BRPI1011190A8 - Derivados de indazol e aza-indazol substituídos como moduladores de gama secretase - Google Patents

Derivados de indazol e aza-indazol substituídos como moduladores de gama secretase

Info

Publication number
BRPI1011190A8
BRPI1011190A8 BRPI1011190A BRPI1011190A BRPI1011190A8 BR PI1011190 A8 BRPI1011190 A8 BR PI1011190A8 BR PI1011190 A BRPI1011190 A BR PI1011190A BR PI1011190 A BRPI1011190 A BR PI1011190A BR PI1011190 A8 BRPI1011190 A8 BR PI1011190A8
Authority
BR
Brazil
Prior art keywords
indazole
aza
gamma secretase
secretase modulators
substituted
Prior art date
Application number
BRPI1011190A
Other languages
English (en)
Inventor
Maria Aloysius Pieters Serge
Berlond Minne Garret
Paul Bischoff François
Jacobus Maria Gijsen Henricus
Original Assignee
Janssen Pharmaceuticals Inc
Cellzome Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceuticals Inc, Cellzome Ltd filed Critical Janssen Pharmaceuticals Inc
Publication of BRPI1011190A2 publication Critical patent/BRPI1011190A2/pt
Publication of BRPI1011190A8 publication Critical patent/BRPI1011190A8/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

DERIVADOS DE INDAZOL E AZA-INDAZOL SUBSTITUÍDOS COMO MODULADORES DE GAMA SECRETASE A presente invenção refere-se aos novos derivados de indazol e aza-indazol substituídos da Fórmula (I), em que R1, R2 , R3 , R4, Y, A1, A2 , A3 , A4, x1, X2 , X3 e Het1 têm o significado definido nas reivindicações. Os compostos de acordo com a presente invenção são úteis como moduladores de gama secretase. A invenção ainda diz respeito aos processos para preparar tais novos compostos, composições farmacêuticas compreendendo os ditos compostos como um ingrediente ativo como também o uso dos ditos compostos como um medicamento.
BRPI1011190A 2009-05-07 2010-05-05 Derivados de indazol e aza-indazol substituídos como moduladores de gama secretase BRPI1011190A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09159615 2009-05-07
PCT/EP2010/056074 WO2010145883A1 (en) 2009-05-07 2010-05-05 Novel substituted indazole and aza-indazole derivatives as gamma secretase modulators

Publications (2)

Publication Number Publication Date
BRPI1011190A2 BRPI1011190A2 (pt) 2016-03-15
BRPI1011190A8 true BRPI1011190A8 (pt) 2016-11-16

Family

ID=40786448

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1011190A BRPI1011190A8 (pt) 2009-05-07 2010-05-05 Derivados de indazol e aza-indazol substituídos como moduladores de gama secretase

Country Status (20)

Country Link
US (1) US8835482B2 (pt)
EP (1) EP2427453B1 (pt)
JP (1) JP5559309B2 (pt)
KR (1) KR20120024555A (pt)
CN (1) CN102439005B (pt)
AR (1) AR076850A1 (pt)
AU (1) AU2010262036B2 (pt)
BR (1) BRPI1011190A8 (pt)
CA (1) CA2755467A1 (pt)
EA (1) EA019702B1 (pt)
ES (1) ES2431619T3 (pt)
IL (1) IL216113A (pt)
MX (1) MX2011011753A (pt)
MY (1) MY152998A (pt)
NZ (1) NZ596843A (pt)
SG (1) SG175317A1 (pt)
TW (1) TWI461419B (pt)
UA (1) UA105377C2 (pt)
WO (1) WO2010145883A1 (pt)
ZA (1) ZA201108117B (pt)

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PA8854101A1 (es) 2008-12-18 2010-07-27 Ortho Mcneil Janssen Pharm Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa
CN102325765B (zh) 2009-02-06 2014-12-24 杨森制药公司 作为γ-分泌酶调节剂的取代的双环杂环化合物
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AU2011206635B2 (en) 2010-01-15 2015-01-22 Cellzome Limited Novel substituted triazole derivatives as gamma secretase modulators
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CN104583208B (zh) 2012-05-16 2016-09-28 杨森制药公司 可用于治疗(尤其是)阿尔茨海默病的取代的3,4-二氢-2H-吡啶并[1,2-a]吡嗪-1,6-二酮衍生物
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AU2014206834B2 (en) 2013-01-17 2017-06-22 Janssen Pharmaceutica Nv Novel substituted pyrido-piperazinone derivatives as gamma secretase modulators
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US10562897B2 (en) 2014-01-16 2020-02-18 Janssen Pharmaceutica Nv Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators
CN103880683B (zh) * 2014-02-26 2018-06-22 南通大学 一种3-溴-2-硝基苯甲醛的化学合成方法
JP6831372B2 (ja) * 2015-09-09 2021-02-17 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 架橋ピペリジン誘導体
CN105585547A (zh) * 2016-03-09 2016-05-18 中国科学院广州生物医药与健康研究院 一种4-五氟化硫苯酚类化合物及制备方法以及五氟化硫取代苯并吡喃类化合物的制备方法
CN114195702A (zh) * 2020-09-18 2022-03-18 瑞博(杭州)医药科技有限公司 一种用于合成抗肿瘤药物尼拉帕利的中间体及其制备方法
CN121405704A (zh) * 2024-07-25 2026-01-27 浙江养生堂天然药物研究所有限公司 氮杂芳基类化合物及其用途

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Also Published As

Publication number Publication date
IL216113A (en) 2015-02-26
EP2427453A1 (en) 2012-03-14
ZA201108117B (en) 2015-06-24
TW201105658A (en) 2011-02-16
KR20120024555A (ko) 2012-03-14
CA2755467A1 (en) 2010-12-23
US20120095036A1 (en) 2012-04-19
NZ596843A (en) 2012-12-21
MY152998A (en) 2014-12-31
CN102439005B (zh) 2015-07-22
JP2012526078A (ja) 2012-10-25
AR076850A1 (es) 2011-07-13
MX2011011753A (es) 2011-11-29
EA201171363A1 (ru) 2012-04-30
BRPI1011190A2 (pt) 2016-03-15
CN102439005A (zh) 2012-05-02
AU2010262036B2 (en) 2014-10-30
EA019702B1 (ru) 2014-05-30
ES2431619T3 (es) 2013-11-27
JP5559309B2 (ja) 2014-07-23
SG175317A1 (en) 2011-11-28
UA105377C2 (uk) 2014-05-12
EP2427453B1 (en) 2013-07-17
TWI461419B (zh) 2014-11-21
US8835482B2 (en) 2014-09-16
AU2010262036A1 (en) 2011-09-22
WO2010145883A1 (en) 2010-12-23
IL216113A0 (en) 2012-01-31

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