BRPI0919777A2 - derivados de peptídeo e uso dos mesmos como vetores para moléculas na forma de conjugados - Google Patents

derivados de peptídeo e uso dos mesmos como vetores para moléculas na forma de conjugados

Info

Publication number: BRPI0919777A2
Authority: BR; Brazil
Prior art keywords: conjugates; vectors; molecules; peptide derivatives; peptide
Prior art date: 2008-10-22

Application number

BRPI0919777A

Other languages

English (en)

Inventor

Marion David

Michel Khrestchatiski

Patrick Vlieghe

Yves Molino

Original Assignee

Centre Nat Rech Scient

Univ Aix Marseille Ii

Vect Horus

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-10-22

Filing date

2009-10-20

Publication date

2016-09-20

2009-10-20 Application filed by Centre Nat Rech Scient, Univ Aix Marseille Ii, Vect Horus filed Critical Centre Nat Rech Scient

2016-09-20 Publication of BRPI0919777A2 publication Critical patent/BRPI0919777A2/pt

2021-09-14 Publication of BRPI0919777B1 publication Critical patent/BRPI0919777B1/pt

Links

108090000765 processed proteins & peptides Proteins 0.000 title 1
239000013598 vector Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K4/00—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Gastroenterology & Hepatology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Zoology (AREA)
Toxicology (AREA)
Virology (AREA)
Hospice & Palliative Care (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Tropical Medicine & Parasitology (AREA)
Orthopedic Medicine & Surgery (AREA)
Psychology (AREA)
Peptides Or Proteins (AREA)
Medicinal Preparation (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

BRPI0919777-0A 2008-10-22 2009-10-20 Derivados de peptídeo e uso dos mesmos como vetores para moléculas na forma de conjugados BRPI0919777B1 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR0857159A FR2937322B1 (fr)	2008-10-22	2008-10-22	Derives peptidiques et leur utilisation comme vecteurs de molecules sous forme de conjugues
FR0857159		2008-10-22
PCT/FR2009/051991 WO2010046588A1 (fr)	2008-10-22	2009-10-20	Derives peptidiques et leur utilisation comme vecteurs de molecules sous forme de conjugues

Publications (2)

Publication Number	Publication Date
BRPI0919777A2 true BRPI0919777A2 (pt)	2016-09-20
BRPI0919777B1 BRPI0919777B1 (pt)	2021-09-14

Family

ID=40852530

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0919777-0A BRPI0919777B1 (pt)	2008-10-22	2009-10-20	Derivados de peptídeo e uso dos mesmos como vetores para moléculas na forma de conjugados

Country Status (16)

Country	Link
US (2)	US8729029B2 (pt)
EP (1)	EP2350117B1 (pt)
JP (2)	JP5808250B2 (pt)
CN (1)	CN102282159B (pt)
AU (1)	AU2009306237B2 (pt)
BR (1)	BRPI0919777B1 (pt)
CA (1)	CA2741098C (pt)
DK (1)	DK2350117T3 (pt)
EA (1)	EA022976B1 (pt)
ES (1)	ES2525649T3 (pt)
FR (1)	FR2937322B1 (pt)
HR (1)	HRP20141139T1 (pt)
PL (1)	PL2350117T3 (pt)
SI (1)	SI2350117T1 (pt)
WO (1)	WO2010046588A1 (pt)
ZA (1)	ZA201103669B (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6849257B2 (en)	2000-02-04	2005-02-01	Children's Hospital Research Foundation	Lipid hydrolysis therapy for atherosclerosis and related diseases
FR2937322B1 (fr)	2008-10-22	2013-02-22	Vect Horus	Derives peptidiques et leur utilisation comme vecteurs de molecules sous forme de conjugues
FR2959229B1 (fr)	2010-04-21	2013-01-18	Vect Horus	Derives peptidiques, leur preparation et leurs utilisations
WO2014060601A1 (en)	2012-10-19	2014-04-24	Vect-Horus	Compositions and methods for drug delivery
FI3205351T3 (fi)	2010-04-23	2023-07-06	Alexion Pharma Inc	Lysosomaalisen kertymätaudin entsyymi
KR20150038636A (ko)	2010-09-09	2015-04-08	시나게바 바이오파르마, 코포레이션	환자에서 리소좀 산 리파제 결핍증의 치료를 위한 리소좀 산 리파제의 용도
WO2012112681A1 (en)	2011-02-15	2012-08-23	Shire Human Genetic Therapies, Inc.	Methods for treating lysosomal acid lipase deficiency
CN104117069A (zh) *	2013-04-26	2014-10-29	复旦大学	一种针对脑胶质瘤的靶向纳米递药系统及其制备方法和应用
US20150093399A1 (en)	2013-08-28	2015-04-02	Bioasis Technologies, Inc.	Cns-targeted conjugates having modified fc regions and methods of use thereof
EP2896402A1 (en) *	2014-01-20	2015-07-22	Vect-Horus	Activated neurotensin molecules and the uses thereof
WO2018118015A1 (en)	2016-12-19	2018-06-28	Morehouse School Of Medicine	Compositions and methods for treating diseases by inhibiting exosome release
WO2018138372A1 (en) *	2017-01-30	2018-08-02	Vect-Horus	Compositions and methods for cancer imaging and radiotherapy
US10688191B2 (en)	2018-01-19	2020-06-23	Hr Biomed, Llc	Delivery of a chemotherapy agent across the blood-brain barrier
CA3124790A1 (en)	2019-01-09	2020-07-16	Vect-Horus	Transferrin receptor-binding molecules, conjugates thereof and their uses
WO2021116079A1 (en)	2019-12-10	2021-06-17	Université de Mons	Peptides binding to ldl-receptor as carriers for crossing the blood brain barrier
CA3128035A1 (en)	2020-08-13	2022-02-13	Bioasis Technologies, Inc.	Combination therapies for delivery across the blood brain barrier
US20260022187A1 (en) *	2022-07-28	2026-01-22	Ohio State Innovation Foundation	Methods and compositions regarding cyclic peptides for use with antibodies and antibody fragments
WO2024228936A1 (en) *	2023-05-03	2024-11-07	Merck Sharp & Dohme Llc	Cyclic peptides as pet imaging agents of granzyme b
EP4731658A1 (en)	2023-06-22	2026-04-29	Vect-Horus	Transferrin receptor-binding molecules, conjugates thereof and their uses to prevent or treat nervous system diseases
EP4480965A1 (en)	2023-06-22	2024-12-25	Vect-Horus	Transferrin receptor-binding molecules, conjugates thereof and their uses to prevent or treat cns diseases
WO2025193680A1 (en) *	2024-03-11	2025-09-18	Ohio State Innovation Foundation	Disulfide cyclic cell-penetrating peptides and uses thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5981478A (en) *	1993-11-24	1999-11-09	La Jolla Cancer Research Foundation	Integrin-binding peptides
US6232287B1 (en) *	1998-03-13	2001-05-15	The Burnham Institute	Molecules that home to various selected organs or tissues
WO1999047566A1 (en) *	1998-03-17	1999-09-23	The Uab Research Foundation	Synthetic peptides that enhance ldl uptake
WO2001047944A2 (en) *	1999-12-28	2001-07-05	Curagen Corporation	Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
US20110131679A2 (en)	2000-04-19	2011-06-02	Thomas La Rosa	Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
JP2004520803A (ja)	2000-04-21	2004-07-15	コリクサコーポレイション	尋常性挫瘡の治療および診断のための組成物および方法
NO20026285D0 (no) *	2002-12-30	2002-12-30	Amersham Health As	Nye peptider
US20050058603A1 (en) *	2003-05-02	2005-03-17	Case Western Reserve University	Drug delivery system based on polymer nanoshells
AU2003286870A1 (en)	2003-06-05	2005-01-04	Salk Institute For Biological Studies	Targeting polypeptides to the central nervous system
US7723474B2 (en) *	2003-10-21	2010-05-25	The Regents Of The University Of California	Molecules that selectively home to vasculature of pre-malignant dysplastic lesions or malignancies
GB0404374D0 (en) *	2004-02-27	2004-03-31	Univ Manchester	Treatment of bacterial infections
FR2889532B1 (fr)	2005-08-03	2007-10-12	Lab Francais Du Fractionnement	Anticorps diriges contre le recepteur du ldl
WO2007145659A1 (en) *	2005-11-10	2007-12-21	The Regents Of The University Of California	Synthetic ldl as targeted drug delivery vehicle
FR2937322B1 (fr)	2008-10-22	2013-02-22	Vect Horus	Derives peptidiques et leur utilisation comme vecteurs de molecules sous forme de conjugues
FR2959229B1 (fr)	2010-04-21	2013-01-18	Vect Horus	Derives peptidiques, leur preparation et leurs utilisations

2008
- 2008-10-22 FR FR0857159A patent/FR2937322B1/fr active Active
2009
- 2009-10-20 DK DK09760175.1T patent/DK2350117T3/en active
- 2009-10-20 EP EP09760175.1A patent/EP2350117B1/fr active Active
- 2009-10-20 CN CN200980150257.2A patent/CN102282159B/zh active Active
- 2009-10-20 US US13/125,634 patent/US8729029B2/en active Active
- 2009-10-20 CA CA2741098A patent/CA2741098C/fr active Active
- 2009-10-20 HR HRP20141139AT patent/HRP20141139T1/hr unknown
- 2009-10-20 AU AU2009306237A patent/AU2009306237B2/en active Active
- 2009-10-20 EA EA201170587A patent/EA022976B1/ru not_active IP Right Cessation
- 2009-10-20 ES ES09760175.1T patent/ES2525649T3/es active Active
- 2009-10-20 JP JP2011532687A patent/JP5808250B2/ja active Active
- 2009-10-20 SI SI200931072T patent/SI2350117T1/sl unknown
- 2009-10-20 WO PCT/FR2009/051991 patent/WO2010046588A1/fr not_active Ceased
- 2009-10-20 PL PL09760175T patent/PL2350117T3/pl unknown
- 2009-10-20 BR BRPI0919777-0A patent/BRPI0919777B1/pt active IP Right Grant
2011
- 2011-05-19 ZA ZA2011/03669A patent/ZA201103669B/en unknown
2014
- 2014-05-14 US US14/277,339 patent/US9328143B2/en active Active
2015
- 2015-05-27 JP JP2015107552A patent/JP6232396B2/ja active Active

Also Published As

Publication number	Publication date
EA201170587A1 (ru)	2012-05-30
US8729029B2 (en)	2014-05-20
JP5808250B2 (ja)	2015-11-10
DK2350117T3 (en)	2014-12-08
US20110230416A1 (en)	2011-09-22
AU2009306237A1 (en)	2010-04-29
US9328143B2 (en)	2016-05-03
JP6232396B2 (ja)	2017-11-15
PL2350117T3 (pl)	2015-04-30
CA2741098A1 (fr)	2010-04-29
FR2937322B1 (fr)	2013-02-22
FR2937322A1 (fr)	2010-04-23
WO2010046588A1 (fr)	2010-04-29
EP2350117A1 (fr)	2011-08-03
AU2009306237B2 (en)	2015-04-09
BRPI0919777B1 (pt)	2021-09-14
CA2741098C (fr)	2017-03-28
CN102282159A (zh)	2011-12-14
US20140243499A1 (en)	2014-08-28
EA022976B1 (ru)	2016-04-29
CN102282159B (zh)	2015-11-25
JP2015212264A (ja)	2015-11-26
ZA201103669B (en)	2012-01-25
SI2350117T1 (sl)	2015-03-31
HRP20141139T1 (en)	2015-03-13
JP2012506407A (ja)	2012-03-15
ES2525649T3 (es)	2014-12-26
EP2350117B1 (fr)	2014-09-10
WO2010046588A9 (fr)	2010-06-24

Legal Events

Date	Code	Title	Description
2017-08-01	B25A	Requested transfer of rights approved	Owner name: UNIVERSITE D'AIX - MARSEILLE (FR)
2018-04-17	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2018-05-08	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2020-04-28	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2020-08-25	B06U	Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
2021-06-08	B350	Update of information on the portal [chapter 15.35 patent gazette]
2021-07-27	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2021-09-14	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 20/10/2009, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.

Publication	Publication Date	Title
BRPI0919777A2 (pt)	2016-09-20	derivados de peptídeo e uso dos mesmos como vetores para moléculas na forma de conjugados
BRPI0922708A2 (pt)	2018-11-06	peptídeos mini-hepcidina e métodos de uso do mesmo
BRPI0816372A2 (pt)	2015-02-24	Ácidos 6-fenilnicotínicos substituídos e seu uso
BRPI1010024A2 (pt)	2019-09-24	derivados de aminopirrolidinona e uso dos mesmos
DOP2010000260A (es)	2010-10-15	Derivado heterociclico fusionado y su uso
BRPI0822366A2 (pt)	2015-06-16	Material de tecido para uso em um artigo absorvente
SMT201500206B (it)	2015-10-30	Composti spiro-ossindolici e loro uso come agenti terapeutici
BRPI0906739A2 (pt)	2015-08-04	Métodos e composições relacionadas para internalizar peptídeos de rgd
BRPI0913710A2 (pt)	2015-10-13	"artigo e métodos para preparação do artigo"
BRPI0821924A2 (pt)	2015-07-07	Moléculas de ligação baseadas em fibronectina melhoradas e seu uso
BRPI0914595A2 (pt)	2015-12-15	material substituto de madeira e seu uso
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BR112012004088A2 (pt)	2017-06-20	processos para dissociação de moléculas alvo e sistema para uso no mesmo
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