BRPI0912110A2 - métodos para diagnosticar a toxicidade do fígado, para determinar se um composto é capaz de induzir a toxicidade no fígado em um indivíduo, e para identificar uma substância para tratar toxicidade do fígado - Google Patents
métodos para diagnosticar a toxicidade do fígado, para determinar se um composto é capaz de induzir a toxicidade no fígado em um indivíduo, e para identificar uma substância para tratar toxicidade do fígadoInfo
- Publication number
- BRPI0912110A2 BRPI0912110A2 BRPI0912110A BRPI0912110A BRPI0912110A2 BR PI0912110 A2 BRPI0912110 A2 BR PI0912110A2 BR PI0912110 A BRPI0912110 A BR PI0912110A BR PI0912110 A BRPI0912110 A BR PI0912110A BR PI0912110 A2 BRPI0912110 A2 BR PI0912110A2
- Authority
- BR
- Brazil
- Prior art keywords
- liver toxicity
- identifying
- substance
- individual
- compound
- Prior art date
Links
- 231100000304 hepatotoxicity Toxicity 0.000 title 3
- 230000007056 liver toxicity Effects 0.000 title 3
- 150000001875 compounds Chemical class 0.000 title 1
- 230000001939 inductive effect Effects 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/08—Hepato-biliairy disorders other than hepatitis
- G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08157117 | 2008-05-28 | ||
| EP09151548 | 2009-01-28 | ||
| PCT/EP2009/056367 WO2009153136A2 (en) | 2008-05-28 | 2009-05-26 | Means and methods for assessing liver toxicity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0912110A2 true BRPI0912110A2 (pt) | 2015-10-06 |
Family
ID=41213188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0912110A BRPI0912110A2 (pt) | 2008-05-28 | 2009-05-26 | métodos para diagnosticar a toxicidade do fígado, para determinar se um composto é capaz de induzir a toxicidade no fígado em um indivíduo, e para identificar uma substância para tratar toxicidade do fígado |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8597875B2 (pt) |
| EP (2) | EP3059592A1 (pt) |
| JP (2) | JP2011522233A (pt) |
| CN (1) | CN102105792A (pt) |
| AU (1) | AU2009259540B2 (pt) |
| BR (1) | BRPI0912110A2 (pt) |
| CA (1) | CA2724247A1 (pt) |
| DE (1) | DE112009001234T5 (pt) |
| WO (1) | WO2009153136A2 (pt) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2724512A1 (en) * | 2008-05-28 | 2009-12-23 | Bennard Van Ravenzwaay | Means and methods for assessing liver enzyme induction |
| EP2464966A1 (en) * | 2009-08-13 | 2012-06-20 | Basf Se | Means and methods for diagnosingthyroid disorders |
| EP2507633A1 (en) * | 2009-12-01 | 2012-10-10 | Metanomics Health GmbH | Means and methods for diagnosing multiple sclerosis |
| EP2529235B1 (en) | 2010-01-29 | 2019-03-06 | Metanomics GmbH | Means and methods for diagnosing heart failure in a subject |
| AU2011260390B2 (en) * | 2010-06-01 | 2016-11-24 | Ernst-Moritz-Arndt Universitat Greifswald | Means and methods for diagnosing pancreatic cancer in a subject |
| WO2012000770A1 (en) * | 2010-06-10 | 2012-01-05 | Metanomics Health Gmbh | Methods to diagnose liver diseases |
| BR112014005472A2 (pt) * | 2011-09-13 | 2017-03-28 | Basf Se | método para diagnosticar toxidade hematopoiética, método para determinar se um composto é capaz de induzir toxidade hematopoiética em um indivíduo, método para identificar uma substância para tratar toxidade hematopoiética, uso pelo menos um biomarcador, dispositivo para diagnosticar toxidade hematopoiética em uma amostra de um indivíduo suspeito de sofrer da mesma e kit para diagnosticar toxidade hematopoiética |
| JP2014530350A (ja) * | 2011-09-14 | 2014-11-17 | ビーエーエスエフ ソシエタス・ヨーロピアBasf Se | 腎臓毒性を評価するための手段及び方法 |
| US20150018244A1 (en) * | 2012-03-09 | 2015-01-15 | Basf Se | Means and methods for assessing hyperthyroidism |
| EP2822455A4 (en) * | 2012-03-09 | 2015-12-09 | Basf Se | MEDIUM AND METHOD FOR ASSESSING LIVER DISORDERS |
| CN103364510B (zh) * | 2012-03-27 | 2015-01-07 | 中国科学院大连化学物理研究所 | Hplc-ms/ms结合代谢流量分析系统评估环境污染物细胞毒性的方法 |
| CN102749396B (zh) * | 2012-07-17 | 2013-10-23 | 陕西科技大学 | 一种气相色谱-质谱联用检测脂肪酸含量的方法 |
| CN103487412B (zh) * | 2013-09-30 | 2015-07-15 | 上海交通大学 | 一种酚类化合物肝毒性快速预测模型的构建方法 |
| CA2955204A1 (en) * | 2014-07-30 | 2016-02-04 | Metabolon, Inc. | Methods, compositions, and kits for analysis of structurally diverse complex lipids |
| CN104280477B (zh) * | 2014-11-03 | 2016-03-30 | 天津中医药大学 | 内源性小分子物质在快速检测肝毒性方面的应用 |
| CN107949635A (zh) * | 2015-03-20 | 2018-04-20 | 休雷尔公司 | 用于表征基于时间的肝毒性的方法 |
| CA3095403A1 (en) * | 2018-04-04 | 2019-10-10 | Metabolon, Inc. | Mass spectrometry assay method for detection and quantitation of liver function metabolites |
| US12009066B2 (en) | 2019-05-22 | 2024-06-11 | International Business Machines Corporation | Automated transitive read-behind analysis in big data toxicology |
| CN114813986B (zh) * | 2022-01-26 | 2024-04-16 | 北京市心肺血管疾病研究所 | 一组用于预测高危型扩张型心肌病的脂质代谢物组 |
| CN114441506B (zh) * | 2022-04-08 | 2022-06-21 | 港湾之星健康生物(深圳)有限公司 | 量子磁光传感器 |
| CN115128257B (zh) * | 2022-07-06 | 2025-02-18 | 南京医科大学 | 肝癌发病风险预测的代谢标志物及其应用 |
| CN116965376B (zh) * | 2023-07-17 | 2024-01-02 | 南方医科大学南方医院 | 一种子痫前期小鼠模型的构建方法与应用 |
| CN117929700A (zh) * | 2023-12-26 | 2024-04-26 | 无锡市妇幼保健院 | 棕榈酸作为检测靶点在制备icp辅助诊断试剂盒中的应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1837867A (en) * | 1926-05-08 | 1931-12-22 | Hilscher Curt | Hosiery knitting machine |
| US4540884A (en) | 1982-12-29 | 1985-09-10 | Finnigan Corporation | Method of mass analyzing a sample by use of a quadrupole ion trap |
| US5397894A (en) | 1993-05-28 | 1995-03-14 | Varian Associates, Inc. | Method of high mass resolution scanning of an ion trap mass spectrometer |
| JP2005526792A (ja) * | 2002-03-26 | 2005-09-08 | カウンシル オブ サイエンティフィク アンド インダストリアル リサーチ | アムラ(Emblicaofficinalis)のチトクロムP−450に関する肝毒性への肝臓治療効果 |
| US20110071767A1 (en) * | 2004-04-07 | 2011-03-24 | Ocimum Biosoluntions, Inc. | Hepatotoxicity Molecular Models |
| WO2005109006A1 (ja) * | 2004-04-23 | 2005-11-17 | Ajinomoto Co., Inc. | 非アルコール性脂肪肝炎鑑別方法 |
| US7860656B2 (en) * | 2005-02-03 | 2010-12-28 | Assistance Publique-Hopitaux De Paris (Ap-Hp) | Diagnosis method of hepatic steatosis using biochemical markers |
| PT1909561E (pt) | 2005-07-25 | 2010-05-06 | Basf Se | Método de apresentação e análise de uma população animal com um metaboloma essencialmente idêntico |
| EP1837657A1 (en) * | 2006-03-24 | 2007-09-26 | Metanomics GmbH | Means and method for predicting or diagnosing diabetes |
| WO2007110357A2 (en) * | 2006-03-24 | 2007-10-04 | Metanomics Gmbh | Means and method for diagnosing diabetes |
| EP3285072B1 (en) | 2006-08-08 | 2020-04-15 | Metabolon, Inc. | Markers of non-alcoholic fatty liver disease (nafld) and non-alcoholic steatohepatitis (nash) and methods of use thereof |
| US20080176266A1 (en) * | 2006-08-17 | 2008-07-24 | Alvin Berger | Biomarkers Of Metabolic Responses To Hepatotoxicants And Carcinogens |
| WO2008063783A2 (en) | 2006-10-13 | 2008-05-29 | Metabolon, Inc. | Biomarkers related to metabolic age and methods using the same |
| WO2009036376A1 (en) | 2007-09-13 | 2009-03-19 | University Of Hawaii | Fatty acid markers for the diagnosis, prognosis and management of cardiovascular disease |
| ES2402142T3 (es) | 2007-11-02 | 2013-04-29 | Metabolon, Inc. | Biomarcadores para la enfermedad del hígado graso y métodos que utilizan los mismos |
-
2009
- 2009-05-26 AU AU2009259540A patent/AU2009259540B2/en not_active Ceased
- 2009-05-26 CN CN2009801293149A patent/CN102105792A/zh active Pending
- 2009-05-26 BR BRPI0912110A patent/BRPI0912110A2/pt not_active IP Right Cessation
- 2009-05-26 WO PCT/EP2009/056367 patent/WO2009153136A2/en not_active Ceased
- 2009-05-26 CA CA2724247A patent/CA2724247A1/en not_active Abandoned
- 2009-05-26 EP EP16158939.5A patent/EP3059592A1/en not_active Withdrawn
- 2009-05-26 DE DE112009001234T patent/DE112009001234T5/de not_active Withdrawn
- 2009-05-26 EP EP09765716.7A patent/EP2286236B1/en not_active Not-in-force
- 2009-05-26 JP JP2011510987A patent/JP2011522233A/ja active Pending
- 2009-05-26 US US12/994,642 patent/US8597875B2/en not_active Expired - Fee Related
-
2014
- 2014-10-03 JP JP2014204451A patent/JP2015038497A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US8597875B2 (en) | 2013-12-03 |
| WO2009153136A2 (en) | 2009-12-23 |
| EP3059592A1 (en) | 2016-08-24 |
| US20110163226A1 (en) | 2011-07-07 |
| WO2009153136A3 (en) | 2010-03-18 |
| EP2286236A2 (en) | 2011-02-23 |
| CA2724247A1 (en) | 2009-12-23 |
| DE112009001234T5 (de) | 2011-04-28 |
| AU2009259540B2 (en) | 2015-11-05 |
| CN102105792A (zh) | 2011-06-22 |
| EP2286236B1 (en) | 2016-04-20 |
| JP2011522233A (ja) | 2011-07-28 |
| JP2015038497A (ja) | 2015-02-26 |
| AU2009259540A1 (en) | 2009-12-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2465 DE 03-04-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |