BRPI0910585A2 - indóis como moduladores de receptor de aceticolina nicotínica do subtipo alfa-7 - Google Patents

indóis como moduladores de receptor de aceticolina nicotínica do subtipo alfa-7

Info

Publication number
BRPI0910585A2
BRPI0910585A2 BRPI0910585A BRPI0910585A BRPI0910585A2 BR PI0910585 A2 BRPI0910585 A2 BR PI0910585A2 BR PI0910585 A BRPI0910585 A BR PI0910585A BR PI0910585 A BRPI0910585 A BR PI0910585A BR PI0910585 A2 BRPI0910585 A2 BR PI0910585A2
Authority
BR
Brazil
Prior art keywords
aceticoline
indoles
alpha
receptor modulators
subtype nicotinic
Prior art date
Application number
BRPI0910585A
Other languages
English (en)
Inventor
Andrew P Lightfoot
Howard Robert Marshall
Kevin Dinnell
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0807050A external-priority patent/GB0807050D0/en
Priority claimed from GB0810229A external-priority patent/GB0810229D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BRPI0910585A2 publication Critical patent/BRPI0910585A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BRPI0910585A 2008-04-17 2009-04-16 indóis como moduladores de receptor de aceticolina nicotínica do subtipo alfa-7 BRPI0910585A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0807050A GB0807050D0 (en) 2008-04-17 2008-04-17 Novel compounds
GB0810229A GB0810229D0 (en) 2008-06-04 2008-06-04 Novel compounds
PCT/EP2009/054495 WO2009127679A1 (en) 2008-04-17 2009-04-16 Indoles as modulators of nicoticic acetylcholine receptor subtype alpha-7

Publications (1)

Publication Number Publication Date
BRPI0910585A2 true BRPI0910585A2 (pt) 2015-09-22

Family

ID=40791353

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0911682A BRPI0911682A2 (pt) 2008-04-17 2009-04-16 indóis como moduladores do recpetor da acetilcolina nicotínico subtipo alfa-71
BRPI0910585A BRPI0910585A2 (pt) 2008-04-17 2009-04-16 indóis como moduladores de receptor de aceticolina nicotínica do subtipo alfa-7

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0911682A BRPI0911682A2 (pt) 2008-04-17 2009-04-16 indóis como moduladores do recpetor da acetilcolina nicotínico subtipo alfa-71

Country Status (19)

Country Link
US (2) US8283365B2 (pt)
EP (2) EP2279183B1 (pt)
JP (2) JP2011516599A (pt)
KR (2) KR20100133016A (pt)
CN (2) CN102066356B (pt)
AR (1) AR071203A1 (pt)
AU (2) AU2009237650B2 (pt)
BR (2) BRPI0911682A2 (pt)
CA (2) CA2725441C (pt)
CL (1) CL2009000916A1 (pt)
EA (2) EA017726B1 (pt)
ES (2) ES2392796T3 (pt)
IL (2) IL208575A (pt)
MX (2) MX2010011359A (pt)
PE (1) PE20091724A1 (pt)
TW (1) TW201004939A (pt)
UY (1) UY31769A1 (pt)
WO (2) WO2009127679A1 (pt)
ZA (2) ZA201006856B (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009050186A1 (en) 2007-10-18 2009-04-23 Janssen Pharmaceutica Nv Trisubstituted 1,2,4-triazoles
JO2784B1 (en) 2007-10-18 2014-03-15 شركة جانسين فارماسوتيكا ان. في 5,3,1 - Triazole substitute derivative
JP5539230B2 (ja) 2008-01-30 2014-07-02 セファロン、インク． ヒスタミンｈ３アンタゴニスト活性を有する置換ピリダジン誘導体
AU2009226988B2 (en) 2008-03-19 2013-05-23 Janssen Pharmaceutica Nv Trisubstituted 1, 2, 4 -triazoles as nicotinic acetylcholine receptor modulators
JP5486591B2 (ja) 2008-05-09 2014-05-07 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ アセチルコリン受容体モジュレーターとしての三置換ピラゾール
EP2419420B1 (en) * 2009-04-16 2013-03-13 Proximagen Limited Indole derivative modulators of the alpha 7 nachr
TWI558398B (zh) 2009-09-22 2016-11-21 諾華公司 菸鹼乙醯膽鹼受體α７活化劑之用途
GB201012686D0 (en) * 2010-07-28 2010-09-15 Glaxo Group Ltd Novel compounds
JO3078B1 (ar) * 2009-11-27 2017-03-15 Janssen Pharmaceutica Nv مورفولينوثيازولات بصفتها منظمات الوستيرية نوع الفا 7 موجبة
CN103443092B (zh) 2011-02-03 2015-11-25 鲁平有限公司 用作α7胆碱受体调节剂的吡咯衍生物
US9072731B2 (en) 2011-02-23 2015-07-07 Lupin Limited Heteroaryl derivatives as alpha7 nAChR modulators
MX2013010698A (es) * 2011-03-18 2014-02-17 Novartis Ag Combinaciones de activadores del receptor de acetil-colina nicotinico alfa-7 y antagonistas del receptor de glutamato metabotropico 5 (mglur5) para usarse en la discinesia inducida por dopamina en la enfermedad de parkinson.
SG193387A1 (en) 2011-03-31 2013-10-30 Lupin Ltd Pyrrole derivatives as nicotinic acetylcholine receptor modulators for use in the treatment of neurodegenerative disorders such as alzheimer's and parkinson's disease
TW201245185A (en) 2011-04-01 2012-11-16 Lundbeck & Co As H New positive allosteric modulators of nicotinic acetylcholine receptor
ES2606043T3 (es) 2011-07-05 2017-03-17 Lupin Limited Derivados de biarilo como moduladores de nAChR
SG11201405239WA (en) 2012-03-06 2014-09-26 Lupin Ltd Thiazole derivatives as alpha 7 nachr modulators
CA2871651A1 (en) * 2012-05-08 2013-11-14 Anvyl Llc Alpha 7 nicotinic acetylcholine receptor allosteric modulators, their derivatives and uses thereof
CA2886010A1 (en) * 2012-10-02 2014-04-10 Sumitomo Dainippon Pharma Co., Ltd. Imidazole derivative
US20150299178A1 (en) 2012-11-12 2015-10-22 Lupin Limited Thiazole Derivatives as Alpha 7 NACHR Modulators
CN103006642B (zh) * 2013-01-04 2014-10-22 中国药科大学 一类炔亚甲基吲哚-2-酮类衍生物的用途
WO2014111839A1 (en) 2013-01-16 2014-07-24 Lupin Limited Pyrrole derivatives as alpha 7 nachr modulators
JP2016512225A (ja) 2013-03-13 2016-04-25 ルピン・リミテッドＬｕｐｉｎ Ｌｉｍｉｔｅｄ アルファー７ｎａｃｈｒモジュレータとしてのピロール誘導体
US10058310B2 (en) 2013-03-13 2018-08-28 Ethicon Llc Electrosurgical device with drum-driven articulation
TW201446243A (zh) 2013-06-03 2014-12-16 Lupin Ltd 4-(5-(4-氯苯基)-2-(2-環丙基乙醯基)-1,4-二甲基-1氫-吡咯-3-基)苯磺醯胺作為α7尼古丁乙醯膽鹼受體調節劑
WO2014203150A1 (en) 2013-06-17 2014-12-24 Lupin Limited Pyrrole derivatives as alpha 7 nachr modulators
US20170182058A1 (en) * 2014-03-25 2017-06-29 Emicipi Llc Treatment of rett syndrome
JP6870304B2 (ja) * 2016-12-05 2021-05-12 住友電気工業株式会社 半導体装置の製造方法
EP3558992A4 (en) * 2016-12-15 2020-12-02 ONO Pharmaceutical Co., Ltd. TREK CHANNEL ACTIVATOR (K + CHANNELS ASSOCIATED WITH TWIK)
HU231478B1 (hu) 2018-07-13 2024-02-28 Richter Gedeon Nyrt. Szubsztituált (aza)indol származékok
HU231414B1 (hu) 2018-07-13 2023-08-28 Richter Gedeon Nyrt. Tiadiazin származékok
HU231333B1 (hu) 2018-07-13 2023-01-28 Richter Gedeon Nyrt Spirokromán származékok
JP7765088B2 (ja) * 2019-12-02 2025-11-06 ストーム・セラピューティクス・リミテッド Ｍｅｔｔｌ３阻害剤としてのポリヘテロ環式化合物
CN111285792B (zh) * 2020-03-23 2023-05-02 三峡大学 2-取代吲哚化合物及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9903997D0 (sv) * 1999-11-03 1999-11-03 Astra Ab New compounds
GB0403155D0 (en) 2004-02-12 2004-03-17 Vernalis Res Ltd Chemical compounds
MX2010008714A (es) * 2008-02-07 2010-09-24 Abbott Lab Derivados de amida como moduladores alostericos positivos y metodos de uso de los mismos.

Also Published As

Publication number Publication date
CN102066356A (zh) 2011-05-18
BRPI0911682A2 (pt) 2015-10-13
EA018113B1 (ru) 2013-05-30
WO2009127679A1 (en) 2009-10-22
TW201004939A (en) 2010-02-01
ZA201006856B (en) 2011-06-29
EA201071201A1 (ru) 2011-04-29
EP2279184A1 (en) 2011-02-02
AU2009237649B2 (en) 2012-07-26
MX2010011358A (es) 2010-11-10
EP2279183B1 (en) 2012-08-08
CN102066357A (zh) 2011-05-18
EA201071202A1 (ru) 2011-06-30
US20110034515A1 (en) 2011-02-10
MX2010011359A (es) 2010-11-12
IL208575A0 (en) 2010-12-30
IL208574A0 (en) 2010-12-30
CN102066357B (zh) 2014-04-09
CA2725441A1 (en) 2009-10-22
AU2009237650A1 (en) 2009-10-22
EP2279184B1 (en) 2012-08-08
JP2011516599A (ja) 2011-05-26
WO2009127678A1 (en) 2009-10-22
EA017726B1 (ru) 2013-02-28
IL208575A (en) 2014-04-30
ZA201006855B (en) 2011-06-29
IL208574A (en) 2014-04-30
ES2392796T3 (es) 2012-12-13
AR071203A1 (es) 2010-06-02
ES2392795T3 (es) 2012-12-13
KR20100135911A (ko) 2010-12-27
CL2009000916A1 (es) 2010-12-31
UY31769A1 (es) 2009-09-30
KR20100133016A (ko) 2010-12-20
AU2009237650B2 (en) 2012-05-31
CA2721630A1 (en) 2009-10-22
CA2725441C (en) 2014-05-27
JP2011516598A (ja) 2011-05-26
US8377941B2 (en) 2013-02-19
US20110028486A1 (en) 2011-02-03
EP2279183A1 (en) 2011-02-02
CN102066356B (zh) 2014-06-11
PE20091724A1 (es) 2009-12-06
AU2009237649A1 (en) 2009-10-22
US8283365B2 (en) 2012-10-09

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]