BRPI1009447A2 - métodos de purificação de proteínas imunofarmacêuticas modulares pequenas - Google Patents

métodos de purificação de proteínas imunofarmacêuticas modulares pequenas

Info

Publication number
BRPI1009447A2
BRPI1009447A2 BRPI1009447A BRPI1009447A BRPI1009447A2 BR PI1009447 A2 BRPI1009447 A2 BR PI1009447A2 BR PI1009447 A BRPI1009447 A BR PI1009447A BR PI1009447 A BRPI1009447 A BR PI1009447A BR PI1009447 A2 BRPI1009447 A2 BR PI1009447A2
Authority
BR
Brazil
Prior art keywords
protein purification
purification methods
small modular
modular immunopharmaceutical
immunopharmaceutical protein
Prior art date
Application number
BRPI1009447A
Other languages
English (en)
Inventor
Aaron Noyes
Christopher Gallo
Daniel Lacasse
James Edward Booth
Jason Cormier
Shujun Sun
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of BRPI1009447A2 publication Critical patent/BRPI1009447A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BRPI1009447A 2009-03-11 2010-03-11 métodos de purificação de proteínas imunofarmacêuticas modulares pequenas BRPI1009447A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15934709P 2009-03-11 2009-03-11
PCT/US2010/026931 WO2010147686A2 (en) 2009-03-11 2010-03-11 Methods of purifying small modular immunopharmaceutical proteins

Publications (1)

Publication Number Publication Date
BRPI1009447A2 true BRPI1009447A2 (pt) 2016-03-01

Family

ID=43012630

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1009447A BRPI1009447A2 (pt) 2009-03-11 2010-03-11 métodos de purificação de proteínas imunofarmacêuticas modulares pequenas

Country Status (11)

Country Link
US (1) US20120141497A1 (pt)
EP (1) EP2406274A2 (pt)
JP (1) JP2010209068A (pt)
KR (1) KR20110139216A (pt)
CN (1) CN102395597A (pt)
AU (1) AU2010260476A1 (pt)
BR (1) BRPI1009447A2 (pt)
CA (1) CA2751000A1 (pt)
IL (1) IL215082A0 (pt)
RU (1) RU2011137030A (pt)
WO (1) WO2010147686A2 (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2813398T3 (es) * 2009-10-20 2021-03-23 Abbvie Inc Aislamiento y purificación de anticuerpos anti-IL-13 usando cromatografía de afinidad a Proteína A
KR101753569B1 (ko) * 2010-01-22 2017-07-04 베링거 인겔하임 인터내셔날 게엠베하 Ｆｃ―함유 단백질을 정제하는 크로마토그래피 방법
US20110301333A1 (en) * 2010-06-08 2011-12-08 Millipore Corporation Removal of protein aggregates from biopharmaceutical preparations using calcium phosphate salts
AR082963A1 (es) 2010-09-17 2013-01-23 Sumitomo Chemical Co Composicion para aerosol de control de plagas
SG10201508401TA (en) * 2010-10-11 2015-11-27 Abbvie Bahamas Ltd Processes for purification of proteins
DK2742152T3 (en) * 2011-08-12 2017-07-31 Qiagen Gmbh PROCEDURE FOR ISOLATING NUCLEIC ACIDS
CN102492040B (zh) * 2011-12-29 2014-06-25 嘉和生物药业有限公司 一种抗her2或/和抗her3抗体蛋白的纯化方法
AU2013344375B2 (en) 2012-11-16 2017-09-14 Transposagen Biopharmaceuticals, Inc. Site-specific enzymes and methods of use
CN102993266B (zh) * 2012-11-30 2019-08-23 广州白云山拜迪生物医药有限公司 一种融合蛋白的纯化和复性方法
AU2014240596B2 (en) 2013-03-14 2018-09-27 Amgen Inc. Removal of leaked affinity purification ligand
CA2906808C (en) * 2013-03-15 2023-08-29 Genzyme Corporation Affinity-based analytical purification of biotherapeutcs for bioprocess monitoring
JP2017518082A (ja) * 2014-06-17 2017-07-06 ポセイダ セラピューティクス， インコーポレイテッド ゲノム中の特異的遺伝子座にタンパク質を指向させるための方法およびその使用
EP3180027A4 (en) * 2014-08-15 2018-01-10 Oncomed Pharmaceuticals, Inc. Rspo1 binding agents and uses thereof
CN107001411B (zh) 2014-12-15 2021-07-23 默克专利股份公司 从粗溶液捕获靶分子
CN104693303B (zh) * 2015-02-28 2018-03-13 苏州金盟生物技术有限公司 一种蛋白制品中的核酸去除方法
ES2886599T3 (es) 2015-06-17 2021-12-20 Poseida Therapeutics Inc Composiciones y métodos para dirigir proteínas a loci específicos en el genoma
JP2019108274A (ja) * 2016-04-18 2019-07-04 昭和電工株式会社 タンパク質凝集体の除去方法
WO2018063980A1 (en) * 2016-09-29 2018-04-05 Bio-Rad Laboratories, Inc. Agarose-filled ceramic apatite
WO2019183334A1 (en) 2018-03-21 2019-09-26 Waters Technologies Corporation Non-antibody high-affinity-based sample preparation, sorbents, devices and methods
CN113166200B (zh) * 2018-12-21 2024-03-01 上海药明生物技术有限公司 一种提高蛋白a层析法去除聚集体的方法
US20220314142A1 (en) * 2019-07-01 2022-10-06 Pfizer Inc. Improvements to wash solutions for protein a chromatography in an antibody purification process
AU2020364071A1 (en) 2019-10-10 2022-05-26 Kodiak Sciences Inc. Methods of treating an eye disorder
BR112022013481A2 (pt) * 2020-01-08 2022-09-13 Regeneron Pharma Uso de aminoácidos para aumentar o sinal em análises espectro de massa
CN114901671B (zh) * 2020-01-20 2024-02-20 上海药明生物技术有限公司 用于亲和层析的新的清洗缓冲溶液
CN115135392A (zh) 2020-02-19 2022-09-30 生物辐射实验室股份有限公司 制备聚合物填充的色谱树脂的方法
CA3251000A1 (en) * 2022-02-10 2023-08-17 Kodiak Sciences Inc. METHODS FOR PURIFYING A PRODUCT
CN115894604B (zh) * 2022-12-16 2024-01-23 康日百奥生物科技(苏州)有限公司 重组蛋白澄清纯化方法
CN116120392B (zh) * 2023-04-18 2023-08-01 上海健士拜生物科技有限公司 聚体蛋白的纯化方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030133939A1 (en) 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
CN101684158A (zh) 2001-01-17 2010-03-31 特鲁比昂药品公司 结合域-免疫球蛋白融合蛋白
US7829084B2 (en) 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
US20040058445A1 (en) 2001-04-26 2004-03-25 Ledbetter Jeffrey Alan Activation of tumor-reactive lymphocytes via antibodies or genes recognizing CD3 or 4-1BB
HUE029951T2 (en) 2003-07-28 2017-04-28 Genentech Inc Reduction of Protein A Dissolution in Protein A Affinity Chromatography
RU2409591C2 (ru) * 2003-10-27 2011-01-20 Вайет Удаление агрегатов с высокой молекулярной массой путем хроматографии на гидроксиапатитах
BRPI0614183A2 (pt) 2005-07-25 2011-03-15 Trubion Pharmaceuticals Inc uso de dose única de moléculas de ligação especìficas para cd20
AR062711A1 (es) 2006-09-08 2008-11-26 Wyeth Corp Lavado de arginina en l a purificacion de proteinas usando cromatografia de afinidad
MX2009003542A (es) * 2006-10-12 2009-04-15 Wyeth Corp Metodos y composiciones con opalescencia reducida.
US7846434B2 (en) * 2006-10-24 2010-12-07 Trubion Pharmaceuticals, Inc. Materials and methods for improved immunoglycoproteins
CN101842389A (zh) 2007-06-12 2010-09-22 惠氏有限责任公司 抗cd20治疗组合物和方法
CA2739352C (en) * 2008-10-29 2021-07-13 Wyeth Llc Methods for purification of single domain antigen binding molecules

Also Published As

Publication number Publication date
IL215082A0 (en) 2011-11-30
US20120141497A1 (en) 2012-06-07
EP2406274A2 (en) 2012-01-18
CA2751000A1 (en) 2010-12-23
KR20110139216A (ko) 2011-12-28
CN102395597A (zh) 2012-03-28
JP2010209068A (ja) 2010-09-24
RU2011137030A (ru) 2013-04-20
WO2010147686A3 (en) 2011-02-24
WO2010147686A2 (en) 2010-12-23
AU2010260476A1 (en) 2011-10-13

Similar Documents

Publication Publication Date Title
IL215082A0 (en) Methods of purifying small modular immunopharmaceutical proteins
DK2598514T3 (da) Proteinoprensning
HUE041436T2 (hu) Tal-effektor-közvetített DNS-módosítás
EP2406399A4 (en) MIRAC PROTEINS
BR112013024521A2 (pt) métodos de purificação de proteínas
PT3056224T (pt) Método de esterilização
DK2307543T3 (da) Forbedret proteinekspressionssystem
IL219715A (en) Sewage treatment apparatus
SMT201500142B (it) Procedimento per la purificazione di proteine
BRPI1015220A2 (pt) purificador de água
EP2519536A4 (en) PROTEIN PURIFICATION BY ION EXCHANGE
DK2273004T3 (da) Rensesystem
BR212012009026U2 (pt) escova de dentes
BRPI1009018A2 (pt) fotobiorreator
BRPI0922716A2 (pt) purificação de polipeptídeo
EP2519537A4 (en) CLEANING PROTEINS
FI20105919A0 (fi) Menetelmä veden puhdistamiseksi
BRPI1010121A2 (pt) método de tratamento biológico
BRPI1015272A2 (pt) Fermentação
BRPI1006155A2 (pt) purificador de água
FI20096202A0 (fi) Biologinen regeneraatti
FR2946103B1 (fr) Support modulaire
IL229383A0 (en) A process for purifying protein with a low acidity level
BRPI0920524A2 (pt) método de purificação
DK2424661T3 (da) Zeolit y

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 4A, 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B350 Update of information on the portal [chapter 15.35 patent gazette]