BRPI0912110A2 - métodos para diagnosticar a toxicidade do fígado, para determinar se um composto é capaz de induzir a toxicidade no fígado em um indivíduo, e para identificar uma substância para tratar toxicidade do fígado - Google Patents

métodos para diagnosticar a toxicidade do fígado, para determinar se um composto é capaz de induzir a toxicidade no fígado em um indivíduo, e para identificar uma substância para tratar toxicidade do fígado

Info

Publication number
BRPI0912110A2
BRPI0912110A2 BRPI0912110A BRPI0912110A BRPI0912110A2 BR PI0912110 A2 BRPI0912110 A2 BR PI0912110A2 BR PI0912110 A BRPI0912110 A BR PI0912110A BR PI0912110 A BRPI0912110 A BR PI0912110A BR PI0912110 A2 BRPI0912110 A2 BR PI0912110A2
Authority
BR
Brazil
Prior art keywords
liver toxicity
identifying
substance
individual
compound
Prior art date
Application number
BRPI0912110A
Other languages
English (en)
Inventor
Alexandre Prokoudine
Bennard Van Ravenzwaay
Edgar Leibold
Eric Fabian
Georgia Coelho Palermo Cunha
Hennicke Kamp
Jan C Wiemer
Michael Manfred Herold
Ralf Looser
Tilmann B Walk
Volker Strauss
Werner Mellert
Original Assignee
Basf Se
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Se filed Critical Basf Se
Publication of BRPI0912110A2 publication Critical patent/BRPI0912110A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/08—Hepato-biliairy disorders other than hepatitis
    • G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
BRPI0912110A 2008-05-28 2009-05-26 métodos para diagnosticar a toxicidade do fígado, para determinar se um composto é capaz de induzir a toxicidade no fígado em um indivíduo, e para identificar uma substância para tratar toxicidade do fígado BRPI0912110A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08157117 2008-05-28
EP09151548 2009-01-28
PCT/EP2009/056367 WO2009153136A2 (en) 2008-05-28 2009-05-26 Means and methods for assessing liver toxicity

Publications (1)

Publication Number Publication Date
BRPI0912110A2 true BRPI0912110A2 (pt) 2015-10-06

Family

ID=41213188

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0912110A BRPI0912110A2 (pt) 2008-05-28 2009-05-26 métodos para diagnosticar a toxicidade do fígado, para determinar se um composto é capaz de induzir a toxicidade no fígado em um indivíduo, e para identificar uma substância para tratar toxicidade do fígado

Country Status (9)

Country Link
US (1) US8597875B2 (pt)
EP (2) EP2286236B1 (pt)
JP (2) JP2011522233A (pt)
CN (1) CN102105792A (pt)
AU (1) AU2009259540B2 (pt)
BR (1) BRPI0912110A2 (pt)
CA (1) CA2724247A1 (pt)
DE (1) DE112009001234T5 (pt)
WO (1) WO2009153136A2 (pt)

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CN102105793A (zh) * 2008-05-28 2011-06-22 巴斯夫欧洲公司 评估肝酶诱导的工具和方法
EP2464966A1 (en) * 2009-08-13 2012-06-20 Basf Se Means and methods for diagnosingthyroid disorders
AU2010326737A1 (en) * 2009-12-01 2012-06-07 Metanomics Health Gmbh Means and methods for diagnosing multiple sclerosis
EP3502707A1 (en) 2010-01-29 2019-06-26 metanomics GmbH Means and methods for diagnosing heart failure in a subject
CA2800023A1 (en) * 2010-06-01 2011-12-08 Metanomics Health Gmbh Means and methods for diagnosing pancreatic cancer in a subject
WO2012000770A1 (en) * 2010-06-10 2012-01-05 Metanomics Health Gmbh Methods to diagnose liver diseases
CA2845621A1 (en) * 2011-09-13 2013-03-21 Basf Se Means and methods for assessing hematopoietic toxicity
KR20140074293A (ko) * 2011-09-14 2014-06-17 바스프 에스이 신장 독성을 평가하기 위한 수단 및 방법
CA2864471A1 (en) * 2012-03-09 2013-09-12 Basf Se Means and methods for assessing liver disorders
EP2822457A4 (en) * 2012-03-09 2015-11-11 Basf Se MEANS AND METHODS FOR ASSESSING HYPERTHYROIDISM
CN103364510B (zh) * 2012-03-27 2015-01-07 中国科学院大连化学物理研究所 Hplc-ms/ms结合代谢流量分析系统评估环境污染物细胞毒性的方法
CN102749396B (zh) * 2012-07-17 2013-10-23 陕西科技大学 一种气相色谱-质谱联用检测脂肪酸含量的方法
CN103487412B (zh) * 2013-09-30 2015-07-15 上海交通大学 一种酚类化合物肝毒性快速预测模型的构建方法
CN107075539B (zh) * 2014-07-30 2021-11-12 麦特宝龙公司 用于分析结构不同的复杂脂质的方法、组合物和试剂盒
CN104280477B (zh) * 2014-11-03 2016-03-30 天津中医药大学 内源性小分子物质在快速检测肝毒性方面的应用
EP3271451A4 (en) * 2015-03-20 2018-09-19 Hurel Corporation Methods for characterizing time-based hepatotoxicity
CN112136043B (zh) * 2018-04-04 2024-03-22 梅塔博隆股份有限公司 用于检测和定量肝功能代谢产物的质谱测定方法
US12009066B2 (en) 2019-05-22 2024-06-11 International Business Machines Corporation Automated transitive read-behind analysis in big data toxicology
CN114813986B (zh) * 2022-01-26 2024-04-16 北京市心肺血管疾病研究所 一组用于预测高危型扩张型心肌病的脂质代谢物组
CN114441506B (zh) * 2022-04-08 2022-06-21 港湾之星健康生物(深圳)有限公司 量子磁光传感器
CN115128257B (zh) * 2022-07-06 2025-02-18 南京医科大学 肝癌发病风险预测的代谢标志物及其应用
CN116965376B (zh) * 2023-07-17 2024-01-02 南方医科大学南方医院 一种子痫前期小鼠模型的构建方法与应用
CN117929700A (zh) * 2023-12-26 2024-04-26 无锡市妇幼保健院 棕榈酸作为检测靶点在制备icp辅助诊断试剂盒中的应用

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EP1751303A2 (en) * 2004-04-07 2007-02-14 Gene Logic, Inc. Hepatotoxicity molecular models
JP4682980B2 (ja) * 2004-04-23 2011-05-11 味の素株式会社 非アルコール性脂肪肝炎鑑別方法
US7860656B2 (en) * 2005-02-03 2010-12-28 Assistance Publique-Hopitaux De Paris (Ap-Hp) Diagnosis method of hepatic steatosis using biochemical markers
BRPI0613942B1 (pt) 2005-07-25 2022-04-05 Basf Aktiengesellschaft Métodos para a identificação de um composto que efetua o metaboloma de um roedor, e, para a identificação de um marcador para um composto que efetua o metaboloma de um roedor
CA2647122A1 (en) * 2006-03-24 2007-10-04 Metanomics Gmbh Means and method for diagnosing diabetes
EP1837657A1 (en) * 2006-03-24 2007-09-26 Metanomics GmbH Means and method for predicting or diagnosing diabetes
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US20080176266A1 (en) * 2006-08-17 2008-07-24 Alvin Berger Biomarkers Of Metabolic Responses To Hepatotoxicants And Carcinogens
EP2813580A1 (en) 2006-10-13 2014-12-17 Metabolon, Inc. Biomarkers related to metabolic age and methods using the same
US20110045520A1 (en) 2007-09-13 2011-02-24 Bhagavan Nadhipuram V Fatty acid markers for the diagnosis, prognosis and management of cardiovascular disease
EP2546649B1 (en) 2007-11-02 2015-02-25 Metabolon Inc. Biomarkers for fatty liver disease and methods using the same

Also Published As

Publication number Publication date
JP2011522233A (ja) 2011-07-28
EP2286236B1 (en) 2016-04-20
US20110163226A1 (en) 2011-07-07
AU2009259540A1 (en) 2009-12-23
AU2009259540B2 (en) 2015-11-05
DE112009001234T5 (de) 2011-04-28
WO2009153136A3 (en) 2010-03-18
EP3059592A1 (en) 2016-08-24
CN102105792A (zh) 2011-06-22
US8597875B2 (en) 2013-12-03
WO2009153136A2 (en) 2009-12-23
CA2724247A1 (en) 2009-12-23
EP2286236A2 (en) 2011-02-23
JP2015038497A (ja) 2015-02-26

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2465 DE 03-04-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.