ES2901892T3 - Sistemas y métodos para medir hematocritos en sangre completa en base a la velocidad de llenado inicial - Google Patents
Sistemas y métodos para medir hematocritos en sangre completa en base a la velocidad de llenado inicial Download PDFInfo
- Publication number
- ES2901892T3 ES2901892T3 ES10252247T ES10252247T ES2901892T3 ES 2901892 T3 ES2901892 T3 ES 2901892T3 ES 10252247 T ES10252247 T ES 10252247T ES 10252247 T ES10252247 T ES 10252247T ES 2901892 T3 ES2901892 T3 ES 2901892T3
- Authority
- ES
- Spain
- Prior art keywords
- sample
- immunosensor
- hematocrit
- reactive protein
- current
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
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- 108010074051 C-Reactive Protein Proteins 0.000 claims abstract description 48
- 102100032752 C-reactive protein Human genes 0.000 claims abstract description 48
- 238000005259 measurement Methods 0.000 claims abstract description 17
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- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
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- 239000010836 blood and blood product Substances 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/06—Investigating concentration of particle suspensions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3273—Devices therefor, e.g. test element readers, circuitry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3274—Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/48—Systems using polarography, i.e. measuring changes in current under a slowly-varying voltage
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4737—C-reactive protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Electrochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Ecology (AREA)
- Dispersion Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/649,509 US8877034B2 (en) | 2009-12-30 | 2009-12-30 | Systems, devices, and methods for measuring whole blood hematocrit based on initial fill velocity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2901892T3 true ES2901892T3 (es) | 2022-03-24 |
Family
ID=43779499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10252247T Active ES2901892T3 (es) | 2009-12-30 | 2010-12-29 | Sistemas y métodos para medir hematocritos en sangre completa en base a la velocidad de llenado inicial |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US8877034B2 (pt) |
| EP (1) | EP2341342B1 (pt) |
| JP (3) | JP5189639B2 (pt) |
| KR (2) | KR101316559B1 (pt) |
| CN (1) | CN102116753B (pt) |
| AU (1) | AU2010257395B2 (pt) |
| BR (1) | BRPI1005655A2 (pt) |
| CA (4) | CA3062504A1 (pt) |
| ES (1) | ES2901892T3 (pt) |
| IL (1) | IL209228A0 (pt) |
| SG (1) | SG172562A1 (pt) |
| TW (1) | TWI540318B (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060091006A1 (en) * | 1999-11-04 | 2006-05-04 | Yi Wang | Analyte sensor with insertion monitor, and methods |
| US8221994B2 (en) * | 2009-09-30 | 2012-07-17 | Cilag Gmbh International | Adhesive composition for use in an immunosensor |
| US8877034B2 (en) * | 2009-12-30 | 2014-11-04 | Lifescan, Inc. | Systems, devices, and methods for measuring whole blood hematocrit based on initial fill velocity |
| US8101065B2 (en) * | 2009-12-30 | 2012-01-24 | Lifescan, Inc. | Systems, devices, and methods for improving accuracy of biosensors using fill time |
| US8932445B2 (en) | 2010-09-30 | 2015-01-13 | Cilag Gmbh International | Systems and methods for improved stability of electrochemical sensors |
| US8617370B2 (en) | 2010-09-30 | 2013-12-31 | Cilag Gmbh International | Systems and methods of discriminating between a control sample and a test fluid using capacitance |
| TWI513978B (zh) * | 2012-06-08 | 2015-12-21 | Hmd Biomedical Inc | 檢測試片、檢測裝置及檢測方法 |
| TWI482964B (zh) * | 2012-11-27 | 2015-05-01 | Broadmaster Biotech Corp | 血比容檢測方法及其檢測系統 |
| US9500616B2 (en) * | 2013-12-23 | 2016-11-22 | Cilag Gmbh International | Multi-orientation test strip |
| US20150369813A1 (en) * | 2014-06-24 | 2015-12-24 | Lifescan Scotland Limited | Analytical test strip with tiered capillary chamber |
| CN106370715A (zh) * | 2015-07-21 | 2017-02-01 | 天津亿朋医疗器械有限公司 | 一种血液成分分析方法及装置 |
| CN110140046A (zh) | 2016-11-25 | 2019-08-16 | 普和希控股公司 | 测量生物体试样的成分的方法 |
| EP3447490A1 (en) | 2017-08-25 | 2019-02-27 | Koninklijke Philips N.V. | Analyser for fluid sample analysis |
| US11541385B2 (en) * | 2018-07-06 | 2023-01-03 | Qorvo Us, Inc. | Methods of measuring hematocrit in fluidic channels including conductivity sensor |
| CN109270145B (zh) * | 2018-11-20 | 2021-09-17 | 三诺生物传感股份有限公司 | 一种双电极的电化学试条的测试方法 |
| US20220074956A1 (en) * | 2018-12-19 | 2022-03-10 | Gentian As | Methods for determining the hematocrit level in a sample of whole blood |
| JP7469309B2 (ja) * | 2019-07-24 | 2024-04-16 | 大塚製薬株式会社 | 測定方法および測定装置 |
| ES3034914A1 (es) * | 2024-02-20 | 2025-08-26 | Biolan Microbiosensores S L | Biosensor electroquimico y metodo para la deteccion o cuantificacion de un analito |
| JP7555166B1 (ja) | 2024-07-04 | 2024-09-24 | 株式会社イムノセンス | 電気化学式免疫センサー |
Family Cites Families (114)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5264103A (en) | 1991-10-18 | 1993-11-23 | Matsushita Electric Industrial Co., Ltd. | Biosensor and a method for measuring a concentration of a substrate in a sample |
| US6319471B1 (en) * | 1992-07-10 | 2001-11-20 | Gambro, Inc. | Apparatus for producing blood component products |
| US5385846A (en) * | 1993-06-03 | 1995-01-31 | Boehringer Mannheim Corporation | Biosensor and method for hematocrit determination |
| US5781455A (en) * | 1993-11-02 | 1998-07-14 | Kyoto Daiichi Kagaku Co., Ltd. | Article of manufacture comprising computer usable medium for a portable blood sugar value measuring apparatus |
| US5620579A (en) * | 1995-05-05 | 1997-04-15 | Bayer Corporation | Apparatus for reduction of bias in amperometric sensors |
| AUPN363995A0 (en) * | 1995-06-19 | 1995-07-13 | Memtec Limited | Electrochemical cell |
| US6413410B1 (en) * | 1996-06-19 | 2002-07-02 | Lifescan, Inc. | Electrochemical cell |
| US6521110B1 (en) * | 1995-11-16 | 2003-02-18 | Lifescan, Inc. | Electrochemical cell |
| AUPN661995A0 (en) | 1995-11-16 | 1995-12-07 | Memtec America Corporation | Electrochemical cell 2 |
| US6638415B1 (en) * | 1995-11-16 | 2003-10-28 | Lifescan, Inc. | Antioxidant sensor |
| US6174420B1 (en) * | 1996-11-15 | 2001-01-16 | Usf Filtration And Separations Group, Inc. | Electrochemical cell |
| US6241862B1 (en) * | 1996-02-14 | 2001-06-05 | Inverness Medical Technology, Inc. | Disposable test strips with integrated reagent/blood separation layer |
| US5962215A (en) * | 1996-04-05 | 1999-10-05 | Mercury Diagnostics, Inc. | Methods for testing the concentration of an analyte in a body fluid |
| US5858648A (en) * | 1996-11-04 | 1999-01-12 | Sienna Biotech, Inc. | Assays using reference microparticles |
| US6632349B1 (en) * | 1996-11-15 | 2003-10-14 | Lifescan, Inc. | Hemoglobin sensor |
| US6291840B1 (en) * | 1996-11-29 | 2001-09-18 | Toyoda Gosei Co., Ltd. | GaN related compound semiconductor light-emitting device |
| ES2184236T3 (es) * | 1997-02-06 | 2003-04-01 | Therasense Inc | Sensor in vitro de analitos de pequeño volumen. |
| AUPO581397A0 (en) * | 1997-03-21 | 1997-04-17 | Memtec America Corporation | Sensor connection means |
| US5997817A (en) | 1997-12-05 | 1999-12-07 | Roche Diagnostics Corporation | Electrochemical biosensor test strip |
| US8071384B2 (en) * | 1997-12-22 | 2011-12-06 | Roche Diagnostics Operations, Inc. | Control and calibration solutions and methods for their use |
| US7494816B2 (en) * | 1997-12-22 | 2009-02-24 | Roche Diagnostic Operations, Inc. | System and method for determining a temperature during analyte measurement |
| US7407811B2 (en) * | 1997-12-22 | 2008-08-05 | Roche Diagnostics Operations, Inc. | System and method for analyte measurement using AC excitation |
| US7390667B2 (en) * | 1997-12-22 | 2008-06-24 | Roche Diagnostics Operations, Inc. | System and method for analyte measurement using AC phase angle measurements |
| US6475360B1 (en) * | 1998-03-12 | 2002-11-05 | Lifescan, Inc. | Heated electrochemical cell |
| JP4256588B2 (ja) | 1998-05-20 | 2009-04-22 | アークレイ株式会社 | 統計的手法を用いた電気化学的測定方法および測定装置 |
| US6830934B1 (en) * | 1999-06-15 | 2004-12-14 | Lifescan, Inc. | Microdroplet dispensing for a medical diagnostic device |
| US6235481B1 (en) * | 1998-10-21 | 2001-05-22 | Arch Development Corporation & Board Of Regents | Polynucleotides encoding calpain 10 |
| JP4132337B2 (ja) | 1998-12-29 | 2008-08-13 | イビデン株式会社 | 金属吸着物質の測定方法 |
| US6475372B1 (en) * | 2000-02-02 | 2002-11-05 | Lifescan, Inc. | Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations |
| US6424847B1 (en) * | 1999-02-25 | 2002-07-23 | Medtronic Minimed, Inc. | Glucose monitor calibration methods |
| US6193873B1 (en) * | 1999-06-15 | 2001-02-27 | Lifescan, Inc. | Sample detection to initiate timing of an electrochemical assay |
| JP2001091512A (ja) * | 1999-07-16 | 2001-04-06 | Matsushita Electric Ind Co Ltd | 血液成分分析装置 |
| US7045054B1 (en) * | 1999-09-20 | 2006-05-16 | Roche Diagnostics Corporation | Small volume biosensor for continuous analyte monitoring |
| US7276146B2 (en) * | 2001-11-16 | 2007-10-02 | Roche Diagnostics Operations, Inc. | Electrodes, methods, apparatuses comprising micro-electrode arrays |
| DE60019547T2 (de) * | 1999-12-27 | 2005-10-06 | Matsushita Electric Industrial Co., Ltd., Kadoma | Biosensor |
| US7890295B2 (en) * | 2000-02-23 | 2011-02-15 | Medtronic Minimed, Inc. | Real time self-adjusting calibration algorithm |
| US6895263B2 (en) * | 2000-02-23 | 2005-05-17 | Medtronic Minimed, Inc. | Real time self-adjusting calibration algorithm |
| US6571651B1 (en) * | 2000-03-27 | 2003-06-03 | Lifescan, Inc. | Method of preventing short sampling of a capillary or wicking fill device |
| RU2278612C2 (ru) * | 2000-07-14 | 2006-06-27 | Лайфскен, Инк. | Иммуносенсор |
| US7455756B2 (en) * | 2001-05-30 | 2008-11-25 | I-Sens, Inc. | Biosensor |
| FR2828369B1 (fr) | 2001-07-31 | 2003-11-28 | Thomson Licensing Sa | Procede de reception d'emissions audiovisuelles proposees par des utilisateurs, terminal et serveur pour la mise en oeuvre du procede |
| RU2297696C2 (ru) * | 2001-10-10 | 2007-04-20 | Лайфскен, Инк. | Электрохимическая ячейка |
| US6797150B2 (en) * | 2001-10-10 | 2004-09-28 | Lifescan, Inc. | Determination of sample volume adequacy in biosensor devices |
| CN100367030C (zh) | 2001-10-12 | 2008-02-06 | 爱科来株式会社 | 浓度测定方法和浓度测定装置 |
| US7018843B2 (en) * | 2001-11-07 | 2006-03-28 | Roche Diagnostics Operations, Inc. | Instrument |
| US6872298B2 (en) * | 2001-11-20 | 2005-03-29 | Lifescan, Inc. | Determination of sample volume adequacy in biosensor devices |
| US6689411B2 (en) * | 2001-11-28 | 2004-02-10 | Lifescan, Inc. | Solution striping system |
| US6749887B1 (en) * | 2001-11-28 | 2004-06-15 | Lifescan, Inc. | Solution drying system |
| US6856125B2 (en) * | 2001-12-12 | 2005-02-15 | Lifescan, Inc. | Biosensor apparatus and method with sample type and volume detection |
| KR100475634B1 (ko) * | 2001-12-24 | 2005-03-15 | 주식회사 아이센스 | 일정 소량의 시료를 빠르게 도입할 수 있는 시료도입부를구비한 바이오 센서 |
| US6946067B2 (en) * | 2002-01-04 | 2005-09-20 | Lifescan, Inc. | Method of forming an electrical connection between an electrochemical cell and a meter |
| US7601249B2 (en) | 2002-02-10 | 2009-10-13 | Agamatrix, Inc. | Method and apparatus for assay of electrochemical properties |
| US7697966B2 (en) * | 2002-03-08 | 2010-04-13 | Sensys Medical, Inc. | Noninvasive targeting system method and apparatus |
| US20060134713A1 (en) * | 2002-03-21 | 2006-06-22 | Lifescan, Inc. | Biosensor apparatus and methods of use |
| US20030180814A1 (en) * | 2002-03-21 | 2003-09-25 | Alastair Hodges | Direct immunosensor assay |
| US6964871B2 (en) * | 2002-04-25 | 2005-11-15 | Home Diagnostics, Inc. | Systems and methods for blood glucose sensing |
| US6743635B2 (en) * | 2002-04-25 | 2004-06-01 | Home Diagnostics, Inc. | System and methods for blood glucose sensing |
| GB0211449D0 (en) | 2002-05-17 | 2002-06-26 | Oxford Biosensors Ltd | Analyte measurement |
| US6780645B2 (en) * | 2002-08-21 | 2004-08-24 | Lifescan, Inc. | Diagnostic kit with a memory storing test strip calibration codes and related methods |
| AU2003234944A1 (en) * | 2002-08-27 | 2004-03-18 | Bayer Healthcare, Llc | Methods of Determining Glucose Concentration in Whole Blood Samples |
| US7291256B2 (en) * | 2002-09-12 | 2007-11-06 | Lifescan, Inc. | Mediator stabilized reagent compositions and methods for their use in electrochemical analyte detection assays |
| US20040120848A1 (en) * | 2002-12-20 | 2004-06-24 | Maria Teodorczyk | Method for manufacturing a sterilized and calibrated biosensor-based medical device |
| AU2003900285A0 (en) | 2003-01-20 | 2003-02-06 | Universal Biosensors Pty Limited | Electrochemical detection method |
| US7132041B2 (en) | 2003-02-11 | 2006-11-07 | Bayer Healthcare Llc | Methods of determining the concentration of an analyte in a fluid test sample |
| US20050176133A1 (en) * | 2003-02-21 | 2005-08-11 | Matsushita Electric Industrial Co., Ltd. | Measuring instrument for biosensor and measuring method using same |
| EP1467206A1 (en) * | 2003-04-08 | 2004-10-13 | Roche Diagnostics GmbH | Biosensor system |
| KR100554649B1 (ko) * | 2003-06-09 | 2006-02-24 | 주식회사 아이센스 | 전기화학적 바이오센서 |
| US7488601B2 (en) * | 2003-06-20 | 2009-02-10 | Roche Diagnostic Operations, Inc. | System and method for determining an abused sensor during analyte measurement |
| US7597793B2 (en) * | 2003-06-20 | 2009-10-06 | Roche Operations Ltd. | System and method for analyte measurement employing maximum dosing time delay |
| US7452457B2 (en) * | 2003-06-20 | 2008-11-18 | Roche Diagnostics Operations, Inc. | System and method for analyte measurement using dose sufficiency electrodes |
| US7723099B2 (en) * | 2003-09-10 | 2010-05-25 | Abbott Point Of Care Inc. | Immunoassay device with immuno-reference electrode |
| JP4449431B2 (ja) * | 2003-11-19 | 2010-04-14 | パナソニック株式会社 | 基質濃度の測定方法 |
| JP4611208B2 (ja) * | 2003-12-04 | 2011-01-12 | パナソニック株式会社 | 血液成分の測定方法およびそれに用いるセンサならびに測定装置 |
| EP2213748B1 (en) * | 2004-01-07 | 2014-03-19 | Arkray, Inc. | Analytical instrument having improved arrangement of reagent section and analytical method |
| CA2557690C (en) * | 2004-03-31 | 2022-04-12 | George A. Mecklenburg | Method and apparatus for implementing threshold based correction functions for biosensors |
| CN1954207A (zh) * | 2004-05-14 | 2007-04-25 | 拜尔健康护理有限责任公司 | 用于在葡萄糖测定中进行血细胞比容调节的方法及其装置 |
| RU2386960C2 (ru) * | 2004-05-14 | 2010-04-20 | БАЙЕР ХЕЛТКЭР ЭлЭлСи | Вольтамперометрическая система для анализа биологических анализируемых веществ |
| WO2006036833A2 (en) | 2004-09-24 | 2006-04-06 | The Regents Of The University Of Michigan | A nanoliter viscometer for analyzing blood plasma and other liquid samples |
| KR100698961B1 (ko) | 2005-02-04 | 2007-03-26 | 주식회사 아이센스 | 전기화학적 바이오센서 |
| AU2006219293A1 (en) * | 2005-03-02 | 2006-09-08 | National Institute Of Advanced Industrial Science And Technology | Biosensor coupled with needle |
| JP4576624B2 (ja) | 2005-03-02 | 2010-11-10 | 独立行政法人産業技術総合研究所 | 針一体型バイオセンサー |
| US20060206018A1 (en) * | 2005-03-04 | 2006-09-14 | Alan Abul-Haj | Method and apparatus for noninvasive targeting |
| JP4965561B2 (ja) | 2005-04-29 | 2012-07-04 | ハネウェル・インターナショナル・インコーポレーテッド | サイトメータ細胞計数及びサイズ測定システム |
| ES2675044T3 (es) * | 2005-06-03 | 2018-07-06 | Board Of Regents Of The University Of Texas System | Electroquímica y quimioluminiscencia electrogenerada con un único electrodo faradaico |
| GB0511270D0 (en) | 2005-06-03 | 2005-07-13 | Hypoguard Ltd | Test system |
| EP1909103A4 (en) * | 2005-07-14 | 2011-05-04 | Panasonic Corp | ANALYZER AND ANALYSIS PROCEDURE |
| CN103558284B (zh) * | 2005-07-20 | 2017-04-12 | 安晟信医疗科技控股公司 | 门控电流分析法 |
| US20070024287A1 (en) * | 2005-08-01 | 2007-02-01 | Mesa Laboratories, Inc. | Apparatus and method for measuring liquid conductivity and electrode series capacitance |
| US7749371B2 (en) * | 2005-09-30 | 2010-07-06 | Lifescan, Inc. | Method and apparatus for rapid electrochemical analysis |
| AU2006297572B2 (en) * | 2005-09-30 | 2012-11-15 | Ascensia Diabetes Care Holdings Ag | Gated Voltammetry |
| US8066866B2 (en) * | 2005-10-17 | 2011-11-29 | Lifescan, Inc. | Methods for measuring physiological fluids |
| US8163162B2 (en) | 2006-03-31 | 2012-04-24 | Lifescan, Inc. | Methods and apparatus for analyzing a sample in the presence of interferents |
| US20070235346A1 (en) | 2006-04-11 | 2007-10-11 | Popovich Natasha D | System and methods for providing corrected analyte concentration measurements |
| JP4785611B2 (ja) | 2006-05-11 | 2011-10-05 | アークレイ株式会社 | 血液試料中の特定成分の濃度測定方法および装置 |
| US8287718B2 (en) * | 2006-07-05 | 2012-10-16 | Panasonic Corporation | Liquid sample measurement method and apparatus |
| WO2008049075A2 (en) * | 2006-10-18 | 2008-04-24 | Agamatrix, Inc. | Electrochemical determination of analytes |
| JP4814952B2 (ja) | 2006-10-19 | 2011-11-16 | パナソニック株式会社 | 血液試料のヘマトクリット値の測定方法、血液試料中の分析物の濃度の測定方法、センサチップおよびセンサユニット |
| US8409424B2 (en) * | 2006-12-19 | 2013-04-02 | Apex Biotechnology Corp. | Electrochemical test strip, electrochemical test system, and measurement method using the same |
| US20080199894A1 (en) * | 2007-02-15 | 2008-08-21 | Abbott Diabetes Care, Inc. | Device and method for automatic data acquisition and/or detection |
| US7751864B2 (en) * | 2007-03-01 | 2010-07-06 | Roche Diagnostics Operations, Inc. | System and method for operating an electrochemical analyte sensor |
| US8080153B2 (en) * | 2007-05-31 | 2011-12-20 | Abbott Diabetes Care Inc. | Analyte determination methods and devices |
| EP2176653B1 (en) * | 2007-07-26 | 2011-09-07 | Nipro Diagnostics, Inc. | System and methods for determination of analyte concentration using time resolved amperometry |
| US7981678B2 (en) * | 2007-08-06 | 2011-07-19 | Bayer Healthcare Llc | System and method for automatic calibration |
| EP2193367B1 (en) * | 2007-09-27 | 2019-01-23 | Philosys CO., LTD. | Method for correcting erroneous results of measurement in biosensors and apparatus using the same |
| US8778168B2 (en) * | 2007-09-28 | 2014-07-15 | Lifescan, Inc. | Systems and methods of discriminating control solution from a physiological sample |
| JP5410292B2 (ja) * | 2007-10-26 | 2014-02-05 | アークレイ株式会社 | 試料検知装置およびこれを備えた測定装置 |
| US7783442B2 (en) * | 2007-10-31 | 2010-08-24 | Medtronic Minimed, Inc. | System and methods for calibrating physiological characteristic sensors |
| JP2009112416A (ja) * | 2007-11-02 | 2009-05-28 | Sumitomo Electric Ind Ltd | 穿刺器、バイオセンサ付穿刺器およびバイオセンサ測定装置 |
| CN102076867A (zh) | 2008-05-13 | 2011-05-25 | 通用原子公司 | 用于直接测定糖化血红蛋白百分比的电化学生物传感器 |
| US8551320B2 (en) | 2008-06-09 | 2013-10-08 | Lifescan, Inc. | System and method for measuring an analyte in a sample |
| SG159463A1 (en) * | 2008-08-14 | 2010-03-30 | Agency Science Tech & Res | Method for detecting biomolecules and use thereof |
| US8221994B2 (en) * | 2009-09-30 | 2012-07-17 | Cilag Gmbh International | Adhesive composition for use in an immunosensor |
| US8877034B2 (en) * | 2009-12-30 | 2014-11-04 | Lifescan, Inc. | Systems, devices, and methods for measuring whole blood hematocrit based on initial fill velocity |
| US8101065B2 (en) * | 2009-12-30 | 2012-01-24 | Lifescan, Inc. | Systems, devices, and methods for improving accuracy of biosensors using fill time |
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- 2010-11-10 IL IL209228A patent/IL209228A0/en unknown
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| JP2011137816A (ja) | 2011-07-14 |
| KR20120107440A (ko) | 2012-10-02 |
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| CA2723353A1 (en) | 2011-06-30 |
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| SG172562A1 (en) | 2011-07-28 |
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| JP5788857B2 (ja) | 2015-10-07 |
| EP2341342B1 (en) | 2021-10-20 |
| IL209228A0 (en) | 2011-02-28 |
| CN102116753B (zh) | 2016-05-18 |
| EP2341342A2 (en) | 2011-07-06 |
| JP5189639B2 (ja) | 2013-04-24 |
| US9927388B2 (en) | 2018-03-27 |
| JP2012194196A (ja) | 2012-10-11 |
| CA2977535A1 (en) | 2011-06-30 |
| EP2341342A3 (en) | 2015-04-01 |
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| CA2723353C (en) | 2017-10-17 |
| US8877034B2 (en) | 2014-11-04 |
| AU2010257395B2 (en) | 2012-07-26 |
| TWI540318B (zh) | 2016-07-01 |
| KR101293940B1 (ko) | 2013-08-08 |
| JP2013050466A (ja) | 2013-03-14 |
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