BRPI0920020A8 - relatório descritivo da patente de invenção: tratamentos de pele contendo derivados de idebenona substituida por ácido carboxílico e métodos de preparação. - Google Patents

relatório descritivo da patente de invenção: tratamentos de pele contendo derivados de idebenona substituida por ácido carboxílico e métodos de preparação.

Info

Publication number: BRPI0920020A8
Authority: BR; Brazil
Prior art keywords: preparation; methods; carboxylic acid; patent specification; containing carboxylic
Prior art date: 2008-10-06

Application number

BRPI0920020A

Other languages

English (en)

Inventor

Andrew S Thompson

Diedrich Falko

Joseph C Dinardo

James Alan Kerschen

Joseph A Ii Lewis

Neudecker Birgit

Peter C Wade

Wieland Eberhard

Original Assignee

Elizabeth Arden International Sarl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-10-06

Filing date

2009-10-06

Publication date

2016-11-16

2009-10-06 Application filed by Elizabeth Arden International Sarl filed Critical Elizabeth Arden International Sarl

2016-10-25 Publication of BRPI0920020A2 publication Critical patent/BRPI0920020A2/pt

2016-11-16 Publication of BRPI0920020A8 publication Critical patent/BRPI0920020A8/pt

2017-05-16 Publication of BRPI0920020B1 publication Critical patent/BRPI0920020B1/pt

Links

150000001732 carboxylic acid derivatives Chemical group 0.000 title 1
JGPMMRGNQUBGND-UHFFFAOYSA-N idebenone Chemical class COC1=C(OC)C(=O)C(CCCCCCCCCCO)=C(C)C1=O JGPMMRGNQUBGND-UHFFFAOYSA-N 0.000 title 1
238000000034 method Methods 0.000 title 1
238000011282 treatment Methods 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/06—Preparations for care of the skin for countering cellulitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q90/00—Cosmetics or similar toiletry preparations for specific uses not provided for in other groups of this subclass
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/14—Preparation of carboxylic acid esters from carboxylic acid halides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/95—Esters of quinone carboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Dermatology (AREA)
Birds (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Gerontology & Geriatric Medicine (AREA)
Toxicology (AREA)
Cosmetics (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Biotechnology (AREA)
Botany (AREA)
Microbiology (AREA)
Mycology (AREA)
Medicinal Preparation (AREA)
Saccharide Compounds (AREA)

BRPI0920020A 2008-10-06 2009-10-06 composto para tratamentos de pele. BRPI0920020B1 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US10304308P	2008-10-06	2008-10-06
PCT/US2009/059673 WO2010051138A2 (en)	2008-10-06	2009-10-06	Skin treatments containing carboxylic acid-substituted idebenone derivatives and methods of preparation and use thereof

Publications (3)

Publication Number	Publication Date
BRPI0920020A2 BRPI0920020A2 (pt)	2016-10-25
BRPI0920020A8 true BRPI0920020A8 (pt)	2016-11-16
BRPI0920020B1 BRPI0920020B1 (pt)	2017-05-16

Family

ID=42049330

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0920020A BRPI0920020B1 (pt)	2008-10-06	2009-10-06	composto para tratamentos de pele.

Country Status (17)

Country	Link
US (4)	US8173703B2 (pt)
EP (1)	EP2344256B1 (pt)
JP (1)	JP5739335B2 (pt)
KR (1)	KR101630240B1 (pt)
CN (1)	CN102231996B (pt)
AU (1)	AU2009309056B2 (pt)
BR (1)	BRPI0920020B1 (pt)
CA (1)	CA2739974C (pt)
DK (1)	DK2344256T3 (pt)
ES (1)	ES2634423T3 (pt)
IL (1)	IL211844A (pt)
MX (1)	MX2011003361A (pt)
NZ (1)	NZ592663A (pt)
RU (1)	RU2537299C2 (pt)
SG (1)	SG194410A1 (pt)
WO (1)	WO2010051138A2 (pt)
ZA (1)	ZA201101965B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7872047B2 (en) *	2008-02-08	2011-01-18	Eastman Chemical Company	Esters of long-chain alcohols and preparation thereof
JP2015528499A (ja) *	2012-09-14	2015-09-28	エリザベスアーデンインコーポレイテッド	イデベノンとｎ−アセチル−ｓ−ファルネシル−ｌ−システインとエルゴチオネインとを含む調合物及びその使用法
WO2016153938A1 (en) *	2015-03-25	2016-09-29	Biosynthetic Technologies, Llc	Ester compounds including triesters having terminal vicinal acyl groups
IT201600111315A1 (it) *	2016-11-04	2018-05-04	Laura Castoldi	Composizione cosmetica anti-età.
FR3091176B1 (fr) *	2018-12-26	2021-04-16	Oreal	Composition cosmétique comprenant des filtres UV hydrosolubles

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4144325A (en)	1976-11-10	1979-03-13	Voyt Walter F	Method of and composition for preventing sunburn while affording tanning
US4248861A (en)	1979-02-21	1981-02-03	Schutt Steven R	Skin treatment methods
JPS6143132A (ja) *	1984-08-06	1986-03-01	Takeda Chem Ind Ltd	キノン誘導体，その製造法およびそれを含んでなる医薬組成物
FR2765881B1 (fr) *	1997-07-09	1999-08-13	Michelin & Cie	Composition de caoutchouc vulcanisable au soufre contenant de la silice
DE19932197A1 (de) *	1999-07-09	2001-01-18	Neudecker Birgit	Topisch anzuwendendes Mittel mit schützender und regenerativer Wirkung
US20050281853A1 (en) *	2002-02-15	2005-12-22	Fox Charles A	Skin compatible cosmetic compositions and delivery methods therefor
EP1664069B8 (en) *	2003-08-22	2015-07-01	Antipodean Pharmaceuticals, Inc.	Mitoquinone derivatives used as mitochondrially targeted antioxidants
AR055453A1 (es) *	2004-01-06	2007-08-22	Creactivar S A	Uso de la idebenona en una composicion destinada a ser aplicada sobre la piel y composicion que la comprende
CN101128193B (zh) *	2004-12-22	2011-11-16	西巴特殊化学制品控股公司	抗自由基剂
US7872047B2 (en) *	2008-02-08	2011-01-18	Eastman Chemical Company	Esters of long-chain alcohols and preparation thereof
US9707417B2 (en) *	2008-06-25	2017-07-18	Basf Se	Use of benzotropolone derivatives as UV absorbers and antioxidants and their use in sunscreens and/or cosmetic compositions

2009
- 2009-10-06 MX MX2011003361A patent/MX2011003361A/es active IP Right Grant
- 2009-10-06 SG SG2013074554A patent/SG194410A1/en unknown
- 2009-10-06 US US12/574,135 patent/US8173703B2/en active Active
- 2009-10-06 CN CN200980139639.5A patent/CN102231996B/zh active Active
- 2009-10-06 ES ES09807729.0T patent/ES2634423T3/es active Active
- 2009-10-06 DK DK09807729.0T patent/DK2344256T3/en active
- 2009-10-06 RU RU2011112707/04A patent/RU2537299C2/ru active
- 2009-10-06 EP EP09807729.0A patent/EP2344256B1/en active Active
- 2009-10-06 WO PCT/US2009/059673 patent/WO2010051138A2/en not_active Ceased
- 2009-10-06 AU AU2009309056A patent/AU2009309056B2/en active Active
- 2009-10-06 BR BRPI0920020A patent/BRPI0920020B1/pt active IP Right Grant
- 2009-10-06 JP JP2011530300A patent/JP5739335B2/ja active Active
- 2009-10-06 CA CA2739974A patent/CA2739974C/en active Active
- 2009-10-06 NZ NZ592663A patent/NZ592663A/xx unknown
- 2009-10-06 KR KR1020117010489A patent/KR101630240B1/ko active Active
2011
- 2011-03-15 ZA ZA2011/01965A patent/ZA201101965B/en unknown
- 2011-03-22 IL IL211844A patent/IL211844A/en active IP Right Grant
2012
- 2012-01-13 US US13/349,651 patent/US8354550B2/en active Active
- 2012-12-13 US US13/714,136 patent/US9290436B2/en active Active
2016
- 2016-02-08 US US15/018,259 patent/US20160151260A1/en not_active Abandoned

Also Published As

Publication number	Publication date
WO2010051138A2 (en)	2010-05-06
US20120130098A1 (en)	2012-05-24
ES2634423T3 (es)	2017-09-27
DK2344256T3 (en)	2017-07-17
US20130101534A1 (en)	2013-04-25
KR20110069849A (ko)	2011-06-23
BRPI0920020B1 (pt)	2017-05-16
AU2009309056A1 (en)	2010-05-06
RU2537299C2 (ru)	2014-12-27
ZA201101965B (en)	2012-09-26
CN102231996A (zh)	2011-11-02
EP2344256B1 (en)	2017-04-26
WO2010051138A3 (en)	2010-06-24
US20100086494A1 (en)	2010-04-08
SG194410A1 (en)	2013-11-29
CA2739974C (en)	2017-06-13
CA2739974A1 (en)	2010-05-06
US8354550B2 (en)	2013-01-15
US20160151260A1 (en)	2016-06-02
IL211844A (en)	2014-08-31
NZ592663A (en)	2012-08-31
JP2012505159A (ja)	2012-03-01
JP5739335B2 (ja)	2015-06-24
HK1162996A1 (en)	2013-04-26
US9290436B2 (en)	2016-03-22
CN102231996B (zh)	2014-11-26
MX2011003361A (es)	2011-07-28
AU2009309056B2 (en)	2013-11-21
RU2011112707A (ru)	2012-11-20
EP2344256A2 (en)	2011-07-20
BRPI0920020A2 (pt)	2016-10-25
US8173703B2 (en)	2012-05-08
KR101630240B1 (ko)	2016-06-14
IL211844A0 (en)	2011-06-30

Legal Events

Date	Code	Title	Description
2016-11-01	B15I	Others concerning applications: loss of priority	Free format text: PERDA DA PRIORIDADE US 61/103,043 DE 06/10/2008 REIVINDICADA NO PCT/US2009/059673, CONFORME AS DISPOSICOES PREVISTAS NA LEI 9.279 DE 14/05/1996 (LPI) ART. 16 7O, ITEM 28 DO ATO NORMATIVO 128/97 E NO ART. 29 DA RESOLUCAO INPI-PR 77/2013. OBSERVA-SE QUE A PRIORIDADE US 61/103,043 DE 06/10/2008 POSSUI COMO TITULARES FALKO DIEDRICH, JOSEPH A. LEWIS II, JOSEPH C. DINARDO, BIRGIT NEUDECKER E EBERHARD WIELAND . ESTA PERDA SE DEU PELO FATO DE O DEPOSITANTE CONSTANTE DA PETICAO DE REQUERIMENTO DO PEDIDO PCT PHARMA COSMETIX RESEARCH, LLC , POSTERIORMENTE ALTERADO PARA PCR TECHNOLOGY HOLDINGS, LC SER DISTINTO DAQUELE QUE DEPOSITOU A PRIORIDADE REIVINDICADA E NAO APRESENTOU DOCUMENTO COMPROBATORIO
2016-11-16	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2017-02-07	B12F	Other appeals [chapter 12.6 patent gazette]
2017-03-07	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2017-05-16	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Publication	Publication Date	Title
FIC20240036I1 (fi)	2024-10-29	Geeniterapia, joka ilmentää ihmisen hyytymistekijä IX:n muunnosta R338L
BRPI0913574A2 (pt)	2015-11-24	composição de tratamento de acne compreendendo nanoprata e usos
BRPI0906389A2 (pt)	2015-07-07	Sistema de terapia de pele
IL217540A (en)	2017-04-30	Oral composition for use in oral disinfection or in treating an oral disease
BRPI0907918A2 (pt)	2015-07-28	Ácidos sulfoperoxicarxílicos, sua preparação e métodos de utilizção como agentes alvejantes e antimicrobianos
PT2376537T (pt)	2016-12-26	Anticorpos humanos contra fator tecidual humano
BRPI0918596A2 (pt)	2016-10-18	conector médico, método de conectar conector e dispositivo de acesso
EP2400916A4 (en)	2015-12-23	DENTAL AND MEDICAL TREATMENTS AND METHOD
IL219277A0 (en)	2012-06-28	Apparatus and methods for the treatment of human or animal tissue by light
BRPI1007100A2 (pt)	2016-03-01	método cirúrgico endoscópico e sistema cirúrgico minimamente invasivo
BRPI0920026A2 (pt)	2015-12-15	método de tratamento de infecção pulmonar, composição farmacêutica e respectivos usos.
BRPI0910874A2 (pt)	2015-10-06	composições e métodos para cuidado da pele
IT1392888B1 (it)	2012-04-02	Dispositivo e metodo di guida di utensili chirurgici mediante imaging ecografico.
IT1391555B1 (it)	2012-01-11	Apparato trattamento extracorporeo sangue
BRPI0919090A2 (pt)	2015-12-15	prepraração de ácido acético.
BRPI0908143A2 (pt)	2015-08-11	Agente de branqueamento e preparação externa da pele
EA201300669A1 (ru)	2013-11-29	Замещенные 1-бензилциклоалкилкарбоновые кислоты и их применение
HUE038785T2 (hu)	2018-11-28	Hagyományos kínai gyógyszerkészítmény szív- és érrendszeri betegségek kezelésére
PT2613798E (pt)	2015-06-02	Utilização de lipase ácida lisossomal para o tratamento da deficiência de lipase ácida lisossomal em doentes
IL240560A0 (en)	2015-09-24	Compositions and methods for the diagnosis and treatment of tumor
PT2542300T (pt)	2016-11-14	Dispositivo de eletroporação da pele tolerável e minimamente invasivo
GB201108964D0 (en)	2011-07-13	Medicament and method of diagnosis
PL2298071T3 (pl)	2013-06-28	Wodny roztwór do konserwacji tkanek i narządów
BRPI0916507A2 (pt)	2015-11-10	compostos, composição cosmética ou farmacêutica, processo de tratamento cosmético não terapêutico da pele e usos não terapêuticos de uma composição cosmética
BRPI0920020A2 (pt)	2016-10-25	relatório descritivo da patente de invenção: tratamentos de pele contendo derivados de idebenona substituida por ácido carboxílico e métodos de preparação.