BRPI1008359B8 - método para produzir partículas de medicamento de tamanho de partícula pequeno - Google Patents

método para produzir partículas de medicamento de tamanho de partícula pequeno

Info

Publication number
BRPI1008359B8
BRPI1008359B8 BRPI1008359A BRPI1008359A BRPI1008359B8 BR PI1008359 B8 BRPI1008359 B8 BR PI1008359B8 BR PI1008359 A BRPI1008359 A BR PI1008359A BR PI1008359 A BRPI1008359 A BR PI1008359A BR PI1008359 B8 BRPI1008359 B8 BR PI1008359B8
Authority
BR
Brazil
Prior art keywords
solvent
particle size
small particle
water
drug particles
Prior art date
Application number
BRPI1008359A
Other languages
English (en)
Inventor
Emre Türeli Akif
Baumstümmler Bernd
Penth Bernd
Langguth Peter
Original Assignee
Instillo Gmbh
Mjr Pharmajet Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instillo Gmbh, Mjr Pharmajet Gmbh filed Critical Instillo Gmbh
Publication of BRPI1008359A2 publication Critical patent/BRPI1008359A2/pt
Publication of BRPI1008359B1 publication Critical patent/BRPI1008359B1/pt
Publication of BRPI1008359B8 publication Critical patent/BRPI1008359B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

método para produzir partículas de medicamento de tamanho de partículas pequeno. as partículas de medicamento de tamanho de partícula pequeno são produzidas pela combinação de um precipitado de solvente-não solvente com um processo de secagem por atomização in situ. um mediamento é disperso em um solvente miscível em água, em particular etanol, e aquecido em uma linha de alimentação sob pressão até acima do ponto de ebulição do solvente até o fármaco dissolver. esta solução colide como um jato de líquido fino com um jato de água fino em um microreator permeado por gás, e a névoa fina assim formada vaporiza rapidamente. o solvente orgânico vaporiza primeiro, depois a água. a água pode conter modificadores de superfície.
BRPI1008359A 2009-02-11 2010-02-11 método para produzir partículas de medicamento de tamanho de partícula pequeno BRPI1008359B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102009008478A DE102009008478A1 (de) 2009-02-11 2009-02-11 Vorrichtung und Verfahren zur Herstellung pharmazeutisch hochfeiner Partikel sowie zur Beschichtung solcher Partikel in Mikroreaktoren
DE102009008478.9 2009-02-11
PCT/DE2010/075015 WO2010091683A2 (de) 2009-02-11 2010-02-11 Vorrichtung und verfahren zur herstellung pharmazeutisch hochfeiner partikel sowie zur beschichtung solcher partikel in mikroreaktoren

Publications (3)

Publication Number Publication Date
BRPI1008359A2 BRPI1008359A2 (pt) 2016-02-23
BRPI1008359B1 BRPI1008359B1 (pt) 2021-01-12
BRPI1008359B8 true BRPI1008359B8 (pt) 2021-05-25

Family

ID=42338614

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1008359A BRPI1008359B8 (pt) 2009-02-11 2010-02-11 método para produzir partículas de medicamento de tamanho de partícula pequeno

Country Status (9)

Country Link
US (1) US8697131B2 (pt)
EP (1) EP2395978B1 (pt)
JP (1) JP5624059B2 (pt)
KR (1) KR101515263B1 (pt)
CN (2) CN105125502A (pt)
BR (1) BRPI1008359B8 (pt)
CA (1) CA2751625C (pt)
DE (1) DE102009008478A1 (pt)
WO (1) WO2010091683A2 (pt)

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US20120167410A1 (en) * 2010-12-21 2012-07-05 Basf Se Spray drying techniques
CN103127889B (zh) * 2011-11-29 2016-01-13 北京大学 制备功能纳米粒子的减压诱导微射流混合法及其应用
BR112015024868A2 (pt) 2013-03-28 2017-07-18 Instillo Gmbh método para produzir dispersões e matérias sólidas através de precipitação, coprecipitação e processo de auto-organização controlados e método para produzir dispersões e matérias sólidas através de precipitação controlada, coprecipitação e processo de auto-organização em um reator de microjato
US9468626B2 (en) 2014-03-13 2016-10-18 Chiesi Farmaceutici S.P.A. Melatonin-based formulations for parenteral administration
CA2947486C (en) 2014-05-19 2023-09-26 The Medicines Company Clevidipine nanoparticles and pharmaceutical compositions thereof
CN104226211B (zh) * 2014-09-17 2018-08-10 天津春发生物科技集团有限公司 一种生物-喷雾干燥法制备香精微胶囊的方法
DE202015100863U1 (de) 2015-02-23 2016-05-30 Care Connection Gmbh Behälter zur Applikation einer Tannin-enthaltenden Deodorant- oder Antitranspirantzusammensetzung
DE202015100862U1 (de) 2015-02-23 2016-05-30 Care Connection Gmbh Tannin-Nanopartikel enthaltende Deodorant- oder Antitranspirantzusammensetzung
EP3270891A1 (en) * 2015-03-17 2018-01-24 Leon-Nanodrugs GmbH Nanoparticles comprising a stabilized boronic acid compound
DE102016101232A1 (de) 2016-01-25 2017-07-27 Instillo Gmbh Verfahren zum Herstellen von Emulsionen
DE102017110292B4 (de) 2017-05-11 2020-06-10 Instillo Gmbh Verfahren zum Herstellen von Reaktionsprodukten
WO2019166322A1 (en) 2018-03-02 2019-09-06 Chiesi Farmaceutici S.P.A. A pharmaceutical formulation for intraduodenal administration comprising melevodopa and carbidopa
CN110385124B (zh) * 2018-04-16 2021-01-26 浙江大学 一种通过分段反应制备MnOx-CeO2混合氧化物催化剂的方法
US10912326B2 (en) 2018-08-22 2021-02-09 Rachelle MACSWEENEY Nanoformulations containing encapsulted omega-3 fatty acids
DE102019112382A1 (de) 2019-05-13 2020-11-19 MyBiotech GmbH Verwendung eines MikroJet-Reaktors zum Zellaufschluss
CA3141534A1 (en) 2019-05-23 2020-11-26 Helm Ag Nanoparticles comprising enzalutamide
EP3795646A1 (de) 2019-12-19 2021-03-24 nanoSaar Lab GmbH Farb- und füllstoffpasten unter verwendung anorganischer partikel mit beschichteter oberfläche als spacer
EP3915544A1 (en) 2020-05-25 2021-12-01 Leon-Nanodrugs GmbH Method for producing a liposome dispersion
EP4008322B1 (de) 2020-05-25 2024-11-27 leon-nanodrugs GmbH Lecithin-partikel im nanometer bereich als wirkstoffträger zur parenteralen verabreichung
EP3915673A1 (de) 2020-05-25 2021-12-01 Leon-Nanodrugs GmbH Verfahren zur überprüfung der funktionsfähigkeit einer anlage zur herstellung von nanopartikeln durch gezielte fällung aus übersättigten lösungen
EP3915546A1 (de) * 2020-05-25 2021-12-01 Leon-Nanodrugs GmbH Verwendung von säure als lösungsmittel für präzipitationen
AU2022270938A1 (en) 2021-05-05 2023-11-02 Leon-Nanodrugs Gmbh Methods for producing nanoparticle dispersions
EP4163006B8 (en) 2021-10-11 2024-03-20 leon-nanodrugs GmbH Methods for validating an apparatus for producing nanoparticles
EP4198105A1 (en) 2021-12-16 2023-06-21 Seaborough IP I B.V. Microjet reactor based synthesis of nanophosphors
CN114669085B (zh) * 2022-01-28 2024-05-31 南京宁源科生物技术有限公司 一种药用颗粒的有机溶剂去除装置
WO2025228668A1 (en) 2024-05-03 2025-11-06 Leon-Nanodrugs Gmbh Method for manufacturing lipid nanoparticles

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DE19617085A1 (de) * 1996-04-29 1997-10-30 Bayer Ag Verfahren zur Herstellung von feinstteiligen Kristallisationsprodukten
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Also Published As

Publication number Publication date
EP2395978B1 (de) 2015-05-27
CA2751625A1 (en) 2010-08-19
CN102316853A (zh) 2012-01-11
DE102009008478A1 (de) 2010-08-19
CN105125502A (zh) 2015-12-09
BRPI1008359B1 (pt) 2021-01-12
KR101515263B1 (ko) 2015-04-24
KR20110118714A (ko) 2011-10-31
US20110294770A1 (en) 2011-12-01
CA2751625C (en) 2014-10-14
EP2395978A2 (de) 2011-12-21
BRPI1008359A2 (pt) 2016-02-23
JP5624059B2 (ja) 2014-11-12
US8697131B2 (en) 2014-04-15
JP2012517403A (ja) 2012-08-02
WO2010091683A2 (de) 2010-08-19
WO2010091683A3 (de) 2010-10-21

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: INSTILLO GMBH (DE)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 12/01/2021, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 11/02/2010 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF