BRPI0917853A2 - composição farmacêutica, polímero reticulado de troca catiônica ou uma composição farmacêutica para remover potássio do trato gastrointestinal, polímetro carboxílico alifático reticulado estabilizado de poliol linear, e, método para fazer um polímetro reticulado de troca catiônica - Google Patents
composição farmacêutica, polímero reticulado de troca catiônica ou uma composição farmacêutica para remover potássio do trato gastrointestinal, polímetro carboxílico alifático reticulado estabilizado de poliol linear, e, método para fazer um polímetro reticulado de troca catiônicaInfo
- Publication number
- BRPI0917853A2 BRPI0917853A2 BRPI0917853A BRPI0917853A BRPI0917853A2 BR PI0917853 A2 BRPI0917853 A2 BR PI0917853A2 BR PI0917853 A BRPI0917853 A BR PI0917853A BR PI0917853 A BRPI0917853 A BR PI0917853A BR PI0917853 A2 BRPI0917853 A2 BR PI0917853A2
- Authority
- BR
- Brazil
- Prior art keywords
- cross
- pharmaceutical composition
- cation exchange
- linked
- polymer
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/78—Polymers containing oxygen of acrylic acid or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/08—Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/16—Organic material
- B01J39/18—Macromolecular compounds
- B01J39/20—Macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/22—Esters containing halogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F212/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring
- C08F212/34—Monomers containing two or more unsaturated aliphatic radicals
- C08F212/36—Divinylbenzene
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Polymers & Plastics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nutrition Science (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9109708P | 2008-08-22 | 2008-08-22 | |
| US9112508P | 2008-08-22 | 2008-08-22 | |
| US9111008P | 2008-08-22 | 2008-08-22 | |
| US16589409P | 2009-04-01 | 2009-04-01 | |
| US16589909P | 2009-04-01 | 2009-04-01 | |
| US16590509P | 2009-04-02 | 2009-04-02 | |
| PCT/US2009/054706 WO2010022383A2 (en) | 2008-08-22 | 2009-08-22 | Crosslinked cation exchange polymers, compositions and use in treating hyperkalemia |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| BRPI0917853A2 true BRPI0917853A2 (pt) | 2015-11-24 |
| BRPI0917853B1 BRPI0917853B1 (pt) | 2020-04-07 |
| BRPI0917853B8 BRPI0917853B8 (pt) | 2020-04-22 |
| BRPI0917853C1 BRPI0917853C1 (pt) | 2021-05-25 |
Family
ID=41707686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0917853A BRPI0917853C1 (pt) | 2008-08-22 | 2009-08-22 | polímero reticulado de troca catiônica |
Country Status (26)
| Country | Link |
|---|---|
| US (4) | US20110236340A1 (pt) |
| EP (4) | EP4201408B1 (pt) |
| JP (7) | JP5756403B2 (pt) |
| KR (5) | KR102178208B1 (pt) |
| CN (2) | CN102202670B (pt) |
| AU (1) | AU2009282721B2 (pt) |
| BR (1) | BRPI0917853C1 (pt) |
| CA (1) | CA2735058C (pt) |
| CY (3) | CY2018002I1 (pt) |
| DE (1) | DE112009002063T5 (pt) |
| DK (3) | DK2957286T3 (pt) |
| ES (4) | ES2699494T3 (pt) |
| FI (1) | FI3431094T3 (pt) |
| GB (4) | GB2495427B (pt) |
| HR (4) | HRP20230091T1 (pt) |
| HU (4) | HUE025934T2 (pt) |
| LT (4) | LT3431094T (pt) |
| LU (1) | LUC00094I2 (pt) |
| MX (3) | MX389664B (pt) |
| NL (1) | NL300962I2 (pt) |
| NO (2) | NO2018004I1 (pt) |
| PL (4) | PL2365988T5 (pt) |
| PT (3) | PT2365988E (pt) |
| SI (2) | SI3431094T1 (pt) |
| SM (2) | SMT201800660T1 (pt) |
| WO (1) | WO2010022383A2 (pt) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8574716B2 (en) * | 2006-01-23 | 2013-11-05 | Hitachi Chemical Co., Ltd. | Ionic polymer devices and methods of fabricating the same |
| PT2365988E (pt) | 2008-08-22 | 2015-10-22 | Relypsa Inc | Polímeros de permuta iónica reticulados, composições e uso no tratamento da hipercalemia |
| US8337824B2 (en) | 2008-08-22 | 2012-12-25 | Relypsa, Inc. | Linear polyol stabilized polyfluoroacrylate compositions |
| KR101839038B1 (ko) * | 2010-03-20 | 2018-03-16 | 리립사, 인크. | 폴리플루오로아크릴레이트 입자를 제조하기 위한 연속식 방법 |
| SI2673237T2 (sl) | 2011-02-11 | 2025-12-31 | Zs Pharma, Inc | Uporaba cirkonijevega silikata v zdravljenju hiperkalemije |
| ES2895909T3 (es) | 2011-06-27 | 2022-02-23 | Vifor Pharma Tech Ltd | Procedimiento para la conversión de un éster polimérico a un ácido polimérico |
| RU2619108C2 (ru) | 2011-06-27 | 2017-05-12 | Релипса, Инк. | Фторирование эфиров акриловой кислоты и их производных |
| CA2879425A1 (en) * | 2012-07-19 | 2014-01-23 | Relypsa, Inc. | Compositions comprising crosslinked cation-binding polymers |
| WO2014023826A1 (en) * | 2012-08-09 | 2014-02-13 | Dsm Ip Assets B.V. | Process for drying polymeric materials |
| KR20210005314A (ko) * | 2012-10-08 | 2021-01-13 | 리립사, 인크. | 고혈압 및 고칼륨혈증을 치료하기 위한 칼륨-결합제 |
| US10695365B2 (en) | 2012-10-22 | 2020-06-30 | ZS Pharma, Inc. | Microporous zirconium silicate for the treatment of hyperkalemia |
| BR112015025438B1 (pt) | 2013-04-05 | 2022-06-07 | Zs Pharma, Inc | Uso de um silicato de zircônio |
| EP3236940B1 (en) * | 2014-12-23 | 2020-02-05 | Ardelyx, Inc. | Compositions and methods for treating hyperkalemia |
| DE112016003948T5 (de) | 2015-08-31 | 2018-05-09 | City Of Sapporo | Molekulare verfahren zum beurteilen einer urothelialen erkrankung |
| US9592253B1 (en) | 2015-10-14 | 2017-03-14 | ZS Pharma, Inc. | Extended use zirconium silicate compositions and methods of use thereof |
| ITUB20159278A1 (it) | 2015-12-23 | 2017-06-23 | Rjw Pharma Llc | Procedimento per la sintesi di patiromer |
| WO2019220450A1 (en) | 2018-05-16 | 2019-11-21 | Solara Active Pharma Sciences Limited | Process for preparation of patiromer |
| BR112021017791A2 (pt) * | 2019-03-13 | 2022-02-01 | Astrazeneca Ab | Agentes de ligação ao potássio para uso em pacientes em hemodiálise |
| WO2021097012A1 (en) * | 2019-11-14 | 2021-05-20 | Relypsa, Inc. | One step synthesis for alkyl 2-fluoroacrylates |
| WO2021191876A1 (en) | 2020-03-27 | 2021-09-30 | Vifor (International) Ltd. | Synthesis of methyl 2-fluoroacrylate |
| CN116323717A (zh) * | 2021-09-13 | 2023-06-23 | 中美华世通生物医药科技(武汉)股份有限公司 | 治疗高钾血症的聚合物药物及其制备方法 |
| US20240139234A1 (en) * | 2021-11-17 | 2024-05-02 | Waterstone Pharmaceuticals (Wuhan) Co., Ltd. | Pharmaceutical polymer for treating hyperkalemia and preparation method thereof |
| CN114369729B (zh) * | 2021-12-28 | 2023-11-03 | 江苏容汇通用锂业股份有限公司 | 一种利用锂矿渣进行浸出液除钾的工艺 |
| CN114394918B (zh) * | 2022-01-19 | 2023-10-20 | 罗长青 | 一种2-[[三(羟甲基)甲基]氨基]乙磺酸的制备方法 |
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