BRPI0915171A2 - Métodos para obter alta densidade de células viáveis em cultura de células de mamífero - Google Patents

Métodos para obter alta densidade de células viáveis em cultura de células de mamífero

Info

Publication number
BRPI0915171A2
BRPI0915171A2 BRPI0915171-0A BRPI0915171A BRPI0915171A2 BR PI0915171 A2 BRPI0915171 A2 BR PI0915171A2 BR PI0915171 A BRPI0915171 A BR PI0915171A BR PI0915171 A2 BRPI0915171 A2 BR PI0915171A2
Authority
BR
Brazil
Prior art keywords
methods
cell culture
high density
mammalian cell
obtain high
Prior art date
Application number
BRPI0915171-0A
Other languages
English (en)
Inventor
Haimanti Dorai
Yun Seung Kyung
Original Assignee
Centocor Ortho Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centocor Ortho Biotech Inc filed Critical Centocor Ortho Biotech Inc
Publication of BRPI0915171A2 publication Critical patent/BRPI0915171A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/34—Sugars
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/48—Regulators of apoptosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
BRPI0915171-0A 2008-06-13 2009-06-12 Métodos para obter alta densidade de células viáveis em cultura de células de mamífero BRPI0915171A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6123308P 2008-06-13 2008-06-13
PCT/US2009/047178 WO2009152413A1 (en) 2008-06-13 2009-06-12 Methods for obtaining high viable cell density in mammalian cell culture

Publications (1)

Publication Number Publication Date
BRPI0915171A2 true BRPI0915171A2 (pt) 2015-08-04

Family

ID=41417135

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0915171-0A BRPI0915171A2 (pt) 2008-06-13 2009-06-12 Métodos para obter alta densidade de células viáveis em cultura de células de mamífero

Country Status (17)

Country Link
US (1) US20090325287A1 (pt)
EP (1) EP2331678B1 (pt)
JP (1) JP2011524172A (pt)
KR (1) KR101648765B1 (pt)
CN (1) CN102083961B (pt)
AU (1) AU2009257336B2 (pt)
BR (1) BRPI0915171A2 (pt)
CA (1) CA2727006A1 (pt)
DK (1) DK2331678T3 (pt)
EA (1) EA019812B1 (pt)
ES (1) ES2557903T3 (pt)
IL (1) IL209516A0 (pt)
MX (1) MX2010013728A (pt)
SI (1) SI2331678T1 (pt)
UA (1) UA106047C2 (pt)
WO (1) WO2009152413A1 (pt)
ZA (1) ZA201100327B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112012030197A2 (pt) 2010-05-28 2015-09-29 Genentech Inc diminuição do nível de lactato e aumento da produção de poliptídeo por subregulação da expressão de lactato desidrogenase e piruvato desidrogenase cinase.
SG11201401220SA (en) * 2011-10-21 2014-07-30 Pfizer Addition of iron to improve cell culture
CA2887581A1 (en) * 2012-10-10 2014-04-17 Bayer Healthcare Llc Methods and systems for optimizing perfusion cell culture system
US11390663B2 (en) 2013-10-11 2022-07-19 Regeneron Pharmaceuticals, Inc. Metabolically optimized cell culture
JP6663854B2 (ja) * 2013-10-11 2020-03-13 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 代謝が最適化された細胞培養
JP2017500017A (ja) * 2013-12-20 2017-01-05 バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． 生物薬剤フェドバッチ生産能力及び生産物品質を改善するための灌流シード培養の使用
KR20160127822A (ko) * 2014-04-07 2016-11-04 도요세이칸 그룹 홀딩스 가부시키가이샤 동물 세포용 배양액 및 배양 용기
GB201509040D0 (en) * 2015-05-27 2015-07-08 Oxford Genetics Ltd Cell lines
KR102290543B1 (ko) 2019-08-02 2021-08-18 주식회사 대양에스티 식판 담금형 애벌세척기
EP4107249A1 (en) * 2020-02-18 2022-12-28 Boehringer Ingelheim International GmbH Mammalian cell culture processes
RU2768735C1 (ru) * 2020-12-31 2022-03-24 Федеральное государственное бюджетное образовательное учреждение высшего образования «Московский государственный университет имени М.В.Ломоносова» (МГУ) Способ получения стабильной клеточной линии-продуцента рекомбинантных белков
EP4493710A4 (en) * 2022-04-06 2026-03-04 Kashiv Biosciences Llc An improved cell culture process for production of protein

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5672502A (en) * 1985-06-28 1997-09-30 Celltech Therapeutics Limited Animal cell culture
EP1348758A1 (en) * 2002-03-28 2003-10-01 Boehringer Ingelheim Pharma GmbH & Co.KG Host cells having improved cell survival properties and methods to generate such cells
US7507579B2 (en) 2002-05-01 2009-03-24 Massachusetts Institute Of Technology Apparatus and methods for simultaneous operation of miniaturized reactors
US7531327B2 (en) * 2004-07-23 2009-05-12 Immunomedics, Inc. Methods and compositions for increasing longevity and protein yield from a cell culture
US20070092947A1 (en) * 2005-10-20 2007-04-26 Immunomedics, Inc. Methods and compositions for increasing longevity and protein yield from a cell culture
WO2007124106A2 (en) * 2006-04-21 2007-11-01 Bayer Healthcare Llc Application of antl-apoptotic genes in mammalian cells for perfusion culture.
AU2007254251A1 (en) * 2006-05-19 2007-11-29 Sangamo Therapeutics, Inc. Methods and compositions for inactivation of dihydrofolate reductase
WO2009023562A2 (en) * 2007-08-09 2009-02-19 Wyeth Use of perfusion to enhance production of fed-batch cell culture in bioreactors

Also Published As

Publication number Publication date
IL209516A0 (en) 2011-01-31
AU2009257336B2 (en) 2016-01-28
SI2331678T1 (sl) 2015-12-31
WO2009152413A1 (en) 2009-12-17
KR20110017911A (ko) 2011-02-22
UA106047C2 (uk) 2014-07-25
KR101648765B1 (ko) 2016-08-17
EP2331678A1 (en) 2011-06-15
US20090325287A1 (en) 2009-12-31
CA2727006A1 (en) 2009-12-17
EA019812B1 (ru) 2014-06-30
MX2010013728A (es) 2011-01-14
CN102083961A (zh) 2011-06-01
EP2331678B1 (en) 2015-09-30
EP2331678A4 (en) 2013-04-10
ES2557903T3 (es) 2016-01-29
JP2011524172A (ja) 2011-09-01
CN102083961B (zh) 2014-06-25
AU2009257336A1 (en) 2009-12-17
ZA201100327B (en) 2012-06-27
EA201170024A1 (ru) 2011-08-30
DK2331678T3 (en) 2015-10-12

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]