BRPI0921335A2 - derivados de pirazolona e seu uso como inibidores de pd4 - Google Patents
derivados de pirazolona e seu uso como inibidores de pd4Info
- Publication number
- BRPI0921335A2 BRPI0921335A2 BRPI0921335A BRPI0921335A BRPI0921335A2 BR PI0921335 A2 BRPI0921335 A2 BR PI0921335A2 BR PI0921335 A BRPI0921335 A BR PI0921335A BR PI0921335 A BRPI0921335 A BR PI0921335A BR PI0921335 A2 BRPI0921335 A2 BR PI0921335A2
- Authority
- BR
- Brazil
- Prior art keywords
- inhibitors
- pyrazolone derivatives
- pyrazolone
- derivatives
- Prior art date
Links
- 229940083761 high-ceiling diuretics pyrazolone derivative Drugs 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- JEXVQSWXXUJEMA-UHFFFAOYSA-N pyrazol-3-one Chemical class O=C1C=CN=N1 JEXVQSWXXUJEMA-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08169143 | 2008-11-14 | ||
| US19333308P | 2008-11-19 | 2008-11-19 | |
| PCT/EP2009/065031 WO2010055083A1 (en) | 2008-11-14 | 2009-11-12 | Novel pyrazolone-derivatives and their use as pd4 inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0921335A2 true BRPI0921335A2 (pt) | 2017-06-06 |
| BRPI0921335A8 BRPI0921335A8 (pt) | 2017-12-05 |
Family
ID=40427227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0921335A BRPI0921335A8 (pt) | 2008-11-14 | 2009-11-12 | Derivados de pirazolona e seu uso como inibidores de pd4 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US8609848B2 (pt) |
| EP (1) | EP2356103B1 (pt) |
| JP (1) | JP5599405B2 (pt) |
| KR (1) | KR20110082616A (pt) |
| CN (1) | CN102369194B (pt) |
| AR (1) | AR074318A1 (pt) |
| AU (1) | AU2009315615A1 (pt) |
| BR (1) | BRPI0921335A8 (pt) |
| CA (1) | CA2742922C (pt) |
| CO (1) | CO6331469A2 (pt) |
| EA (1) | EA018585B1 (pt) |
| EC (1) | ECSP11011034A (pt) |
| ES (1) | ES2553754T3 (pt) |
| GE (1) | GEP20135918B (pt) |
| IL (1) | IL212700A0 (pt) |
| MA (1) | MA32885B1 (pt) |
| ME (1) | ME01134B (pt) |
| MX (1) | MX2011005030A (pt) |
| MY (1) | MY154019A (pt) |
| NZ (1) | NZ593262A (pt) |
| PE (1) | PE20110539A1 (pt) |
| TW (1) | TWI460172B (pt) |
| UA (1) | UA105910C2 (pt) |
| WO (1) | WO2010055083A1 (pt) |
| ZA (1) | ZA201102028B (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR074318A1 (es) * | 2008-11-14 | 2011-01-05 | Nycomed Gmbh | Derivados heterociclicos de pirazolona, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades de las vias respiratorias. |
| WO2014090990A1 (en) * | 2012-12-13 | 2014-06-19 | Ludwig Aigner | Leukotriene pathway antagonists for the treatment of dementia, cognitive deficits in parkinson's disease and/or learning and memory deficiencies in parkinson's disease |
| WO2017089347A1 (en) | 2015-11-25 | 2017-06-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2903460A (en) | 1956-04-07 | 1959-09-08 | Sandoz Ag | Pyrazolone derivatives |
| US4550119A (en) | 1983-05-23 | 1985-10-29 | Warner-Lambert Company | 2,4-Dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones |
| BR9806752A (pt) | 1997-01-15 | 2000-03-14 | Byk Gulden Lomberg Chem Fab | Ftalazinonas. |
| CZ20032491A3 (cs) | 2001-02-15 | 2004-01-14 | Altana Pharma Ag | Ftalazinonpiperidinové deriváty |
| EP1385848A2 (en) | 2001-04-25 | 2004-02-04 | ALTANA Pharma AG | Phtalazinones derivatives useful as pde4/7 inhibitors |
| WO2004018449A1 (en) | 2002-08-10 | 2004-03-04 | Altana Pharma Ag | Piperidine-derivatives as pde4 inhibitors |
| EP1556369A1 (en) | 2002-08-10 | 2005-07-27 | ALTANA Pharma AG | Pyridazinone-derivatives as pde4 inhibitors |
| BR0313330A (pt) | 2002-08-10 | 2005-06-14 | Altana Pharma Ag | Piperidina-ftalazonas substituìdas com pirrolidinadiona como inibidores de pde4 |
| WO2005075457A1 (en) | 2004-02-04 | 2005-08-18 | Altana Pharma Ag | Phthalazinone-derivatives as pde4 inhibitors |
| DE602005005638T2 (de) | 2004-02-04 | 2009-05-14 | Nycomed Gmbh | 2-(piperidin-4-yl)-4,5-dihydro-2h-pyridazin-3-on-derivate als pde4-inhibitoren |
| PL2589599T4 (pl) | 2004-03-03 | 2015-06-30 | Takeda Gmbh | Nowe hydroksy-6-heteroarylofenantrydyny i ich zastosowanie jako inhibitorów PDE4 |
| CA2565599C (en) * | 2004-05-18 | 2012-07-31 | Schering Corporation | Substituted 2-quinolyl-oxazoles useful as pde4 inhibitors |
| WO2007092435A2 (en) | 2006-02-07 | 2007-08-16 | Wyeth | 11-beta hsd1 inhibitors |
| ES2427442T3 (es) * | 2007-05-16 | 2013-10-30 | Takeda Gmbh | Derivados de pirazolona como inhibidores de PDE4 |
| JPWO2008156102A1 (ja) | 2007-06-19 | 2010-08-26 | 杏林製薬株式会社 | ピラゾロン誘導体及びそれらを有効成分とするpde阻害剤 |
| AR074318A1 (es) * | 2008-11-14 | 2011-01-05 | Nycomed Gmbh | Derivados heterociclicos de pirazolona, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades de las vias respiratorias. |
-
2009
- 2009-11-11 AR ARP090104358A patent/AR074318A1/es unknown
- 2009-11-12 WO PCT/EP2009/065031 patent/WO2010055083A1/en not_active Ceased
- 2009-11-12 EA EA201100740A patent/EA018585B1/ru not_active IP Right Cessation
- 2009-11-12 US US13/128,051 patent/US8609848B2/en not_active Expired - Fee Related
- 2009-11-12 MY MYPI2011001414A patent/MY154019A/en unknown
- 2009-11-12 CA CA2742922A patent/CA2742922C/en not_active Expired - Fee Related
- 2009-11-12 ME MEP-2011-81A patent/ME01134B/me unknown
- 2009-11-12 PE PE2011000973A patent/PE20110539A1/es not_active Application Discontinuation
- 2009-11-12 ES ES09752352T patent/ES2553754T3/es active Active
- 2009-11-12 CN CN200980145860.1A patent/CN102369194B/zh not_active Expired - Fee Related
- 2009-11-12 MX MX2011005030A patent/MX2011005030A/es active IP Right Grant
- 2009-11-12 KR KR1020117013038A patent/KR20110082616A/ko not_active Withdrawn
- 2009-11-12 NZ NZ593262A patent/NZ593262A/xx not_active IP Right Cessation
- 2009-11-12 UA UAA201107341A patent/UA105910C2/uk unknown
- 2009-11-12 AU AU2009315615A patent/AU2009315615A1/en not_active Abandoned
- 2009-11-12 GE GEAP200912248A patent/GEP20135918B/en unknown
- 2009-11-12 EP EP09752352.6A patent/EP2356103B1/en active Active
- 2009-11-12 JP JP2011536009A patent/JP5599405B2/ja not_active Expired - Fee Related
- 2009-11-12 BR BRPI0921335A patent/BRPI0921335A8/pt not_active IP Right Cessation
- 2009-11-13 TW TW098138693A patent/TWI460172B/zh active
-
2011
- 2011-03-17 ZA ZA2011/02028A patent/ZA201102028B/en unknown
- 2011-05-05 IL IL212700A patent/IL212700A0/en unknown
- 2011-05-06 EC EC2011011034A patent/ECSP11011034A/es unknown
- 2011-05-12 CO CO11058443A patent/CO6331469A2/es active IP Right Grant
- 2011-06-08 MA MA33922A patent/MA32885B1/fr unknown
-
2013
- 2013-11-15 US US14/080,881 patent/US9340522B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0920448A2 (pt) | compostos spiro-oxindol e seu uso como agentes terapêuticos | |
| HRP20190016T1 (hr) | Heterociklički spojevi i njihova upotreba | |
| BRPI0908225A2 (pt) | derivados de piridazina e seu uso como agentes terapêuticos | |
| BRPI0913885A8 (pt) | tiadiazoliloxifenilamidinas e seu uso como fungicidas | |
| BRPI0817681A2 (pt) | Compostos de tienopirimidina e pirazolopirimidina e seu uso como inibidores de mtor quinase e pi3 quinase | |
| BRPI0813831A2 (pt) | Compostos de heteroarila bicíclica e seu uso como inibidores de quinase | |
| BRPI1011066A2 (pt) | "pirazolopirimidinas e heterociclos relacionados como inibidores de quinase | |
| BRPI0810679A2 (pt) | Derivados de 4-aza indol e seu uso como fungicidas | |
| BR112013014314A2 (pt) | derivados de 6-amino-2-fenilamino-1h-benzimidazol-5-carboxamida e seu uso como inibidores de prostaglandina e2 sintase-1 microssômicas | |
| BRPI0914652A2 (pt) | compostos e composições como inibidores de quinase | |
| CR20130360A (es) | Compuesto heterocíclico y su uso | |
| BRPI0912668A2 (pt) | composto e composições como inibidores de quinase | |
| BRPI0908849A2 (pt) | Composto e composições como c-kit e inibidores de pdgfr quinase | |
| BRPI0814065A2 (pt) | Derivados de alcoóis de 1-fenil-2-piridinil alquila como inibidores da fosfodiesterase | |
| BRPI0918128A2 (pt) | derivados de heterozril amida e seu uso como ativadores de glicocinase | |
| BRPI0920135A2 (pt) | imidazopiridazinacarbonitrilos úteis como inibidores de quinase | |
| BRPI0911356A2 (pt) | compositos de 2-imino-3-metil pirrol pirimidina substituída por fenila como inibidores de bace-1, composições, e seu uso | |
| BRPI0913580A2 (pt) | pirrolopiridinas como inibidores de quinase | |
| BRPI0914536A2 (pt) | tiadiazoliloxifenilamidinas e o uso destas como fungicidas | |
| BRPI1016150A2 (pt) | compostos heterocíclicos e seus usos. | |
| BRPI0913879A2 (pt) | fenilpirazinonas como inibidores de quinase | |
| BRPI0911228A2 (pt) | compostos e composições como inibidores de proteínas quinase | |
| EP2132299A4 (en) | OBTAINING, ISOLATING, AND CRYOKON SUSPENSION OF ENDOMETRY / MENSTRUATION CELLS | |
| BRPI0922095A2 (pt) | derivados de piridina e pirimidina como inibidores de fosfodiesterase 10 | |
| BRPI0921598A2 (pt) | derivados de piridina e pirimidina como inibidores de fosfodiesterase 10 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25D | Requested change of name of applicant approved |
Owner name: TAKEDA GMBH (DE) |
|
| B25A | Requested transfer of rights approved |
Owner name: NYCOMED ASSET MANAGEMENT GMBH (DE) |
|
| B25A | Requested transfer of rights approved |
Owner name: NYCOMED GERMANY HOLDING GMBH (DE) |
|
| B25D | Requested change of name of applicant approved |
Owner name: TAKEDA GMBH (DE) |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 10A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2540 DE 10-09-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |