BRPI0915171A2 - Métodos para obter alta densidade de células viáveis em cultura de células de mamífero - Google Patents

Métodos para obter alta densidade de células viáveis em cultura de células de mamífero

Info

Publication number
BRPI0915171A2
BRPI0915171A2 BRPI0915171-0A BRPI0915171A BRPI0915171A2 BR PI0915171 A2 BRPI0915171 A2 BR PI0915171A2 BR PI0915171 A BRPI0915171 A BR PI0915171A BR PI0915171 A2 BRPI0915171 A2 BR PI0915171A2
Authority
BR
Brazil
Prior art keywords
methods
cell culture
high density
mammalian cell
obtain high
Prior art date
Application number
BRPI0915171-0A
Other languages
English (en)
Inventor
Haimanti Dorai
Yun Seung Kyung
Original Assignee
Centocor Ortho Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centocor Ortho Biotech Inc filed Critical Centocor Ortho Biotech Inc
Publication of BRPI0915171A2 publication Critical patent/BRPI0915171A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/34—Sugars
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/48—Regulators of apoptosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
BRPI0915171-0A 2008-06-13 2009-06-12 Métodos para obter alta densidade de células viáveis em cultura de células de mamífero BRPI0915171A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6123308P 2008-06-13 2008-06-13
PCT/US2009/047178 WO2009152413A1 (en) 2008-06-13 2009-06-12 Methods for obtaining high viable cell density in mammalian cell culture

Publications (1)

Publication Number Publication Date
BRPI0915171A2 true BRPI0915171A2 (pt) 2015-08-04

Family

ID=41417135

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0915171-0A BRPI0915171A2 (pt) 2008-06-13 2009-06-12 Métodos para obter alta densidade de células viáveis em cultura de células de mamífero

Country Status (17)

Country Link
US (1) US20090325287A1 (pt)
EP (1) EP2331678B1 (pt)
JP (1) JP2011524172A (pt)
KR (1) KR101648765B1 (pt)
CN (1) CN102083961B (pt)
AU (1) AU2009257336B2 (pt)
BR (1) BRPI0915171A2 (pt)
CA (1) CA2727006A1 (pt)
DK (1) DK2331678T3 (pt)
EA (1) EA019812B1 (pt)
ES (1) ES2557903T3 (pt)
IL (1) IL209516A0 (pt)
MX (1) MX2010013728A (pt)
SI (1) SI2331678T1 (pt)
UA (1) UA106047C2 (pt)
WO (1) WO2009152413A1 (pt)
ZA (1) ZA201100327B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2800728C (en) * 2010-05-28 2020-10-27 Genentech, Inc. Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase
RU2663794C2 (ru) * 2011-10-21 2018-08-09 Пфайзер Инк. Добавление железа для улучшения культивирования клеток
MX2015004516A (es) * 2012-10-10 2015-10-14 Bayer Healthcare Llc Procedimientos y sistemas para optimizar el sistema de cultivo de celulas de perfusion.
US11390663B2 (en) 2013-10-11 2022-07-19 Regeneron Pharmaceuticals, Inc. Metabolically optimized cell culture
KR102243980B1 (ko) * 2013-10-11 2021-04-26 리제너론 파마슈티칼스 인코포레이티드 대사적으로 최적화된 세포 배양
WO2015095809A1 (en) * 2013-12-20 2015-06-25 Biogen Idec Ma Inc. Use of perfusion seed cultures to improve biopharmaceutical fed-batch production capacity and product quality
EP3130661A4 (en) * 2014-04-07 2018-03-07 Toyo Seikan Group Holdings, Ltd. Culture liquid for animal cells, and culture vessel
GB201509040D0 (en) * 2015-05-27 2015-07-08 Oxford Genetics Ltd Cell lines
KR102290543B1 (ko) 2019-08-02 2021-08-18 주식회사 대양에스티 식판 담금형 애벌세척기
KR20220143108A (ko) * 2020-02-18 2022-10-24 베링거 인겔하임 인터내셔날 게엠베하 포유 동물 세포 배양 공정
RU2768735C1 (ru) * 2020-12-31 2022-03-24 Федеральное государственное бюджетное образовательное учреждение высшего образования «Московский государственный университет имени М.В.Ломоносова» (МГУ) Способ получения стабильной клеточной линии-продуцента рекомбинантных белков
WO2023194946A1 (en) * 2022-04-06 2023-10-12 Kashiv Biosciences, Llc An improved cell culture process for production of protein

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5672502A (en) 1985-06-28 1997-09-30 Celltech Therapeutics Limited Animal cell culture
EP1348758A1 (en) * 2002-03-28 2003-10-01 Boehringer Ingelheim Pharma GmbH & Co.KG Host cells having improved cell survival properties and methods to generate such cells
US7507579B2 (en) 2002-05-01 2009-03-24 Massachusetts Institute Of Technology Apparatus and methods for simultaneous operation of miniaturized reactors
US7531327B2 (en) * 2004-07-23 2009-05-12 Immunomedics, Inc. Methods and compositions for increasing longevity and protein yield from a cell culture
US20070092947A1 (en) * 2005-10-20 2007-04-26 Immunomedics, Inc. Methods and compositions for increasing longevity and protein yield from a cell culture
US20100167396A1 (en) * 2006-04-21 2010-07-01 Bayer Healthcare Llc Application of Anti-Apoptotic Gene Expression in Mammalian Cells for Perfusion Culture
WO2007136685A2 (en) * 2006-05-19 2007-11-29 Sangamo Biosciences, Inc. Methods and compositions for inactivation of dihydrofolate reductase
ES2657055T3 (es) * 2007-08-09 2018-03-01 Wyeth Llc Uso de perfusión para mejorar la producción de un cultivo de células alimentado por lotes en biorreactores

Also Published As

Publication number Publication date
MX2010013728A (es) 2011-01-14
EA201170024A1 (ru) 2011-08-30
WO2009152413A1 (en) 2009-12-17
CN102083961B (zh) 2014-06-25
UA106047C2 (uk) 2014-07-25
AU2009257336A1 (en) 2009-12-17
AU2009257336B2 (en) 2016-01-28
CN102083961A (zh) 2011-06-01
DK2331678T3 (en) 2015-10-12
KR101648765B1 (ko) 2016-08-17
SI2331678T1 (sl) 2015-12-31
ZA201100327B (en) 2012-06-27
EP2331678B1 (en) 2015-09-30
EP2331678A1 (en) 2011-06-15
EA019812B1 (ru) 2014-06-30
JP2011524172A (ja) 2011-09-01
EP2331678A4 (en) 2013-04-10
US20090325287A1 (en) 2009-12-31
IL209516A0 (en) 2011-01-31
CA2727006A1 (en) 2009-12-17
KR20110017911A (ko) 2011-02-22
ES2557903T3 (es) 2016-01-29

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]