BRPI1012246A2 - composição farmacêutica contendo um fármaco e sirna - Google Patents

composição farmacêutica contendo um fármaco e sirna

Info

Publication number
BRPI1012246A2
BRPI1012246A2 BRPI1012246A BRPI1012246A BRPI1012246A2 BR PI1012246 A2 BRPI1012246 A2 BR PI1012246A2 BR PI1012246 A BRPI1012246 A BR PI1012246A BR PI1012246 A BRPI1012246 A BR PI1012246A BR PI1012246 A2 BRPI1012246 A2 BR PI1012246A2
Authority
BR
Brazil
Prior art keywords
sirna
drug
pharmaceutical composition
composition containing
pharmaceutical
Prior art date
Application number
BRPI1012246A
Other languages
English (en)
Inventor
Giancarlo Francese
Michael Keller
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI1012246A2 publication Critical patent/BRPI1012246A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI1012246A 2009-03-25 2010-03-24 composição farmacêutica contendo um fármaco e sirna BRPI1012246A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09156232 2009-03-25
PCT/EP2010/053802 WO2010108934A1 (en) 2009-03-25 2010-03-24 Pharmaceutical composition containing a drug and sirna

Publications (1)

Publication Number Publication Date
BRPI1012246A2 true BRPI1012246A2 (pt) 2016-03-29

Family

ID=41100625

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1012246A BRPI1012246A2 (pt) 2009-03-25 2010-03-24 composição farmacêutica contendo um fármaco e sirna

Country Status (11)

Country Link
US (1) US20120015026A1 (pt)
EP (1) EP2410988A1 (pt)
JP (1) JP2012521389A (pt)
KR (1) KR20120013336A (pt)
CN (1) CN102361631A (pt)
AU (1) AU2010227549B2 (pt)
BR (1) BRPI1012246A2 (pt)
CA (1) CA2756499A1 (pt)
MX (1) MX2011010045A (pt)
RU (1) RU2011142620A (pt)
WO (1) WO2010108934A1 (pt)

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DE202009009305U1 (de) 2009-06-17 2009-11-05 Ormazabal Gmbh Schalteinrichtung für Mittel-, Hoch- oder Höchstspannung mit einem Füllmedium
WO2011108955A1 (en) * 2010-03-03 2011-09-09 Universidade De Coimbra Multi -targeting system comprising a nanocarrier, nucleic acid(s) and non-nucleic acid based drug(s)
WO2011162818A2 (en) * 2010-06-23 2011-12-29 Controlled Nanovolumes, Inc. Lecithin carrier vesicles and methods of making the same
RU2621900C2 (ru) 2010-12-14 2017-06-08 Абб Текнолоджи Аг Диэлектрическая изолирующая среда
RU2649133C2 (ru) * 2011-07-06 2018-03-29 Новартис Аг Катионные эмульсии масло-в-воде
KR101494594B1 (ko) 2011-08-30 2015-02-23 주식회사 종근당 약리학적 활성물질의 서방성 지질 초기제제 및 이를 포함하는 약제학적 조성물
WO2013087700A1 (en) 2011-12-13 2013-06-20 Abb Technology Ag Sealed and gas insulated high voltage converter environment for offshore platforms
CN103536920A (zh) * 2012-07-10 2014-01-29 复旦大学 一种抑制胰腺癌细胞增殖的药物组合物及其应用
KR101586790B1 (ko) 2012-12-28 2016-01-19 주식회사 종근당 음이온성 약리학적 활성물질의 서방성 지질 초기제제 및 이를 포함하는 약제학적 조성물
KR101601035B1 (ko) 2013-02-28 2016-03-08 주식회사 종근당 키토산 및 액상결정 형성 물질을 포함하는 유전자 전달용 조성물
EP2968149B1 (en) 2013-03-14 2024-05-08 Dicerna Pharmaceuticals, Inc. Process for formulating an anionic agent
WO2015009544A1 (en) * 2013-07-11 2015-01-22 Texas Heart Institute Rna interference of fabp4 for the treatment of atherosclerosis
CN103599549A (zh) * 2013-11-22 2014-02-26 大连民族学院 一种siRNA/抗癌药物联合转运复合载体及其制备方法和应用
CN104258416B (zh) * 2014-09-25 2018-05-25 山东大学 基于寡聚核苷酸共递送药物和基因的纳米载体及制备方法
JP2018507227A (ja) 2015-03-03 2018-03-15 キュアポート インコーポレイテッド 二薬搭載リポソーム医薬製剤
EP3265059A4 (en) 2015-03-03 2018-08-29 Cureport Inc. Combination liposomal pharmaceutical formulations
CN107746857B (zh) * 2017-08-07 2021-02-05 中国农业大学 一种抑制基因表达的rna干扰方法
CN109419773B (zh) * 2017-08-23 2022-06-17 上海交通大学医学院附属仁济医院 复合纳米脂质给药系统及其对妇科肿瘤的治疗作用
CN113166783B (zh) 2018-10-09 2024-10-11 不列颠哥伦比亚大学 包含无有机溶剂和去污剂的转染活性囊泡的组合物和系统以及与之相关的方法
CN112870373B (zh) * 2021-04-02 2022-12-30 四川大学 用于mRNA递送的多肽聚合物复合纳米颗粒及其制备方法和用途
CN113908288B (zh) * 2021-09-29 2023-10-13 深圳市人民医院 一种mRNA递送系统及其制备方法和应用
JPWO2023229023A1 (pt) * 2022-05-25 2023-11-30
WO2024049164A1 (ko) * 2022-08-30 2024-03-07 한양대학교 산학협력단 세포막 유래 핵산 전달용 나노소낭 및 이의 제조 방법

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AU705644B2 (en) * 1995-08-01 1999-05-27 Novartis Ag Liposomal oligonucleotide compositions
US6302838B1 (en) * 1998-02-25 2001-10-16 Novartis Ag Cancer treatment with epothilones
JP2003504322A (ja) * 1999-07-07 2003-02-04 カナダ国 リポソームにより被包された抗酸化剤の送達およびその適用
GB9918429D0 (en) * 1999-08-04 1999-10-06 Novartis Ag Organic compounds
JP4975964B2 (ja) * 2002-06-26 2012-07-11 メディゲーネ アクチエンゲゼルシャフト 脂肪親和性化合物から成る陽イオン性リポソームの製法
WO2004017944A1 (en) * 2002-08-23 2004-03-04 Neopharm, Inc. Liposomal gemcitabine compositions for better drug delivery
ATE411006T1 (de) * 2004-06-03 2008-10-15 Bracco Research Sa Liposomale anordnung für die therapeutische und/oder diagnostische anwendung
EP1811962A2 (en) * 2004-10-29 2007-08-01 Neopharm, Inc. Manufacturing process for liposomal preparations
WO2006113679A2 (en) * 2005-04-15 2006-10-26 Board Of Regents, The University Of Texas System Delivery of sirna by neutral lipid compositions
EP2094238A2 (en) * 2006-10-13 2009-09-02 Novosom AG Improvements in or relating to amphoteric liposomes
TW200819137A (en) * 2006-10-31 2008-05-01 Iner Aec Executive Yuan Method for preparation of lipid-spacer radical- reactions of functional group-peptide
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WO2008105178A1 (ja) * 2007-02-28 2008-09-04 National University Corporation Hokkaido University リポソーム用生体成分抵抗性増強剤及びこれにより修飾されたリポソーム
US8067390B2 (en) * 2007-03-02 2011-11-29 The Board Of Regents Of The University Of Texas System Therapeutic targeting of interleukins using siRNA in neutral liposomes
WO2008109105A2 (en) 2007-03-06 2008-09-12 Flagship Ventures Methods and compositions for improved therapeutic effects with sirna
EP3494964B1 (en) * 2007-05-14 2021-04-07 Konica Minolta Holdings, Inc. Liposome and method for producing liposome
CA2710983A1 (en) * 2007-12-27 2009-10-01 The Ohio State University Research Foundation Lipid nanoparticle compositions and methods of making and using the same
JP5697988B2 (ja) * 2007-12-27 2015-04-08 プロチバ バイオセラピューティクス インコーポレイティッド 干渉ｒｎａを使用したポロ様キナーゼ発現のサイレンシング方法
US20100129430A1 (en) * 2008-11-24 2010-05-27 Stavroula Sofou Liposome drug carriers with ph-sensitivity

Also Published As

Publication number Publication date
AU2010227549B2 (en) 2014-02-27
MX2011010045A (es) 2011-10-11
RU2011142620A (ru) 2013-04-27
CA2756499A1 (en) 2010-09-30
WO2010108934A1 (en) 2010-09-30
AU2010227549A1 (en) 2011-09-22
JP2012521389A (ja) 2012-09-13
CN102361631A (zh) 2012-02-22
KR20120013336A (ko) 2012-02-14
EP2410988A1 (en) 2012-02-01
US20120015026A1 (en) 2012-01-19

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.