BRPI0918128A2 - derivados de heterozril amida e seu uso como ativadores de glicocinase - Google Patents

derivados de heterozril amida e seu uso como ativadores de glicocinase

Info

Publication number
BRPI0918128A2
BRPI0918128A2 BRPI0918128A BRPI0918128A BRPI0918128A2 BR PI0918128 A2 BRPI0918128 A2 BR PI0918128A2 BR PI0918128 A BRPI0918128 A BR PI0918128A BR PI0918128 A BRPI0918128 A BR PI0918128A BR PI0918128 A2 BRPI0918128 A2 BR PI0918128A2
Authority
BR
Brazil
Prior art keywords
heterozril
amide derivatives
glucokinase activators
glucokinase
activators
Prior art date
Application number
BRPI0918128A
Other languages
English (en)
Inventor
Jeffrey Allen Pferfferkorn
Jihong Lou
John William Benbow
Meihua Mike Tu
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41228587&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0918128(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of BRPI0918128A2 publication Critical patent/BRPI0918128A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI0918128A 2008-09-11 2009-08-28 derivados de heterozril amida e seu uso como ativadores de glicocinase BRPI0918128A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9605608P 2008-09-11 2008-09-11
US23257809P 2009-08-10 2009-08-10
PCT/IB2009/053773 WO2010029461A1 (en) 2008-09-11 2009-08-28 Heteroaryls amide derivatives and their use as glucokinase activators

Publications (1)

Publication Number Publication Date
BRPI0918128A2 true BRPI0918128A2 (pt) 2015-11-24

Family

ID=41228587

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0918128A BRPI0918128A2 (pt) 2008-09-11 2009-08-28 derivados de heterozril amida e seu uso como ativadores de glicocinase

Country Status (29)

Country Link
US (4) US7977367B2 (pt)
EP (1) EP2344458A1 (pt)
JP (2) JP4907746B2 (pt)
KR (1) KR101258331B1 (pt)
CN (1) CN102216276A (pt)
AP (1) AP2011005613A0 (pt)
AR (1) AR073283A1 (pt)
AU (1) AU2009290474A1 (pt)
BR (1) BRPI0918128A2 (pt)
CA (1) CA2735184C (pt)
CL (1) CL2011000478A1 (pt)
CO (1) CO6361937A2 (pt)
CR (1) CR20110103A (pt)
DO (1) DOP2011000076A (pt)
EA (1) EA201100311A1 (pt)
EC (1) ECSP11010885A (pt)
GE (1) GEP20135793B (pt)
IL (1) IL211411A0 (pt)
MA (1) MA32627B1 (pt)
MX (1) MX2011002613A (pt)
NI (1) NI201100050A (pt)
NZ (1) NZ591366A (pt)
PA (1) PA8842101A1 (pt)
PE (1) PE20110303A1 (pt)
SV (1) SV2011003855A (pt)
TW (1) TWI382026B (pt)
UY (1) UY32098A (pt)
WO (1) WO2010029461A1 (pt)
ZA (1) ZA201101364B (pt)

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Also Published As

Publication number Publication date
US20110230445A1 (en) 2011-09-22
PA8842101A1 (es) 2010-04-21
PE20110303A1 (es) 2011-05-21
JP4907746B2 (ja) 2012-04-04
AR073283A1 (es) 2010-10-28
NI201100050A (es) 2011-09-27
ZA201101364B (en) 2012-04-25
TWI382026B (zh) 2013-01-11
JP2012092115A (ja) 2012-05-17
DOP2011000076A (es) 2011-03-31
CN102216276A (zh) 2011-10-12
US20130165452A1 (en) 2013-06-27
MA32627B1 (fr) 2011-09-01
EA201100311A1 (ru) 2011-10-31
KR101258331B1 (ko) 2013-04-26
WO2010029461A1 (en) 2010-03-18
US8389552B2 (en) 2013-03-05
AP2011005613A0 (en) 2011-04-30
US20120225910A1 (en) 2012-09-06
US20100063063A1 (en) 2010-03-11
ECSP11010885A (es) 2011-04-29
JP5225452B2 (ja) 2013-07-03
CL2011000478A1 (es) 2011-06-17
IL211411A0 (en) 2011-05-31
US7977367B2 (en) 2011-07-12
UY32098A (es) 2010-04-30
CA2735184A1 (en) 2010-03-18
CA2735184C (en) 2013-05-28
SV2011003855A (es) 2011-05-16
CR20110103A (es) 2011-03-14
NZ591366A (en) 2012-05-25
EP2344458A1 (en) 2011-07-20
TW201010998A (en) 2010-03-16
CO6361937A2 (es) 2012-01-20
MX2011002613A (es) 2011-05-23
JP2012502091A (ja) 2012-01-26
AU2009290474A1 (en) 2010-03-18
GEP20135793B (en) 2013-03-25
US8329920B2 (en) 2012-12-11
KR20110043748A (ko) 2011-04-27

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