BRPI1011206A2 - administração contínua de ligantes de integrina para tratar câncer - Google Patents
administração contínua de ligantes de integrina para tratar câncerInfo
- Publication number
- BRPI1011206A2 BRPI1011206A2 BRPI1011206A BRPI1011206A BRPI1011206A2 BR PI1011206 A2 BRPI1011206 A2 BR PI1011206A2 BR PI1011206 A BRPI1011206 A BR PI1011206A BR PI1011206 A BRPI1011206 A BR PI1011206A BR PI1011206 A2 BRPI1011206 A2 BR PI1011206A2
- Authority
- BR
- Brazil
- Prior art keywords
- treat cancer
- continuous administration
- integrin ligands
- integrin
- ligands
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09006941 | 2009-05-25 | ||
| PCT/EP2010/003162 WO2010136168A2 (en) | 2009-05-25 | 2010-05-25 | Continuous administration of integrin ligands for treating cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1011206A2 true BRPI1011206A2 (pt) | 2016-03-15 |
Family
ID=43223150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1011206A BRPI1011206A2 (pt) | 2009-05-25 | 2010-05-25 | administração contínua de ligantes de integrina para tratar câncer |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20120130146A1 (pt) |
| EP (1) | EP2445534A2 (pt) |
| JP (1) | JP2012528079A (pt) |
| KR (1) | KR20120104491A (pt) |
| CN (1) | CN102448497A (pt) |
| AU (1) | AU2010252280A1 (pt) |
| BR (1) | BRPI1011206A2 (pt) |
| CA (1) | CA2763275A1 (pt) |
| CL (1) | CL2011002962A1 (pt) |
| EA (1) | EA201101651A1 (pt) |
| EC (1) | ECSP11011552A (pt) |
| IL (1) | IL216537A0 (pt) |
| MX (1) | MX2011012491A (pt) |
| NZ (1) | NZ597339A (pt) |
| SG (1) | SG176103A1 (pt) |
| WO (1) | WO2010136168A2 (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9220771B2 (en) * | 2010-07-16 | 2015-12-29 | Merck Patent Gmbh | Peptide for use in the treatment of breast cancer and/or bone metastases |
| WO2013009701A2 (en) | 2011-07-08 | 2013-01-17 | The University Of North Carolina At Chapel Hill | Metal bisphosphonate nanoparticles for anti-cancer therapy and imaging and for treating bone disorders |
| EP2780363B1 (en) | 2011-11-17 | 2019-07-03 | Glia SP Z.O.O. | Compositions and methods for treating glioma |
| KR101470700B1 (ko) * | 2011-11-25 | 2014-12-12 | 서울대학교산학협력단 | 표적 항암제의 내성 극복 방법 |
| HRP20211709T8 (hr) * | 2014-04-04 | 2022-03-04 | Taiho Pharmaceutical Co., Ltd. | Antitumorski lijek koji sadrži antitumorski kompleks platine, i pojačivač antitumorskog efekta |
| US10806694B2 (en) | 2014-10-14 | 2020-10-20 | The University Of Chicago | Nanoparticles for photodynamic therapy, X-ray induced photodynamic therapy, radiotherapy, radiodynamic therapy, chemotherapy, immunotherapy, and any combination thereof |
| WO2016061256A1 (en) | 2014-10-14 | 2016-04-21 | The University Of Chicago | Nanoparticles for photodynamic therapy, x-ray induced photodynamic therapy, radiotherapy, chemotherapy, immunotherapy, and any combination thereof |
| US11246877B2 (en) | 2016-05-20 | 2022-02-15 | The University Of Chicago | Nanoparticles for chemotherapy, targeted therapy, photodynamic therapy, immunotherapy, and any combination thereof |
| CN110831665B (zh) * | 2017-06-29 | 2022-03-04 | 医视特有限公司 | 用于破坏靶组织以进行治疗以及评估靶组织破坏的系统 |
| WO2019028250A1 (en) | 2017-08-02 | 2019-02-07 | The University Of Chicago | NOMOGENEOUS ORGANOMETALLIC ORGANOMETRIC ORGANOMETRIC LAYERS FOR X-RAY INDUCED PHOTODYNAMIC THERAPY, RADIOTHERAPY, RODIODYNAMIC THERAPY, CHEMOTHERAPY, IMMUNOTHERAPY, AND ANY COMBINATION THEREOF |
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| US4342566A (en) | 1980-02-22 | 1982-08-03 | Scripps Clinic & Research Foundation | Solid phase anti-C3 assay for detection of immune complexes |
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| US5260291A (en) | 1981-08-24 | 1993-11-09 | Cancer Research Campaign Technology Limited | Tetrazine derivatives |
| US4792525A (en) | 1982-08-04 | 1988-12-20 | La Jolla Cancer Research Foundation | Tetrapeptide |
| US4614517A (en) | 1982-08-04 | 1986-09-30 | La Jolla Cancer Research Foundation | Tetrapeptide |
| US4517686A (en) | 1982-08-04 | 1985-05-21 | La Jolla Cancer Research Foundation | Polypeptide |
| US4578079A (en) | 1982-08-04 | 1986-03-25 | La Jolla Cancer Research Foundation | Tetrapeptide |
| US4589881A (en) | 1982-08-04 | 1986-05-20 | La Jolla Cancer Research Foundation | Polypeptide |
| US4661111A (en) | 1982-08-04 | 1987-04-28 | La Jolla Cancer Research Foundation | Polypeptide |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
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| FI941572A7 (fi) | 1991-10-07 | 1994-05-27 | Oncologix Inc | Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenete lmä |
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| JPH10504807A (ja) | 1994-06-29 | 1998-05-12 | スミスクライン・ビーチャム・コーポレイション | ビトロネクチン受容体拮抗剤 |
| BR9508178A (pt) | 1994-06-29 | 1997-11-18 | Smithkline Beecham Corp | Antagonistas de receptor de vitronectina |
| IT1271688B (it) | 1994-08-04 | 1997-06-04 | Menarini Ricerche Sud Spa | Molecole ibride per il trattamento antitumorale loro preparazione e loro uso in composizioni farmaceutiche |
| WO1996006087A1 (en) | 1994-08-22 | 1996-02-29 | Smithkline Beecham Corporation | Bicyclic compounds |
| WO1996026190A1 (en) | 1995-02-22 | 1996-08-29 | Smithkline Beecham Corporation | Integrin receptor antagonists |
| US5780426A (en) | 1995-06-07 | 1998-07-14 | Ixsys, Incorporated | Fivemer cyclic peptide inhibitors of diseases involving αv β3 |
| PT910563E (pt) | 1995-06-29 | 2003-09-30 | Smithkline Beecham Corp | Antagonistas de receptores de integrina |
| DE19534177A1 (de) | 1995-09-15 | 1997-03-20 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren |
| EP0895475A4 (en) | 1995-12-29 | 2000-08-23 | Smithkline Beecham Corp | VITRONECTIN RECEPTOR ANTAGONISTS |
| WO1997024124A1 (en) | 1995-12-29 | 1997-07-10 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
| JP2000502354A (ja) | 1995-12-29 | 2000-02-29 | スミスクライン・ビーチャム・コーポレイション | ビトロネクチン受容体アンタゴニスト |
| AU728852B2 (en) | 1996-03-20 | 2001-01-18 | Genentech Inc. | Tricyclic compounds having an activity vis-a-vis integrins in particular vis-a-vis alphavbeta3 integrins, their preparation process and inttermediates of this process, their use as medicaments and the pharmaceutical compositions containing them |
| US5925655A (en) | 1996-04-10 | 1999-07-20 | Merck & Co., Inc. | αv β3 antagonists |
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| WO1997041844A1 (en) | 1996-05-09 | 1997-11-13 | Alcon Laboratories, Inc. | Combinations of angiostatic compounds |
| KR20000016301A (ko) | 1996-05-31 | 2000-03-25 | 빙검 더글라스 에이. | 혈관 형성 억제에 유용한 방법 및 조성물 |
| US5786146A (en) | 1996-06-03 | 1998-07-28 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
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| US5981546A (en) | 1996-08-29 | 1999-11-09 | Merck & Co., Inc. | Integrin antagonists |
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| US5919792A (en) | 1996-10-30 | 1999-07-06 | Merck & Co., Inc. | Integrin antagonists |
| DE69720771T2 (de) | 1996-10-30 | 2004-01-29 | Merck & Co Inc | Integrin antagonist |
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| DE19653647A1 (de) | 1996-12-20 | 1998-06-25 | Hoechst Ag | Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung |
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| DE19653646A1 (de) | 1996-12-20 | 1998-06-25 | Hoechst Ag | Substituierte Purinderivate, Verfahren zu deren Herstellung, sie enthaltende Mittel und deren Verwendung |
| CO4920232A1 (es) | 1997-01-08 | 2000-05-29 | Smithkline Beecham Corp | Acidos aceticos dibenzo [a,d] cicloheptano con actividad antagonista del receptor de vitronectin |
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| CA2304117A1 (en) | 1997-09-04 | 1999-03-11 | Dirk A. Heerding | Integrin receptor antagonists |
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| AU9577498A (en) | 1997-09-24 | 1999-04-12 | Smithkline Beecham Corporation | Vitronectin receptor antagonist |
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| FR2768734B1 (fr) | 1997-09-24 | 2000-01-28 | Roussel Uclaf | Nouveaux composes tricycliques, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
| JP2002500162A (ja) | 1997-09-24 | 2002-01-08 | スミスクライン・ビーチャム・コーポレイション | ビトロネクチン受容体アンタゴニスト |
| CA2315189C (en) | 1997-12-17 | 2005-04-19 | Merck & Co., Inc. | Integrin receptor antagonists |
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| ID24955A (id) | 1997-12-17 | 2000-08-31 | Merck & Co Inc | Antagonis-antagonis reseptor integrin |
| US6048861A (en) | 1997-12-17 | 2000-04-11 | Merck & Co., Inc. | Integrin receptor antagonists |
| AU738452B2 (en) | 1997-12-17 | 2001-09-20 | Merck & Co., Inc. | Integrin receptor antagonists |
| JP2002508323A (ja) | 1997-12-17 | 2002-03-19 | メルク エンド カムパニー インコーポレーテッド | インテグリン受容体拮抗薬 |
| CA2319160A1 (en) | 1998-01-23 | 1999-07-29 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Monoclonal antibody anti .alpha.v-integrin and its use to inhibit .alpha.v.beta.6-integrin attachment to fibronectin |
| JP2002521450A (ja) | 1998-07-29 | 2002-07-16 | メルク エンド カムパニー インコーポレーテッド | インテグリン受容体アンタゴニスト |
| EP1105389A4 (en) | 1998-08-13 | 2001-10-17 | Merck & Co Inc | INTEGRIN RECEPTOR ANTAGONISTS |
| DE19842415A1 (de) | 1998-09-16 | 2000-03-23 | Merck Patent Gmbh | Pharmazeutische Zubereitung |
| CZ20012321A3 (cs) | 1998-12-23 | 2002-10-16 | G. D. Searle & Co. | Léčivo s obsahem inhibitoru cyklooxygenázy-2 a inhibitoru matricové metaloproteinázy pro kombinační terapii při léčení neoplasie |
| DK1187592T3 (da) | 1999-06-02 | 2007-11-05 | Merck & Co Inc | Alfa v-integrinreceptorantagonister |
| US6773897B2 (en) | 2000-09-29 | 2004-08-10 | The Johns Hopkins University School Of Medicine | Method of predicting the clinical response to chemotherapeutic treatment with alkylating agents |
| CN101370522A (zh) * | 2006-01-18 | 2009-02-18 | 默克专利有限公司 | 使用整联蛋白配体治疗癌症的特别疗法 |
| US20100069302A1 (en) * | 2007-07-18 | 2010-03-18 | Stefan Krueger | Specific therapy and medicament using integrin ligands for treating cancer |
-
2010
- 2010-05-25 CN CN2010800227000A patent/CN102448497A/zh active Pending
- 2010-05-25 EA EA201101651A patent/EA201101651A1/xx unknown
- 2010-05-25 NZ NZ597339A patent/NZ597339A/xx not_active IP Right Cessation
- 2010-05-25 SG SG2011084381A patent/SG176103A1/en unknown
- 2010-05-25 AU AU2010252280A patent/AU2010252280A1/en not_active Abandoned
- 2010-05-25 JP JP2012511202A patent/JP2012528079A/ja active Pending
- 2010-05-25 CA CA2763275A patent/CA2763275A1/en not_active Abandoned
- 2010-05-25 US US13/322,391 patent/US20120130146A1/en not_active Abandoned
- 2010-05-25 BR BRPI1011206A patent/BRPI1011206A2/pt not_active Application Discontinuation
- 2010-05-25 EP EP20100721342 patent/EP2445534A2/en not_active Withdrawn
- 2010-05-25 MX MX2011012491A patent/MX2011012491A/es not_active Application Discontinuation
- 2010-05-25 KR KR1020117030945A patent/KR20120104491A/ko not_active Withdrawn
- 2010-05-25 WO PCT/EP2010/003162 patent/WO2010136168A2/en not_active Ceased
-
2011
- 2011-11-22 IL IL216537A patent/IL216537A0/en unknown
- 2011-11-24 CL CL2011002962A patent/CL2011002962A1/es unknown
- 2011-12-23 EC EC2011011552A patent/ECSP11011552A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010252280A1 (en) | 2012-01-19 |
| CL2011002962A1 (es) | 2012-06-01 |
| KR20120104491A (ko) | 2012-09-21 |
| SG176103A1 (en) | 2011-12-29 |
| IL216537A0 (en) | 2012-02-29 |
| CN102448497A (zh) | 2012-05-09 |
| ECSP11011552A (es) | 2012-01-31 |
| EA201101651A1 (ru) | 2012-08-30 |
| WO2010136168A2 (en) | 2010-12-02 |
| US20120130146A1 (en) | 2012-05-24 |
| CA2763275A1 (en) | 2010-12-02 |
| EP2445534A2 (en) | 2012-05-02 |
| JP2012528079A (ja) | 2012-11-12 |
| MX2011012491A (es) | 2011-12-14 |
| WO2010136168A8 (en) | 2011-09-22 |
| WO2010136168A3 (en) | 2011-07-07 |
| NZ597339A (en) | 2013-10-25 |
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