BRPI1005349A2 - proteína para imunocastração de mamíferos - Google Patents
proteína para imunocastração de mamíferosInfo
- Publication number
- BRPI1005349A2 BRPI1005349A2 BRPI1005349A BRPI1005349A BRPI1005349A2 BR PI1005349 A2 BRPI1005349 A2 BR PI1005349A2 BR PI1005349 A BRPI1005349 A BR PI1005349A BR PI1005349 A BRPI1005349 A BR PI1005349A BR PI1005349 A2 BRPI1005349 A2 BR PI1005349A2
- Authority
- BR
- Brazil
- Prior art keywords
- fusion protein
- immunocastration
- mammalian
- protein
- vaccine
- Prior art date
Links
- 230000002130 immunocastration Effects 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 abstract 7
- 102000037865 fusion proteins Human genes 0.000 abstract 7
- 229960005486 vaccine Drugs 0.000 abstract 3
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 101150108262 gnrh1 gene Proteins 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 abstract 1
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 238000006206 glycosylation reaction Methods 0.000 abstract 1
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 abstract 1
- 229940035638 gonadotropin-releasing hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0006—Contraceptive vaccins; Vaccines against sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Reproductive Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
proteína de fusão para imunocastração, sequências de dna, vacina veterinária e uso da mesma, processo para produção de uma vacina veterinária e processo para preparar uma proteína de fusão a presente invenção refere-se a uma proteína de fusão que incorpora o hormônio liberador de gonadotrofinas (gnrh) para a imunocastração de mamíferos, sequências de dna que codificam a referida proteína de fusão, vacina que compreende a referida proteína de fusão, e processo para preparar a proteína de fusão. a proteína de fusão incorpora a sequência aminoacídica do hormônio gnrh fundida a uma de acordo com a seq id no: 14, não derivada de patógeno, com capacidade imunogênica e que contém sítios de 0-glicosilação.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CL900-2009 | 2009-04-15 | ||
| CL2009000900A CL2009000900A1 (es) | 2009-04-15 | 2009-04-15 | Proteina de fusion que comprende la hormona liberadora de gonadotrofinas fusionada a una secuencia con capacidad inmunogenica con sitios de o-glicosilacion; secuencia de adn que la codifica; procedimiento de produccion; vacuna que las comprende; y su uso para inmunocastracion de mamiferos. |
| PCT/CL2010/000014 WO2010118547A1 (es) | 2009-04-15 | 2010-04-14 | Proteína de inmunocastración de mamíferos |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI1005349A2 true BRPI1005349A2 (pt) | 2019-07-02 |
| BRPI1005349B1 BRPI1005349B1 (pt) | 2021-05-25 |
Family
ID=42635208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1005349-2A BRPI1005349B1 (pt) | 2009-04-15 | 2010-04-14 | Proteína de fusão para imunocastração, sequências de dna, vacina veterinária e uso da mesma, processo para produção de uma vacina veterinária e processo para preparar uma proteína de fusão |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8940693B2 (pt) |
| EP (1) | EP2431052B1 (pt) |
| AR (1) | AR075953A1 (pt) |
| BR (1) | BRPI1005349B1 (pt) |
| CL (1) | CL2009000900A1 (pt) |
| DK (1) | DK2431052T5 (pt) |
| ES (1) | ES2467702T3 (pt) |
| PL (1) | PL2431052T3 (pt) |
| WO (1) | WO2010118547A1 (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102477054B1 (ko) * | 2020-03-24 | 2022-12-14 | 주식회사 바이오앱 | 웅취 제거용 재조합 단백질 및 이를 포함하는 백신 조성물 |
| CN116478257B (zh) * | 2023-04-21 | 2026-07-07 | 成都信然博创生物科技有限公司 | 一种基于新型载体蛋白偶联GnRH多肽制备生殖疫苗的方法及产品 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4975420A (en) | 1987-09-30 | 1990-12-04 | University Of Saskatchewan | Agents and procedures for provoking an immune response to GnRH and immuno sterilizing mammals |
| US6761890B1 (en) | 1995-06-07 | 2004-07-13 | Pepscan Systems B.V. | Peptide, immunogenic composition and vaccine or medical preparation, a method to immunize animals against the hormone LHRH, and analogs of the LHRH tandem repeat peptide and their use as vaccine |
| US6013770A (en) | 1997-07-21 | 2000-01-11 | Washington State University | Chimeric contraceptive vaccines |
| US20060121051A1 (en) * | 1998-02-19 | 2006-06-08 | Kenten John H | Heat shock fusion-based vaccine system |
| US6783761B2 (en) | 2000-05-05 | 2004-08-31 | Aphton Corporation | Chimeric peptide immunogens |
| WO2003089590A2 (en) | 2002-04-16 | 2003-10-30 | Vaxin, Inc. | TRANSIENT AND/OR PERMANENT MODIFICATION OF SEXUAL BEHAVIOR AND/OR FERTILITY USING RECOMBINANT CHIMERIC GnRH |
| US20040202673A1 (en) * | 2003-04-08 | 2004-10-14 | Jen-Pin Huang | Constructs of branched synthetic peptide immunogens with artificial T helper cell epitopes coupled to B cell epitopes |
| WO2007137586A2 (en) * | 2006-05-31 | 2007-12-06 | Pharmexa A/S | Random insertion of peptides |
-
2009
- 2009-04-15 CL CL2009000900A patent/CL2009000900A1/es unknown
-
2010
- 2010-04-14 AR ARP100101253A patent/AR075953A1/es active IP Right Grant
- 2010-04-14 EP EP10721286.2A patent/EP2431052B1/en active Active
- 2010-04-14 ES ES10721286.2T patent/ES2467702T3/es active Active
- 2010-04-14 WO PCT/CL2010/000014 patent/WO2010118547A1/es not_active Ceased
- 2010-04-14 DK DK10721286.2T patent/DK2431052T5/da active
- 2010-04-14 US US13/262,265 patent/US8940693B2/en active Active
- 2010-04-14 PL PL10721286T patent/PL2431052T3/pl unknown
- 2010-04-14 BR BRPI1005349-2A patent/BRPI1005349B1/pt active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| US8940693B2 (en) | 2015-01-27 |
| BRPI1005349B1 (pt) | 2021-05-25 |
| CL2009000900A1 (es) | 2009-08-14 |
| PL2431052T3 (pl) | 2014-09-30 |
| DK2431052T3 (da) | 2014-06-30 |
| EP2431052A1 (en) | 2012-03-21 |
| DK2431052T5 (da) | 2014-07-07 |
| ES2467702T3 (es) | 2014-06-12 |
| AR075953A1 (es) | 2011-05-11 |
| WO2010118547A1 (es) | 2010-10-21 |
| EP2431052B1 (en) | 2014-04-02 |
| US20120093846A1 (en) | 2012-04-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B06A | Notification to applicant to reply to the report for non-patentability or inadequacy of the application [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 14/04/2010, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |