BRPI1007027A2 - combinação de um derivado de ciclosporina e nucleosídeos para tratar do hcv - Google Patents

combinação de um derivado de ciclosporina e nucleosídeos para tratar do hcv

Info

Publication number: BRPI1007027A2
Authority: BR; Brazil
Prior art keywords: cyclosporin; combination; nucleoside derivative; treat hcv; hcv
Prior art date: 2009-01-07

Application number

BRPI1007027A

Other languages

English (en)

Inventor

Earl Hopkins Samuel

Original Assignee

Scynexis Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-01-07

Filing date

2010-01-07

Publication date

2019-09-24

2010-01-07 Application filed by Scynexis Inc filed Critical Scynexis Inc

2019-09-24 Publication of BRPI1007027A2 publication Critical patent/BRPI1007027A2/pt

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title 1
229930105110 Cyclosporin A Natural products 0.000 title 1
108010036949 Cyclosporine Proteins 0.000 title 1
229960001265 ciclosporin Drugs 0.000 title 1
229930182912 cyclosporin Natural products 0.000 title 1
150000003833 nucleoside derivatives Chemical class 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Virology (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Gastroenterology & Hepatology (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Communicable Diseases (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)

BRPI1007027A 2009-01-07 2010-01-07 combinação de um derivado de ciclosporina e nucleosídeos para tratar do hcv BRPI1007027A2 (pt)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US14306209P	2009-01-07	2009-01-07
US15602609P	2009-02-27	2009-02-27
US25723109P	2009-11-02	2009-11-02
PCT/US2010/020323 WO2010080878A1 (en)	2009-01-07	2010-01-07	Combination of a cyclosporine derivative and nucleosides for treating hcv

Publications (1)

Publication Number	Publication Date
BRPI1007027A2 true BRPI1007027A2 (pt)	2019-09-24

Family

ID=42084646

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI1007027A BRPI1007027A2 (pt)	2009-01-07	2010-01-07	combinação de um derivado de ciclosporina e nucleosídeos para tratar do hcv

Country Status (11)

Country	Link
US (1)	US20100227801A1 (pt)
EP (1)	EP2385833A1 (pt)
JP (1)	JP2012514606A (pt)
CN (1)	CN102271688A (pt)
AU (1)	AU2010203660A1 (pt)
BR (1)	BRPI1007027A2 (pt)
CA (1)	CA2748792A1 (pt)
IL (1)	IL213862A0 (pt)
MX (1)	MX2011007194A (pt)
RU (1)	RU2011127079A (pt)
WO (1)	WO2010080878A1 (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI1802650T1 (sl) *	2004-10-01	2012-03-30	Scynexis Inc	Eter in tioeter substituirani ciklosporinski derivati za zdravljenje in preventivo pred infekcijami s hepatitisom c
EP1931696B1 (en) *	2005-09-30	2011-02-16	Scynexis, Inc.	Arylalkyl and heteroarylalkyl derivatives of cyclosporine a for the treatment and prevention of viral infection
EP2023918B1 (en)	2006-05-19	2011-03-23	Scynexis, Inc.	Cyclosporins for the treatment and prevention of ocular disorders
CN101502196A (zh) *	2006-06-02	2009-08-05	克洛德·安妮·佩里西恩	激活电子的管理
US7964580B2 (en)	2007-03-30	2011-06-21	Pharmasset, Inc.	Nucleoside phosphoramidate prodrugs
CN102083852A (zh)	2008-06-06	2011-06-01	西尼克斯公司	环孢菌素类似物及其在治疗hcv感染中的应用
US8173621B2 (en)	2008-06-11	2012-05-08	Gilead Pharmasset Llc	Nucleoside cyclicphosphates
AU2009329872B2 (en) *	2008-12-23	2016-07-07	Gilead Pharmasset Llc	Synthesis of purine nucleosides
EP2376524B1 (en) *	2008-12-31	2017-03-15	Cypralis Limited	Derivatives of cyclosporin a
US8618076B2 (en)	2009-05-20	2013-12-31	Gilead Pharmasset Llc	Nucleoside phosphoramidates
TWI583692B (zh)	2009-05-20	2017-05-21	基利法瑪席特有限責任公司	核苷磷醯胺
US8563530B2 (en)	2010-03-31	2013-10-22	Gilead Pharmassel LLC	Purine nucleoside phosphoramidate
SG184324A1 (en)	2010-03-31	2012-11-29	Gilead Pharmasset Llc	Nucleoside phosphoramidates
CA2818853A1 (en)	2010-11-30	2012-06-07	Gilead Pharmasset Llc	2'-spirocyclo-nucleosides for use in therapy of hcv or dengue virus
EP2709613B2 (en)	2011-09-16	2020-08-12	Gilead Pharmasset LLC	Methods for treating hcv
US8889159B2 (en)	2011-11-29	2014-11-18	Gilead Pharmasset Llc	Compositions and methods for treating hepatitis C virus
EP2950786B1 (en)	2013-01-31	2019-11-27	Gilead Pharmasset LLC	Combination formulation of two antiviral compounds
WO2014197400A1 (en) *	2013-06-04	2014-12-11	Gilead Pharmasset Llc	Preventing and treating recurrence of hcv infection after liver transplant
PT3038601T (pt)	2013-08-27	2020-06-30	Gilead Pharmasset Llc	Formulação combinada de dois compostos antivirais
CN106536538A (zh) *	2014-04-24	2017-03-22	共晶制药股份有限公司	用于治疗黄病毒家族病毒和癌症的2’‑双取代核苷类似物
WO2020118714A1 (en)	2018-12-14	2020-06-18	Waterstone Pharmaceuticals (Wuhan) Co., Ltd.	Maleate of scy-635 and uses thereof in medicine
CA3128410A1 (en) *	2019-10-11	2021-04-15	Waterstone Pharmaceuticals (Wuhan) Co., Ltd.	Ws-635 uses thereof in medicine
CA3126560A1 (en) *	2020-06-04	2021-12-04	Waterstone Pharmaceuticals (Wuhan) Co., Ltd.	Treatment or prevention of coronaviridae infection
US20250009777A1 (en) *	2021-11-12	2025-01-09	National University Corporation Hokkaido University	Antiviral agent
JP2023072634A (ja) *	2021-11-12	2023-05-24	国立大学法人北海道大学	抗ウイルス剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUE029877T2 (en) *	2003-05-30	2017-04-28	Gilead Pharmasset Llc	Modified fluorinated nucleoside analogues
JP5517454B2 (ja) *	2005-09-30	2014-06-11	スシネキスインク	Ｃ型肝炎感染の治療及び予防のための方法及び医薬組成物
CA2632626C (en) *	2005-12-09	2011-10-11	F. Hoffmann-La Roche Ag	Ester prodrugs of 2'-fluoro-2'-alkyl-2'-deoxycytidines and their use in the treatment of hcv infection

2010
- 2010-01-07 MX MX2011007194A patent/MX2011007194A/es not_active Application Discontinuation
- 2010-01-07 EP EP10704436A patent/EP2385833A1/en not_active Withdrawn
- 2010-01-07 AU AU2010203660A patent/AU2010203660A1/en not_active Abandoned
- 2010-01-07 CN CN2010800041088A patent/CN102271688A/zh active Pending
- 2010-01-07 BR BRPI1007027A patent/BRPI1007027A2/pt not_active IP Right Cessation
- 2010-01-07 CA CA2748792A patent/CA2748792A1/en not_active Abandoned
- 2010-01-07 WO PCT/US2010/020323 patent/WO2010080878A1/en not_active Ceased
- 2010-01-07 US US12/683,691 patent/US20100227801A1/en not_active Abandoned
- 2010-01-07 RU RU2011127079/15A patent/RU2011127079A/ru unknown
- 2010-01-07 JP JP2011544685A patent/JP2012514606A/ja active Pending
2011
- 2011-06-30 IL IL213862A patent/IL213862A0/en unknown

Also Published As

Publication number	Publication date
MX2011007194A (es)	2013-07-12
JP2012514606A (ja)	2012-06-28
EP2385833A1 (en)	2011-11-16
AU2010203660A1 (en)	2011-07-28
US20100227801A1 (en)	2010-09-09
AU2010203660A2 (en)	2011-09-29
WO2010080878A1 (en)	2010-07-15
CA2748792A1 (en)	2010-07-15
IL213862A0 (en)	2011-07-31
CN102271688A (zh)	2011-12-07
RU2011127079A (ru)	2013-02-20

Legal Events

Date	Code	Title	Description
2019-10-01	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
2020-01-21	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

Publication	Publication Date	Title
BRPI1007027A2 (pt)	2019-09-24	combinação de um derivado de ciclosporina e nucleosídeos para tratar do hcv
PT2496691T (pt)	2017-05-31	Composições de nucleases terapêuticas e métodos
HRP20181602T1 (hr)	2018-11-30	Postupak pročišćavanja prokariotskih varijanti i fenilalanin-amonijak-lijaze
BRPI0919404A2 (pt)	2015-12-15	combinações sinergísticas de um inibidor macrocíclico do hcv e de um nucleosídeo
BRPI1007476A2 (pt)	2016-02-16	análogos de ciclosporina para prevenir ou tratar infecção por hepatite c
EP2515946A4 (en)	2015-10-07	NANOCONJUGATE AND NANOCONJUGATE FORMULATIONS
EP2491033A4 (en)	2013-03-13	AZAINDAZOLES FOR THE TREATMENT OF FLAVIVIRIDAE VIRUS INFECTION
EP2424873A4 (en)	2013-05-08	NOVEL GALECTIN GALACTOSIDHEMMER
SMT201600291B (it)	2016-11-10	Inibitori di proteasi hcv
DOP2012000114A (es)	2012-08-15	Inhibidor bromodominio de benzodiazepina
EP2400987A4 (en)	2012-08-22	Benda MUSTIN-CYCLOPOLYSACCHARIDZUSAMMENSETZUNGEN
BRPI0922180A2 (pt)	2015-12-29	insoindolinona e análogos correlatos como moduladores de sirtuína
BR112012005438A2 (pt)	2018-03-20	inibidores de vírus flaviviridae
FI20095291L (fi)	2010-09-21	Kuitujen käsittely muovausta kestäväksi
EP2442821A4 (en)	2013-07-31	SAFE ADMINISTRATION OF DESMOPRESSIN
UY33155A (es)	2011-07-29	Indolil-piperidinil bencilaminas como inhibidores de beta-triptasa
DK2511282T3 (da)	2014-07-07	Uracylspirooxetannukleosider
PL2435825T3 (pl)	2015-12-31	Sposoby leczenia chorób
PT2504298T (pt)	2016-12-29	Preparação e purificação de iodoxanol
BR112012000907A2 (pt)	2017-08-08	copolimero de impacto para preparar um copolimero de impacto
BRPI0816806A2 (pt)	2015-03-10	Derivados de azaciclil-isoquinolinona e isoindolinona como antagonista de histamina-3
BRPI1008253A2 (pt)	2015-08-25	Metoso para tratar biomassa
BRPI1008744A2 (pt)	2016-03-15	hidrotratamento de caboidratos
BR112012005371A2 (pt)	2016-03-29	desmontagem de componentes interligados
BRPI1007196A2 (pt)	2016-09-27	profármacos e derivado de espiroindolinona