BRPI1008359A2 - método para produzir partículas de medicamento de tamanho de partícula pequeno - Google Patents
método para produzir partículas de medicamento de tamanho de partícula pequenoInfo
- Publication number
- BRPI1008359A2 BRPI1008359A2 BRPI1008359A BRPI1008359A BRPI1008359A2 BR PI1008359 A2 BRPI1008359 A2 BR PI1008359A2 BR PI1008359 A BRPI1008359 A BR PI1008359A BR PI1008359 A BRPI1008359 A BR PI1008359A BR PI1008359 A2 BRPI1008359 A2 BR PI1008359A2
- Authority
- BR
- Brazil
- Prior art keywords
- particle size
- small particle
- producing small
- medicine particles
- size medicine
- Prior art date
Links
- 239000002245 particle Substances 0.000 title 2
- 239000003814 drug Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009008478A DE102009008478A1 (de) | 2009-02-11 | 2009-02-11 | Vorrichtung und Verfahren zur Herstellung pharmazeutisch hochfeiner Partikel sowie zur Beschichtung solcher Partikel in Mikroreaktoren |
| DE102009008478.9 | 2009-02-11 | ||
| PCT/DE2010/075015 WO2010091683A2 (de) | 2009-02-11 | 2010-02-11 | Vorrichtung und verfahren zur herstellung pharmazeutisch hochfeiner partikel sowie zur beschichtung solcher partikel in mikroreaktoren |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI1008359A2 true BRPI1008359A2 (pt) | 2016-02-23 |
| BRPI1008359B1 BRPI1008359B1 (pt) | 2021-01-12 |
| BRPI1008359B8 BRPI1008359B8 (pt) | 2021-05-25 |
Family
ID=42338614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1008359A BRPI1008359B8 (pt) | 2009-02-11 | 2010-02-11 | método para produzir partículas de medicamento de tamanho de partícula pequeno |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8697131B2 (pt) |
| EP (1) | EP2395978B1 (pt) |
| JP (1) | JP5624059B2 (pt) |
| KR (1) | KR101515263B1 (pt) |
| CN (2) | CN105125502A (pt) |
| BR (1) | BRPI1008359B8 (pt) |
| CA (1) | CA2751625C (pt) |
| DE (1) | DE102009008478A1 (pt) |
| WO (1) | WO2010091683A2 (pt) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR201816320T4 (tr) | 2010-03-22 | 2018-11-21 | Instillo Gmbh | Mikro- veya nanopartikül üretimi işlemi. |
| WO2012087350A2 (en) * | 2010-12-21 | 2012-06-28 | President And Fellows Of Harvard College | Spray drying techniques |
| CN103127889B (zh) * | 2011-11-29 | 2016-01-13 | 北京大学 | 制备功能纳米粒子的减压诱导微射流混合法及其应用 |
| JP2016515934A (ja) * | 2013-03-28 | 2016-06-02 | インスティロ ゲーエムベーハー | 分散物および固体の生産のための装置および方法 |
| US9468626B2 (en) | 2014-03-13 | 2016-10-18 | Chiesi Farmaceutici S.P.A. | Melatonin-based formulations for parenteral administration |
| WO2015179334A1 (en) | 2014-05-19 | 2015-11-26 | The Medicines Company | Clevidipine nanoparticles and pharmaceutical compositions thereof |
| CN104226211B (zh) * | 2014-09-17 | 2018-08-10 | 天津春发生物科技集团有限公司 | 一种生物-喷雾干燥法制备香精微胶囊的方法 |
| DE202015100863U1 (de) | 2015-02-23 | 2016-05-30 | Care Connection Gmbh | Behälter zur Applikation einer Tannin-enthaltenden Deodorant- oder Antitranspirantzusammensetzung |
| DE202015100862U1 (de) | 2015-02-23 | 2016-05-30 | Care Connection Gmbh | Tannin-Nanopartikel enthaltende Deodorant- oder Antitranspirantzusammensetzung |
| EP3270891A1 (en) * | 2015-03-17 | 2018-01-24 | Leon-Nanodrugs GmbH | Nanoparticles comprising a stabilized boronic acid compound |
| DE102016101232A1 (de) * | 2016-01-25 | 2017-07-27 | Instillo Gmbh | Verfahren zum Herstellen von Emulsionen |
| DE102017110292B4 (de) | 2017-05-11 | 2020-06-10 | Instillo Gmbh | Verfahren zum Herstellen von Reaktionsprodukten |
| US11844860B2 (en) | 2018-03-02 | 2023-12-19 | Chiesi Farmaceutici S.P.A. | Pharmaceutical formulation for intraduodenal administration comprising melevodopa and carbidopa |
| CN110385124B (zh) * | 2018-04-16 | 2021-01-26 | 浙江大学 | 一种通过分段反应制备MnOx-CeO2混合氧化物催化剂的方法 |
| US10912326B2 (en) | 2018-08-22 | 2021-02-09 | Rachelle MACSWEENEY | Nanoformulations containing encapsulted omega-3 fatty acids |
| DE102019112382A1 (de) * | 2019-05-13 | 2020-11-19 | MyBiotech GmbH | Verwendung eines MikroJet-Reaktors zum Zellaufschluss |
| US20220249388A1 (en) | 2019-05-23 | 2022-08-11 | Helm Ag | Nanoparticles comprising enzalutamide |
| EP3795646A1 (de) | 2019-12-19 | 2021-03-24 | nanoSaar Lab GmbH | Farb- und füllstoffpasten unter verwendung anorganischer partikel mit beschichteter oberfläche als spacer |
| EP3915673A1 (de) | 2020-05-25 | 2021-12-01 | Leon-Nanodrugs GmbH | Verfahren zur überprüfung der funktionsfähigkeit einer anlage zur herstellung von nanopartikeln durch gezielte fällung aus übersättigten lösungen |
| EP4008322B1 (de) | 2020-05-25 | 2024-11-27 | leon-nanodrugs GmbH | Lecithin-partikel im nanometer bereich als wirkstoffträger zur parenteralen verabreichung |
| EP3915546A1 (de) * | 2020-05-25 | 2021-12-01 | Leon-Nanodrugs GmbH | Verwendung von säure als lösungsmittel für präzipitationen |
| EP3915544A1 (en) | 2020-05-25 | 2021-12-01 | Leon-Nanodrugs GmbH | Method for producing a liposome dispersion |
| CA3216600A1 (en) | 2021-05-05 | 2022-11-10 | Christian DUBIELLA | Methods for producing nanoparticle dispersions |
| EP4163006B8 (en) | 2021-10-11 | 2024-03-20 | leon-nanodrugs GmbH | Methods for validating an apparatus for producing nanoparticles |
| EP4198105A1 (en) | 2021-12-16 | 2023-06-21 | Seaborough IP I B.V. | Microjet reactor based synthesis of nanophosphors |
| CN114669085B (zh) * | 2022-01-28 | 2024-05-31 | 南京宁源科生物技术有限公司 | 一种药用颗粒的有机溶剂去除装置 |
| WO2025228668A1 (en) | 2024-05-03 | 2025-11-06 | Leon-Nanodrugs Gmbh | Method for manufacturing lipid nanoparticles |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69112917T2 (de) | 1990-06-15 | 1996-05-15 | Merck & Co Inc | Kristallisationsverfahren zur Verbesserung der Kristallstruktur und -grösse. |
| DE19617085A1 (de) | 1996-04-29 | 1997-10-30 | Bayer Ag | Verfahren zur Herstellung von feinstteiligen Kristallisationsprodukten |
| GB9828721D0 (en) | 1998-12-24 | 1999-02-17 | Glaxo Group Ltd | Novel apparatus and process |
| AU4910300A (en) * | 1999-04-08 | 2000-11-14 | Bernd Penth | Method and device for carrying out chemical and physical processes |
| CZ20011726A3 (cs) | 2000-05-26 | 2002-02-13 | Pfizer Products Inc. | Způsob reakční krystalizace, který umoľňuje řídit velikost částic |
| US6884436B2 (en) | 2000-12-22 | 2005-04-26 | Baxter International Inc. | Method for preparing submicron particle suspensions |
| AU2002249836B2 (en) * | 2000-12-22 | 2006-12-14 | Baxter International Inc. | Method for preparing submicron particle suspensions |
| DE10214031A1 (de) | 2002-03-27 | 2004-02-19 | Pharmatech Gmbh | Verfahren zur Herstellung und Anwendung von Mikro- und Nanoteilchen durch aufbauende Mikronisation |
| US7041144B2 (en) * | 2003-03-04 | 2006-05-09 | Five Star Technologies, Inc. | Hydrodynamic cavitation crystallization process |
| KR20060052849A (ko) * | 2003-08-06 | 2006-05-19 | 에자이 가부시키가이샤 | 약물 초미립자의 제조 방법 및 제조 장치 |
| TWI371274B (en) * | 2003-10-23 | 2012-09-01 | Bristol Myers Squibb Co | Process for making sterile aripiprazole of desired mean particle size |
| DE102005048201A1 (de) | 2004-10-11 | 2006-04-20 | Penth, Bernd, Dr. | Kontinuierliche Fällung von nanoskaligen Produkten in Mikroreaktoren |
| DE102005011786A1 (de) | 2005-03-11 | 2006-09-14 | Pharmasol Gmbh | Verfahren zur Herstellung ultrafeiner Submicron-Suspensionen |
| DE102005017777A1 (de) | 2005-04-13 | 2006-10-19 | Pharmasol Gmbh | Verfahren zur schonenden Herstellung von hochfeinen Partikelsuspensionen |
| DE102005048021B3 (de) | 2005-10-06 | 2007-04-12 | Abb Patent Gmbh | Lokal bedienbares Automatisierungsgerät |
| DE102005053862A1 (de) | 2005-11-04 | 2007-05-10 | Pharmasol Gmbh | Verfahren und Vorrichtung zur Herstellung hochfeiner Partikel sowie zur Beschichtung solcher Partikel |
-
2009
- 2009-02-11 DE DE102009008478A patent/DE102009008478A1/de not_active Withdrawn
-
2010
- 2010-02-11 KR KR1020117021104A patent/KR101515263B1/ko active Active
- 2010-02-11 JP JP2011548532A patent/JP5624059B2/ja active Active
- 2010-02-11 BR BRPI1008359A patent/BRPI1008359B8/pt active IP Right Grant
- 2010-02-11 CA CA2751625A patent/CA2751625C/en active Active
- 2010-02-11 CN CN201510359931.5A patent/CN105125502A/zh active Pending
- 2010-02-11 WO PCT/DE2010/075015 patent/WO2010091683A2/de not_active Ceased
- 2010-02-11 US US13/138,389 patent/US8697131B2/en active Active
- 2010-02-11 EP EP10710995.1A patent/EP2395978B1/de active Active
- 2010-02-11 CN CN2010800073233A patent/CN102316853A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR101515263B1 (ko) | 2015-04-24 |
| BRPI1008359B8 (pt) | 2021-05-25 |
| CN105125502A (zh) | 2015-12-09 |
| WO2010091683A3 (de) | 2010-10-21 |
| DE102009008478A1 (de) | 2010-08-19 |
| BRPI1008359B1 (pt) | 2021-01-12 |
| US20110294770A1 (en) | 2011-12-01 |
| US8697131B2 (en) | 2014-04-15 |
| JP2012517403A (ja) | 2012-08-02 |
| KR20110118714A (ko) | 2011-10-31 |
| CN102316853A (zh) | 2012-01-11 |
| EP2395978A2 (de) | 2011-12-21 |
| EP2395978B1 (de) | 2015-05-27 |
| WO2010091683A2 (de) | 2010-08-19 |
| JP5624059B2 (ja) | 2014-11-12 |
| CA2751625C (en) | 2014-10-14 |
| CA2751625A1 (en) | 2010-08-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25D | Requested change of name of applicant approved |
Owner name: INSTILLO GMBH (DE) |
|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 12/01/2021, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 11/02/2010 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |