BRPI0918985A2 - derivados de benzo[d]isoxazol-3-il-piperazina úteis como moduladores dos receptores d3 de dopamina - Google Patents
derivados de benzo[d]isoxazol-3-il-piperazina úteis como moduladores dos receptores d3 de dopaminaInfo
- Publication number
- BRPI0918985A2 BRPI0918985A2 BRPI0918985A BRPI0918985A BRPI0918985A2 BR PI0918985 A2 BRPI0918985 A2 BR PI0918985A2 BR PI0918985 A BRPI0918985 A BR PI0918985A BR PI0918985 A BRPI0918985 A BR PI0918985A BR PI0918985 A2 BRPI0918985 A2 BR PI0918985A2
- Authority
- BR
- Brazil
- Prior art keywords
- isoxazol
- dopamine
- benzo
- receptor modulators
- derivatives useful
- Prior art date
Links
- ZDFQBFVFCPABKQ-UHFFFAOYSA-N 3-piperazin-1-yl-1,2-benzoxazole Chemical class C1CNCCN1C1=NOC2=CC=CC=C12 ZDFQBFVFCPABKQ-UHFFFAOYSA-N 0.000 title 1
- 102000004073 Dopamine D3 Receptors Human genes 0.000 title 1
- 108090000525 Dopamine D3 Receptors Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08164903 | 2008-09-23 | ||
| PCT/EP2009/061906 WO2010034646A1 (en) | 2008-09-23 | 2009-09-15 | Benzo[d]isoxazol-3-yl-piperazin derivatives useful as modulators of dopamine d3 receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0918985A2 true BRPI0918985A2 (pt) | 2015-12-01 |
Family
ID=41210461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0918985A BRPI0918985A2 (pt) | 2008-09-23 | 2009-09-15 | derivados de benzo[d]isoxazol-3-il-piperazina úteis como moduladores dos receptores d3 de dopamina |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7939535B2 (pt) |
| EP (1) | EP2344482B1 (pt) |
| JP (1) | JP2012502947A (pt) |
| KR (1) | KR20110059649A (pt) |
| CN (1) | CN102164914A (pt) |
| AU (1) | AU2009296045B2 (pt) |
| BR (1) | BRPI0918985A2 (pt) |
| CA (1) | CA2736724A1 (pt) |
| ES (1) | ES2391712T3 (pt) |
| IL (1) | IL211572A0 (pt) |
| MX (1) | MX2011002752A (pt) |
| WO (1) | WO2010034646A1 (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000032987A (ja) * | 1998-07-16 | 2000-02-02 | Dai Ichi Seiyaku Co Ltd | Dna |
| BRPI0919342A2 (pt) * | 2008-09-23 | 2015-12-29 | Hoffmann La Roche | derivados do isoxazol [4,5] piridin-3-il-piperazina, seu processo de preparação, seu medicamento e seu uso |
| US8586579B2 (en) | 2010-06-21 | 2013-11-19 | Hoffmann-La Roche Inc. | Anellated pyridine compounds |
| US8470828B2 (en) | 2010-07-06 | 2013-06-25 | Hoffmann-La Roche Inc. | Anellated pyridine compounds |
| US8877778B2 (en) | 2010-12-15 | 2014-11-04 | Hoffmann-La Roche Inc. | Benzofurane compounds |
| US8921397B2 (en) | 2011-05-04 | 2014-12-30 | Hoffmann-La Roche Inc. | Benzofurane-piperidine compounds |
| CN104140421B (zh) * | 2013-05-08 | 2017-04-05 | 上海医药工业研究院 | 苯并异噻唑类化合物及在制备抗精神分裂症药物中的应用 |
| WO2017045599A1 (zh) * | 2015-09-15 | 2017-03-23 | 浙江京新药业股份有限公司 | 环己烷衍生物或其立体异构体或盐及其制备与应用 |
| CN106518841B (zh) * | 2015-09-15 | 2019-03-05 | 浙江京新药业股份有限公司 | 环己烷衍生物或其立体异构体或盐及其制备与应用 |
| WO2018021447A1 (ja) | 2016-07-28 | 2018-02-01 | 塩野義製薬株式会社 | ドーパミンd3受容体拮抗作用を有する含窒素縮環化合物 |
| US11447484B2 (en) | 2018-01-26 | 2022-09-20 | Shionogi & Co., Ltd. | Cyclic compound having dopamine D3 receptor antagonistic effect |
| CA3089498A1 (en) | 2018-01-26 | 2019-08-01 | Shionogi & Co., Ltd. | Condensed ring compounds having dopamine d3 receptor antagonistic effect |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5776963A (en) * | 1989-05-19 | 1998-07-07 | Hoechst Marion Roussel, Inc. | 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility |
| CN1187192A (zh) * | 1995-06-06 | 1998-07-08 | 赫彻斯特马里恩鲁斯公司 | 作为抗精神病剂的苯并异噁唑和吲唑衍生物 |
| FR2749304B1 (fr) * | 1996-06-04 | 1998-06-26 | Adir | Nouveaux derives du 3-(piperid-4-yl)1,2-benzisoxazole et du 3-(piperazin-4-yl)1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| ATE412638T1 (de) * | 2001-02-16 | 2008-11-15 | Aventis Pharma Inc | Heterocyclische substituierte carbonyl derivate und ihre verwendung als dopamin d3 rezeptor liganden |
| OA12923A (en) * | 2002-09-17 | 2006-10-13 | Warner Lambert Co | Heterocyclic substituted piperazines for the treatment of schizophrenia. |
| BRPI0919342A2 (pt) * | 2008-09-23 | 2015-12-29 | Hoffmann La Roche | derivados do isoxazol [4,5] piridin-3-il-piperazina, seu processo de preparação, seu medicamento e seu uso |
-
2009
- 2009-09-15 EP EP09782999A patent/EP2344482B1/en not_active Not-in-force
- 2009-09-15 CN CN2009801374131A patent/CN102164914A/zh active Pending
- 2009-09-15 BR BRPI0918985A patent/BRPI0918985A2/pt not_active IP Right Cessation
- 2009-09-15 WO PCT/EP2009/061906 patent/WO2010034646A1/en not_active Ceased
- 2009-09-15 MX MX2011002752A patent/MX2011002752A/es active IP Right Grant
- 2009-09-15 CA CA2736724A patent/CA2736724A1/en not_active Abandoned
- 2009-09-15 JP JP2011527301A patent/JP2012502947A/ja active Pending
- 2009-09-15 ES ES09782999T patent/ES2391712T3/es active Active
- 2009-09-15 AU AU2009296045A patent/AU2009296045B2/en not_active Ceased
- 2009-09-15 KR KR1020117008870A patent/KR20110059649A/ko not_active Withdrawn
- 2009-09-16 US US12/560,471 patent/US7939535B2/en not_active Expired - Fee Related
-
2011
- 2011-03-03 IL IL211572A patent/IL211572A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010034646A1 (en) | 2010-04-01 |
| US7939535B2 (en) | 2011-05-10 |
| CN102164914A (zh) | 2011-08-24 |
| AU2009296045A1 (en) | 2010-04-01 |
| KR20110059649A (ko) | 2011-06-02 |
| JP2012502947A (ja) | 2012-02-02 |
| CA2736724A1 (en) | 2010-04-01 |
| EP2344482A1 (en) | 2011-07-20 |
| EP2344482B1 (en) | 2012-08-15 |
| MX2011002752A (es) | 2011-04-07 |
| ES2391712T3 (es) | 2012-11-29 |
| US20100075985A1 (en) | 2010-03-25 |
| AU2009296045B2 (en) | 2013-07-04 |
| IL211572A0 (en) | 2011-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2376 DE 19-07-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |