BRPI1009447A2 - métodos de purificação de proteínas imunofarmacêuticas modulares pequenas - Google Patents

métodos de purificação de proteínas imunofarmacêuticas modulares pequenas

Info

Publication number
BRPI1009447A2
BRPI1009447A2 BRPI1009447A BRPI1009447A BRPI1009447A2 BR PI1009447 A2 BRPI1009447 A2 BR PI1009447A2 BR PI1009447 A BRPI1009447 A BR PI1009447A BR PI1009447 A BRPI1009447 A BR PI1009447A BR PI1009447 A2 BRPI1009447 A2 BR PI1009447A2
Authority
BR
Brazil
Prior art keywords
protein purification
purification methods
small modular
modular immunopharmaceutical
immunopharmaceutical protein
Prior art date
Application number
BRPI1009447A
Other languages
English (en)
Inventor
Aaron Noyes
Christopher Gallo
Daniel Lacasse
James Edward Booth
Jason Cormier
Shujun Sun
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of BRPI1009447A2 publication Critical patent/BRPI1009447A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BRPI1009447A 2009-03-11 2010-03-11 métodos de purificação de proteínas imunofarmacêuticas modulares pequenas BRPI1009447A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15934709P 2009-03-11 2009-03-11
PCT/US2010/026931 WO2010147686A2 (en) 2009-03-11 2010-03-11 Methods of purifying small modular immunopharmaceutical proteins

Publications (1)

Publication Number Publication Date
BRPI1009447A2 true BRPI1009447A2 (pt) 2016-03-01

Family

ID=43012630

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1009447A BRPI1009447A2 (pt) 2009-03-11 2010-03-11 métodos de purificação de proteínas imunofarmacêuticas modulares pequenas

Country Status (11)

Country Link
US (1) US20120141497A1 (pt)
EP (1) EP2406274A2 (pt)
JP (1) JP2010209068A (pt)
KR (1) KR20110139216A (pt)
CN (1) CN102395597A (pt)
AU (1) AU2010260476A1 (pt)
BR (1) BRPI1009447A2 (pt)
CA (1) CA2751000A1 (pt)
IL (1) IL215082A0 (pt)
RU (1) RU2011137030A (pt)
WO (1) WO2010147686A2 (pt)

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EP3037104B1 (en) * 2009-10-20 2020-05-27 AbbVie Inc. Isolation and purification of anti-il-13 antibodies using protein a affinity chromatography
CA2784959C (en) * 2010-01-22 2018-06-26 Boehringer Ingelheim International Gmbh Chromatographic method for purifying fc-containing proteins
US20110301333A1 (en) * 2010-06-08 2011-12-08 Millipore Corporation Removal of protein aggregates from biopharmaceutical preparations using calcium phosphate salts
AR082963A1 (es) 2010-09-17 2013-01-23 Sumitomo Chemical Co Composicion para aerosol de control de plagas
JP6023715B2 (ja) * 2010-10-11 2016-11-09 アッヴィ・バハマズ・リミテッド タンパク質の精製方法
EP3789500A1 (en) * 2011-08-12 2021-03-10 QIAGEN GmbH Method for isolating nucleic acids
CN102492040B (zh) * 2011-12-29 2014-06-25 嘉和生物药业有限公司 一种抗her2或/和抗her3抗体蛋白的纯化方法
EP2920319B1 (en) 2012-11-16 2020-02-19 Poseida Therapeutics, Inc. Site-specific enzymes and methods of use
CN102993266B (zh) * 2012-11-30 2019-08-23 广州白云山拜迪生物医药有限公司 一种融合蛋白的纯化和复性方法
PT3395423T (pt) 2013-03-14 2023-11-14 Amgen Inc Remoção de ligandos escapados de cromatografia de afinidade
MX2015013182A (es) * 2013-03-15 2016-04-20 Genzyme Corp Purificacion analitica basada en la afinidad de compuestos bioterapeuticos para el control de bioprocesos.
JP2017518082A (ja) * 2014-06-17 2017-07-06 ポセイダ セラピューティクス， インコーポレイテッド ゲノム中の特異的遺伝子座にタンパク質を指向させるための方法およびその使用
MA40363A (fr) * 2014-08-15 2017-06-21 Oncomed Pharm Inc Agents de liaison de rspo1 et leurs utilisations
US10617975B2 (en) 2014-12-15 2020-04-14 Merck Patent Gmbh Target molecule capture from crude solutions
CN104693303B (zh) * 2015-02-28 2018-03-13 苏州金盟生物技术有限公司 一种蛋白制品中的核酸去除方法
EP3929286A1 (en) 2015-06-17 2021-12-29 Poseida Therapeutics, Inc. Compositions and methods for directing proteins to specific loci in the genome
JP2019108274A (ja) * 2016-04-18 2019-07-04 昭和電工株式会社 タンパク質凝集体の除去方法
US10814305B2 (en) * 2016-09-29 2020-10-27 Bio-Rad Laboratories, Inc. Agarose-filled ceramic apatite
WO2019183334A1 (en) 2018-03-21 2019-09-26 Waters Technologies Corporation Non-antibody high-affinity-based sample preparation, sorbents, devices and methods
WO2020125757A1 (en) * 2018-12-21 2020-06-25 Wuxi Biologics (Shanghai) Co., Ltd. A method for improving aggregate removal by protein a chromatography
US20220314142A1 (en) * 2019-07-01 2022-10-06 Pfizer Inc. Improvements to wash solutions for protein a chromatography in an antibody purification process
US11912784B2 (en) 2019-10-10 2024-02-27 Kodiak Sciences Inc. Methods of treating an eye disorder
AU2021205910A1 (en) * 2020-01-08 2022-09-01 Regeneron Pharmaceuticals, Inc. Use of amino acids to enhance signal in mass spectral analyses
KR20220130692A (ko) * 2020-01-20 2022-09-27 우시 바이올로직스 아일랜드 리미티드 친화성 크로마토그래피를 위한 신규한 세척 완충제 용액
WO2021163910A1 (en) 2020-02-19 2021-08-26 Bio-Rad Laboratories, Inc. Method of preparing polymer-filled chromatography resin
CN119032099A (zh) * 2022-02-10 2024-11-26 科达制药股份有限公司 纯化产品的方法
CN115894604B (zh) * 2022-12-16 2024-01-23 康日百奥生物科技(苏州)有限公司 重组蛋白澄清纯化方法
CN116120392B (zh) * 2023-04-18 2023-08-01 上海健士拜生物科技有限公司 聚体蛋白的纯化方法

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CA2433877C (en) 2001-01-17 2014-11-18 Aptevo Research And Development Llc Binding domain-immunoglobulin fusion proteins
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US20030133939A1 (en) 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
US7829084B2 (en) 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
US20040058445A1 (en) 2001-04-26 2004-03-25 Ledbetter Jeffrey Alan Activation of tumor-reactive lymphocytes via antibodies or genes recognizing CD3 or 4-1BB
PT3095793T (pt) 2003-07-28 2020-05-04 Genentech Inc Redução da lixiviação de proteína a durante a cromatografia por afinidade com proteína a
PT1678208E (pt) * 2003-10-27 2013-07-10 Wyeth Llc Remoção de agregados de elevado peso molecular utilizando cromatografia de hidroxiapatite
CA2616386A1 (en) * 2005-07-25 2007-02-01 Trubion Pharmaceuticals Inc. Single dose use of cd20-specific binding molecules
CL2007002615A1 (es) 2006-09-08 2008-04-18 Wyeth Corp Metodos para aislar o purificar un producto que comprende poner el producto enlazado en contacto con al menos una solucion de lavado que comprende arginina y luego eluir el producto; y dicho producto.
BRPI0719250A2 (pt) * 2006-10-12 2015-06-16 Wyeth Corp Métodos e composições com opalescência reduzida.
US7846434B2 (en) * 2006-10-24 2010-12-07 Trubion Pharmaceuticals, Inc. Materials and methods for improved immunoglycoproteins
EP2164871A2 (en) 2007-06-12 2010-03-24 Wyeth a Corporation of the State of Delaware Anti-cd20 therapeutic compositions and methods
KR20110079693A (ko) * 2008-10-29 2011-07-07 와이어쓰 엘엘씨 단일 도메인 항원 결합 분자의 정제 방법

Also Published As

Publication number Publication date
AU2010260476A1 (en) 2011-10-13
JP2010209068A (ja) 2010-09-24
US20120141497A1 (en) 2012-06-07
WO2010147686A2 (en) 2010-12-23
KR20110139216A (ko) 2011-12-28
CA2751000A1 (en) 2010-12-23
EP2406274A2 (en) 2012-01-18
RU2011137030A (ru) 2013-04-20
CN102395597A (zh) 2012-03-28
IL215082A0 (en) 2011-11-30
WO2010147686A3 (en) 2011-02-24

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B350 Update of information on the portal [chapter 15.35 patent gazette]