ECSP10010558A - Tiazolopiridin-2-iloxi-fenil y tiazolopirazin-2-iloxi-fenil aminas como moduladores de la leucotrieno a4 hidrolasa - Google Patents

Tiazolopiridin-2-iloxi-fenil y tiazolopirazin-2-iloxi-fenil aminas como moduladores de la leucotrieno a4 hidrolasa

Info

Publication number: ECSP10010558A
Authority: EC; Ecuador
Prior art keywords: iloxi; fenil; tiazolopiridin; tiazolopirazin; hydrolass
Prior art date: 2008-04-11

Application number

EC2010010558A

Other languages

English (en)

Inventor

Cheryl A Grice

Xiaohu Deng

Jimmy T Liang

Neelakandha Mani

Anne M Fourie

Laurent Gomez

Aaron M Kearney

Genesis M Bacani

Diego Broggini

Eugene Y Cheung

Christa C Chrovian

Adrienne M Landry-Bayle

Alice Lee-Dutra

Alejandro Santillan Jr

Kathleen C Sappey

Kia Sepassi

Virginia M Tanis

Alvah T Wickboldt

John J M Weiner

Hartmut Zinser

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-04-11

Filing date

2010-10-20

Publication date

2010-11-30

2010-10-20 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2010-11-30 Publication of ECSP10010558A publication Critical patent/ECSP10010558A/es

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P17/04—Antipruritics
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- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Immunology (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Physical Education & Sports Medicine (AREA)
Neurology (AREA)
Cardiology (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Gastroenterology & Hepatology (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Neurosurgery (AREA)
Oncology (AREA)
Vascular Medicine (AREA)
Communicable Diseases (AREA)
Urology & Nephrology (AREA)
Ophthalmology & Optometry (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

EC2010010558A 2008-04-11 2010-10-20 Tiazolopiridin-2-iloxi-fenil y tiazolopirazin-2-iloxi-fenil aminas como moduladores de la leucotrieno a4 hidrolasa ECSP10010558A (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US4434908P	2008-04-11	2008-04-11
US14912909P	2009-02-02	2009-02-02

Publications (1)

Publication Number	Publication Date
ECSP10010558A true ECSP10010558A (es)	2010-11-30

Family

ID=41130551

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EC2010010558A ECSP10010558A (es)	2008-04-11	2010-10-20	Tiazolopiridin-2-iloxi-fenil y tiazolopirazin-2-iloxi-fenil aminas como moduladores de la leucotrieno a4 hidrolasa

Country Status (35)

Country	Link
US (3)	US7939527B2 (es)
EP (2)	EP2336125B1 (es)
JP (2)	JP5530423B2 (es)
KR (1)	KR101228378B1 (es)
CN (1)	CN102056933B (es)
AR (1)	AR072353A1 (es)
AU (1)	AU2009234140B2 (es)
BR (1)	BRPI0911336A2 (es)
CA (1)	CA2721099C (es)
CL (1)	CL2009000877A1 (es)
CO (1)	CO6260069A2 (es)
CY (1)	CY1114628T1 (es)
DK (2)	DK2268646T3 (es)
EA (1)	EA018802B1 (es)
EC (1)	ECSP10010558A (es)
ES (2)	ES2440746T3 (es)
HN (1)	HN2010002074A (es)
HR (2)	HRP20131192T1 (es)
IL (2)	IL208480A (es)
JO (1)	JO2911B1 (es)
MX (1)	MX2010011154A (es)
MY (1)	MY157597A (es)
NI (1)	NI201000168A (es)
NZ (2)	NZ599853A (es)
PE (1)	PE20091779A1 (es)
PH (1)	PH12013500094A1 (es)
PL (2)	PL2336125T3 (es)
PT (2)	PT2336125E (es)
RS (2)	RS53081B (es)
SI (2)	SI2336125T1 (es)
SV (1)	SV2010003694A (es)
TW (2)	TWI461196B (es)
UY (1)	UY31760A (es)
WO (1)	WO2009126806A2 (es)
ZA (1)	ZA201008054B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL1976828T3 (pl)	2005-12-29	2017-07-31	Celtaxsys, Inc.	Pochodne diaminy jako inhibitory hydrolazy leukotrienu a4
EP2336125B1 (en) *	2008-04-11	2013-01-09	Janssen Pharmaceutica N.V.	Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase
JP6080226B2 (ja)	2012-03-06	2017-02-15	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	他の活性物質と組み合わせたロイコトリエン産生阻害用ベンゾジオキサン
AR091315A1 (es) *	2012-03-06	2015-01-28	Boehringer Ingelheim Int	Inhibidores de benzodioxano de la produccion de leucotrieno
US9403830B2 (en)	2012-07-17	2016-08-02	Boehringer Ingelheim International Gmbh	Inhibitors of leukotriene production
EP2746260A1 (en)	2012-12-21	2014-06-25	Basf Se	Substituted [1,2,4]triazole and imidazole compounds
EP2746259A1 (en)	2012-12-21	2014-06-25	Basf Se	Substituted [1,2,4]triazole and imidazole compounds
JP6527851B2 (ja)	2013-03-12	2019-06-05	セルタクシス，インコーポレイテッド	ロイコトリエンａ４加水分解酵素を阻害する方法
AU2014239585B2 (en) *	2013-03-14	2019-04-04	Celtaxsys, Inc.	Inhibitors of leukotriene A4 hydrolase
EP2968264A4 (en)	2013-03-14	2016-11-02	Celtaxsys Inc	INHIBITORS OF LEUCOTRIENE A4 HYDROLASE
CA3102077A1 (en)	2018-05-31	2019-12-05	Sanjeev AHUJA	Method of reducing pulmonary exacerbations in respiratory disease patients
SG11202107080VA (en) *	2019-01-11	2021-07-29	Naegis Pharmaceuticals Inc	Leukotriene synthesis inhibitors

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5008A (en) *		1847-03-13		Machinery for cleaning
IL59004A0 (en) *	1978-12-30	1980-03-31	Beecham Group Ltd	Substituted benzamides their preparation and pharmaceutical compositions containing them
US4329466A (en)	1979-01-16	1982-05-11	Delalande S.A.	Certain nor-tropan-8-amine-3-aryl or heteroaryl derivatives
US4424358A (en)	1979-01-16	1984-01-03	Delalande S.A.	β-3-Amino nor-tropane compounds
US4321378A (en) *	1979-01-16	1982-03-23	Delalande S.A.	8-(5-Pyrimidinecarboxamide)nor-tropane derivatives
FR2476088A2 (fr)	1979-01-16	1981-08-21	Delalande Sa	Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique
FR2446823A1 (fr)	1979-01-16	1980-08-14	Delalande Sa	Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique
US4352802A (en)	1980-06-10	1982-10-05	Beecham Group Limited	Bicyclo[3.3.1]nonyl-benzamide
NZ199080A (en)	1980-12-12	1984-07-31	Beecham Group Ltd	2-alkoxy-4-amino-5-alkylsulphonyl-n-(3beta-(8-hydrocarbyl-8-azabicyclo (3,2,1)octyl))benzamides
US4432983A (en) *	1981-04-30	1984-02-21	Research Corporation	Conformationally restricted histamine H2 -receptor antagonists containing a tropane ring
DE3137996A1 (de) *	1981-09-24	1983-04-28	Hoechst Ag, 6230 Frankfurt	Heterocyclische phenylaether, verfahren zu deren herstellung und diese enthaltende herbizide mittel
US4571396A (en) *	1984-04-16	1986-02-18	Warner-Lambert Company	Antibacterial agents
US4873346A (en) *	1985-09-20	1989-10-10	The Upjohn Company	Substituted benzothiazoles, benzimidazoles, and benzoxazoles
NZ222047A (en)	1986-10-08	1991-01-29	Bristol Myers Co	Quinoline - or naphthyridine - carboxylic acid anti-bacterial agents
CA1319144C (en) *	1986-11-14	1993-06-15	Quirico Branca	Tetrahydronaphthalene derivatives
JPS63170356A (ja)	1986-12-30	1988-07-14	Yamanouchi Pharmaceut Co Ltd	アニリン誘導体及びその製造法
FI91859C (fi) *	1987-06-17	1994-08-25	Eisai Co Ltd	Analogiamenetelmä antiallergisena aineena aktiivisen bentsotiatsolijohdannaisen valmistamiseksi
US5070094A (en)	1989-09-05	1991-12-03	G. D. Searle & Co.	N-benzyltropaneamides
US5220063A (en) *	1991-05-10	1993-06-15	Hoechst Celanese Corporation	Method for the preparation of arylalkanolacylamides
US5296486A (en) *	1991-09-24	1994-03-22	Boehringer Ingelheim Pharmaceuticals, Inc.	Leukotriene biosynthesis inhibitors
US5472964A (en) *	1992-12-22	1995-12-05	Merck Frosst Canada, Inc.	Diaryl 5,6-fused heterocyclic acids as leukotriene antagonists
TW251287B (es)	1993-04-30	1995-07-11	Nissei Co Ltd
US5585492A (en)	1994-10-11	1996-12-17	G. D. Searle & Co.	LTA4 Hydrolase inhibitors
US6506876B1 (en)	1994-10-11	2003-01-14	G.D. Searle & Co.	LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use
US5700816A (en)	1995-06-12	1997-12-23	Isakson; Peter C.	Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor
US6632976B1 (en) *	1995-08-29	2003-10-14	Kirin Beer Kabushiki Kaisha	Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene
US5794887A (en)	1995-11-17	1998-08-18	Komerath; Narayanan M.	Stagnation point vortex controller
PT880363E (pt) *	1996-02-13	2002-12-31	Searle & Co	Combinacoes com efeitos imunossupressores cntendo um inibidor da ciclooxigenase-2 e um inibidor da hidrolase do leucotrieno a4
US6110994A (en) *	1996-06-14	2000-08-29	Cabot Corporation	Polymeric products containing modified carbon products and methods of making and using the same
US6110944A (en)	1997-03-12	2000-08-29	G. D. Searle & Co.	LTA4, hydrolase inhibitors
US6632823B1 (en)	1997-12-22	2003-10-14	Merck & Co., Inc.	Substituted pyridine compounds useful as modulators of acetylcholine receptors
US6432976B1 (en)	1999-10-29	2002-08-13	Merck & Co., Inc.	8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists
US6559140B2 (en)	2000-03-09	2003-05-06	Abbott Laboratories	Cyclic and bicyclic diamino histamine-3 receptor antagonists
MY145722A (en)	2000-04-27	2012-03-30	Abbott Lab	Diazabicyclic central nervous system active agents
FR2831884B1 (fr) *	2001-11-02	2003-12-26	Pf Medicament	Nouveaux derives amides heteroaromatiques de 3 beta-amino azabicyclooctane, leur procede de preparation et leurs applications en therapeutique
US7152144B2 (en) *	2002-05-29	2006-12-19	Hitachi, Ltd.	Centralized storage management method
US7329682B2 (en) *	2003-04-03	2008-02-12	Ewha University-Industry Collaboration Foundation	Method for inhibiting 5-lipoxygenase using a benzoxazole derivative
SE0301373D0 (sv) *	2003-05-09	2003-05-09	Astrazeneca Ab	Novel compounds
EP1626713A2 (en)	2003-05-16	2006-02-22	Ambit Biosciences Corporation	Heterocyclic compounds and uses thereof
UA87986C2 (uk) *	2003-07-28	2009-09-10	Янссен Фармацевтика Н.В.	Бензімідазольні, бензтіазольні та бензоксазольні похідні і їх застосування як lta4h модуляторів
US7825109B2 (en) *	2003-08-29	2010-11-02	Ono Pharmaceutical Co., Ltd.	Compound capable of binding S1P receptor and pharmaceutical use thereof
US7435831B2 (en) *	2004-03-03	2008-10-14	Chemocentryx, Inc.	Bicyclic and bridged nitrogen heterocycles
TW200610761A (en)	2004-04-23	2006-04-01	Astrazeneca Ab	Chemical compounds
JP2008503585A (ja)	2004-06-22	2008-02-07	シェーリング　コーポレイション	カンナビノイドレセプターリガンド
GB2415818B (en)	2004-06-30	2008-12-31	Autoliv Dev	Arrangement for triggering a vehicle safety device
KR101231466B1 (ko)	2004-09-13	2013-02-07	오노 야꾸힝 고교 가부시키가이샤	질소 함유 복소환 유도체 및 이들을 유효 성분으로 하는약제
JP2008536825A (ja) *	2005-03-31	2008-09-11	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	フェニルおよびピリジルｌｔａ４ｈモジュレータ
ES2277745B1 (es)	2005-06-14	2008-06-01	Laboratorios Almirall S.A.	Derivados n-amida de 8-azabiciclo /3.2.1/oct-3-ilo como antagonistas de ccr1.
GB0514018D0 (en)	2005-07-07	2005-08-17	Ionix Pharmaceuticals Ltd	Chemical compounds
PL1976828T3 (pl) *	2005-12-29	2017-07-31	Celtaxsys, Inc.	Pochodne diaminy jako inhibitory hydrolazy leukotrienu a4
US20090156465A1 (en)	2005-12-30	2009-06-18	Sattigeri Jitendra A	Derivatives of beta-amino acid as dipeptidyl peptidase-iv inhibitors
CA2659512C (en)	2006-06-06	2015-09-08	Critical Therapeutics, Inc.	Novel piperazines, pharmaceutical compositions and methods of use thereof
WO2008016811A2 (en)	2006-07-31	2008-02-07	Neurogen Corporation	Aminopiperidines and realted compounds
CA2673566A1 (en) *	2006-12-19	2008-06-26	Auspex Pharmaceuticals, Inc.	Preparation and utility of ccr5 inhibitors
TW200906396A (en) *	2007-02-14	2009-02-16	Janssen Pharmaceutica Nv	LTA4H modulators and uses thereof
PE20091017A1 (es) *	2007-10-31	2009-07-16	Janssen Pharmaceutica Nv	Diaminas en puente o fusionadas sustituidas con arilo como moduladores de leucotrieno a4 hidrolasa
EP2336125B1 (en)	2008-04-11	2013-01-09	Janssen Pharmaceutica N.V.	Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase

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Publication number	Publication date
HRP20130278T1 (en)	2013-06-30
PH12013500094B1 (en)	2015-02-23
CO6260069A2 (es)	2011-03-22
US20110159563A1 (en)	2011-06-30
SV2010003694A (es)	2011-03-17
PT2268646E (pt)	2013-12-10
NI201000168A (es)	2015-05-27
EP2268646B9 (en)	2014-11-19
TW201420100A (zh)	2014-06-01
SI2336125T1 (sl)	2013-04-30
JP2011516571A (ja)	2011-05-26
MY157597A (en)	2016-06-30
ES2400875T3 (es)	2013-04-15
DK2336125T3 (da)	2013-04-08
PE20091779A1 (es)	2009-11-14
WO2009126806A3 (en)	2010-03-18
AU2009234140B2 (en)	2013-04-11
US8357684B2 (en)	2013-01-22
WO2009126806A2 (en)	2009-10-15
CA2721099C (en)	2017-04-25
JO2911B1 (en)	2015-09-15
CY1114628T1 (el)	2016-10-05
PH12013500094A1 (en)	2015-02-23
CL2009000877A1 (es)	2009-11-27
US20090258854A1 (en)	2009-10-15
NZ588341A (en)	2012-06-29
JP2014144949A (ja)	2014-08-14
EA201071186A1 (ru)	2011-06-30
CN102056933B (zh)	2014-09-17
KR20110013386A (ko)	2011-02-09
CA2721099A1 (en)	2009-10-15
EA018802B1 (ru)	2013-10-30
HK1158208A1 (en)	2012-07-13
IL208480A (en)	2014-11-30
HK1152041A1 (en)	2012-02-17
AR072353A1 (es)	2010-08-25
SI2268646T1 (sl)	2013-12-31
UY31760A (es)	2009-11-10
HRP20131192T1 (hr)	2014-01-17
RS52712B (sr)	2013-08-30
CN102056933A (zh)	2011-05-11
JP5530423B2 (ja)	2014-06-25
ZA201008054B (en)	2012-04-25
BRPI0911336A2 (pt)	2021-06-29
TW201002320A (en)	2010-01-16
IL208480A0 (en)	2010-12-30
JP5675943B2 (ja)	2015-02-25
MX2010011154A (es)	2010-12-21
IL226244A (en)	2014-12-31
AU2009234140A1 (en)	2009-10-15
RS53081B (sr)	2014-06-30
PL2268646T3 (pl)	2014-02-28
EP2336125A1 (en)	2011-06-22
ES2440746T3 (es)	2014-01-30
EP2268646B1 (en)	2013-10-02
WO2009126806A8 (en)	2010-11-18
KR101228378B1 (ko)	2013-01-31
US20110190503A1 (en)	2011-08-04
IL226244A0 (en)	2013-06-27
TWI461196B (zh)	2014-11-21
US7939527B2 (en)	2011-05-10
NZ599853A (en)	2012-08-31
EP2336125B1 (en)	2013-01-09
DK2268646T3 (da)	2013-11-18
HN2010002074A (es)	2012-12-03
EP2268646A2 (en)	2011-01-05
PL2336125T3 (pl)	2013-06-28
PT2336125E (pt)	2013-03-18

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