BRPI1006850B8 - processo para determinar a susceptibilidade para contrair infecção nosocomial - Google Patents

processo para determinar a susceptibilidade para contrair infecção nosocomial

Info

Publication number
BRPI1006850B8
BRPI1006850B8 BRPI1006850A BRPI1006850A BRPI1006850B8 BR PI1006850 B8 BRPI1006850 B8 BR PI1006850B8 BR PI1006850 A BRPI1006850 A BR PI1006850A BR PI1006850 A BRPI1006850 A BR PI1006850A BR PI1006850 B8 BRPI1006850 B8 BR PI1006850B8
Authority
BR
Brazil
Prior art keywords
nosocomial infection
patient
susceptibility
evolution
contracting
Prior art date
Application number
BRPI1006850A
Other languages
English (en)
Inventor
Lepape Alain
Pachot Alexandre
Mougin Bruno
Monneret Guillaume
Cazalis Marie-Angélique
Original Assignee
Biomerieux Sa
Hospices Civils Lyon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0950306A external-priority patent/FR2941240B1/fr
Priority claimed from FR0950305A external-priority patent/FR2941239B1/fr
Application filed by Biomerieux Sa, Hospices Civils Lyon filed Critical Biomerieux Sa
Publication of BRPI1006850A2 publication Critical patent/BRPI1006850A2/pt
Publication of BRPI1006850B1 publication Critical patent/BRPI1006850B1/pt
Publication of BRPI1006850B8 publication Critical patent/BRPI1006850B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6865—Promoter-based amplification, e.g. nucleic acid sequence amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/10—Nucleotidyl transfering
    • C12Q2521/107—RNA dependent DNA polymerase,(i.e. reverse transcriptase)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2545/00—Reactions characterised by their quantitative nature
    • C12Q2545/10—Reactions characterised by their quantitative nature the purpose being quantitative analysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2561/00—Nucleic acid detection characterised by assay method
    • C12Q2561/113—Real time assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/26—Infectious diseases, e.g. generalised sepsis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

processo para determinar a susceptibilidade para contrair infecção nosocominal em um paciente e para estabelecer um prognóstico de evolução de síndrome séptica e uso de reagente específico de produto de expressão do gene s100a9 e/ou do gene s100a8. a presente invenção refere-se a um processo para determinar a susceptibilidade para contrair uma infecção nosocomial em um paciente e um processo para estabelecer um prognóstico de evolução de uma síndrome séptica em um paciente, segundo os quais: a) se dispõe de uma amostra biológica do paciente e se extrai material biológico de amostra biológico; b) se dispõe de pelo menos um reagente específico de um produto de expressão de pelo menos um gene-alvo escolhido dentre os genes-alvo s100a9 e s100a8; c) se determina a expressão de pelo menos um dos genes-alvo a100a9 e s100a8, uma superexpressão em relação a um valor limite determinado, sendo uma indicação de uma susceptibilidade para contrair uma infecção nosocomial e uma indicação de um mau prognóstico de evolução de uma síndrome séptica.
BRPI1006850A 2009-01-19 2010-01-18 processo para determinar a susceptibilidade para contrair infecção nosocomial BRPI1006850B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
FR0950305 2009-01-19
FR0950306A FR2941240B1 (fr) 2009-01-19 2009-01-19 Procede pour determiner la sensibilite d'un patient a contracter une infection nosocomiale.
FR0950306 2009-01-19
FR0950305A FR2941239B1 (fr) 2009-01-19 2009-01-19 Procede pour determiner la susceptibilite a contracter une infection nosocomiale chez un patient presentant une reponse systemique inflammatoire associee ou non a une infection.
PCT/FR2010/050070 WO2010082004A1 (fr) 2009-01-19 2010-01-18 Procedes pour determiner la susceptibilite a contracter une infection nosocomiale chez un patient et pour etablir un pronostic d'evolution d'un syndrome septique

Publications (3)

Publication Number Publication Date
BRPI1006850A2 BRPI1006850A2 (pt) 2016-08-09
BRPI1006850B1 BRPI1006850B1 (pt) 2021-04-06
BRPI1006850B8 true BRPI1006850B8 (pt) 2021-07-27

Family

ID=42101520

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1006850A BRPI1006850B8 (pt) 2009-01-19 2010-01-18 processo para determinar a susceptibilidade para contrair infecção nosocomial

Country Status (10)

Country Link
US (1) US11299768B2 (pt)
EP (1) EP2379752B1 (pt)
JP (2) JP5832903B2 (pt)
KR (2) KR101834993B1 (pt)
CN (2) CN102301008B (pt)
BR (1) BRPI1006850B8 (pt)
ES (1) ES2556771T3 (pt)
MX (1) MX2011007624A (pt)
RU (2) RU2525707C2 (pt)
WO (1) WO2010082004A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2970975B1 (fr) 2011-01-27 2016-11-04 Biomerieux Sa Procede et kit pour determiner in vitro le statut immunitaire d'un individu
FR2988479B1 (fr) * 2012-03-23 2014-12-19 Hospices Civils Lyon Procede de determination de la susceptibilite aux infections nosocomiales
FR3010792B1 (fr) 2013-09-18 2017-03-17 Biomerieux Sa Procede d'evaluation du risque de mortalite chez les patients qui presentent une reponse inflammatoire systemique (sirs) ou des syndromes septiques
FR3101358A1 (fr) * 2019-09-27 2021-04-02 Bioaster Procédé pour déterminer le risque de survenue d’une infection associée aux soins chez un patient
RU2743453C1 (ru) * 2020-07-03 2021-02-18 Федеральное Государственное Бюджетное Научное Учреждение "Федеральный Научно-Клинический Центр Реаниматологии И Реабилитологии" (Фнкц Рр) Способ прогнозирования инфекционных осложнений критических состояний
KR102501195B1 (ko) 2020-07-21 2023-02-21 주식회사 카카오헬스케어 병원의 의사결정 장치, 방법, 컴퓨터 판독 가능한 기록매체 및 컴퓨터 프로그램
FR3125300A1 (fr) * 2021-07-19 2023-01-20 Biomerieux Utilisation du virus torque teno (ttv) en tant que marqueurs pour determiner le risque de complication chez un patient admis au sein d’un etablissement de sante
EP4414456A1 (en) 2023-02-13 2024-08-14 Biomérieux Method using a transcriptomic score for assessing the clinical outcome of a patient in a clinical setting, and means for its implementation

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4672040A (en) 1983-05-12 1987-06-09 Advanced Magnetics, Inc. Magnetic particles for use in separations
US5750338A (en) 1986-10-23 1998-05-12 Amoco Corporation Target and background capture methods with amplification for affinity assays
CA2005589C (en) 1988-12-16 2001-02-06 Akzo Nobel Nv Self-sustained, sequence replication system
US5234809A (en) 1989-03-23 1993-08-10 Akzo N.V. Process for isolating nucleic acid
CA2020958C (en) 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
FR2663040B1 (fr) 1990-06-11 1995-09-15 Bio Merieux Procede de detection d'une sequence nucleotidique selon la technique d'hybridation sandwich.
DE69324678T2 (de) 1992-11-27 1999-12-09 Naamloze Vennootschap Innogenetics S.A., Gent Verfahren zur typisierung von hcv-isolaten
US6218529B1 (en) * 1995-07-31 2001-04-17 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer
FR2749082B1 (fr) 1996-05-24 1998-06-26 Bio Merieux Particules superparamagnetiques et monodispersees
JP4469026B2 (ja) * 1996-10-31 2010-05-26 ヒューマン ジノーム サイエンシーズ，インコーポレイテッド Ｓｔｒｅｐｔｏｃｏｃｃｕｓ ｐｎｅｕｍｏｎｉａｅの抗原およびワクチン
DK1015199T3 (da) 1997-09-19 2002-08-26 Univ Abertay Fremgangsmåde til forbedring af imprægneringsevne for træ ved hjælp af svampe
FR2773416B1 (fr) 1998-01-06 2000-02-11 Bio Merieux Particules magnetiques perfectionnees, leurs procedes d'obtention et leurs utilisations dans la separation de molecules
FR2777293B1 (fr) 1998-04-10 2000-05-19 Bio Merieux Procede d'electro-separation d'un echantillon biologique et dispositif de mise en oeuvre
FR2781500B1 (fr) 1998-07-23 2000-09-08 Bio Merieux Dispositif perfectionne et procede de lyse de micro-organismes
ATE466930T1 (de) * 2000-06-21 2010-05-15 Qiagen Gaithersburg Inc Universelles sammelmedium
EP1337667A2 (en) * 2000-11-16 2003-08-27 Cedars-Sinai Medical Center Profiling tumor specific markers for the diagnosis and treatment of neoplastic disease
ATE272214T1 (de) 2001-12-04 2004-08-15 Brahms Ag Verfahren zur diagnose von sepsis unter bestimmung von s100b
AU2003212246A1 (en) 2002-02-15 2003-09-04 Johannes Roth Method for diagnosis of inflammatory diseases using mrp8/mrp14
GB0215509D0 (en) * 2002-07-04 2002-08-14 Novartis Ag Marker genes
US20040152107A1 (en) * 2002-09-18 2004-08-05 C. Anthony Altar Gene signature of electroshock therapy and methods of use
CA2505251A1 (en) * 2002-11-05 2004-05-27 Brigham And Women's Hospital, Inc. Mesenchymal stem cells and methods of use thereof
WO2004081573A1 (en) 2003-03-10 2004-09-23 Novartis Ag Method to evaluate the likelihood of development of bone metastasis based on the determination of calcium proteins
EP1611255A2 (de) * 2003-04-02 2006-01-04 SIRS-Lab GmbH Verfahren zur erkennung akuter generalisierter entzündlicher zustände (sirs), sepsis, sepsis ähnlichen zuständen und systemischen infektionen
DE10324997A1 (de) 2003-06-03 2004-12-23 Switch Biotech Ag Mrp8/Mrp14 Inhibitoren und ihre Verwendung zur Prävention und/oder Behandlung von hypertrophen Narben und Keloiden
US8060315B2 (en) * 2004-07-27 2011-11-15 Carefusion 303, Inc. Method for measuring the incidence of hospital acquired infections
WO2006029184A2 (en) * 2004-09-08 2006-03-16 Expression Diagnostics, Inc. Genes useful for diagnosing and monitoring inflammation related disorders
AU2005286876A1 (en) * 2004-09-20 2006-03-30 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Multiple mode multiplex reaction quenching method
WO2006063133A2 (en) 2004-12-06 2006-06-15 The Johns Hopkins University Biomarker for inflammatory bowel disease
WO2006122723A1 (en) * 2005-05-19 2006-11-23 Vaecgene Biotech Gmbh Method for the prevention and/or treatment of autoimmune disease or allogeneic transplant rejections
AU2006299417A1 (en) 2005-10-03 2007-04-12 Biosite Incorporated Methods and compositions for diagnosis and/or prognosis in Systemic Inflammatory Response Syndromes
US7732664B2 (en) * 2006-03-08 2010-06-08 Universidade De Sao Paulo - Usp. Genes associated to sucrose content
WO2007109749A2 (en) * 2006-03-21 2007-09-27 Wyeth Methods for preventing and treating amyloidogenic diseases
RU2310850C1 (ru) * 2006-05-02 2007-11-20 Государственное образовательное учреждение высшего профессионального образования "Уральская государственная медицинская академия Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО УГМА Росздрава) Способ прогнозирования послеоперационного нагноения раны
EP1950310A1 (en) * 2007-01-23 2008-07-30 Charite-Universitätsmedizin Berlin Method for risk prediction of a postoperative sepsis in a human
US8283131B2 (en) * 2008-10-28 2012-10-09 Assistance Publique-Hopitaux De Paris Methods and kits for the rapid determination of patients at high risk of death during severe sepsis and septic shock
US20110287433A1 (en) * 2008-10-28 2011-11-24 Didier Payen De La Garanderie Methods and Kits for the Rapid Determination of Patients at High Risk of Death During Severe Sepsis and Septic Shock

Also Published As

Publication number Publication date
KR20180026561A (ko) 2018-03-12
WO2010082004A9 (fr) 2010-09-30
KR101834993B1 (ko) 2018-03-06
CN102301008A (zh) 2011-12-28
RU2011134644A (ru) 2013-02-27
JP6254975B2 (ja) 2017-12-27
EP2379752B1 (fr) 2015-09-30
BRPI1006850B1 (pt) 2021-04-06
RU2014122607A (ru) 2015-12-10
RU2525707C2 (ru) 2014-08-20
CN103923980A (zh) 2014-07-16
US20110250592A1 (en) 2011-10-13
EP2379752A1 (fr) 2011-10-26
JP5832903B2 (ja) 2015-12-16
KR20110111491A (ko) 2011-10-11
US11299768B2 (en) 2022-04-12
BRPI1006850A2 (pt) 2016-08-09
CN103923980B (zh) 2017-01-11
JP2016005453A (ja) 2016-01-14
WO2010082004A1 (fr) 2010-07-22
JP2012514993A (ja) 2012-07-05
RU2663724C2 (ru) 2018-08-08
CN102301008B (zh) 2015-05-13
MX2011007624A (es) 2011-10-12
ES2556771T3 (es) 2016-01-20

Similar Documents

Publication Publication Date Title
BRPI1006850B8 (pt) processo para determinar a susceptibilidade para contrair infecção nosocomial
HK1223987A1 (zh) 用序列标签进行大规模生物分子分析
BR112018069849A2 (pt) kit, dispositivo e método para a detecção de câncer pancreático precoce ou de lesão precursora do câncer pancreático
WO2012112970A3 (en) Methods and compositions for detecting genetic material
IL315032A (en) Analysis of cell-free dna in urine and other samples
NZ608384A (en) Biomarkers of renal injury
EA201171046A1 (ru) Зонды и праймеры для детектирования вируса чикунгуньи
CA2873099C (en) Aptamer-based multiplexed assays
BR112014007214A2 (pt) predição de evento de risco cardiovascular e utilização do mesmo
BR112013003391A2 (pt) biomarcadores de câncer pancreático e usos dos mesmos
WO2011103502A3 (en) Materials and methods for profiling micrornas
MX379058B (es) Metodo para analisis de metilacion.
IN2014CN03508A (pt)
EP3543362A3 (en) Pcr primer set for bacterial dna amplification, kit for detecting and/or identifying bacterial species, and method for detecting and/or identifying bacterial species
BR112013003656A2 (pt) sondas e indicadores para a detecção da dengue.
CN103627818B (zh) 检测主要亚型禽白血病病毒的lamp试剂盒
MX2016002210A (es) Analisis digital de analitos moleculares usando metodos electricos.
BR112015019425A2 (pt) Métodos e kits para identificar e ajustar desvio no sequenciamento de amostras de polinucleotídeos
CN103555859B (zh) 一种检测甘蔗条纹花叶病毒的荧光定量rt-pcr试剂盒
ES2684746T3 (es) Prueba de cribado para detectar la presencia de virus VPH oncogénicos
CN105316429A (zh) 检测牛腺病毒的试剂盒及其应用
WO2012163941A3 (en) Marker for the detection and classification of leukemia from blood samples
US20200255897A1 (en) Method for expecting and diagnosing uqcrb-related disease
MY172900A (en) An electrochemical dna biosensor for gender and variety identification
CN103409541B (zh) 一种试剂盒在检测多种生物pcr反应假阴性中的用途

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 3A ANUIDADE.

B08H Application fees: decision cancelled [chapter 8.8 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2385 DE 20/09/2016.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 06/04/2021, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 18/01/2010, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 15A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2810 DE 12-11-2024 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.