BRPI0917017A2 - inibidores de pirrol de s-nitrosoglutationa redutase como agentes terapêuticos - Google Patents

inibidores de pirrol de s-nitrosoglutationa redutase como agentes terapêuticos

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Publication number
BRPI0917017A2
BRPI0917017A2 BRPI0917017A BRPI0917017A BRPI0917017A2 BR PI0917017 A2 BRPI0917017 A2 BR PI0917017A2 BR PI0917017 A BRPI0917017 A BR PI0917017A BR PI0917017 A BRPI0917017 A BR PI0917017A BR PI0917017 A2 BRPI0917017 A2 BR PI0917017A2
Authority
BR
Brazil
Prior art keywords
pyrrolase
inhibitors
therapeutic agents
nitrosoglutathione reductase
nitrosoglutathione
Prior art date
Application number
BRPI0917017A
Other languages
English (en)
Inventor
Gary J Rosenthal
Jan Wasley
Jian Qiu
Sarah Strong
Xicheng Sun
Original Assignee
N30 Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by N30 Pharmaceuticals Llc filed Critical N30 Pharmaceuticals Llc
Publication of BRPI0917017A2 publication Critical patent/BRPI0917017A2/pt
Publication of BRPI0917017B1 publication Critical patent/BRPI0917017B1/pt
Publication of BRPI0917017B8 publication Critical patent/BRPI0917017B8/pt

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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HUE031580T2 (en) 2017-07-28
IL211056A (en) 2014-04-30
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ZA201100966B (en) 2012-04-25
US9498466B2 (en) 2016-11-22
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US9180119B2 (en) 2015-11-10
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US8673961B2 (en) 2014-03-18
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WO2010019910A1 (en) 2010-02-18
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