BRPI1005655A2 - Sistemas, dispositivos e métodos para medição do hematócrito de sangue integral com base na velocidade de preenchimento inicial - Google Patents

Sistemas, dispositivos e métodos para medição do hematócrito de sangue integral com base na velocidade de preenchimento inicial Download PDF

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Publication number
BRPI1005655A2
BRPI1005655A2 BRPI1005655-6A BRPI1005655A BRPI1005655A2 BR PI1005655 A2 BRPI1005655 A2 BR PI1005655A2 BR PI1005655 A BRPI1005655 A BR PI1005655A BR PI1005655 A2 BRPI1005655 A2 BR PI1005655A2
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Brazil
Prior art keywords
devices
systems
blood
methods
hematocrit
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BRPI1005655-6A
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English (en)
Inventor
C. Chatelier Ronald
Rylatt Dennis
Raineri Linda
M. Hodges Alastair
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Lifescan, Inc.
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Publication of BRPI1005655A2 publication Critical patent/BRPI1005655A2/pt

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/06—Investigating concentration of particle suspensions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3273—Devices therefor, e.g. test element readers, circuitry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3274—Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/48—Systems using polarography, i.e. measuring changes in current under a slowly-varying voltage
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4737—C-reactive protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Ecology (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)

Abstract

SISTEMAS, DISPOSITIVOS E METODOS PARA MEDIÇçO DO HEMATOCRITO DE SANGUE INTEGRAL COM BASE NA VELOCIDADE DE PREENCHIMENTO INICIAL. A presente invenção refere-se a métodos para determinar o hematócrito de uma amostra de sangue, e a dispositivos e sistemas usados em conjunto com os mesmos. O valor de hematôcrito pode ser determinado por si só e, adicionalmente, pode ser usado para determinar uma concentração de um analito em uma amostra. Em uma modalidade exemplificadora de um método para determinação do valor de hematócrito em uma amostra de sangue, um volume de sangue é colocado em um dispositivo para análise de amostras que tem um eletrodo de trabalho e um contraeletrodo. Um potencial elétrico é aplicado entre os eletrodos, sendo calculada uma velocidade de preenchimento inicial da amostra no dispositivo. Pode-se, então, determinar o hematócrito do sangue, bem como a concentração de um analito em vista da velocidade de preenchimento inicial. São apresentados, também, sistemas e dispositivos que têm a vantagem do uso de uma velocidade de preenchimento inicial para determinar os níveis de hematócrito e fazer determinações quanto à concentração de analito.
BRPI1005655-6A 2009-12-30 2010-12-29 Sistemas, dispositivos e métodos para medição do hematócrito de sangue integral com base na velocidade de preenchimento inicial BRPI1005655A2 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12/649,509 US8877034B2 (en) 2009-12-30 2009-12-30 Systems, devices, and methods for measuring whole blood hematocrit based on initial fill velocity

Publications (1)

Publication Number Publication Date
BRPI1005655A2 true BRPI1005655A2 (pt) 2012-03-06

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BRPI1005655-6A BRPI1005655A2 (pt) 2009-12-30 2010-12-29 Sistemas, dispositivos e métodos para medição do hematócrito de sangue integral com base na velocidade de preenchimento inicial

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Country Link
US (3) US8877034B2 (pt)
EP (1) EP2341342B1 (pt)
JP (3) JP5189639B2 (pt)
KR (2) KR101316559B1 (pt)
CN (1) CN102116753B (pt)
AU (1) AU2010257395B2 (pt)
BR (1) BRPI1005655A2 (pt)
CA (4) CA2977537A1 (pt)
ES (1) ES2901892T3 (pt)
IL (1) IL209228A0 (pt)
SG (1) SG172562A1 (pt)
TW (1) TWI540318B (pt)

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US20150027907A1 (en) 2015-01-29
KR101293940B1 (ko) 2013-08-08
JP2011137816A (ja) 2011-07-14
JP5596752B2 (ja) 2014-09-24
KR101316559B1 (ko) 2013-10-15
ES2901892T3 (es) 2022-03-24
CN102116753B (zh) 2016-05-18
EP2341342A3 (en) 2015-04-01
JP5189639B2 (ja) 2013-04-24
KR20120107440A (ko) 2012-10-02
EP2341342A2 (en) 2011-07-06
EP2341342B1 (en) 2021-10-20
US20180195994A1 (en) 2018-07-12
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US8877034B2 (en) 2014-11-04
CA2723353A1 (en) 2011-06-30
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