BRPI1008557A2 - processo para a preparação de 5-/6-nitrofluoresceína - Google Patents

processo para a preparação de 5-/6-nitrofluoresceína

Info

Publication number: BRPI1008557A2
Authority: BR; Brazil
Prior art keywords: nitrofluorescein; preparation
Prior art date: 2009-02-12

Application number

BRPI1008557A

Other languages

English (en)

Inventor

Stuart Wharton

Tomos Huw Roberts

Original Assignee

Norgine Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-02-12

Filing date

2010-02-10

Publication date

2015-09-15

2010-02-10 Application filed by Norgine Bv filed Critical Norgine Bv

2015-09-15 Publication of BRPI1008557A2 publication Critical patent/BRPI1008557A2/pt

Links

GYWGQAIDMYGOLU-UHFFFAOYSA-N 3',6'-dihydroxy-5-nitrospiro[2-benzofuran-3,9'-xanthene]-1-one Chemical compound O1C(=O)C2=CC=C([N+]([O-])=O)C=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GYWGQAIDMYGOLU-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B57/00—Other synthetic dyes of known constitution
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Immunology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Urology & Nephrology (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Physics & Mathematics (AREA)
Biochemistry (AREA)
Cell Biology (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Biotechnology (AREA)
Analytical Chemistry (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Furan Compounds (AREA)

BRPI1008557A 2009-02-12 2010-02-10 processo para a preparação de 5-/6-nitrofluoresceína BRPI1008557A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB0902286A GB2467901A (en)	2009-02-12	2009-02-12	3',6'-dihydroxy-5(6)-nitrospiro[2-benzofuran-3,9'-xanthene]-1-one mixt. by reacting 4-nitrophthalic acid/anhydride & benzene-1,3-diol in methanesulphonic acid
PCT/GB2010/050206 WO2010092382A1 (en)	2009-02-12	2010-02-10	Process for the preparation of 5-/6-nitrofluorescein

Publications (1)

Publication Number	Publication Date
BRPI1008557A2 true BRPI1008557A2 (pt)	2015-09-15

Family

ID=40527205

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI1008557A BRPI1008557A2 (pt)	2009-02-12	2010-02-10	processo para a preparação de 5-/6-nitrofluoresceína

Country Status (11)

Country	Link
US (1)	US20120220787A1 (pt)
EP (1)	EP2396336B1 (pt)
JP (1)	JP2012517464A (pt)
KR (1)	KR20110126681A (pt)
CN (1)	CN102317292A (pt)
BR (1)	BRPI1008557A2 (pt)
CA (1)	CA2752290A1 (pt)
GB (1)	GB2467901A (pt)
NZ (1)	NZ594253A (pt)
RU (1)	RU2011137488A (pt)
WO (1)	WO2010092382A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20120208824A1 (en)	2006-01-20	2012-08-16	Cell Signaling Technology, Inc.	ROS Kinase in Lung Cancer
CN103087545B (zh) *	2012-12-13	2014-06-25	大连理工大学	一类以荧光素为母体的荧光染料、其制备方法及应用
EP3604292B1 (en) *	2018-08-01	2023-01-18	Delmar Chemicals Inc.	Process for preparing fluorescein quinoid form
RU2725666C1 (ru) *	2019-12-17	2020-07-03	ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ УНИТАРНОЕ ПРЕДПРИЯТИЕ "ИНСТИТУТ ХИМИЧЕСКИХ РЕАКТИВОВ И ОСОБО ЧИСТЫХ ХИМИЧЕСКИХ ВЕЩЕСТВ НАЦИОНАЛЬНОГО ИССЛЕДОВАТЕЛЬСКОГО ЦЕНТРА "КУРЧАТОВСКИЙ ИНСТИТУТ" (НИЦ "Курчатовский институт - ИРЕА)	Способ получения 5-, 6-аминофлуоресцеинов
CN114736213B (zh) *	2022-04-01	2024-02-02	合肥华纳生物医药科技有限公司	一种羧基-四氯-荧光素的制备方法
CN118027054A (zh) *	2023-12-25	2024-05-14	浙江鑫科医疗科技有限公司	一种高纯度5-酰胺荧光素的制备工艺

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SU457710A1 (ru)	1973-01-09	1975-01-25	Березниковский Химический Комбинат	Способ получени флуоресцеина
SU727663A1 (ru)	1978-05-15	1980-04-15	Кировский Политехнический Институт	Способ получени нитрофлуоресцеина
US5637733A (en) *	1995-09-27	1997-06-10	Warner-Jenkinson Company, Inc.	Syntheses of fluorescein compounds with excess resorcinol as a solvent
US6162931A (en) *	1996-04-12	2000-12-19	Molecular Probes, Inc.	Fluorinated xanthene derivatives
AU2001282574A1 (en) *	2000-08-31	2002-03-13	Daiichi Pure Chemicals Co., Ltd.	Reagent for determining singlet oxygen

2009
- 2009-02-12 GB GB0902286A patent/GB2467901A/en not_active Withdrawn
2010
- 2010-02-10 JP JP2011549668A patent/JP2012517464A/ja active Pending
- 2010-02-10 NZ NZ594253A patent/NZ594253A/xx not_active IP Right Cessation
- 2010-02-10 CN CN201080008028XA patent/CN102317292A/zh active Pending
- 2010-02-10 EP EP10703948.9A patent/EP2396336B1/en active Active
- 2010-02-10 WO PCT/GB2010/050206 patent/WO2010092382A1/en not_active Ceased
- 2010-02-10 RU RU2011137488/04A patent/RU2011137488A/ru not_active Application Discontinuation
- 2010-02-10 US US13/201,372 patent/US20120220787A1/en not_active Abandoned
- 2010-02-10 KR KR1020117021237A patent/KR20110126681A/ko not_active Withdrawn
- 2010-02-10 CA CA2752290A patent/CA2752290A1/en not_active Abandoned
- 2010-02-10 BR BRPI1008557A patent/BRPI1008557A2/pt not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO2010092382A1 (en)	2010-08-19
CN102317292A (zh)	2012-01-11
GB2467901A (en)	2010-08-18
CA2752290A1 (en)	2010-08-19
GB0902286D0 (en)	2009-03-25
NZ594253A (en)	2012-12-21
US20120220787A1 (en)	2012-08-30
EP2396336A1 (en)	2011-12-21
JP2012517464A (ja)	2012-08-02
EP2396336B1 (en)	2013-05-15
KR20110126681A (ko)	2011-11-23
RU2011137488A (ru)	2013-03-20

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Legal Events

Date	Code	Title	Description
2015-12-08	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE A 5A ANUIDADE.
2016-04-05	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2344 DE 08-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.