BRPI1011445B8 - Adenovírus oncolíticos para o tratamento de câncer - Google Patents

Adenovírus oncolíticos para o tratamento de câncer

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Publication number
BRPI1011445B8
BRPI1011445B8 BRPI1011445A BRPI1011445A BRPI1011445B8 BR PI1011445 B8 BRPI1011445 B8 BR PI1011445B8 BR PI1011445 A BRPI1011445 A BR PI1011445A BR PI1011445 A BRPI1011445 A BR PI1011445A BR PI1011445 B8 BRPI1011445 B8 BR PI1011445B8
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BR
Brazil
Prior art keywords
oncolytic adenovirus
adenovirus
oncolytic
cancer treatment
cancer
Prior art date
Application number
BRPI1011445A
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English (en)
Inventor
GUEDAN CARRIó Sònia
Maria Cascallo Piqueras Manel
Alemany Bonastre Ramon
Original Assignee
Fundacio Inst Dinvestigacio Biomedica De Bellvitge
Fundacio Privada Inst Dinvestigacio Biomedica De Bellvitge
Inst Catala Doncologia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43050014&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI1011445(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Fundacio Inst Dinvestigacio Biomedica De Bellvitge, Fundacio Privada Inst Dinvestigacio Biomedica De Bellvitge, Inst Catala Doncologia filed Critical Fundacio Inst Dinvestigacio Biomedica De Bellvitge
Publication of BRPI1011445A2 publication Critical patent/BRPI1011445A2/pt
Publication of BRPI1011445B1 publication Critical patent/BRPI1011445B1/pt
Publication of BRPI1011445B8 publication Critical patent/BRPI1011445B8/pt

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/761—Adenovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2474—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
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    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10371—Demonstrated in vivo effect

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  • Health & Medical Sciences (AREA)
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  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

ADENOVÍRUS ONCOLÍTICOS PARA O TRATAMENTO DE CÂNCER A invenção se relaciona a um adenovírus oncolítico que compreende uma sequência que codifica uma enzima hialuronidase inserida no seu genoma. Este adenovírus distribui-se de forma mais eficiente pela massa do tumor e, consequentemente, o efeito oncolítico é aumentado. A injeção endovenosa do adenovírus oncolítico da invenção gera regressões no volume do tumor. Portanto, o adenovírus oncolítico da presente invenção é de utilidade para o tratamento de um câncer ou de um estado pré-maligno do mesmo.
BRPI1011445A 2009-05-06 2010-05-05 Adenovírus oncolíticos para o tratamento de câncer BRPI1011445B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ESP200901201 2009-05-06
ES200901201A ES2385251B1 (es) 2009-05-06 2009-05-06 Adenovirus oncolíticos para el tratamiento del cáncer.
PCT/ES2010/000196 WO2010128182A1 (es) 2009-05-06 2010-05-05 Adenovirus oncolíticos para el tratamiento del cáncer

Publications (3)

Publication Number Publication Date
BRPI1011445A2 BRPI1011445A2 (pt) 2020-09-15
BRPI1011445B1 BRPI1011445B1 (pt) 2022-10-04
BRPI1011445B8 true BRPI1011445B8 (pt) 2022-10-25

Family

ID=43050014

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1011445A BRPI1011445B8 (pt) 2009-05-06 2010-05-05 Adenovírus oncolíticos para o tratamento de câncer

Country Status (15)

Country Link
US (3) US10316065B2 (pt)
EP (1) EP2428229B2 (pt)
JP (1) JP2012525833A (pt)
KR (1) KR101878274B1 (pt)
CN (2) CN102548584A (pt)
AU (1) AU2010244348B2 (pt)
BR (1) BRPI1011445B8 (pt)
CA (1) CA2761183C (pt)
ES (2) ES2385251B1 (pt)
FI (1) FI2428229T4 (pt)
HK (1) HK1244679A1 (pt)
MX (1) MX2011011818A (pt)
PL (1) PL2428229T5 (pt)
RU (1) RU2536931C2 (pt)
WO (1) WO2010128182A1 (pt)

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ES2385251B1 (es) 2013-05-06
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AU2010244348B2 (en) 2016-08-11
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US12129280B2 (en) 2024-10-29
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