BRPI1007027A2 - combinação de um derivado de ciclosporina e nucleosídeos para tratar do hcv - Google Patents

combinação de um derivado de ciclosporina e nucleosídeos para tratar do hcv

Info

Publication number: BRPI1007027A2
Authority: BR; Brazil
Prior art keywords: cyclosporin; combination; nucleoside derivative; treat hcv; hcv
Prior art date: 2009-01-07

Application number

BRPI1007027A

Other languages

English (en)

Inventor

Earl Hopkins Samuel

Original Assignee

Scynexis Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-01-07

Filing date

2010-01-07

Publication date

2019-09-24

2010-01-07 Application filed by Scynexis Inc filed Critical Scynexis Inc

2019-09-24 Publication of BRPI1007027A2 publication Critical patent/BRPI1007027A2/pt

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title 1
229930105110 Cyclosporin A Natural products 0.000 title 1
108010036949 Cyclosporine Proteins 0.000 title 1
229960001265 ciclosporin Drugs 0.000 title 1
229930182912 cyclosporin Natural products 0.000 title 1
150000003833 nucleoside derivatives Chemical class 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Virology (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)

BRPI1007027A 2009-01-07 2010-01-07 combinação de um derivado de ciclosporina e nucleosídeos para tratar do hcv BRPI1007027A2 (pt)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US14306209P	2009-01-07	2009-01-07
US15602609P	2009-02-27	2009-02-27
US25723109P	2009-11-02	2009-11-02
PCT/US2010/020323 WO2010080878A1 (en)	2009-01-07	2010-01-07	Combination of a cyclosporine derivative and nucleosides for treating hcv

Publications (1)

Publication Number	Publication Date
BRPI1007027A2 true BRPI1007027A2 (pt)	2019-09-24

Family

ID=42084646

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI1007027A BRPI1007027A2 (pt)	2009-01-07	2010-01-07	combinação de um derivado de ciclosporina e nucleosídeos para tratar do hcv

Country Status (11)

Country	Link
US (1)	US20100227801A1 (pt)
EP (1)	EP2385833A1 (pt)
JP (1)	JP2012514606A (pt)
CN (1)	CN102271688A (pt)
AU (1)	AU2010203660A1 (pt)
BR (1)	BRPI1007027A2 (pt)
CA (1)	CA2748792A1 (pt)
IL (1)	IL213862A0 (pt)
MX (1)	MX2011007194A (pt)
RU (1)	RU2011127079A (pt)
WO (1)	WO2010080878A1 (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT1802650E (pt) *	2004-10-01	2011-12-30	Scynexis Inc	Derivados da ciclosporina 3-éter e 3-tioéter substituída para o tratamento e prevenção da infecção de hepatite c
WO2007041631A1 (en) *	2005-09-30	2007-04-12	Scynexis, Inc.	ARYIiALKYL AND HETEROARYLALKYL DERIVATIVES OF CYCLOSPORINE A FOR THE TREATMENT AND PREVENTION OF VIRAL INFECTION
CA2652662C (en)	2006-05-19	2015-11-03	Scynexis, Inc.	Methods for the treatment and prevention of ocular disorders
KR101089112B1 (ko) *	2006-06-02	2011-12-06	피씨 제스띠옹 에스.아.에스.	활성 전자 관리
US7964580B2 (en)	2007-03-30	2011-06-21	Pharmasset, Inc.	Nucleoside phosphoramidate prodrugs
JP5820722B2 (ja)	2008-06-06	2015-11-24	スシネキスインク	シクロスポリン類似体及びｈｃｖ感染の治療におけるその使用
US8173621B2 (en)	2008-06-11	2012-05-08	Gilead Pharmasset Llc	Nucleoside cyclicphosphates
CL2009002206A1 (es)	2008-12-23	2011-08-26	Gilead Pharmasset Llc	Compuestos derivados de pirrolo -(2-3-d]-pirimidin-7(6h)-tetrahidrofuran-2-il fosfonamidato, composicion farmaceutica; y su uso en el tratamiento de enfermedades virales.
US8536114B2 (en) *	2008-12-31	2013-09-17	Scynexis, Inc.	Macrocycles
TWI576352B (zh)	2009-05-20	2017-04-01	基利法瑪席特有限責任公司	核苷磷醯胺
US8618076B2 (en)	2009-05-20	2013-12-31	Gilead Pharmasset Llc	Nucleoside phosphoramidates
PL3290428T3 (pl)	2010-03-31	2022-02-07	Gilead Pharmasset Llc	Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
AP2012006535A0 (en)	2010-03-31	2012-10-31	Gilead Pharmasset Llc	Stereoselective synthesis of phosphorous containing actives
ES2716158T3 (es)	2010-11-30	2019-06-10	Gilead Pharmasset Llc	2'-spiro-nucleótidos para el tratamiento de hepatitis C
HRP20180237T4 (hr)	2011-09-16	2020-12-11	Gilead Pharmasset Llc	Metode za liječenje hcv-a
US8889159B2 (en)	2011-11-29	2014-11-18	Gilead Pharmasset Llc	Compositions and methods for treating hepatitis C virus
EP2950786B1 (en)	2013-01-31	2019-11-27	Gilead Pharmasset LLC	Combination formulation of two antiviral compounds
WO2014197400A1 (en) *	2013-06-04	2014-12-11	Gilead Pharmasset Llc	Preventing and treating recurrence of hcv infection after liver transplant
EA201690473A1 (ru)	2013-08-27	2017-03-31	ГАЙЛИД ФАРМАССЕТ ЭлЭлСи	Комбинированный состав двух противовирусных соединений
CA2946867C (en) *	2014-04-24	2023-03-07	Cocrystal Pharma, Inc.	2'-disubstituted nucleoside analogs for treatment of the flaviviridae family of viruses and cancer
ES2987605T3 (es) *	2018-12-14	2024-11-15	Waterstone Pharmaceuticals Wuhan Co Ltd	Maleato de SCY-635 y usos del mismo en medicina
CA3128410A1 (en) *	2019-10-11	2021-04-15	Waterstone Pharmaceuticals (Wuhan) Co., Ltd.	Ws-635 uses thereof in medicine
EP4161557B1 (en) *	2020-06-04	2026-03-11	Waterstone Pharmaceuticals (Wuhan) Co., Ltd.	Ws-635 for use in the treatment or prevention of sars-cov-2 infection
JP2023072634A (ja) *	2021-11-12	2023-05-24	国立大学法人北海道大学	抗ウイルス剤
US20250009777A1 (en) *	2021-11-12	2025-01-09	National University Corporation Hokkaido University	Antiviral agent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2358979C2 (ru) *	2003-05-30	2009-06-20	Фармассет, Инк.	Модифицированные фторированные аналоги нуклеозида
WO2007041632A2 (en) *	2005-09-30	2007-04-12	Scynexis, Inc.	Methods and pharmaceutical compositions for the treatment and prevention of hepatitis c infection
BRPI0619563A2 (pt) *	2005-12-09	2011-10-04	Pharmasset Inc	nucleosìdeos antivirais

2010
- 2010-01-07 CN CN2010800041088A patent/CN102271688A/zh active Pending
- 2010-01-07 WO PCT/US2010/020323 patent/WO2010080878A1/en not_active Ceased
- 2010-01-07 AU AU2010203660A patent/AU2010203660A1/en not_active Abandoned
- 2010-01-07 RU RU2011127079/15A patent/RU2011127079A/ru unknown
- 2010-01-07 US US12/683,691 patent/US20100227801A1/en not_active Abandoned
- 2010-01-07 MX MX2011007194A patent/MX2011007194A/es not_active Application Discontinuation
- 2010-01-07 EP EP10704436A patent/EP2385833A1/en not_active Withdrawn
- 2010-01-07 JP JP2011544685A patent/JP2012514606A/ja active Pending
- 2010-01-07 CA CA2748792A patent/CA2748792A1/en not_active Abandoned
- 2010-01-07 BR BRPI1007027A patent/BRPI1007027A2/pt not_active IP Right Cessation
2011
- 2011-06-30 IL IL213862A patent/IL213862A0/en unknown

Also Published As

Publication number	Publication date
RU2011127079A (ru)	2013-02-20
US20100227801A1 (en)	2010-09-09
JP2012514606A (ja)	2012-06-28
AU2010203660A2 (en)	2011-09-29
IL213862A0 (en)	2011-07-31
WO2010080878A1 (en)	2010-07-15
AU2010203660A1 (en)	2011-07-28
EP2385833A1 (en)	2011-11-16
CA2748792A1 (en)	2010-07-15
CN102271688A (zh)	2011-12-07
MX2011007194A (es)	2013-07-12

Legal Events

Date	Code	Title	Description
2019-10-01	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
2020-01-21	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

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HRP20181602T1 (hr)	2018-11-30	Postupak pročišćavanja prokariotskih varijanti i fenilalanin-amonijak-lijaze
IL213862A0 (en)	2011-07-31	Combination of a cyclosporine derivative and nucleosides for treating hcv
BRPI0919404A2 (pt)	2015-12-15	combinações sinergísticas de um inibidor macrocíclico do hcv e de um nucleosídeo
BRPI1007476A2 (pt)	2016-02-16	análogos de ciclosporina para prevenir ou tratar infecção por hepatite c
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