 (pt) 2017-10-31

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