BRPI1009189A2 - método para melhorar o rendimento de um polipetídeo - Google Patents

método para melhorar o rendimento de um polipetídeo

Info

Publication number
BRPI1009189A2
BRPI1009189A2 BRPI1009189A BRPI1009189A BRPI1009189A2 BR PI1009189 A2 BRPI1009189 A2 BR PI1009189A2 BR PI1009189 A BRPI1009189 A BR PI1009189A BR PI1009189 A BRPI1009189 A BR PI1009189A BR PI1009189 A2 BRPI1009189 A2 BR PI1009189A2
Authority
BR
Brazil
Prior art keywords
polypeptide
yield
improving
Prior art date
Application number
BRPI1009189A
Other languages
English (en)
Inventor
Alrik Pieter Los
Herman Jan Pel
Jan Metske Van Der Laan
Johannes Andries Roubos
Liang Wu
Lucie Parenicova
Noel Nicolaas Maria Elisabeth Van Peij
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of BRPI1009189A2 publication Critical patent/BRPI1009189A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
BRPI1009189A 2009-03-10 2010-03-08 método para melhorar o rendimento de um polipetídeo BRPI1009189A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09154783 2009-03-10
PCT/EP2010/052918 WO2010102982A1 (en) 2009-03-10 2010-03-08 Method for improving the yield of a polypeptide

Publications (1)

Publication Number Publication Date
BRPI1009189A2 true BRPI1009189A2 (pt) 2015-09-15

Family

ID=40912127

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1009189A BRPI1009189A2 (pt) 2009-03-10 2010-03-08 método para melhorar o rendimento de um polipetídeo

Country Status (11)

Country Link
US (1) US9181573B2 (pt)
EP (1) EP2406386B1 (pt)
JP (1) JP2012520064A (pt)
CN (1) CN102741421B (pt)
AU (1) AU2010223354A1 (pt)
BR (1) BRPI1009189A2 (pt)
CA (1) CA2754851A1 (pt)
DK (1) DK2406386T3 (pt)
EA (1) EA021205B1 (pt)
MX (1) MX346700B (pt)
WO (1) WO2010102982A1 (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2803222A1 (en) 2010-07-01 2012-01-05 Dsm Ip Assets B.V. A method for the production of a compound of interest
CN103596970A (zh) 2011-03-11 2014-02-19 帝斯曼知识产权资产管理有限公司 载体-宿主系统
MX357482B (es) 2012-07-19 2018-07-11 Dsm Ip Assets Bv Cepa deficiente en agse.
WO2014044782A1 (en) 2012-09-19 2014-03-27 Dsm Ip Assets B.V. Cell modification method using essential genes as markers and optionally recycling these
WO2014202623A2 (en) * 2013-06-19 2014-12-24 Dsm Ip Assets B.V. Rasamsonia gene and use thereof
WO2015082488A1 (en) 2013-12-02 2015-06-11 Dsm Ip Assets B.V. Ice structuring protein
WO2015091455A1 (en) 2013-12-17 2015-06-25 Dpx Holdings B.V. Bioreactor
SG10201801320UA (en) 2014-11-03 2018-04-27 Merck Patent Gmbh Soluble intein fusion proteins and methods for purifying biomolecules
CN108064287A (zh) 2015-01-06 2018-05-22 帝斯曼知识产权资产管理有限公司 用于解脂酵母宿主细胞的crispr-cas系统
US11396665B2 (en) 2015-01-06 2022-07-26 Dsm Ip Assets B.V. CRISPR-CAS system for a filamentous fungal host cell
DK3280264T3 (da) 2015-04-10 2021-03-29 Dsm Ip Assets Bv Fremgangsmåde til fremstilling af en dej
WO2016193292A1 (en) 2015-06-02 2016-12-08 Dsm Ip Assets B.V. Use of ice structuring protein afp19 expressed in filamentous fungal strains for preparing food
JP2019520069A (ja) 2016-07-13 2019-07-18 ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． 藻類宿主細胞用のｃｒｉｓｐｒ−ｃａｓシステム
DK3516056T3 (da) 2016-09-23 2025-02-17 Dsm Ip Assets Bv Et guide-rna-ekspressionssystem til en værtscelle
CN110431224A (zh) 2017-03-13 2019-11-08 帝斯曼知识产权资产管理有限公司 锌双核簇转录调控因子缺陷型菌株
US20200032252A1 (en) 2017-04-06 2020-01-30 Dsm Ip Assets B.V. Self-guiding integration construct (sgic)
EP3728603A2 (en) 2017-12-20 2020-10-28 DSM IP Assets B.V. A method for genome editing in a host cell
WO2019063849A1 (en) 2017-12-20 2019-04-04 Dsm Ip Assets B.V. PURIFICATION OF A POLYPEPTIDE OF INTEREST
EP3790969A1 (en) 2018-05-09 2021-03-17 DSM IP Assets B.V. Crispr transient expression construct (ctec)
US20220056460A1 (en) 2018-12-05 2022-02-24 Dsm Ip Assets B.V. Crispr guide-rna expression strategies for multiplex genome engineering
DK3715464T3 (da) 2019-03-28 2021-07-26 Dsm Ip Assets Bv Drivhusgasforbedret fermentering
US20230212634A1 (en) * 2020-01-14 2023-07-06 The Protein Brewery B.V. Expression of Ovalbumin and its Natural Variants
WO2021228880A1 (en) 2020-05-14 2021-11-18 Dsm Ip Assets B.V. Fed-batch fermentation process
CN112480139B (zh) * 2021-01-05 2022-04-19 遵义医科大学 罗丹明类荧光探针的制备方法及其检测有机自由基方法
US20250311734A1 (en) 2022-05-14 2025-10-09 Novozymes A/S Compositions and Methods for Preventing, Treating, Suppressing and/or Eliminatting Phytopathogenic Infestations and Infections
WO2025099225A1 (en) 2023-11-08 2025-05-15 Dsm Ip Assets B.V. Improved enzyme variants
WO2025099224A1 (en) 2023-11-08 2025-05-15 Dsm Ip Assets B.V. Improved enzyme variants

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0635574B1 (en) 1993-07-23 2003-04-23 Dsm N.V. Selection marker gene free recombinant strains, a method for obtaining them and the use of these strains
US5888773A (en) * 1994-08-17 1999-03-30 The United States Of America As Represented By The Department Of Health And Human Services Method of producing single-chain Fv molecules
ATE219517T1 (de) * 1995-08-18 2002-07-15 Morphosys Ag Protein-/(poly)peptidbibliotheken
US6265186B1 (en) 1997-04-11 2001-07-24 Dsm N.V. Yeast cells comprising at least two copies of a desired gene integrated into the chromosomal genome at more than one non-ribosomal RNA encoding domain, particularly with Kluyveromyces
EP0979294B1 (en) 1997-04-11 2015-05-27 DSM IP Assets B.V. Gene conversion as a tool for the construction of recombinant industrial filamentous fungi
PL341760A1 (en) 1997-12-22 2001-05-07 Dsm Nv Expression cloning in mildew fungi
CN1195058C (zh) 1999-02-22 2005-03-30 诺维信公司 草酰乙酸水解酶缺陷型真菌宿主细胞
US6544765B1 (en) 1999-02-22 2003-04-08 Novozymes, A/S Oxaloacetate hydrolase deficient fungal host cells
WO2001021779A2 (en) 1999-09-17 2001-03-29 Dsm N.V. Penicillium chrysogenum transcriptional activator blar, a pathway specific regulator of beta-lactam biosynthesis, and uses therof
DK1354056T3 (en) * 2000-10-10 2015-02-23 Danisco Us Inc IMPROVED secretion of a polypeptide by a microorganism
RU2225442C2 (ru) * 2001-02-22 2004-03-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Рекомбинантная днк для контроля экспрессии, способ контроля экспрессии целевого гена, способ получения целевого вещества
US6797493B2 (en) * 2001-10-01 2004-09-28 Lee-Hwei K. Sun Fc fusion proteins of human granulocyte colony-stimulating factor with increased biological activities
WO2005095624A2 (en) 2004-04-02 2005-10-13 Dsm Ip Assets B.V. Filamentous fungal mutants with improved homologous recombination efficiency
JP4783359B2 (ja) 2004-04-16 2011-09-28 ディーエスエム アイピー アセッツ ビー．ブイ． 真菌細胞において遺伝子を発現させるための真菌プロモーター
CN101094919B (zh) 2004-10-12 2014-09-03 帝斯曼知识产权资产管理有限公司 在生产多肽的方法中有用的真菌转录活化因子
AU2006207463B2 (en) 2005-01-24 2011-03-17 Dsm Ip Assets B.V. Method for producing a compound of interest in a filamentous fungal cell
ES2534282T3 (es) 2006-06-29 2015-04-21 Dsm Ip Assets B.V. Un método para lograr la expresión polipeptídica mejorada
BRPI0717882A2 (pt) * 2006-10-31 2013-10-29 Immunogem Inc Métodos para aumentar a produção de um anticorpo humanizado, murino humanizado ou anticorpo parental; ou um fragmento, fragmento de ligação a epitopo ou fragmento de ligação a antígeno dos mesmos em uma célula hospedeira pela reengenharia de sequência, anti-corpo e anticorpo variante ou fragmento de ligação a epitopo do mesmo e ácido nucléico isolado
EP2185591B1 (en) * 2007-08-20 2014-05-14 Glaxo Group Limited Production method

Also Published As

Publication number Publication date
MX2011009059A (es) 2011-11-18
MX346700B (es) 2017-03-28
EA201101306A1 (ru) 2012-02-28
CA2754851A1 (en) 2010-09-16
US9181573B2 (en) 2015-11-10
WO2010102982A1 (en) 2010-09-16
EA021205B1 (ru) 2015-04-30
US20110318752A1 (en) 2011-12-29
JP2012520064A (ja) 2012-09-06
AU2010223354A1 (en) 2011-09-08
EP2406386B1 (en) 2019-01-23
DK2406386T3 (en) 2019-04-23
CN102741421B (zh) 2015-03-25
EP2406386A1 (en) 2012-01-18
CN102741421A (zh) 2012-10-17

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B11D Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time