BRPI0908635A2 - composto, composição farmacêutica e método de tratamento de câncer - Google Patents
composto, composição farmacêutica e método de tratamento de câncerInfo
- Publication number
- BRPI0908635A2 BRPI0908635A2 BRPI0908635A BRPI0908635A BRPI0908635A2 BR PI0908635 A2 BRPI0908635 A2 BR PI0908635A2 BR PI0908635 A BRPI0908635 A BR PI0908635A BR PI0908635 A BRPI0908635 A BR PI0908635A BR PI0908635 A2 BRPI0908635 A2 BR PI0908635A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- pharmaceutical composition
- treatment method
- cancer treatment
- cancer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/164,610 US8426430B2 (en) | 2008-06-30 | 2008-06-30 | Quinazoline derivatives |
| US12/164,610 | 2008-06-30 | ||
| PCT/US2009/049182 WO2010002845A2 (en) | 2008-06-30 | 2009-06-30 | Quinazoline derivatives |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| BRPI0908635A2 true BRPI0908635A2 (pt) | 2015-10-13 |
| BRPI0908635A8 BRPI0908635A8 (pt) | 2018-12-18 |
| BRPI0908635B1 BRPI0908635B1 (pt) | 2020-09-01 |
| BRPI0908635B8 BRPI0908635B8 (pt) | 2021-05-25 |
Family
ID=41466556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0908635A BRPI0908635B8 (pt) | 2008-06-30 | 2009-06-30 | composto e/ou um sal farmaceuticamente aceitável do mesmo e composição farmacêutica |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US8426430B2 (pt) |
| EP (1) | EP2318378B1 (pt) |
| JP (1) | JP5602729B2 (pt) |
| KR (1) | KR101664503B1 (pt) |
| AU (1) | AU2009267136B2 (pt) |
| BR (1) | BRPI0908635B8 (pt) |
| CA (1) | CA2726040C (pt) |
| CY (1) | CY1114842T1 (pt) |
| DK (1) | DK2318378T3 (pt) |
| ES (1) | ES2442946T3 (pt) |
| HR (1) | HRP20140066T8 (pt) |
| MX (1) | MX2010012692A (pt) |
| MY (1) | MY150493A (pt) |
| NZ (1) | NZ589191A (pt) |
| PH (1) | PH12010502934A1 (pt) |
| PL (1) | PL2318378T3 (pt) |
| PT (1) | PT2318378E (pt) |
| RU (1) | RU2505534C2 (pt) |
| SG (2) | SG167561A1 (pt) |
| SI (1) | SI2318378T1 (pt) |
| TW (1) | TWI407962B (pt) |
| WO (1) | WO2010002845A2 (pt) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9166071B2 (en) | 2009-10-27 | 2015-10-20 | Silicor Materials Inc. | Polarization resistant solar cell design using an oxygen-rich interface layer |
| WO2012000182A1 (en) * | 2010-06-30 | 2012-01-05 | Hutchison Medipharma Limited | Quinazoline compounds |
| CN102311438A (zh) * | 2010-06-30 | 2012-01-11 | 和记黄埔医药（上海）有限公司 | 喹唑啉化合物 |
| CN102906086B (zh) * | 2010-06-30 | 2014-02-12 | 和记黄埔医药（上海）有限公司 | 喹唑啉化合物 |
| TWI466888B (zh) * | 2011-05-25 | 2015-01-01 | Hutchison Medipharma Ltd | 喹唑啉化合物 |
| AR092289A1 (es) * | 2011-11-14 | 2015-04-15 | Sunshine Lake Pharma Co Ltd | Derivados de aminoquinazolina y sus sales y metodos de uso |
| CN102659692B (zh) | 2012-05-04 | 2014-04-09 | 郑州泰基鸿诺药物科技有限公司 | 双联厄洛替尼及其制备方法 |
| CN102702115A (zh) * | 2012-05-24 | 2012-10-03 | 盛世泰科生物医药技术(苏州)有限公司 | 一种4-氯-7-氟-6-硝基喹唑啉的合成方法 |
| CN102775315A (zh) * | 2012-07-31 | 2012-11-14 | 上海应用技术学院 | 一种间氨基苯乙炔的制备方法 |
| CN103275018B (zh) * | 2013-04-26 | 2016-03-02 | 浙江工业大学 | 4-[3-氯-4-取代苯胺基]-6-取代甲酰氨基喹唑啉类化合物及制备和应用 |
| CN108863951A (zh) * | 2017-05-16 | 2018-11-23 | 和记黄埔医药（上海）有限公司 | 化合物的盐及其晶型 |
| WO2020007219A1 (zh) * | 2018-07-02 | 2020-01-09 | 南京明德新药研发有限公司 | 一种egfr抑制剂的晶型及其制备方法 |
| CN110903253B (zh) * | 2019-12-13 | 2020-12-25 | 西安交通大学医学院第一附属医院 | 一种喹唑啉酮类化合物及其制备方法和应用 |
| KR20230159543A (ko) * | 2021-03-26 | 2023-11-21 | 메드샤인 디스커버리 아이엔씨. | 6-카바메이트로 치환된 헤테로방향족 고리 유도체 |
| WO2023030216A1 (zh) * | 2021-08-30 | 2023-03-09 | 浙江海正药业股份有限公司 | 喹唑啉类衍生物、或其制备方法和用途 |
| TW202400588A (zh) * | 2022-02-28 | 2024-01-01 | 香港商維泰瑞隆（香港）生物科技有限公司 | Ｒｉｐ１調製劑、其製備及用途 |
| CN118834200A (zh) * | 2024-06-27 | 2024-10-25 | 辽宁大学 | 含酰胺结构的4-苯胺基喹唑啉类化合物及其应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9300059D0 (en) | 1992-01-20 | 1993-03-03 | Zeneca Ltd | Quinazoline derivatives |
| US5430148A (en) * | 1992-03-31 | 1995-07-04 | Agouron Pharmaceuticals, Inc. | Antiproliferative quinazolines |
| JP2994165B2 (ja) * | 1992-06-26 | 1999-12-27 | ゼネカ・リミテッド | キナゾリン誘導体、その製造法および該キナゾリン誘導体を含有する抗癌作用を得るための医薬調剤 |
| GB9510757D0 (en) | 1994-09-19 | 1995-07-19 | Wellcome Found | Therapeuticaly active compounds |
| GB9508565D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quiazoline derivative |
| EA001595B1 (ru) * | 1996-04-12 | 2001-06-25 | Варнер-Ламберт Компани | Необратимые ингибиторы тирозинкиназ |
| HRP970371A2 (en) | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
| GB9718972D0 (en) * | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| US6235741B1 (en) | 1997-05-30 | 2001-05-22 | Merck & Co., Inc. | Angiogenesis inhibitors |
| ZA986732B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
| BR9814116A (pt) | 1997-11-06 | 2000-10-03 | American Cyanamid Co | Uso de derivados de quinazolina como inibidores de cinase de tirosina para tratamento de pólipo colÈnico |
| PT1154774E (pt) | 1999-02-10 | 2005-10-31 | Astrazeneca Ab | Derivados de quinazolina como inibidores de angiogenese |
| US6943161B2 (en) | 1999-12-28 | 2005-09-13 | Pharmacopela Drug Discovery, Inc. | Pyrimidine and triazine kinase inhibitors |
| EP1292591B1 (en) | 2000-06-22 | 2005-02-02 | Pfizer Products Inc. | Substituted bicyclic derivatives for the treatment of abnormal cell growth |
| DE10063435A1 (de) | 2000-12-20 | 2002-07-04 | Boehringer Ingelheim Pharma | Chinazolinderviate,diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| ATE340165T1 (de) * | 2001-02-26 | 2006-10-15 | Univ Mcgill | Kombi-moleküle, welche eine inhibierende wirkung auf die signalübertragung und dna-schädigende eigenschaften haben |
| HUP0400606A2 (hu) | 2001-03-01 | 2004-12-28 | Ono Pharmaceutical Co., Ltd. | 2-Metil-indol-4-ecetsav és intermedierei és eljárás előállításukra |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| DE10204462A1 (de) | 2002-02-05 | 2003-08-07 | Boehringer Ingelheim Pharma | Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung inflammatorischer Prozesse |
| GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
| HRP20050089B1 (hr) | 2002-07-29 | 2015-06-19 | Rigel Pharmaceuticals | Upotreba 2,4 pirimidindiaminskog spoja za proizvodnju lijeka za lijeäśenje ili sprjeäśavanje autoimunosne bolesti |
| JO2785B1 (en) | 2003-05-27 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | Quinazoline derivatives |
| US7442698B2 (en) | 2003-07-24 | 2008-10-28 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
| GB0321710D0 (en) | 2003-09-16 | 2003-10-15 | Novartis Ag | Organic compounds |
| AU2004309166B2 (en) | 2003-12-23 | 2008-02-21 | Pfizer Inc. | Novel quinoline derivatives |
| WO2006071079A1 (en) | 2004-12-29 | 2006-07-06 | Hanmi Pharm. Co., Ltd. | Quinazoline derivatives for inhibiting cancer cell growth and method for the preparation thereof |
| KR100735639B1 (ko) * | 2004-12-29 | 2007-07-04 | 한미약품 주식회사 | 암세포 성장 억제 효과를 갖는 퀴나졸린 유도체 및 이의제조방법 |
| NZ564222A (en) | 2005-06-14 | 2011-10-28 | Taigen Biotechnology Co Ltd | Pyrimidine compounds |
| WO2007063934A1 (ja) * | 2005-12-02 | 2007-06-07 | Mitsubishi Tanabe Pharma Corporation | 脂環式複素環化合物 |
| AU2007299080B2 (en) | 2006-09-18 | 2013-04-18 | Boehringer Ingelheim International Gmbh | Method for treating cancer harboring EGFR mutations |
-
2008
- 2008-06-30 US US12/164,610 patent/US8426430B2/en not_active Expired - Fee Related
- 2008-07-04 TW TW097125257A patent/TWI407962B/zh not_active IP Right Cessation
-
2009
- 2009-06-30 SG SG201009559A patent/SG167561A1/en unknown
- 2009-06-30 BR BRPI0908635A patent/BRPI0908635B8/pt not_active IP Right Cessation
- 2009-06-30 AU AU2009267136A patent/AU2009267136B2/en not_active Ceased
- 2009-06-30 ES ES09774296.9T patent/ES2442946T3/es active Active
- 2009-06-30 SI SI200930832T patent/SI2318378T1/sl unknown
- 2009-06-30 MX MX2010012692A patent/MX2010012692A/es active IP Right Grant
- 2009-06-30 MY MYPI20105323 patent/MY150493A/en unknown
- 2009-06-30 PH PH12010502934A patent/PH12010502934A1/en unknown
- 2009-06-30 WO PCT/US2009/049182 patent/WO2010002845A2/en not_active Ceased
- 2009-06-30 CA CA2726040A patent/CA2726040C/en not_active Expired - Fee Related
- 2009-06-30 PT PT97742969T patent/PT2318378E/pt unknown
- 2009-06-30 DK DK09774296.9T patent/DK2318378T3/da active
- 2009-06-30 RU RU2011103207/04A patent/RU2505534C2/ru active
- 2009-06-30 PL PL09774296T patent/PL2318378T3/pl unknown
- 2009-06-30 KR KR1020107025451A patent/KR101664503B1/ko not_active Expired - Fee Related
- 2009-06-30 SG SG10201604677RA patent/SG10201604677RA/en unknown
- 2009-06-30 NZ NZ589191A patent/NZ589191A/xx not_active IP Right Cessation
- 2009-06-30 HR HRP20140066AT patent/HRP20140066T8/hr unknown
- 2009-06-30 EP EP09774296.9A patent/EP2318378B1/en active Active
- 2009-06-30 JP JP2011516797A patent/JP5602729B2/ja not_active Expired - Fee Related
-
2013
- 2013-03-18 US US13/846,140 patent/US20130217661A1/en not_active Abandoned
- 2013-11-26 CY CY20131101057T patent/CY1114842T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
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