BRPI0910585A2 - indóis como moduladores de receptor de aceticolina nicotínica do subtipo alfa-7 - Google Patents

indóis como moduladores de receptor de aceticolina nicotínica do subtipo alfa-7

Info

Publication number
BRPI0910585A2
BRPI0910585A2 BRPI0910585A BRPI0910585A BRPI0910585A2 BR PI0910585 A2 BRPI0910585 A2 BR PI0910585A2 BR PI0910585 A BRPI0910585 A BR PI0910585A BR PI0910585 A BRPI0910585 A BR PI0910585A BR PI0910585 A2 BRPI0910585 A2 BR PI0910585A2
Authority
BR
Brazil
Prior art keywords
aceticoline
indoles
alpha
receptor modulators
subtype nicotinic
Prior art date
Application number
BRPI0910585A
Other languages
English (en)
Inventor
Andrew P Lightfoot
Howard Robert Marshall
Kevin Dinnell
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0807050A external-priority patent/GB0807050D0/en
Priority claimed from GB0810229A external-priority patent/GB0810229D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BRPI0910585A2 publication Critical patent/BRPI0910585A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BRPI0910585A 2008-04-17 2009-04-16 indóis como moduladores de receptor de aceticolina nicotínica do subtipo alfa-7 BRPI0910585A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0807050A GB0807050D0 (en) 2008-04-17 2008-04-17 Novel compounds
GB0810229A GB0810229D0 (en) 2008-06-04 2008-06-04 Novel compounds
PCT/EP2009/054495 WO2009127679A1 (en) 2008-04-17 2009-04-16 Indoles as modulators of nicoticic acetylcholine receptor subtype alpha-7

Publications (1)

Publication Number Publication Date
BRPI0910585A2 true BRPI0910585A2 (pt) 2015-09-22

Family

ID=40791353

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0910585A BRPI0910585A2 (pt) 2008-04-17 2009-04-16 indóis como moduladores de receptor de aceticolina nicotínica do subtipo alfa-7
BRPI0911682A BRPI0911682A2 (pt) 2008-04-17 2009-04-16 indóis como moduladores do recpetor da acetilcolina nicotínico subtipo alfa-71

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0911682A BRPI0911682A2 (pt) 2008-04-17 2009-04-16 indóis como moduladores do recpetor da acetilcolina nicotínico subtipo alfa-71

Country Status (19)

Country Link
US (2) US8377941B2 (pt)
EP (2) EP2279183B1 (pt)
JP (2) JP2011516599A (pt)
KR (2) KR20100133016A (pt)
CN (2) CN102066357B (pt)
AR (1) AR071203A1 (pt)
AU (2) AU2009237649B2 (pt)
BR (2) BRPI0910585A2 (pt)
CA (2) CA2721630A1 (pt)
CL (1) CL2009000916A1 (pt)
EA (2) EA018113B1 (pt)
ES (2) ES2392796T3 (pt)
IL (2) IL208575A (pt)
MX (2) MX2010011358A (pt)
PE (1) PE20091724A1 (pt)
TW (1) TW201004939A (pt)
UY (1) UY31769A1 (pt)
WO (2) WO2009127679A1 (pt)
ZA (2) ZA201006855B (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011500625A (ja) 2007-10-18 2011-01-06 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ トリ置換された１，２，４−トリアゾール
JO2784B1 (en) 2007-10-18 2014-03-15 شركة جانسين فارماسوتيكا ان. في 5,3,1 - Triazole substitute derivative
CA2712885A1 (en) 2008-01-30 2009-08-06 Cephalon, Inc. Substituted pyridazine derivatives which have histamine h3 antagonist activity
MY152486A (en) 2008-03-19 2014-10-15 Janssen Pharmaceutica Nv Trisubstituted 1,2,4 - triazoles as nicotinic acetylcholine receptor modulators
WO2009135944A1 (en) 2008-05-09 2009-11-12 Janssen Pharmaceutica Nv Trisubstituted pyrazoles as acetylcholine receptor modulators
AU2010238518A1 (en) * 2009-04-16 2011-12-01 Proximagen Limited Indole derivative modulators of the alpha 7 nAChR
JO3250B1 (ar) 2009-09-22 2018-09-16 Novartis Ag إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7
GB201012686D0 (en) * 2010-07-28 2010-09-15 Glaxo Group Ltd Novel compounds
JO3078B1 (ar) * 2009-11-27 2017-03-15 Janssen Pharmaceutica Nv مورفولينوثيازولات بصفتها منظمات الوستيرية نوع الفا 7 موجبة
CA2825519A1 (en) 2011-02-03 2012-09-08 Lupin Limited Pyrrole derivatives used as modulators of alpha7 nachr
RS55433B1 (sr) 2011-02-23 2017-04-28 Lupin Ltd Derivati heteroarila kao modulatori nachr alfa7
US20140228398A1 (en) * 2011-03-18 2014-08-14 Novartis Ag COMBINATIONS OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATORS AND mGluR5 ANTAGONISTS FOR USE IN DOPAMINE INDUCED DYSKINESIA IN PARKINSON'S DISEASE
AU2012235779B2 (en) 2011-03-31 2017-03-02 Lupin Limited Pyrrole derivatives as nicotinic acetylcholine receptor modulators for use in the treatment of neurodegenerative disorders such as Alzheimer's and Parkinson's disease
TW201245185A (en) 2011-04-01 2012-11-16 Lundbeck & Co As H New positive allosteric modulators of nicotinic acetylcholine receptor
US8946432B2 (en) 2011-07-05 2015-02-03 Lupin Limited Biaryl derivatives as nAChR modulators
NZ629453A (en) 2012-03-06 2016-04-29 Lupin Ltd Thiazole derivatives as alpha 7 nachr modulators
AU2013259565A1 (en) * 2012-05-08 2014-11-13 Anvyl Llc Alpha 7 nicotinic acetylcholine receptor allosteric modulators, their derivatives and uses thereof
JPWO2014054635A1 (ja) * 2012-10-02 2016-08-25 大日本住友製薬株式会社 イミダゾール誘導体
EP2945936A1 (en) 2012-11-12 2015-11-25 Lupin Limited Thiazole derivatives as alpha 7 nachr modulators
CN103006642B (zh) * 2013-01-04 2014-10-22 中国药科大学 一类炔亚甲基吲哚-2-酮类衍生物的用途
EP2945941B1 (en) 2013-01-16 2016-12-07 Lupin Limited Pyrrole derivatives as alpha 7 nachr modulators
US9617210B2 (en) 2013-03-13 2017-04-11 Lupin Limited Pyrrole derivatives as alpha 7 NACHR modulators
US10058310B2 (en) 2013-03-13 2018-08-28 Ethicon Llc Electrosurgical device with drum-driven articulation
TW201446243A (zh) 2013-06-03 2014-12-16 Lupin Ltd 4-(5-(4-氯苯基)-2-(2-環丙基乙醯基)-1,4-二甲基-1氫-吡咯-3-基)苯磺醯胺作為α7尼古丁乙醯膽鹼受體調節劑
WO2014203150A1 (en) 2013-06-17 2014-12-24 Lupin Limited Pyrrole derivatives as alpha 7 nachr modulators
US20170182058A1 (en) * 2014-03-25 2017-06-29 Emicipi Llc Treatment of rett syndrome
JP6870304B2 (ja) * 2016-12-05 2021-05-12 住友電気工業株式会社 半導体装置の製造方法
EP3558992A4 (en) 2016-12-15 2020-12-02 ONO Pharmaceutical Co., Ltd. TREK CHANNEL ACTIVATOR (K + CHANNELS ASSOCIATED WITH TWIK)
HU231414B1 (hu) 2018-07-13 2023-08-28 Richter Gedeon Nyrt. Tiadiazin származékok
HU231333B1 (hu) 2018-07-13 2023-01-28 Richter Gedeon Nyrt Spirokromán származékok
HU231478B1 (hu) 2018-07-13 2024-02-28 Richter Gedeon Nyrt. Szubsztituált (aza)indol származékok
CN115151540A (zh) 2019-12-02 2022-10-04 风暴治疗有限公司 作为mettl3抑制剂的多杂环化合物
CN111285792B (zh) * 2020-03-23 2023-05-02 三峡大学 2-取代吲哚化合物及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9903997D0 (sv) * 1999-11-03 1999-11-03 Astra Ab New compounds
GB0403155D0 (en) * 2004-02-12 2004-03-17 Vernalis Res Ltd Chemical compounds
BRPI0907492A2 (pt) * 2008-02-07 2017-06-13 Abbott Lab derivados amida como moduladores alostéricos positivos e métodos de sua utilização

Also Published As

Publication number Publication date
US8377941B2 (en) 2013-02-19
WO2009127679A1 (en) 2009-10-22
AU2009237650A1 (en) 2009-10-22
ES2392796T3 (es) 2012-12-13
CN102066357B (zh) 2014-04-09
US20110028486A1 (en) 2011-02-03
EP2279183B1 (en) 2012-08-08
CA2721630A1 (en) 2009-10-22
UY31769A1 (es) 2009-09-30
AU2009237649B2 (en) 2012-07-26
AR071203A1 (es) 2010-06-02
EA201071201A1 (ru) 2011-04-29
JP2011516599A (ja) 2011-05-26
CN102066356A (zh) 2011-05-18
CA2725441A1 (en) 2009-10-22
IL208574A0 (en) 2010-12-30
IL208575A0 (en) 2010-12-30
US20110034515A1 (en) 2011-02-10
IL208574A (en) 2014-04-30
TW201004939A (en) 2010-02-01
MX2010011358A (es) 2010-11-10
ZA201006855B (en) 2011-06-29
PE20091724A1 (es) 2009-12-06
CN102066357A (zh) 2011-05-18
AU2009237650B2 (en) 2012-05-31
ES2392795T3 (es) 2012-12-13
WO2009127678A1 (en) 2009-10-22
KR20100133016A (ko) 2010-12-20
AU2009237649A1 (en) 2009-10-22
EP2279184A1 (en) 2011-02-02
BRPI0911682A2 (pt) 2015-10-13
IL208575A (en) 2014-04-30
CN102066356B (zh) 2014-06-11
EP2279184B1 (en) 2012-08-08
CL2009000916A1 (es) 2010-12-31
EA018113B1 (ru) 2013-05-30
ZA201006856B (en) 2011-06-29
EA201071202A1 (ru) 2011-06-30
MX2010011359A (es) 2010-11-12
JP2011516598A (ja) 2011-05-26
CA2725441C (en) 2014-05-27
EP2279183A1 (en) 2011-02-02
US8283365B2 (en) 2012-10-09
EA017726B1 (ru) 2013-02-28
KR20100135911A (ko) 2010-12-27

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]