BRPI1011994B8 - derivados de naftaleno carboxamida como inibidores de proteína quinase e histona desacetilase, métodos de preparação e usos - Google Patents

derivados de naftaleno carboxamida como inibidores de proteína quinase e histona desacetilase, métodos de preparação e usos

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Publication number
BRPI1011994B8
BRPI1011994B8 BRPI1011994A BRPI1011994A BRPI1011994B8 BR PI1011994 B8 BRPI1011994 B8 BR PI1011994B8 BR PI1011994 A BRPI1011994 A BR PI1011994A BR PI1011994 A BRPI1011994 A BR PI1011994A BR PI1011994 B8 BRPI1011994 B8 BR PI1011994B8
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Brazil
Prior art keywords
protein kinase
diseases
histone deacetylase
carboxamide derivatives
naphthalene carboxamide
Prior art date
Application number
BRPI1011994A
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English (en)
Inventor
Yu Jindi
Shan Song
Lu Xianping
Ning Zhiqiang
Li Zhibin
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Shenzhen Chipscreen Biosciences Ltd
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Application filed by Shenzhen Chipscreen Biosciences Ltd filed Critical Shenzhen Chipscreen Biosciences Ltd
Publication of BRPI1011994A2 publication Critical patent/BRPI1011994A2/pt
Publication of BRPI1011994B1 publication Critical patent/BRPI1011994B1/pt
Publication of BRPI1011994B8 publication Critical patent/BRPI1011994B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P11/06—Antiasthmatics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C07D215/28—Alcohols; Ethers thereof with halogen atoms or nitro radicals in positions 5, 6 or 7
    • C—CHEMISTRY; METALLURGY
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Diabetes (AREA)
  • Cardiology (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
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  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

derivados de naftaleno carboxamida como inibidores de proteína quinase e histona desacetilase, métodos de preparação e usos. são fornecidos derivados de naftaleno carboxamida, métodos de preparação e usos dos mesmos. a estrutura dos mesmos é mostrada como a fórmula (l), quando as definições de r1, r2, r3, d4 e z são as mesmas descritas na descrição. os compostos têm atividades de inibição de proteína quinase e atividades de inibição de histona desacetilase simultaneamente, e podem ser usados para para tratar doenças associadas com atividade de proteína quinase anormal ou atividade de historia desacetilase anormal, incluindo inflamação, doenças autoimunes, câncer, doenças do sistema nervoso e doenças neurodegenerativas, doenças carduovasculares e doenças metabólicas, asma alérgica e doenças relacionadas a hormônios.
BRPI1011994A 2009-06-04 2010-03-05 derivados de naftaleno carboxamida como inibidores de proteína quinase e histona desacetilase, métodos de preparação e usos BRPI1011994B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN200910143978 2009-06-04
PCT/CN2010/000272 WO2010139180A1 (zh) 2009-06-04 2010-03-05 作为蛋白激酶抑制剂和组蛋白去乙酰化酶抑制剂的萘酰胺衍生物、其制备方法及应用

Publications (3)

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BRPI1011994A2 BRPI1011994A2 (pt) 2016-05-10
BRPI1011994B1 BRPI1011994B1 (pt) 2020-04-07
BRPI1011994B8 true BRPI1011994B8 (pt) 2021-05-25

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Country Status (18)

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EP (1) EP2439195B1 (pt)
JP (1) JP5484568B2 (pt)
KR (2) KR101421786B1 (pt)
CN (1) CN101906076B (pt)
AU (1) AU2010256246B9 (pt)
BR (1) BRPI1011994B8 (pt)
CA (1) CA2763822C (pt)
DK (1) DK2439195T3 (pt)
ES (1) ES2509615T3 (pt)
HR (1) HRP20140717T1 (pt)
MX (1) MX2011012752A (pt)
PL (1) PL2439195T3 (pt)
PT (1) PT2439195E (pt)
RU (1) RU2497809C2 (pt)
SI (1) SI2439195T1 (pt)
UA (1) UA103092C2 (pt)
WO (1) WO2010139180A1 (pt)
ZA (1) ZA201109030B (pt)

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CN109803645B (zh) * 2017-04-10 2022-03-25 师健友 一种用于治疗肿瘤疾病以及具有抗菌、抗病毒和抗炎作用的药物
CN109985039A (zh) * 2017-12-29 2019-07-09 深圳微芯生物科技股份有限公司 用于治疗白血病的联合用药物及其在制备用于治疗急性髓性白血病的药物中的用途
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PT2439195E (pt) 2014-09-10
PL2439195T3 (pl) 2015-02-27
WO2010139180A1 (zh) 2010-12-09
AU2010256246A1 (en) 2012-01-12
CA2763822C (en) 2014-12-09
DK2439195T3 (da) 2014-09-22
JP5484568B2 (ja) 2014-05-07
HRP20140717T1 (hr) 2014-11-21
UA103092C2 (ru) 2013-09-10
CN101906076B (zh) 2013-03-13
CA2763822A1 (en) 2010-12-09
EP2439195B1 (en) 2014-07-16
RU2497809C2 (ru) 2013-11-10
ZA201109030B (en) 2013-02-27
KR20140014313A (ko) 2014-02-05
AU2010256246B2 (en) 2013-04-11
ES2509615T3 (es) 2014-10-17
SI2439195T1 (sl) 2014-12-31
MX2011012752A (es) 2012-03-07
AU2010256246B9 (en) 2014-01-30
BRPI1011994A2 (pt) 2016-05-10
EP2439195A1 (en) 2012-04-11
JP2012528800A (ja) 2012-11-15
KR20120016659A (ko) 2012-02-24
EP2439195A4 (en) 2012-10-31
WO2010139180A8 (zh) 2012-01-05
CN101906076A (zh) 2010-12-08
BRPI1011994B1 (pt) 2020-04-07
KR101421786B1 (ko) 2014-07-22

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