BRPI1007215A2 - Método de acoplamento covalente de duas ou mais porções, primeira e segunda porções, primeiro porção acoplada a uma segunda porção, par de primeiro e segundo ligantes, e, uso de um par de ligantes. - Google Patents

Método de acoplamento covalente de duas ou mais porções, primeira e segunda porções, primeiro porção acoplada a uma segunda porção, par de primeiro e segundo ligantes, e, uso de um par de ligantes.

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Publication number
BRPI1007215A2
BRPI1007215A2 BRPI1007215A BRPI1007215A BRPI1007215A2 BR PI1007215 A2 BRPI1007215 A2 BR PI1007215A2 BR PI1007215 A BRPI1007215 A BR PI1007215A BR PI1007215 A BRPI1007215 A BR PI1007215A BR PI1007215 A2 BRPI1007215 A2 BR PI1007215A2
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BR
Brazil
Prior art keywords
linkers
pair
portions
moieties
covalent bond
Prior art date
Application number
BRPI1007215A
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English (en)
Inventor
Jayasinghe Lakmal
Milton John
Mcneill Like
Clarke James
White James
Moysey Ruth
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Oxford Nanopore Tech Ltd
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Publication date
Application filed by Oxford Nanopore Tech Ltd filed Critical Oxford Nanopore Tech Ltd
Publication of BRPI1007215A2 publication Critical patent/BRPI1007215A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Medicinal Preparation (AREA)

Abstract

MÉTODO DE ACOPLAMENTO COVALENTE DE DUAS OU MAIS PORÇÕES, PRIMEIRA E SEGUNDA PORÇÕES, PRIMEIRA PORÇÃO ACOPLADA A UMA SEGUNDA PORÇÃO, PAR DE PRIMEIRO E SEGUNDO LIGANTES, E, USO DE UM PAR DE LIGANTES. A invenção fornece um método de acoplamento covalente de duas ou mais porções, o método compreendendo: a) fomecer uma primeira porção tendo anexado covalentemente à mesma (i) pelo menos um primeiro ligante compreendendo uma primeira região hibridizável e (ii) pelo menos um primeiro grupo capaz de formar uma ligação covalente; b) fornecer uma segunda porção tendo anexado covalentemente à mesma (1) pelo menos um segundo ligante compreendendo uma segunda região hibridizável capaz de hibridizar à primeira região hibridizável e (ii) pelo menos um segundo grupo capaz de formar uma ligação covalente com o primeiro grupo; c) entrar em contato com a primeira e a segunda porção sob condições que permitem que a primeira e segunda região hibridizável hibridizem e ligar as porções; e d) expor as poções ligadas às condições que permitem a formação de uma ligação covalente entre o primeiro e o segundo grupos.
BRPI1007215A 2009-01-30 2010-01-29 Método de acoplamento covalente de duas ou mais porções, primeira e segunda porções, primeiro porção acoplada a uma segunda porção, par de primeiro e segundo ligantes, e, uso de um par de ligantes. BRPI1007215A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14872609P 2009-01-30 2009-01-30
PCT/GB2010/000132 WO2010086602A1 (en) 2009-01-30 2010-01-29 Hybridization linkers

Publications (1)

Publication Number Publication Date
BRPI1007215A2 true BRPI1007215A2 (pt) 2017-08-29

Family

ID=42110047

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1007215A BRPI1007215A2 (pt) 2009-01-30 2010-01-29 Método de acoplamento covalente de duas ou mais porções, primeira e segunda porções, primeiro porção acoplada a uma segunda porção, par de primeiro e segundo ligantes, e, uso de um par de ligantes.

Country Status (9)

Country Link
US (2) US20120100530A1 (pt)
EP (2) EP2391655B1 (pt)
JP (1) JP2012516145A (pt)
KR (1) KR20110125226A (pt)
CN (2) CN102439043A (pt)
AU (1) AU2010209508C1 (pt)
BR (1) BRPI1007215A2 (pt)
CA (1) CA2750874A1 (pt)
WO (2) WO2010086603A1 (pt)

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