BRPI1010833A2 - derivados de tieno[2,3-b]piridina como inibidores de replicação viral, uso dos mesmos na fabricação de medicamentos e como ferramentas químicas em virologia ou bioquímica, método para preparação dos ditos compostos e composição farmacêutica - Google Patents

derivados de tieno[2,3-b]piridina como inibidores de replicação viral, uso dos mesmos na fabricação de medicamentos e como ferramentas químicas em virologia ou bioquímica, método para preparação dos ditos compostos e composição farmacêutica

Info

Publication number
BRPI1010833A2
BRPI1010833A2 BRPI1010833A BRPI1010833A BRPI1010833A2 BR PI1010833 A2 BRPI1010833 A2 BR PI1010833A2 BR PI1010833 A BRPI1010833 A BR PI1010833A BR PI1010833 A BRPI1010833 A BR PI1010833A BR PI1010833 A2 BRPI1010833 A2 BR PI1010833A2
Authority
BR
Brazil
Prior art keywords
thieno
virology
medicaments
biochemistry
preparing
Prior art date
Application number
BRPI1010833A
Other languages
English (en)
Inventor
Arnaud Marchand
Arnout Voet
Damien Marchand
Dorothée Bardiot
Frauke Christ
Marc De Maeyer
Patrick Chaltin
Zeger Debyser
Original Assignee
Univ Leuven Kath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40834066&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI1010833(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Leuven Kath filed Critical Univ Leuven Kath
Publication of BRPI1010833A2 publication Critical patent/BRPI1010833A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Biochemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BRPI1010833A 2009-05-15 2010-05-17 derivados de tieno[2,3-b]piridina como inibidores de replicação viral, uso dos mesmos na fabricação de medicamentos e como ferramentas químicas em virologia ou bioquímica, método para preparação dos ditos compostos e composição farmacêutica BRPI1010833A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0908394.0A GB0908394D0 (en) 2009-05-15 2009-05-15 Novel viral replication inhibitors
US34380310P 2010-05-03 2010-05-03
PCT/EP2010/056754 WO2010130842A1 (en) 2009-05-15 2010-05-17 Thieno [2, 3-b] pyridine derivatives as viral replication inhibitors

Publications (1)

Publication Number Publication Date
BRPI1010833A2 true BRPI1010833A2 (pt) 2016-04-05

Family

ID=40834066

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1010833A BRPI1010833A2 (pt) 2009-05-15 2010-05-17 derivados de tieno[2,3-b]piridina como inibidores de replicação viral, uso dos mesmos na fabricação de medicamentos e como ferramentas químicas em virologia ou bioquímica, método para preparação dos ditos compostos e composição farmacêutica

Country Status (29)

Country Link
US (2) US8785638B2 (pt)
EP (1) EP2430029B1 (pt)
JP (2) JP2012526778A (pt)
KR (2) KR20120035162A (pt)
CN (2) CN105367583A (pt)
AP (1) AP2939A (pt)
BR (1) BRPI1010833A2 (pt)
CA (1) CA2759500A1 (pt)
CL (1) CL2011002878A1 (pt)
CO (1) CO6460769A2 (pt)
CR (1) CR20110601A (pt)
CU (1) CU24117B1 (pt)
DO (1) DOP2011000343A (pt)
EA (1) EA201171376A1 (pt)
EC (1) ECSP11011456A (pt)
GB (1) GB0908394D0 (pt)
GE (1) GEP20146115B (pt)
IL (1) IL216357A0 (pt)
MA (1) MA33274B1 (pt)
MX (1) MX2011012146A (pt)
MY (1) MY161085A (pt)
NI (1) NI201100194A (pt)
NZ (1) NZ596392A (pt)
PE (1) PE20120779A1 (pt)
SG (1) SG175255A1 (pt)
TN (1) TN2012000074A1 (pt)
UA (1) UA104021C2 (pt)
WO (1) WO2010130842A1 (pt)
ZA (1) ZA201107618B (pt)

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AU2016290151A1 (en) 2015-07-08 2018-01-18 VIIV Healthcare UK (No.5) Limited Pyridin-3-YL acetic acid derivatives as inhibitors of human immunodeficiency virus replication
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EP3331868A1 (en) 2015-08-07 2018-06-13 VIIV Healthcare UK (No.5) Limited Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
EP3334741A1 (en) 2015-08-10 2018-06-20 VIIV Healthcare UK (No.5) Limited Imidazopyridine macrocycles as inhibitors of human immunodeficiency virus replication
TWI657086B (zh) 2015-08-11 2019-04-21 英商Viiv醫療保健英國(No.5)有限公司 做為人類免疫缺陷病毒複製抑制劑之５－（ｎ－苯甲基四氫異喹啉－６－基）吡啶－３－基乙酸衍生物
TW201718537A (zh) 2015-08-12 2017-06-01 Ｖｉｉｖ醫療保健英國（Ｎｏ．５）有限公司 做為人類免疫缺陷病毒複製抑制劑之吡啶－３－基乙酸衍生物
KR20180032650A (ko) 2015-08-12 2018-03-30 비브 헬스케어 유케이 (넘버5) 리미티드 인간 면역결핍 바이러스 복제의 억제제로서 5-(n-[6,5]-융합된 바이사이클릭 아릴 테트라하이드로이소퀴놀린-6-일) 피리딘-3-일 아세트산 유도체
CA2995087A1 (en) 2015-08-12 2017-02-16 John F. Kadow 5-(n-fused tricyclic aryl tetrahydroisoquinolin-6-yl) pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
KR20180038047A (ko) 2015-08-20 2018-04-13 비브 헬스케어 유케이 (넘버5) 리미티드 인간 면역결핍 바이러스 복제의 억제제로서 피리딘-3-일 아세트산 유도체
JP2018536001A (ja) 2015-12-04 2018-12-06 ヴィーブ ヘルスケア ユーケー リミテッド イソインドリン誘導体
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EP3455215A1 (en) 2016-05-11 2019-03-20 ViiV Healthcare UK (No.5) Limited Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
EP3455217A1 (en) 2016-05-11 2019-03-20 ViiV Healthcare UK (No.5) Limited Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
WO2018127801A1 (en) 2017-01-03 2018-07-12 VIIV Healthcare UK (No.5) Limited Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
TW201835068A (zh) 2017-01-03 2018-10-01 英商Viiv醫療保健英國(No.5)有限公司 作為人類免疫缺乏病毒複製之抑制劑之吡啶-3-基乙酸衍生物
WO2019244066A2 (en) 2018-06-19 2019-12-26 VIIV Healthcare UK (No.5) Limited Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
WO2020003093A1 (en) 2018-06-25 2020-01-02 VIIV Healthcare UK (No.5) Limited Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
CN113286792B (zh) * 2018-12-14 2023-12-05 豪夫迈·罗氏有限公司 用于治疗和预防乙型肝炎病毒感染的含n色烯-4-酮衍生物
US20240317774A1 (en) * 2021-06-15 2024-09-26 Glaxosmithkline Intellectual Property Development Limited Pharmaceutical Compound
CN113603655B (zh) * 2021-07-14 2022-12-16 上海应用技术大学 一种4-羟基-2-甲基-3-(苯磺酰基)噻唑烷-2-羧酸甲酯化合物的制备方法
CN113461632B (zh) * 2021-07-15 2022-12-16 上海应用技术大学 3-((4-氟苯基)磺酰基)-4-羟基-2-甲基噻唑烷-2-羧酸甲酯的制备方法
CN119699325B (zh) * 2024-12-17 2025-12-16 宁夏农林科学院植物保护研究所（宁夏植物病虫害防治重点实验室） 一种西花蓟马引诱组合物及应用

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