BRPI0912175A2 - métodos para diagnosticar indução de enzima do fígado, para determinar se um composto é capaz de induzir indução de enzima do fígado em um indivíduo, e para identificar uma substância para tratar indução de enzima do fígado - Google Patents

métodos para diagnosticar indução de enzima do fígado, para determinar se um composto é capaz de induzir indução de enzima do fígado em um indivíduo, e para identificar uma substância para tratar indução de enzima do fígado

Info

Publication number
BRPI0912175A2
BRPI0912175A2 BRPI0912175A BRPI0912175A BRPI0912175A2 BR PI0912175 A2 BRPI0912175 A2 BR PI0912175A2 BR PI0912175 A BRPI0912175 A BR PI0912175A BR PI0912175 A BRPI0912175 A BR PI0912175A BR PI0912175 A2 BRPI0912175 A2 BR PI0912175A2
Authority
BR
Brazil
Prior art keywords
liver enzyme
enzyme induction
identify
substance
individual
Prior art date
Application number
BRPI0912175A
Other languages
English (en)
Inventor
Alexandre Prokoudine
Bennard Van Ravenzwaay
Edgar Leibold
Eric Fabian
Georgia Coelho Palermo Cunha
Hennicke Kamp
Jan C Wiemer
Michael Manfred Herold
Ralf Looser
Timann B Walk
Volker Strauss
Werner Mellert
Original Assignee
Basf Se
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Se filed Critical Basf Se
Publication of BRPI0912175A2 publication Critical patent/BRPI0912175A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/08—Hepato-biliairy disorders other than hepatitis
    • G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Inorganic Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
BRPI0912175A 2008-05-28 2009-05-25 métodos para diagnosticar indução de enzima do fígado, para determinar se um composto é capaz de induzir indução de enzima do fígado em um indivíduo, e para identificar uma substância para tratar indução de enzima do fígado BRPI0912175A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08157077 2008-05-28
EP09151546 2009-01-28
PCT/EP2009/056312 WO2009153131A1 (en) 2008-05-28 2009-05-25 Means and methods for assessing liver enzyme induction

Publications (1)

Publication Number Publication Date
BRPI0912175A2 true BRPI0912175A2 (pt) 2015-10-06

Family

ID=41151807

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0912175A BRPI0912175A2 (pt) 2008-05-28 2009-05-25 métodos para diagnosticar indução de enzima do fígado, para determinar se um composto é capaz de induzir indução de enzima do fígado em um indivíduo, e para identificar uma substância para tratar indução de enzima do fígado

Country Status (9)

Country Link
US (1) US8808979B2 (pt)
EP (1) EP2286235A1 (pt)
JP (2) JP2011522231A (pt)
CN (1) CN102105793A (pt)
AU (1) AU2009259535B2 (pt)
BR (1) BRPI0912175A2 (pt)
CA (1) CA2724512A1 (pt)
DE (1) DE112009001245T5 (pt)
WO (1) WO2009153131A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9285378B2 (en) 2010-01-29 2016-03-15 Metanomics Gmbh Means and methods for diagnosing heart failure in a subject
EP2863227B1 (en) * 2010-06-10 2017-09-27 Metanomics Health GmbH Means and methods for metabolic differentiation of non-alcoholic steatohepatitis from liver disease
WO2022187228A1 (en) * 2021-03-01 2022-09-09 Board Of Regents, The University Of Texas System Methods of detecting advanced liver fibrosis or hepatocellular carcinoma biomarkers in a sample

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4540884A (en) 1982-12-29 1985-09-10 Finnigan Corporation Method of mass analyzing a sample by use of a quadrupole ion trap
US5397894A (en) 1993-05-28 1995-03-14 Varian Associates, Inc. Method of high mass resolution scanning of an ion trap mass spectrometer
GB9519490D0 (en) * 1995-09-25 1995-11-29 Melvin William T Use of a cytochrome P450 enzyme in tumour cells as a marker and target
JP4571408B2 (ja) * 2002-01-07 2010-10-27 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 癌治療薬としての、ｓ−ジメチルアルシノ−チオコハク酸、ｓ−ジメチルアルシノ−２−チオ安息香酸、ｓ−（ジメチルアルシノ）グルタチオン
JP2006502693A (ja) * 2002-02-04 2006-01-26 ジーン ロジック インコーポレイテッド 初代ラット肝細胞毒性モデリング
US20040005547A1 (en) * 2002-03-14 2004-01-08 Franziska Boess Biomarkers and expression profiles for toxicology
KR20040101374A (ko) * 2002-03-26 2004-12-02 카운슬 오브 사이언티픽 앤드 인더스트리얼 리서치 시토크롬 ｐ-４５０ 관련된 간독성에 대한 아말라의간치료 효과
CA2541380A1 (en) * 2003-10-10 2005-04-21 Multicell Technologies, Inc. Use of cell lines to produce active therapeutic proteins
JP4682980B2 (ja) * 2004-04-23 2011-05-11 味の素株式会社 非アルコール性脂肪肝炎鑑別方法
ES2732071T3 (es) * 2005-04-01 2019-11-20 Univ Florida Biomarcadores de lesiones hepáticas
PL1909561T3 (pl) 2005-07-25 2010-11-30 Basf Se Sposób dostarczania i analizy populacji zwierząt o zasadniczo identycznym metabolomie
US7615361B2 (en) * 2006-03-06 2009-11-10 Ceetox, Inc. Toxicity screening methods
EP1837657A1 (en) * 2006-03-24 2007-09-26 Metanomics GmbH Means and method for predicting or diagnosing diabetes
ES2525345T3 (es) * 2006-03-24 2014-12-22 Metanomics Gmbh Procedimiento de diagnóstico de diabetes de tipo II
JP5363984B2 (ja) * 2006-10-13 2013-12-11 メタボロン インコーポレイテッド 代謝年齢に関するバイオマーカー及びその使用方法
US20110045520A1 (en) * 2007-09-13 2011-02-24 Bhagavan Nadhipuram V Fatty acid markers for the diagnosis, prognosis and management of cardiovascular disease
EP2930512B1 (en) * 2007-11-02 2018-01-31 Metabolon, Inc. Biomarkers for fatty liver disease and methods using the same
EP2286236B1 (en) * 2008-05-28 2016-04-20 Basf Se Methods for assessing liver toxicity
EP2157431A1 (en) * 2008-08-11 2010-02-24 One Way Liver Genomics, S.L. Method for the diagnosis of NASH using metabolic profiles
US8658353B2 (en) * 2008-11-25 2014-02-25 Corning Incorporated Liver cell toxicity assay

Also Published As

Publication number Publication date
AU2009259535B2 (en) 2016-01-21
CA2724512A1 (en) 2009-12-23
WO2009153131A1 (en) 2009-12-23
CN102105793A (zh) 2011-06-22
AU2009259535A1 (en) 2009-12-23
AU2009259535A8 (en) 2011-02-03
DE112009001245T5 (de) 2012-03-15
US20110091929A1 (en) 2011-04-21
EP2286235A1 (en) 2011-02-23
US8808979B2 (en) 2014-08-19
JP2015042985A (ja) 2015-03-05
JP2011522231A (ja) 2011-07-28

Similar Documents

Publication Publication Date Title
BRPI0912110A2 (pt) métodos para diagnosticar a toxicidade do fígado, para determinar se um composto é capaz de induzir a toxicidade no fígado em um indivíduo, e para identificar uma substância para tratar toxicidade do fígado
IL252119B (en) Improved cell composition and methods of making the same
SMT201700037B (it) Nuovi inibitori pirrolici della s-nitrosoglutatione riduttasi come agenti terapeutici
BR112012001325A2 (pt) tratamento de distúrbios do fígado com inibidaores de pi3k
BRPI0920498A2 (pt) método de tratamento de uma condição em um sujeito
BRPI0920054A2 (pt) execução em modo seguro de plug-ins
IL230580A0 (en) Polymorphic forms of compounds as prolyl hydroxylase inhibitor, and uses thereof
FI20086085L (fi) Menetelmä ja laite resurssien virtualisoimiseksi
EP2714970A4 (en) Enzyme QUANTIFICATION
EP2424488A4 (en) MICRO-SECONDED COMPOSITIONS AND METHOD FOR TISSUE ANALYSIS
BRPI0913165A2 (pt) método para detectar malware em dispositivos de computação
PL3721880T3 (pl) Kompozycja i sposób naprawy i regeneracji mięśni
BRPI1014544A2 (pt) anticorpors anti-il-17f e metodos de uso dos mesmos
BR112014007267A2 (pt) kit para otimizar o desempenho de usuário em uma atividade, conjunto de dois kits e método para seleção de um aparelho oral para o kit
PL2758655T3 (pl) Urządzenie i sposób ulepszenia wirników wodnych
PT2311470E (pt) Método para indução simultânea de ctl e células gama delta
BRPI0913398A2 (pt) composição e métodos de adesivo para dentaduras
BRPI0916157A2 (pt) método para tingir fibras queratinosas e kit para implementação do dito método para tingir fibras queratinosas
FI20115150A7 (fi) Menetelmä ja laite energian kulutuksen arvioimiseksi
PL2334768T3 (pl) Sposób uzyskiwania biogazu i instalacja uzyskiwania biogazu
BR112013012360A2 (pt) métodos para conferir uma imagem a uma superfície e kits para usar com eles
EE201100051A (et) Meetod ja testssteem B-kompleksi vitamiinide aktiivsuse samaaegseks kvantitatiivseks m„„ramiseks toidus
PL2166284T3 (pl) Piec bębnowy obrotowy i sposób użytkowania
BR112012020848A2 (pt) instrumento e método para detectar descargas elétricas parciais
DE112011101245A5 (de) Betriebsgerät für Leuchtmittel zum Ermitteln eines Energie- oder Leistungsverbrauchs und Verfahren zum Erfassen desselbigen

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 3A ANUIDADE.

B08H Application fees: decision cancelled [chapter 8.8 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 NA RPI 2344 DE 08/12/2015

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]