ATE319432T1 - Verfahren zur herstellung von submikropartikel- suspensionen pharmazeutischer substanzen - Google Patents
Verfahren zur herstellung von submikropartikel- suspensionen pharmazeutischer substanzenInfo
- Publication number
- ATE319432T1 ATE319432T1 AT01998077T AT01998077T ATE319432T1 AT E319432 T1 ATE319432 T1 AT E319432T1 AT 01998077 T AT01998077 T AT 01998077T AT 01998077 T AT01998077 T AT 01998077T AT E319432 T1 ATE319432 T1 AT E319432T1
- Authority
- AT
- Austria
- Prior art keywords
- submicroparticle
- suspensions
- producing
- pharmaceutical substances
- solvent
- Prior art date
Links
- 239000000725 suspension Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 3
- 238000010899 nucleation Methods 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Silicates, Zeolites, And Molecular Sieves (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25816000P | 2000-12-22 | 2000-12-22 | |
| US09/874,637 US6869617B2 (en) | 2000-12-22 | 2001-06-05 | Microprecipitation method for preparing submicron suspensions |
| US09/874,499 US7037528B2 (en) | 2000-12-22 | 2001-06-05 | Microprecipitation method for preparing submicron suspensions |
| US09/874,799 US6607784B2 (en) | 2000-12-22 | 2001-06-05 | Microprecipitation method for preparing submicron suspensions |
| US09/953,979 US6951656B2 (en) | 2000-12-22 | 2001-09-17 | Microprecipitation method for preparing submicron suspensions |
| US10/035,821 US6977085B2 (en) | 2000-12-22 | 2001-10-19 | Method for preparing submicron suspensions with polymorph control |
| US10/021,692 US6884436B2 (en) | 2000-12-22 | 2001-12-12 | Method for preparing submicron particle suspensions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE319432T1 true ATE319432T1 (de) | 2006-03-15 |
Family
ID=27567644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01998077T ATE319432T1 (de) | 2000-12-22 | 2001-12-20 | Verfahren zur herstellung von submikropartikel- suspensionen pharmazeutischer substanzen |
Country Status (16)
| Country | Link |
|---|---|
| EP (2) | EP1642571A3 (de) |
| JP (1) | JP4376518B2 (de) |
| CN (1) | CN100512798C (de) |
| AT (1) | ATE319432T1 (de) |
| AU (2) | AU2002249836B2 (de) |
| BR (1) | BR0116377A (de) |
| CA (1) | CA2431705C (de) |
| DE (1) | DE60117873T2 (de) |
| DK (1) | DK1347747T3 (de) |
| ES (1) | ES2260337T3 (de) |
| HU (1) | HUP0501030A3 (de) |
| IL (1) | IL156310A0 (de) |
| MX (1) | MXPA03005496A (de) |
| NO (1) | NO20032860L (de) |
| NZ (1) | NZ526608A (de) |
| WO (1) | WO2002055059A2 (de) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030072807A1 (en) * | 2000-12-22 | 2003-04-17 | Wong Joseph Chung-Tak | Solid particulate antifungal compositions for pharmaceutical use |
| US7037528B2 (en) | 2000-12-22 | 2006-05-02 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
| US20050048126A1 (en) | 2000-12-22 | 2005-03-03 | Barrett Rabinow | Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug |
| US6951656B2 (en) | 2000-12-22 | 2005-10-04 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
| US7193084B2 (en) | 2000-12-22 | 2007-03-20 | Baxter International Inc. | Polymorphic form of itraconazole |
| US20040022862A1 (en) * | 2000-12-22 | 2004-02-05 | Kipp James E. | Method for preparing small particles |
| US6884436B2 (en) | 2000-12-22 | 2005-04-26 | Baxter International Inc. | Method for preparing submicron particle suspensions |
| US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
| US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
| US6977085B2 (en) | 2000-12-22 | 2005-12-20 | Baxter International Inc. | Method for preparing submicron suspensions with polymorph control |
| BR0212833A (pt) | 2001-09-26 | 2004-10-13 | Baxter Int | Preparação de nanopartìculas de tamanho submìcron através de dispersão e de remoção de solvente ou de fase lìquida |
| US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
| US7112340B2 (en) | 2001-10-19 | 2006-09-26 | Baxter International Inc. | Compositions of and method for preparing stable particles in a frozen aqueous matrix |
| GB0216700D0 (en) * | 2002-07-18 | 2002-08-28 | Astrazeneca Ab | Process |
| US20040028747A1 (en) * | 2002-08-06 | 2004-02-12 | Tucker Christopher J. | Crystalline drug particles prepared using a controlled precipitation process |
| GB0302673D0 (en) | 2003-02-06 | 2003-03-12 | Astrazeneca Ab | Pharmaceutical formulations |
| US7511079B2 (en) * | 2003-03-24 | 2009-03-31 | Baxter International Inc. | Methods and apparatuses for the comminution and stabilization of small particles |
| EP1617818A1 (de) * | 2003-04-29 | 2006-01-25 | Baxter International Inc. | Formulierung, um ein antimikrobielles arzneimittel gegen organismen wirksam zu machen, die normalerweise als resistent dagegen gelten |
| AU2004249172A1 (en) | 2003-06-24 | 2004-12-29 | Baxter International Inc. | Specific delivery of drugs to the brain |
| US8986736B2 (en) | 2003-06-24 | 2015-03-24 | Baxter International Inc. | Method for delivering particulate drugs to tissues |
| BRPI0412735A (pt) * | 2003-07-18 | 2006-09-26 | Baxter Int | métodos para a fabricação, uso e composição de partìculas esféricas pequenas preparadas mediante a separação de fase controlada |
| US20060151899A1 (en) * | 2003-08-06 | 2006-07-13 | Akira Kato | Process for producing drug ultramicroparticle and apparatus therefor |
| GB0327390D0 (en) * | 2003-11-25 | 2003-12-31 | Pfizer Ltd | Pharmaceutical formulations |
| US9682043B2 (en) * | 2003-12-09 | 2017-06-20 | Medcrystalforms, Llc | Method of preparation of mixed phase co-crystals with active agents |
| US20050202094A1 (en) * | 2004-01-29 | 2005-09-15 | Werling Jane O. | Nanosuspensions of anti-retroviral agents for increased central nervous system delivery |
| PL1731138T3 (pl) * | 2004-03-31 | 2016-10-31 | Drobnoziarnista dyspersja słabo rozpuszczalnego leku i sposób jej wytwarzania | |
| RU2006144851A (ru) | 2004-06-15 | 2008-06-20 | Бакстер Интернэшнл Инк. (Us) | Применение терапевтических средств ex-vivo в виде твердых микрочастиц |
| DE102004031538A1 (de) * | 2004-06-29 | 2006-02-09 | Baxter International Inc., Deerfield | Pharmazeutische Darreichungsform zur oralen Verabreichung eines schwerlöslichen Wirkstoffs, Verfahren zu deren Herstellung und Kit |
| CA2590675A1 (en) * | 2004-12-15 | 2006-06-22 | Elan Pharma International Ltd. | Nanoparticulate tacrolimus formulations |
| MX2007011494A (es) * | 2005-03-17 | 2007-12-06 | Elan Pharma Int Ltd | Composiciones inyectables de compuestos inmunosupresores nanoparticulados. |
| DE102005053862A1 (de) | 2005-11-04 | 2007-05-10 | Pharmasol Gmbh | Verfahren und Vorrichtung zur Herstellung hochfeiner Partikel sowie zur Beschichtung solcher Partikel |
| US20070134341A1 (en) * | 2005-11-15 | 2007-06-14 | Kipp James E | Compositions of lipoxygenase inhibitors |
| RU2496482C2 (ru) | 2008-03-05 | 2013-10-27 | Бакстер Интернэшнл Инк. | Композиции и способы для доставки лекарственных средств |
| DE102009008478A1 (de) * | 2009-02-11 | 2010-08-19 | PHAST Gesellschaft für pharmazeutische Qualitätsstandards mbH | Vorrichtung und Verfahren zur Herstellung pharmazeutisch hochfeiner Partikel sowie zur Beschichtung solcher Partikel in Mikroreaktoren |
| US10952965B2 (en) | 2009-05-15 | 2021-03-23 | Baxter International Inc. | Compositions and methods for drug delivery |
| NZ602674A (en) | 2010-03-22 | 2013-10-25 | Mjr Pharmjet Gmbh | Method and device for producing microparticles or nanoparticles |
| CN102384973B (zh) * | 2011-08-10 | 2014-09-10 | 华南理工大学 | 快速定量检测羟甲基糠醛的免疫层析试纸条及其制备方法 |
| CN102268103B (zh) * | 2011-09-02 | 2013-06-05 | 中国海洋大学 | 一种壳聚糖醋酸盐的制备方法 |
| US9248139B2 (en) * | 2011-12-21 | 2016-02-02 | Bristol-Myers Squibb Company | Co-processing method and formulations for HIV attachment inhibitor prodrug compound and excipients |
| CN103212079A (zh) * | 2013-04-26 | 2013-07-24 | 陆媛 | 一种预防和/或治疗感冒的含服药物组合物及其应用 |
| CN104905262B (zh) * | 2015-05-29 | 2017-12-22 | 湖北省农业科学院农产品加工与核农技术研究所 | 一种制备虫草灵芝复合制剂的方法 |
| KR101725508B1 (ko) * | 2015-07-31 | 2017-04-11 | 국방과학연구소 | 헥사나이트로스틸벤 입자의 제조 방법과 그 장치 |
| CN105969316B (zh) * | 2016-06-03 | 2020-11-10 | 宁海德宝立新材料有限公司 | 一种用于热敷的相变储热复合材料 |
| CA3030308C (en) | 2016-07-29 | 2022-04-05 | The Board Of Trustees Of Western Michigan University | Magnetic nanoparticle-based gyroscopic sensor |
| EP3638212B1 (de) * | 2017-06-15 | 2024-05-01 | Savior Lifetec Corporation | Verfahren zur herstellung von partikeln eines wirkstoffs |
| CN108031142A (zh) * | 2017-12-13 | 2018-05-15 | 上海合全药物研发有限公司 | 一种简化的利用湿磨来制备大量微晶种的装置及方法 |
| CN115349630A (zh) * | 2022-06-20 | 2022-11-18 | 海宁凤鸣叶绿素有限公司 | 水分散性叶黄素微囊粉的制备方法 |
| EP4637720A1 (de) * | 2022-12-22 | 2025-10-29 | Nanomi B.V. | Verfahren zur herstellung stabiler nanopartikel und zusammensetzung davon |
| EP4706636A3 (de) | 2023-01-18 | 2026-04-22 | Nanoform Finland Oyj | Verfahren zur kristallisation von pharmazeutischen wirkstoffen |
| CN116143803B (zh) * | 2023-01-29 | 2024-11-08 | 山东省分析测试中心 | 一种大颗粒头孢哌酮钠球形晶体的制备方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4826689A (en) * | 1984-05-21 | 1989-05-02 | University Of Rochester | Method for making uniformly sized particles from water-insoluble organic compounds |
| CA1282405C (en) * | 1984-05-21 | 1991-04-02 | Michael R. Violante | Method for making uniformly sized particles from water-insoluble organic compounds |
| US4606940A (en) * | 1984-12-21 | 1986-08-19 | The Ohio State University Research Foundation | Small particle formation and encapsulation |
| FR2634397B2 (fr) * | 1986-12-31 | 1991-04-19 | Centre Nat Rech Scient | Procede de preparation de systemes colloidaux dispersibles d'une proteine sous forme de nanoparticules |
| FR2608988B1 (fr) * | 1986-12-31 | 1991-01-11 | Centre Nat Rech Scient | Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules |
| IL86211A (en) * | 1987-05-04 | 1992-03-29 | Ciba Geigy Ag | Oral forms of administration for carbamazepine in the forms of stable aqueous suspension with delayed release and their preparation |
| ES2078447T3 (es) * | 1990-06-15 | 1995-12-16 | Merck & Co Inc | Un procedimiento de cristalizacion para mejorar la estructura y el tamaño de los cristales. |
| US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| GB9413202D0 (en) * | 1994-06-30 | 1994-08-24 | Univ Bradford | Method and apparatus for the formation of particles |
| SE9403846D0 (sv) * | 1994-11-09 | 1994-11-09 | Univ Ohio State Res Found | Small particle formation |
| KR19990001564A (ko) * | 1997-06-16 | 1999-01-15 | 유충식 | 용해도를 개선한 아졸계 항진균제 및 이를 함유하는 제제 |
| FI973804A7 (fi) * | 1997-09-26 | 1999-03-27 | Orion Yhtymae Oy | Levosimendaanin oraalisia koostumuksia |
| PT1039909E (pt) * | 1997-12-31 | 2003-02-28 | Choongwae Pharma Corp | Metodo de producao e composicao de uma preparacao oral de itraconazole |
| KR100635456B1 (ko) * | 1998-05-29 | 2006-10-18 | 스키에파마 캐나다 인코포레이티드 | 열보호화 마이크로입자 조성물 및 그의 말단의 스팀멸균방법 |
| SI1104291T1 (sl) * | 1998-07-17 | 2006-02-28 | Janssen Pharmaceutica Nv | Pelete, ki imajo jedro oblozeno s fungicidom in polimerom |
| ES2251985T3 (es) * | 1999-03-24 | 2006-05-16 | R.P. Scherer Technologies, Inc. | Particula granulada para mejorar la solubilidad acuosa de farmacos, y su procedimiento de preparacion. |
| KR100331529B1 (ko) * | 1999-06-16 | 2002-04-06 | 민경윤 | 난용성 항진균제의 경구투여용 조성물 및 그의 제조 방법 |
-
2001
- 2001-12-20 NZ NZ526608A patent/NZ526608A/en not_active IP Right Cessation
- 2001-12-20 AU AU2002249836A patent/AU2002249836B2/en not_active Ceased
- 2001-12-20 HU HU0501030A patent/HUP0501030A3/hu unknown
- 2001-12-20 EP EP05077486A patent/EP1642571A3/de not_active Withdrawn
- 2001-12-20 BR BR0116377-9A patent/BR0116377A/pt not_active IP Right Cessation
- 2001-12-20 JP JP2002555793A patent/JP4376518B2/ja not_active Expired - Fee Related
- 2001-12-20 IL IL15631001A patent/IL156310A0/xx unknown
- 2001-12-20 MX MXPA03005496A patent/MXPA03005496A/es active IP Right Grant
- 2001-12-20 AT AT01998077T patent/ATE319432T1/de active
- 2001-12-20 CA CA2431705A patent/CA2431705C/en not_active Expired - Fee Related
- 2001-12-20 WO PCT/US2001/049737 patent/WO2002055059A2/en not_active Ceased
- 2001-12-20 CN CNB018211038A patent/CN100512798C/zh not_active Expired - Fee Related
- 2001-12-20 ES ES01998077T patent/ES2260337T3/es not_active Expired - Lifetime
- 2001-12-20 EP EP01998077A patent/EP1347747B1/de not_active Expired - Lifetime
- 2001-12-20 DK DK01998077T patent/DK1347747T3/da active
- 2001-12-20 DE DE60117873T patent/DE60117873T2/de not_active Expired - Lifetime
-
2003
- 2003-06-20 NO NO20032860A patent/NO20032860L/no not_active Application Discontinuation
-
2006
- 2006-05-10 AU AU2006201943A patent/AU2006201943A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2431705A1 (en) | 2002-07-18 |
| NZ526608A (en) | 2006-06-30 |
| CN100512798C (zh) | 2009-07-15 |
| EP1347747B1 (de) | 2006-03-08 |
| JP4376518B2 (ja) | 2009-12-02 |
| DK1347747T3 (da) | 2006-04-10 |
| HUP0501030A2 (en) | 2007-02-28 |
| WO2002055059A3 (en) | 2002-09-06 |
| JP2004538249A (ja) | 2004-12-24 |
| NO20032860D0 (no) | 2003-06-20 |
| DE60117873D1 (de) | 2006-05-04 |
| EP1347747A2 (de) | 2003-10-01 |
| HUP0501030A3 (en) | 2008-04-28 |
| MXPA03005496A (es) | 2004-05-14 |
| WO2002055059A2 (en) | 2002-07-18 |
| NO20032860L (no) | 2003-08-21 |
| CN1505503A (zh) | 2004-06-16 |
| EP1642571A3 (de) | 2007-06-27 |
| EP1642571A2 (de) | 2006-04-05 |
| AU2002249836B2 (en) | 2006-12-14 |
| ES2260337T3 (es) | 2006-11-01 |
| BR0116377A (pt) | 2005-12-13 |
| AU2006201943A1 (en) | 2006-06-01 |
| DE60117873T2 (de) | 2006-08-24 |
| IL156310A0 (en) | 2004-01-04 |
| CA2431705C (en) | 2010-10-05 |
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