BRPI0916735A2 - moduladores de tgr5 e métodos de uso do mesmo - Google Patents

moduladores de tgr5 e métodos de uso do mesmo

Info

Publication number
BRPI0916735A2
BRPI0916735A2 BRPI0916735A BRPI0916735A BRPI0916735A2 BR PI0916735 A2 BRPI0916735 A2 BR PI0916735A2 BR PI0916735 A BRPI0916735 A BR PI0916735A BR PI0916735 A BRPI0916735 A BR PI0916735A BR PI0916735 A2 BRPI0916735 A2 BR PI0916735A2
Authority
BR
Brazil
Prior art keywords
methods
tgr5 modulators
tgr5
modulators
Prior art date
Application number
BRPI0916735A
Other languages
English (en)
Inventor
Roberto Pellicciari
Original Assignee
Intercept Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40433897&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0916735(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Intercept Pharmaceuticals Inc filed Critical Intercept Pharmaceuticals Inc
Publication of BRPI0916735A2 publication Critical patent/BRPI0916735A2/pt
Publication of BRPI0916735B1 publication Critical patent/BRPI0916735B1/pt
Publication of BRPI0916735B8 publication Critical patent/BRPI0916735B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BRPI0916735A 2008-07-30 2009-07-30 compostos moduladores de tgr5, composições farmacêuticas compreendendo os mesmos e seus usos BRPI0916735B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08013676 2008-07-30
EP08013676.5 2008-07-30
PCT/US2009/052290 WO2010014836A2 (en) 2008-07-30 2009-07-30 Tgr5 modulators and methods of use thereof

Publications (3)

Publication Number Publication Date
BRPI0916735A2 true BRPI0916735A2 (pt) 2015-11-03
BRPI0916735B1 BRPI0916735B1 (pt) 2020-07-28
BRPI0916735B8 BRPI0916735B8 (pt) 2021-05-25

Family

ID=40433897

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0916735A BRPI0916735B8 (pt) 2008-07-30 2009-07-30 compostos moduladores de tgr5, composições farmacêuticas compreendendo os mesmos e seus usos

Country Status (8)

Country Link
US (2) US8796249B2 (pt)
EP (1) EP2324046B1 (pt)
CN (2) CN102164940B (pt)
AU (1) AU2009276507B2 (pt)
BR (1) BRPI0916735B8 (pt)
CA (1) CA2732323C (pt)
EA (1) EA020310B1 (pt)
WO (1) WO2010014836A2 (pt)

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HUE036887T2 (hu) * 2012-10-26 2018-08-28 Intercept Pharmaceuticals Inc Eljárás epesav-származékok elõállítására
SG11201503697TA (en) * 2012-11-28 2015-06-29 Intercept Pharmaceuticals Inc Treatment of pulmonary disease
WO2014200349A1 (en) 2013-06-13 2014-12-18 Fast Forward Pharmaceutical B.V. Cd40 signalling inhibitor and a further compound, wherein the further compound is a bile acid, a bile acid derivative, an tgr5-receptor agonist, an fxr agonist or a combination thereof, for the treatment of chronic inflammation, and the prevention of gastrointestinal cancer or fibrosis.
EP3027637B1 (en) 2013-08-01 2019-10-09 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services The glycine conjugate of beta-muricholic acid as an inhibitor of the farnesoid x receptor for the treatment of obesity, insulin resistance or non-alcoholic fatty liver disease
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HK1243930A1 (zh) 2014-11-06 2018-07-27 英安塔制药有限公司 作爲fxr/tgr5激动剂的胆汁酸类似物和其使用方法
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JP6698085B2 (ja) 2014-11-19 2020-05-27 エヌゼットピー ユーケー リミテッド ステロイドＦＸＲモジュレーター製造のための中間体としての６α−アルキル−６，７−ジオン−ステロイド
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US10208081B2 (en) 2014-11-26 2019-02-19 Enanta Pharmaceuticals, Inc. Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
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WO2024110621A1 (en) 2022-11-25 2024-05-30 Danmarks Tekniske Universitet Treatment of milk samples for improved analysis
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Also Published As

Publication number Publication date
HK1217335A1 (zh) 2017-01-06
CN105037476B (zh) 2018-06-12
EP2324046A2 (en) 2011-05-25
WO2010014836A2 (en) 2010-02-04
AU2009276507A1 (en) 2010-02-04
CN102164940B (zh) 2015-08-19
US20160052956A1 (en) 2016-02-25
US8796249B2 (en) 2014-08-05
US20110172198A1 (en) 2011-07-14
EA020310B1 (ru) 2014-10-30
WO2010014836A3 (en) 2010-04-01
EP2324046B1 (en) 2014-09-03
CN102164940A (zh) 2011-08-24
AU2009276507B2 (en) 2015-11-19
CN105037476A (zh) 2015-11-11
BRPI0916735B8 (pt) 2021-05-25
BRPI0916735B1 (pt) 2020-07-28
CA2732323A1 (en) 2010-02-04
EA201170276A1 (ru) 2011-10-31
CA2732323C (en) 2017-06-27
HK1158212A1 (en) 2012-07-13
US9540414B2 (en) 2017-01-10

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B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
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B16C Correction of notification of the grant [chapter 16.3 patent gazette]

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Owner name: INTERCEPT PHARMACEUTICALS, INC. (US)

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B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2733 DE 23-05-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.