IT1212835B - Derivati di acidi biliari, procedimento per la loro preparazione e relative composizioni farmaceutiche. - Google Patents

Derivati di acidi biliari, procedimento per la loro preparazione e relative composizioni farmaceutiche.

Info

Publication number
IT1212835B
IT1212835B IT8322572A IT2257283A IT1212835B IT 1212835 B IT1212835 B IT 1212835B IT 8322572 A IT8322572 A IT 8322572A IT 2257283 A IT2257283 A IT 2257283A IT 1212835 B IT1212835 B IT 1212835B
Authority
IT
Italy
Prior art keywords
procedure
preparation
pharmaceutical compositions
acid derivatives
related pharmaceutical
Prior art date
Application number
IT8322572A
Other languages
English (en)
Other versions
IT8322572A0 (it
Inventor
Virginio Castagnola
Giuliano E Frigerio
Roberto Pellicciari
Aldo Roda
Original Assignee
Lehner Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lehner Ag filed Critical Lehner Ag
Priority to IT8322572A priority Critical patent/IT1212835B/it
Publication of IT8322572A0 publication Critical patent/IT8322572A0/it
Priority to AT84109811T priority patent/ATE50583T1/de
Priority to DE8484109811T priority patent/DE3481419D1/de
Priority to EP84109811A priority patent/EP0135782B1/en
Priority to JP59171376A priority patent/JPH0144197B2/ja
Priority to ES535267A priority patent/ES535267A0/es
Priority to US07/415,614 priority patent/US4981983A/en
Application granted granted Critical
Publication of IT1212835B publication Critical patent/IT1212835B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
IT8322572A 1983-08-18 1983-08-18 Derivati di acidi biliari, procedimento per la loro preparazione e relative composizioni farmaceutiche. IT1212835B (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
IT8322572A IT1212835B (it) 1983-08-18 1983-08-18 Derivati di acidi biliari, procedimento per la loro preparazione e relative composizioni farmaceutiche.
AT84109811T ATE50583T1 (de) 1983-08-18 1984-08-17 Gallensaeure-derivate, verfahren zu ihrer herstellung und pharmazeutische praeparate, die sie enthalten.
DE8484109811T DE3481419D1 (de) 1983-08-18 1984-08-17 Gallensaeure-derivate, verfahren zu ihrer herstellung und pharmazeutische praeparate, die sie enthalten.
EP84109811A EP0135782B1 (en) 1983-08-18 1984-08-17 New derivatives of biliary acids, process for the production thereof and corresponding pharmaceutical compositions
JP59171376A JPH0144197B2 (en) 1983-08-18 1984-08-17 Gallic acid derivatives, manufacture and pharmaceutical composition
ES535267A ES535267A0 (es) 1983-08-18 1984-08-17 Un procedimiento para la preparacion de compuestos
US07/415,614 US4981983A (en) 1983-08-18 1989-10-02 Derivatives of biliary acids, process for the production thereof and corresponding pharmaceutical compositions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8322572A IT1212835B (it) 1983-08-18 1983-08-18 Derivati di acidi biliari, procedimento per la loro preparazione e relative composizioni farmaceutiche.

Publications (2)

Publication Number Publication Date
IT8322572A0 IT8322572A0 (it) 1983-08-18
IT1212835B true IT1212835B (it) 1989-11-30

Family

ID=11197972

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8322572A IT1212835B (it) 1983-08-18 1983-08-18 Derivati di acidi biliari, procedimento per la loro preparazione e relative composizioni farmaceutiche.

Country Status (7)

Country Link
US (1) US4981983A (it)
EP (1) EP0135782B1 (it)
JP (1) JPH0144197B2 (it)
AT (1) ATE50583T1 (it)
DE (1) DE3481419D1 (it)
ES (1) ES535267A0 (it)
IT (1) IT1212835B (it)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1196377B (it) * 1984-12-21 1988-11-16 Lehner Ag Derivati di acidi biliari,procedimento per la loro preparazione e relative composizioni farmaceutiche
HU206367B (en) * 1988-04-30 1992-10-28 Sandoz Ag Process for producing acid addition salts of steroid carboxylic acid-amidated taurine and glycine, as well as pharmaceutical compositions comprising such salts
IT1255449B (it) * 1992-06-30 1995-10-31 Fabio Berlati Uso di nor- e omo-derivati di acidi biliari come promotori di assorbimento di farmaci.
IT1270853B (it) * 1993-05-20 1997-05-13 Sanofi Elf Procedimento per la preparazione di derivati taurocolanici
US6350738B1 (en) 1998-03-06 2002-02-26 Brigham Young University Steroid derived antibiotics
US6767904B2 (en) 1998-03-06 2004-07-27 Bringham Young University Steroid derived antibiotics
ATE303399T1 (de) 2001-03-12 2005-09-15 Intercept Pharmaceuticals Inc Steroide als agonisten für fxr
US10987362B2 (en) 2004-03-12 2021-04-27 Intercept Pharmaceuticals, Inc. Treatment of fibrosis using FXR ligands
PL1734970T3 (pl) 2004-03-12 2015-05-29 Intercept Pharmaceuticals Inc Leczenie zwłóknienia z zastosowaniem ligandów FXR
ITMI20050912A1 (it) 2005-05-19 2006-11-20 Erregierre Spa Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici
JP5292310B2 (ja) * 2007-01-19 2013-09-18 インターセプト ファーマシューティカルズ， インコーポレイテッド Ｔｇｒ５調節剤としての２３−置換胆汁酸およびその使用方法
EP1947108A1 (en) * 2007-01-19 2008-07-23 Intercept Pharmaceuticals, Inc. TGR5 modulators and methods of use thereof
EA020310B1 (ru) 2008-07-30 2014-10-30 Интерсепт Фармасьютикалз, Инк. Модуляторы рецептора tgr5 и их применение
ES2663948T3 (es) 2008-11-19 2018-04-17 Intercept Pharmaceuticals, Inc. Moduladores de TGR5 y método de uso de los mismos
PT3336097T (pt) 2012-06-19 2020-10-29 Intercept Pharmaceuticals Inc Preparação da forma não cristalina de ácido obeticólico
US9982008B2 (en) 2012-06-19 2018-05-29 Intercept Pharmaceuticals, Inc. Preparation and uses of obeticholic acid
US20140206657A1 (en) * 2013-01-18 2014-07-24 City Of Hope Bile acid analog tgr5 agonists

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3997664A (en) * 1971-02-09 1976-12-14 Sandoz, Inc. Substituted carbinol derivatives
US4104285A (en) * 1977-04-22 1978-08-01 Hoffmann-La Roche Inc. Taurine and glycine derivatives
US4117121A (en) * 1977-04-22 1978-09-26 Hoffmann-La Roche Inc. Method of increasing bile flow and decreasing lipid levels
NL8003999A (nl) * 1980-07-11 1982-02-01 Akzo Nv Nieuwe 8 alfa-oestra-1,3,5(10)-trieen-derivaten en de bereiding daarvan.
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
DE3260462D1 (en) * 1981-05-29 1984-08-30 Glaxo Group Ltd 11-alpha-amino-androstanes
AU8428582A (en) * 1981-05-29 1982-12-02 Glaxo Group Limited 11-alpha-amino androstanes
FR2522328B1 (fr) * 1982-03-01 1986-02-14 Roussel Uclaf Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments
EP0101554B1 (en) * 1982-07-29 1986-10-15 Lehner A.G. New derivatives of biliary acids, process for the production thereof and pharmaceutical compositions containing the same
FR2610933B1 (fr) * 1987-02-18 1989-06-09 Roussel Uclaf Nouveaux 19-nor steroides substitues en position 7, leur preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant

Also Published As

Publication number Publication date
JPH0144197B2 (en) 1989-09-26
EP0135782A3 (en) 1985-12-11
ATE50583T1 (de) 1990-03-15
IT8322572A0 (it) 1983-08-18
ES8506047A1 (es) 1985-06-16
DE3481419D1 (de) 1990-04-05
ES535267A0 (es) 1985-06-16
US4981983A (en) 1991-01-01
JPS6075495A (ja) 1985-04-27
EP0135782A2 (en) 1985-04-03
EP0135782B1 (en) 1990-02-28

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Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19960731