BRPI0917661A2 - produto que contém macitentan, composição farmacêutica que o contém e uso de macitentan - Google Patents

produto que contém macitentan, composição farmacêutica que o contém e uso de macitentan

Info

Publication number: BRPI0917661A2
Authority: BR; Brazil
Prior art keywords: macitentan; pharmaceutical composition; composition containing; product containing; product
Prior art date: 2008-08-13

Application number

BRPI0917661A

Other languages

English (en)

Inventor

Martine Clozel

Original Assignee

Actelion Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-08-13

Filing date

2009-08-12

Publication date

2015-12-01

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41346591&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0917661(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-08-12 Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd

2015-12-01 Publication of BRPI0917661A2 publication Critical patent/BRPI0917661A2/pt

2019-12-17 Publication of BRPI0917661B1 publication Critical patent/BRPI0917661B1/pt

2021-05-25 Publication of BRPI0917661B8 publication Critical patent/BRPI0917661B8/pt

Links

JGCMEBMXRHSZKX-UHFFFAOYSA-N macitentan Chemical compound C=1C=C(Br)C=CC=1C=1C(NS(=O)(=O)NCCC)=NC=NC=1OCCOC1=NC=C(Br)C=N1 JGCMEBMXRHSZKX-UHFFFAOYSA-N 0.000 title 2
229960001039 macitentan Drugs 0.000 title 2
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5578—Eicosanoids, e.g. leukotrienes or prostaglandins having a pentalene ring system, e.g. carbacyclin, iloprost
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

BRPI0917661A 2008-08-13 2009-08-12 produto, composição farmacêutica e uso da combinação de macitentan com um composto que é dotado de propriedades agonistas do receptor de prostaciclina BRPI0917661B8 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IB2008053252		2008-08-13
PCT/IB2009/053553 WO2010018549A2 (en)	2008-08-13	2009-08-12	Therapeutic compositions containing macitentan

Publications (3)

Publication Number	Publication Date
BRPI0917661A2 true BRPI0917661A2 (pt)	2015-12-01
BRPI0917661B1 BRPI0917661B1 (pt)	2019-12-17
BRPI0917661B8 BRPI0917661B8 (pt)	2021-05-25

Family

ID=41346591

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0917661A BRPI0917661B8 (pt)	2008-08-13	2009-08-12	produto, composição farmacêutica e uso da combinação de macitentan com um composto que é dotado de propriedades agonistas do receptor de prostaciclina

Country Status (30)

Country	Link
US (3)	US8809334B2 (pt)
EP (2)	EP2315587B1 (pt)
JP (3)	JP5764061B2 (pt)
KR (1)	KR101678699B1 (pt)
CN (1)	CN102099026B (pt)
AR (1)	AR073031A1 (pt)
AU (1)	AU2009280843B2 (pt)
BR (1)	BRPI0917661B8 (pt)
CA (1)	CA2731370C (pt)
CY (2)	CY1119826T1 (pt)
DK (2)	DK3300729T3 (pt)
ES (2)	ES2763176T3 (pt)
HK (1)	HK1253355B (pt)
HR (2)	HRP20171917T1 (pt)
HU (2)	HUE036071T2 (pt)
IL (1)	IL211143A0 (pt)
LT (2)	LT2315587T (pt)
MA (1)	MA32614B1 (pt)
MX (1)	MX350011B (pt)
MY (1)	MY178894A (pt)
NO (1)	NO2315587T3 (pt)
NZ (1)	NZ591601A (pt)
PL (2)	PL3300729T3 (pt)
PT (2)	PT2315587T (pt)
RU (1)	RU2519161C2 (pt)
SI (2)	SI2315587T1 (pt)
SM (2)	SMT201700592T1 (pt)
TW (1)	TWI446911B (pt)
WO (1)	WO2010018549A2 (pt)
ZA (1)	ZA201101900B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT1928409E (pt)	2005-09-12	2012-11-27	Actelion Pharmaceuticals Ltd	Composição farmacêutica estável que compreende uma pirimidina-sulfamida
MX2010001837A (es)	2007-08-17	2010-03-10	Actelion Pharmaceuticals Ltd	Derivados de 4-pirimidinasulfamida.
HRP20201352T1 (hr) *	2008-02-28	2020-11-27	Nippon Shinyaku Co., Ltd.	Inhibitor fibroze
LT2315587T (lt)	2008-08-13	2018-01-10	Actelion Pharmaceuticals Ltd.	Terapinės kompozicijos, turinčios macitentano
US9505737B2 (en)	2013-01-11	2016-11-29	Corsair Pharma, Inc.	Treprostinil derivative compounds and methods of using same
EP3712142B1 (en)	2013-01-11	2022-07-06	Corsair Pharma, Inc.	Prodrugs of treprostinil
US9643911B2 (en)	2015-06-17	2017-05-09	Corsair Pharma, Inc.	Treprostinil derivatives and compositions and uses thereof
US9394227B1 (en)	2015-06-17	2016-07-19	Corsair Pharma, Inc.	Treprostinil derivatives and compositions and uses thereof
US9794795B1 (en)	2016-04-29	2017-10-17	Corning Optical Communications Wireless Ltd	Implementing a live distributed antenna system (DAS) configuration from a virtual DAS design using an original equipment manufacturer (OEM) specific software system in a DAS
EP4620525A3 (en)	2016-12-14	2025-12-03	Respira Therapeutics, Inc.	Methods and compositions for treatment of pulmonary hypertension and other lung disorders
MX2021001820A (es) *	2018-09-14	2021-04-28	Pharmosa Biopharm Inc	Composicion farmaceutica para la liberacion controlada de farmacos acidos debiles y usos de los mismos.
CA3123990A1 (en) *	2018-12-21	2020-06-25	Actelion Pharmaceuticals Ltd	Pharmaceutical composition for the treatment of pulmonary arterial hypertension
TW202042818A (zh)	2019-01-25	2020-12-01	瑞士商艾克泰聯製藥有限公司	用於治療慢性血栓性肺高血壓之醫藥組成物
CN114728002A (zh)	2019-11-29	2022-07-08	埃科特莱茵药品有限公司	治疗肺动脉高血压的方法
WO2021126884A1 (en)	2019-12-16	2021-06-24	Tenax Therapeutics, Inc.	LEVOSIMENDAN FOR TREATING PULMONARY HYPERTENSION WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION (PH-HF-pEF)
EP4456897A4 (en)	2021-12-31	2025-12-10	Tenax Therapeutics Inc	ORAL FORMULATIONS OF LEVOSIMENDAN FOR THE TREATMENT OF PULMONARY HYPERTENSION WITH HEART FAILURE AND PRESERVED EJECTION FRACTION

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4539333A (en) *	1976-05-11	1985-09-03	Burroughs Wellcome Co.	Prostacyclin, methods of using and method of making
DE2845770A1 (de) *	1978-10-19	1980-04-30	Schering Ag	Neue prostacyclin-derivate und verfahren zu ihrer herstellung
JPS58124778A (ja)	1982-01-20	1983-07-25	Toray Ind Inc	５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体
US4683330A (en)	1984-03-08	1987-07-28	The Upjohn Company	Interphenylene carbacyclin derivatives
HU229403B1 (en) *	2000-12-18	2013-12-30	Actelion Pharmaceuticals Ltd	Novel sulfamides and their use as endothelin receptor antagonists
EP1343506A1 (de) *	2000-12-19	2003-09-17	MERCK PATENT GmbH	Pharmazeutische formulierung enthaltend pyrazolo 4,3-d]pyrimidine und antithrombotica, calcium-antagonisten, prostaglandine oder prostaglandinderivate
DE10100426B4 (de)	2001-01-08	2006-04-06	Steag Hamatech Ag	Verfahren und Vorrichtung zum Zusammenfügen von Substraten
TWI316055B (pt) *	2001-04-26	2009-10-21	Nippon Shinyaku Co Ltd
WO2004017993A1 (en) *	2002-08-12	2004-03-04	Actelion Pharmaceuticals Ltd	Combination of prostacyclin or prostacyclin analogues and endothelin receptor antagonists for the treatment of pulmonary arterial hypertension
JP4769460B2 (ja) *	2002-12-02	2011-09-07	アクテリオンファーマシューティカルズリミテッド	新規スルファミド類
US20050101608A1 (en)	2003-09-24	2005-05-12	Santel Donald J.	Iloprost in combination therapies for the treatment of pulmonary arterial hypertension
TW200628467A (en) *	2004-11-11	2006-08-16	Actelion Pharmaceuticals Ltd	Novel sulfamides
PT1928409E (pt) *	2005-09-12	2012-11-27	Actelion Pharmaceuticals Ltd	Composição farmacêutica estável que compreende uma pirimidina-sulfamida
AR062501A1 (es)	2006-08-29	2008-11-12	Actelion Pharmaceuticals Ltd	Composiciones terapeuticas
US8541433B2 (en)	2008-02-20	2013-09-24	Actelion Pharmaceuticals, Ltd.	Combination comprising macitentan and paclitaxel for treating multi-drug resistant ovarian cancer
LT2315587T (lt)	2008-08-13	2018-01-10	Actelion Pharmaceuticals Ltd.	Terapinės kompozicijos, turinčios macitentano

2009
- 2009-08-12 LT LTEP09786912.7T patent/LT2315587T/lt unknown
- 2009-08-12 TW TW098127151A patent/TWI446911B/zh active
- 2009-08-12 DK DK17191033.4T patent/DK3300729T3/da active
- 2009-08-12 HU HUE09786912A patent/HUE036071T2/hu unknown
- 2009-08-12 SM SM20170592T patent/SMT201700592T1/it unknown
- 2009-08-12 AR ARP090103113A patent/AR073031A1/es not_active Application Discontinuation
- 2009-08-12 PL PL17191033T patent/PL3300729T3/pl unknown
- 2009-08-12 MY MYPI2011000637A patent/MY178894A/en unknown
- 2009-08-12 NO NO09786912A patent/NO2315587T3/no unknown
- 2009-08-12 ES ES17191033T patent/ES2763176T3/es active Active
- 2009-08-12 EP EP09786912.7A patent/EP2315587B1/en not_active Revoked
- 2009-08-12 CA CA2731370A patent/CA2731370C/en active Active
- 2009-08-12 EP EP17191033.4A patent/EP3300729B1/en not_active Revoked
- 2009-08-12 SI SI200931770T patent/SI2315587T1/en unknown
- 2009-08-12 US US13/058,639 patent/US8809334B2/en active Active
- 2009-08-12 JP JP2011522608A patent/JP5764061B2/ja not_active Expired - Fee Related
- 2009-08-12 CN CN2009801279936A patent/CN102099026B/zh not_active Expired - Fee Related
- 2009-08-12 NZ NZ591601A patent/NZ591601A/xx unknown
- 2009-08-12 BR BRPI0917661A patent/BRPI0917661B8/pt not_active IP Right Cessation
- 2009-08-12 PT PT97869127T patent/PT2315587T/pt unknown
- 2009-08-12 ES ES09786912.7T patent/ES2652590T3/es active Active
- 2009-08-12 PT PT171910334T patent/PT3300729T/pt unknown
- 2009-08-12 LT LTEP17191033.4T patent/LT3300729T/lt unknown
- 2009-08-12 PL PL09786912T patent/PL2315587T3/pl unknown
- 2009-08-12 SI SI200932016T patent/SI3300729T1/sl unknown
- 2009-08-12 SM SM20190740T patent/SMT201900740T1/it unknown
- 2009-08-12 MX MX2011001625A patent/MX350011B/es active IP Right Grant
- 2009-08-12 HU HUE17191033A patent/HUE047767T2/hu unknown
- 2009-08-12 RU RU2011109084/15A patent/RU2519161C2/ru active
- 2009-08-12 HR HRP20171917TT patent/HRP20171917T1/hr unknown
- 2009-08-12 KR KR1020117003547A patent/KR101678699B1/ko active Active
- 2009-08-12 AU AU2009280843A patent/AU2009280843B2/en active Active
- 2009-08-12 DK DK09786912.7T patent/DK2315587T3/en active
- 2009-08-12 WO PCT/IB2009/053553 patent/WO2010018549A2/en not_active Ceased
2011
- 2011-02-10 IL IL211143A patent/IL211143A0/en active IP Right Grant
- 2011-03-07 MA MA33675A patent/MA32614B1/fr unknown
- 2011-03-11 ZA ZA2011/01900A patent/ZA201101900B/en unknown
2014
- 2014-07-18 US US14/335,657 patent/US9173881B2/en active Active
2015
- 2015-06-12 JP JP2015119021A patent/JP5956026B2/ja active Active
- 2015-06-12 JP JP2015119020A patent/JP5956025B2/ja active Active
- 2015-10-02 US US14/873,787 patent/US9597331B2/en active Active
2018
- 2018-01-19 CY CY20181100074T patent/CY1119826T1/el unknown
- 2018-10-03 HK HK18112650.6A patent/HK1253355B/en not_active IP Right Cessation
2019
- 2019-12-06 HR HRP20192204TT patent/HRP20192204T1/hr unknown
2020
- 2020-01-08 CY CY20201100016T patent/CY1122641T1/el unknown

Also Published As

Publication number	Publication date
EP2315587B1 (en)	2017-10-25
US9597331B2 (en)	2017-03-21
JP5956026B2 (ja)	2016-07-20
NZ591601A (en)	2012-12-21
HK1253355A1 (en)	2019-06-14
RU2011109084A (ru)	2012-09-20
SI2315587T1 (en)	2018-04-30
HK1253355B (en)	2020-06-19
JP5764061B2 (ja)	2015-08-12
EP2315587A2 (en)	2011-05-04
DK2315587T3 (en)	2018-01-02
JP2015187148A (ja)	2015-10-29
HRP20192204T1 (hr)	2020-03-06
NO2315587T3 (pt)	2018-03-24
SMT201700592T1 (it)	2018-03-08
CY1119826T1 (el)	2018-06-27
TWI446911B (zh)	2014-08-01
TW201010985A (en)	2010-03-16
ES2763176T3 (es)	2020-05-27
MA32614B1 (fr)	2011-09-01
KR20110045006A (ko)	2011-05-03
JP5956025B2 (ja)	2016-07-20
EP3300729B1 (en)	2019-10-09
US8809334B2 (en)	2014-08-19
PL2315587T3 (pl)	2018-03-30
SI3300729T1 (sl)	2020-02-28
KR101678699B1 (ko)	2016-11-23
RU2519161C2 (ru)	2014-06-10
AU2009280843B2 (en)	2015-03-05
HRP20171917T1 (hr)	2018-02-09
CA2731370C (en)	2017-03-14
AR073031A1 (es)	2010-10-06
US20140329824A1 (en)	2014-11-06
MY178894A (en)	2020-10-21
PL3300729T3 (pl)	2020-04-30
SMT201900740T1 (it)	2020-01-14
US20160022678A1 (en)	2016-01-28
IL211143A0 (en)	2011-04-28
HUE036071T2 (hu)	2018-06-28
LT3300729T (lt)	2020-01-10
LT2315587T (lt)	2018-01-10
EP3300729A1 (en)	2018-04-04
WO2010018549A3 (en)	2010-07-29
MX2011001625A (es)	2011-03-29
JP2015180683A (ja)	2015-10-15
WO2010018549A2 (en)	2010-02-18
ZA201101900B (en)	2012-08-29
US9173881B2 (en)	2015-11-03
CA2731370A1 (en)	2010-02-18
PT3300729T (pt)	2020-01-20
US20110136818A1 (en)	2011-06-09
JP2011530581A (ja)	2011-12-22
DK3300729T3 (da)	2020-01-20
MX350011B (es)	2017-08-22
ES2652590T3 (es)	2018-02-05
BRPI0917661B1 (pt)	2019-12-17
HUE047767T2 (hu)	2020-05-28
AU2009280843A1 (en)	2010-02-18
PT2315587T (pt)	2018-01-31
BRPI0917661B8 (pt)	2021-05-25
CN102099026A (zh)	2011-06-15
CY1122641T1 (el)	2021-03-12
CN102099026B (zh)	2012-08-29

Legal Events

Date	Code	Title	Description
2017-10-10	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2018-04-17	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2018-04-24	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2018-08-28	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2019-02-05	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2019-10-15	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2019-12-17	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 17/12/2019, OBSERVADAS AS CONDICOES LEGAIS.
2021-05-25	B16C	Correction of notification of the grant [chapter 16.3 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 12/08/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF
2024-06-04	B21F	Lapse acc. art. 78, item iv - on non-payment of the annual fees in time	Free format text: REFERENTE A 15A ANUIDADE.
2024-09-24	B24J	Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)	Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2787 DE 04-06-2024 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

Publication	Publication Date	Title
BRPI0917661A2 (pt)	2015-12-01	produto que contém macitentan, composição farmacêutica que o contém e uso de macitentan
BRPI0809667A2 (pt)	2014-10-07	Composto, medicamento e composição farmacêutica que o contém e uso do composto
BRPI0912717A2 (pt)	2014-12-23	Composição farmacêutica, e, uso de 5-azacitidina
BRPI0921699A2 (pt)	2016-02-16	complexo antioxidante, composicoes cosmeticas e farmaceutica contendo o referido complexo e uso deste complexo
BRPI0917315A2 (pt)	2015-11-17	anticorpo, composicao farmaceutico, e, uso de uma composicao farmaceutica
BRPI0814593A2 (pt)	2015-01-20	Composto, composição farmacêutica que o contém e uso do composto.
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