BRPI0917370A2 - anticorpos anti-il-13 manipulados, composições, métodos e usos. - Google Patents

anticorpos anti-il-13 manipulados, composições, métodos e usos.

Info

Publication number
BRPI0917370A2
BRPI0917370A2 BRPI0917370A BRPI0917370A BRPI0917370A2 BR PI0917370 A2 BRPI0917370 A2 BR PI0917370A2 BR PI0917370 A BRPI0917370 A BR PI0917370A BR PI0917370 A BRPI0917370 A BR PI0917370A BR PI0917370 A2 BRPI0917370 A2 BR PI0917370A2
Authority
BR
Brazil
Prior art keywords
antibodies
compositions
methods
engineered anti
engineered
Prior art date
Application number
BRPI0917370A
Other languages
English (en)
Inventor
Alexey V Teplyakov
Ellen Chi
Gopalan Raghunathan
Hong Mimi Zhou
Jill Giles-Komar
Jill M Carton
Johann Fransson
Juan C Almagro
Karyn T O'neil
Linus Hyun
Ronald V Swanson
Shanrong Zhao
Wendy Cordier
Yiqing Feng
Original Assignee
Centocor Ortho Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centocor Ortho Biotech Inc filed Critical Centocor Ortho Biotech Inc
Publication of BRPI0917370A2 publication Critical patent/BRPI0917370A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
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    • G—PHYSICS
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    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/5437—IL-13

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  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Immunology (AREA)
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  • Diabetes (AREA)
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  • Neurology (AREA)
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  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Addiction (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
BRPI0917370A 2008-08-20 2009-08-11 anticorpos anti-il-13 manipulados, composições, métodos e usos. BRPI0917370A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9047208P 2008-08-20 2008-08-20
US9723208P 2008-09-16 2008-09-16
PCT/US2009/053425 WO2010021874A2 (en) 2008-08-20 2009-08-11 Engineered anti-il-13 antibodies, compositions, methods and uses

Publications (1)

Publication Number Publication Date
BRPI0917370A2 true BRPI0917370A2 (pt) 2015-11-17

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Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0917370A BRPI0917370A2 (pt) 2008-08-20 2009-08-11 anticorpos anti-il-13 manipulados, composições, métodos e usos.

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US (2) US8399630B2 (pt)
EP (1) EP2328615A2 (pt)
JP (2) JP2012506695A (pt)
KR (1) KR20110043786A (pt)
CN (1) CN102264391A (pt)
AR (1) AR073088A1 (pt)
AU (1) AU2009283008A1 (pt)
BR (1) BRPI0917370A2 (pt)
CA (1) CA2734645A1 (pt)
CO (1) CO6341573A2 (pt)
CR (1) CR20110152A (pt)
EA (1) EA201170357A1 (pt)
EC (1) ECSP11010840A (pt)
IL (1) IL211087A0 (pt)
MX (1) MX2011001909A (pt)
NI (1) NI201100040A (pt)
NZ (1) NZ591098A (pt)
UY (1) UY32060A (pt)
WO (1) WO2010021874A2 (pt)
ZA (1) ZA201102081B (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
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US7306925B2 (en) 2001-11-09 2007-12-11 Vanderbilt University Phage antibodies to radiation-inducible neoantigens
US7906102B2 (en) 2001-10-03 2011-03-15 Vanderbilt University Ligands to radiation-induced molecules
EP2328615A2 (en) * 2008-08-20 2011-06-08 Centocor Ortho Biotech Inc. Engineered anti-il-13 antibodies, compositions, methods and uses
GB0904214D0 (en) 2009-03-11 2009-04-22 Ucb Pharma Sa Biological products
US8580714B2 (en) * 2009-10-14 2013-11-12 Janssen Biotech, Inc. Methods of affinity maturing antibodies
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