BRPI1007027A2 - combinação de um derivado de ciclosporina e nucleosídeos para tratar do hcv - Google Patents

combinação de um derivado de ciclosporina e nucleosídeos para tratar do hcv

Info

Publication number: BRPI1007027A2
Authority: BR; Brazil
Prior art keywords: cyclosporin; combination; nucleoside derivative; treat hcv; hcv
Prior art date: 2009-01-07

Application number

BRPI1007027A

Other languages

English (en)

Inventor

Earl Hopkins Samuel

Original Assignee

Scynexis Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-01-07

Filing date

2010-01-07

Publication date

2019-09-24

2010-01-07 Application filed by Scynexis Inc filed Critical Scynexis Inc

2019-09-24 Publication of BRPI1007027A2 publication Critical patent/BRPI1007027A2/pt

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title 1
229930105110 Cyclosporin A Natural products 0.000 title 1
108010036949 Cyclosporine Proteins 0.000 title 1
229960001265 ciclosporin Drugs 0.000 title 1
229930182912 cyclosporin Natural products 0.000 title 1
150000003833 nucleoside derivatives Chemical class 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Virology (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Gastroenterology & Hepatology (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)

BRPI1007027A 2009-01-07 2010-01-07 combinação de um derivado de ciclosporina e nucleosídeos para tratar do hcv BRPI1007027A2 (pt)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US14306209P	2009-01-07	2009-01-07
US15602609P	2009-02-27	2009-02-27
US25723109P	2009-11-02	2009-11-02
PCT/US2010/020323 WO2010080878A1 (en)	2009-01-07	2010-01-07	Combination of a cyclosporine derivative and nucleosides for treating hcv

Publications (1)

Publication Number	Publication Date
BRPI1007027A2 true BRPI1007027A2 (pt)	2019-09-24

Family

ID=42084646

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI1007027A BRPI1007027A2 (pt)	2009-01-07	2010-01-07	combinação de um derivado de ciclosporina e nucleosídeos para tratar do hcv

Country Status (11)

Country	Link
US (1)	US20100227801A1 (pt)
EP (1)	EP2385833A1 (pt)
JP (1)	JP2012514606A (pt)
CN (1)	CN102271688A (pt)
AU (1)	AU2010203660A1 (pt)
BR (1)	BRPI1007027A2 (pt)
CA (1)	CA2748792A1 (pt)
IL (1)	IL213862A0 (pt)
MX (1)	MX2011007194A (pt)
RU (1)	RU2011127079A (pt)
WO (1)	WO2010080878A1 (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI1802650T1 (sl) *	2004-10-01	2012-03-30	Scynexis Inc	Eter in tioeter substituirani ciklosporinski derivati za zdravljenje in preventivo pred infekcijami s hepatitisom c
CA2623864C (en) *	2005-09-30	2014-12-16	Scynexis, Inc.	Arylalkyl and heteroarylalkyl derivatives of cyclosporine a for the treatment and prevention of viral infection
EP2023918B1 (en)	2006-05-19	2011-03-23	Scynexis, Inc.	Cyclosporins for the treatment and prevention of ocular disorders
KR101089112B1 (ko) *	2006-06-02	2011-12-06	피씨 제스띠옹 에스.아.에스.	활성 전자 관리
US7964580B2 (en)	2007-03-30	2011-06-21	Pharmasset, Inc.	Nucleoside phosphoramidate prodrugs
JP5820722B2 (ja)	2008-06-06	2015-11-24	スシネキスインク	シクロスポリン類似体及びｈｃｖ感染の治療におけるその使用
US8173621B2 (en)	2008-06-11	2012-05-08	Gilead Pharmasset Llc	Nucleoside cyclicphosphates
EP2376515A1 (en) *	2008-12-23	2011-10-19	Pharmasset, Inc.	Synthesis of purine nucleosides
CA2748389A1 (en) *	2008-12-31	2010-07-08	Scynexis, Inc.	Derivatives of cyclosporin a
TWI598358B (zh)	2009-05-20	2017-09-11	基利法瑪席特有限責任公司	核苷磷醯胺
US8618076B2 (en)	2009-05-20	2013-12-31	Gilead Pharmasset Llc	Nucleoside phosphoramidates
CL2011000718A1 (es)	2010-03-31	2012-04-09	Gilead Pharmasset Llc	Proceso para la preparacion de compuestos fosforados enantiomericos.
PL3290428T3 (pl)	2010-03-31	2022-02-07	Gilead Pharmasset Llc	Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
PT3042910T (pt)	2010-11-30	2019-04-16	Gilead Pharmasset Llc	2'-espiro-nucleósidos para utilização na terapia da hepatite c
AU2012308295B2 (en)	2011-09-16	2017-10-26	Gilead Sciences, Inc.	Methods for treating HCV
US8889159B2 (en)	2011-11-29	2014-11-18	Gilead Pharmasset Llc	Compositions and methods for treating hepatitis C virus
MY172166A (en)	2013-01-31	2019-11-15	Gilead Pharmasset Llc	Combination formulation of two antiviral compounds
WO2014197400A1 (en) *	2013-06-04	2014-12-11	Gilead Pharmasset Llc	Preventing and treating recurrence of hcv infection after liver transplant
EP3650014B1 (en)	2013-08-27	2021-10-06	Gilead Pharmasset LLC	Combination formulation of two antiviral compounds
EP3134423A4 (en) *	2014-04-24	2017-11-29	Cocrystal Pharma, Inc.	2' -disubstituted nucleoside analogs for treatment of the flaviviridae family of viruses and cancer
WO2020118714A1 (en)	2018-12-14	2020-06-18	Waterstone Pharmaceuticals (Wuhan) Co., Ltd.	Maleate of scy-635 and uses thereof in medicine
US12226446B2 (en) *	2019-10-11	2025-02-18	Waterstone Pharmaceuticals(Wuhan) Co., Ltd.	WS-635 uses thereof in medicine
WO2021243658A1 (en) *	2020-06-04	2021-12-09	Waterstone Pharmaceuticals (Wuhan) Co., Ltd.	Treatment or prevention of coronaviridae infection
JP2023072634A (ja) *	2021-11-12	2023-05-24	国立大学法人北海道大学	抗ウイルス剤
EP4431100A4 (en) *	2021-11-12	2025-01-15	National University Corporation Hokkaido University	ANTIVIRAL AGENT

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN100503628C (zh) *	2003-05-30	2009-06-24	法莫赛特股份有限公司	修饰的氟化核苷类似物
CN105169369B (zh) *	2005-09-30	2019-10-18	中美华世通生物医药科技（武汉）有限公司	治疗和预防丙型肝炎感染的方法和药物组合物
WO2007065829A1 (en) *	2005-12-09	2007-06-14	F. Hoffmann-La Roche Ag	Antiviral nucleosides

2010
- 2010-01-07 AU AU2010203660A patent/AU2010203660A1/en not_active Abandoned
- 2010-01-07 CN CN2010800041088A patent/CN102271688A/zh active Pending
- 2010-01-07 WO PCT/US2010/020323 patent/WO2010080878A1/en not_active Ceased
- 2010-01-07 BR BRPI1007027A patent/BRPI1007027A2/pt not_active IP Right Cessation
- 2010-01-07 CA CA2748792A patent/CA2748792A1/en not_active Abandoned
- 2010-01-07 MX MX2011007194A patent/MX2011007194A/es not_active Application Discontinuation
- 2010-01-07 RU RU2011127079/15A patent/RU2011127079A/ru unknown
- 2010-01-07 EP EP10704436A patent/EP2385833A1/en not_active Withdrawn
- 2010-01-07 US US12/683,691 patent/US20100227801A1/en not_active Abandoned
- 2010-01-07 JP JP2011544685A patent/JP2012514606A/ja active Pending
2011
- 2011-06-30 IL IL213862A patent/IL213862A0/en unknown

Also Published As

Publication number	Publication date
CA2748792A1 (en)	2010-07-15
WO2010080878A1 (en)	2010-07-15
EP2385833A1 (en)	2011-11-16
AU2010203660A1 (en)	2011-07-28
US20100227801A1 (en)	2010-09-09
JP2012514606A (ja)	2012-06-28
RU2011127079A (ru)	2013-02-20
MX2011007194A (es)	2013-07-12
AU2010203660A2 (en)	2011-09-29
CN102271688A (zh)	2011-12-07
IL213862A0 (en)	2011-07-31

Legal Events

Date	Code	Title	Description
2019-10-01	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
2020-01-21	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

Publication	Publication Date	Title
BRPI1007027A2 (pt)	2019-09-24	combinação de um derivado de ciclosporina e nucleosídeos para tratar do hcv
BRPI0919404A2 (pt)	2015-12-15	combinações sinergísticas de um inibidor macrocíclico do hcv e de um nucleosídeo
BRPI1007476A2 (pt)	2016-02-16	análogos de ciclosporina para prevenir ou tratar infecção por hepatite c
EP2491033A4 (en)	2013-03-13	AZAINDAZOLES FOR THE TREATMENT OF FLAVIVIRIDAE VIRUS INFECTION
EP2424873A4 (en)	2013-05-08	NOVEL GALECTIN GALACTOSIDHEMMER
SMT201600291B (it)	2016-11-10	Inibitori di proteasi hcv
DOP2012000114A (es)	2012-08-15	Inhibidor bromodominio de benzodiazepina
EP2400987A4 (en)	2012-08-22	Benda MUSTIN-CYCLOPOLYSACCHARIDZUSAMMENSETZUNGEN
BRPI0922180A2 (pt)	2015-12-29	insoindolinona e análogos correlatos como moduladores de sirtuína
BR112012005438A2 (pt)	2018-03-20	inibidores de vírus flaviviridae
FI20095291L (fi)	2010-09-21	Kuitujen käsittely muovausta kestäväksi
EP2442821A4 (en)	2013-07-31	SAFE ADMINISTRATION OF DESMOPRESSIN
UY33155A (es)	2011-07-29	Indolil-piperidinil bencilaminas como inhibidores de beta-triptasa
DK2511282T3 (da)	2014-07-07	Uracylspirooxetannukleosider
PL2435825T3 (pl)	2015-12-31	Sposoby leczenia chorób
PT2504298T (pt)	2016-12-29	Preparação e purificação de iodoxanol
BR112012000907A2 (pt)	2017-08-08	copolimero de impacto para preparar um copolimero de impacto
BRPI0816806A2 (pt)	2015-03-10	Derivados de azaciclil-isoquinolinona e isoindolinona como antagonista de histamina-3
BRPI1008253A2 (pt)	2015-08-25	Metoso para tratar biomassa
BRPI1008744A2 (pt)	2016-03-15	hidrotratamento de caboidratos
BR112012005371A2 (pt)	2016-03-29	desmontagem de componentes interligados
BR112012010242A2 (pt)	2015-09-29	derivados de heteroarilpiperidina e heteroarilpiperazina
BRPI1007196A2 (pt)	2016-09-27	profármacos e derivado de espiroindolinona
DK2453858T3 (da)	2014-11-03	Fremgangsmåde
PT2492266E (pt)	2015-11-18	Derivado de 5-hidroxipirimidino-4-carboxamida