BRPI0918970A2 - algoritmo para projeto de inibidores irreversíveis - Google Patents

algoritmo para projeto de inibidores irreversíveis

Info

Publication number
BRPI0918970A2
BRPI0918970A2 BRPI0918970A BRPI0918970A BRPI0918970A2 BR PI0918970 A2 BRPI0918970 A2 BR PI0918970A2 BR PI0918970 A BRPI0918970 A BR PI0918970A BR PI0918970 A BRPI0918970 A BR PI0918970A BR PI0918970 A2 BRPI0918970 A2 BR PI0918970A2
Authority
BR
Brazil
Prior art keywords
algorithm
irreversible inhibitor
inhibitor design
design
irreversible
Prior art date
Application number
BRPI0918970A
Other languages
English (en)
Inventor
Niu Deqiang
Singh Juswinder
Colyn Petter Russel
Original Assignee
Avila Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avila Therapeutics Inc filed Critical Avila Therapeutics Inc
Publication of BRPI0918970A2 publication Critical patent/BRPI0918970A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/203—Unsaturated compounds containing keto groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C49/205—Methyl-vinyl ketone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/50—Molecular design, e.g. of drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional [2D] or three-dimensional [3D] molecular structures, e.g. structural or functional relations or structure alignment

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Computing Systems (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Evolutionary Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
BRPI0918970A 2008-09-05 2009-09-04 algoritmo para projeto de inibidores irreversíveis BRPI0918970A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9478208P 2008-09-05 2008-09-05
PCT/US2009/056025 WO2010028236A1 (en) 2008-09-05 2009-09-04 Algorithm for designing irreversible inhibitors

Publications (1)

Publication Number Publication Date
BRPI0918970A2 true BRPI0918970A2 (pt) 2019-09-24

Family

ID=41797504

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0918970A BRPI0918970A2 (pt) 2008-09-05 2009-09-04 algoritmo para projeto de inibidores irreversíveis

Country Status (15)

Country Link
US (1) US20100185419A1 (pt)
EP (1) EP2352827A4 (pt)
JP (2) JP2012501654A (pt)
KR (1) KR101341876B1 (pt)
CN (2) CN105574346A (pt)
AU (1) AU2009289602B2 (pt)
BR (1) BRPI0918970A2 (pt)
CA (1) CA2735937A1 (pt)
IL (1) IL211553A0 (pt)
MX (1) MX2011002484A (pt)
MY (1) MY156789A (pt)
NZ (2) NZ621143A (pt)
RU (2) RU2542963C2 (pt)
SG (1) SG193859A1 (pt)
WO (1) WO2010028236A1 (pt)

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Also Published As

Publication number Publication date
CN102405284B (zh) 2016-01-20
EP2352827A4 (en) 2016-07-20
RU2014150660A (ru) 2015-07-20
WO2010028236A1 (en) 2010-03-11
MX2011002484A (es) 2011-09-26
EP2352827A1 (en) 2011-08-10
JP2012501654A (ja) 2012-01-26
IL211553A0 (en) 2011-05-31
RU2011108531A (ru) 2012-10-10
KR101341876B1 (ko) 2013-12-20
CA2735937A1 (en) 2010-03-11
SG193859A1 (en) 2013-10-30
AU2009289602B2 (en) 2014-02-13
MY156789A (en) 2016-03-31
NZ621143A (en) 2016-08-26
JP2015062428A (ja) 2015-04-09
US20100185419A1 (en) 2010-07-22
AU2009289602A1 (en) 2010-03-11
CN102405284A (zh) 2012-04-04
RU2542963C2 (ru) 2015-02-27
KR20110084169A (ko) 2011-07-21
HK1169139A1 (zh) 2013-01-18
NZ603495A (en) 2014-05-30
CN105574346A (zh) 2016-05-11

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