BRPI1012246A2 - composição farmacêutica contendo um fármaco e sirna - Google Patents

composição farmacêutica contendo um fármaco e sirna

Info

Publication number
BRPI1012246A2
BRPI1012246A2 BRPI1012246A BRPI1012246A BRPI1012246A2 BR PI1012246 A2 BRPI1012246 A2 BR PI1012246A2 BR PI1012246 A BRPI1012246 A BR PI1012246A BR PI1012246 A BRPI1012246 A BR PI1012246A BR PI1012246 A2 BRPI1012246 A2 BR PI1012246A2
Authority
BR
Brazil
Prior art keywords
sirna
drug
pharmaceutical composition
composition containing
pharmaceutical
Prior art date
Application number
BRPI1012246A
Other languages
English (en)
Inventor
Giancarlo Francese
Michael Keller
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI1012246A2 publication Critical patent/BRPI1012246A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI1012246A 2009-03-25 2010-03-24 composição farmacêutica contendo um fármaco e sirna BRPI1012246A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09156232 2009-03-25
PCT/EP2010/053802 WO2010108934A1 (en) 2009-03-25 2010-03-24 Pharmaceutical composition containing a drug and sirna

Publications (1)

Publication Number Publication Date
BRPI1012246A2 true BRPI1012246A2 (pt) 2016-03-29

Family

ID=41100625

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1012246A BRPI1012246A2 (pt) 2009-03-25 2010-03-24 composição farmacêutica contendo um fármaco e sirna

Country Status (11)

Country Link
US (1) US20120015026A1 (pt)
EP (1) EP2410988A1 (pt)
JP (1) JP2012521389A (pt)
KR (1) KR20120013336A (pt)
CN (1) CN102361631A (pt)
AU (1) AU2010227549B2 (pt)
BR (1) BRPI1012246A2 (pt)
CA (1) CA2756499A1 (pt)
MX (1) MX2011010045A (pt)
RU (1) RU2011142620A (pt)
WO (1) WO2010108934A1 (pt)

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DE112009002045T5 (de) 2009-06-12 2011-07-28 Abb Technology Ag Dielektrisches Isolationsmedium
DE202009009305U1 (de) 2009-06-17 2009-11-05 Ormazabal Gmbh Schalteinrichtung für Mittel-, Hoch- oder Höchstspannung mit einem Füllmedium
WO2011108955A1 (en) * 2010-03-03 2011-09-09 Universidade De Coimbra Multi -targeting system comprising a nanocarrier, nucleic acid(s) and non-nucleic acid based drug(s)
EP2585046A4 (en) * 2010-06-23 2013-11-06 Brightside Innovations Inc LECITHINTRÄGERVESIKEL AND METHOD FOR THE PRODUCTION THEREOF
DK2652752T3 (en) 2010-12-14 2016-01-11 Abb Technology Ag Dielectric INSULATION MEDIUM
MX350258B (es) * 2011-07-06 2017-08-31 Novartis Ag Emulsiones cationicas de aceite en agua.
KR101494594B1 (ko) 2011-08-30 2015-02-23 주식회사 종근당 약리학적 활성물질의 서방성 지질 초기제제 및 이를 포함하는 약제학적 조성물
CN103988382B (zh) 2011-12-13 2018-02-16 Abb 技术有限公司 转换器建筑物及运行或提供转换器建筑物的方法
CN103536920A (zh) * 2012-07-10 2014-01-29 复旦大学 一种抑制胰腺癌细胞增殖的药物组合物及其应用
KR101586790B1 (ko) 2012-12-28 2016-01-19 주식회사 종근당 음이온성 약리학적 활성물질의 서방성 지질 초기제제 및 이를 포함하는 약제학적 조성물
KR101601035B1 (ko) 2013-02-28 2016-03-08 주식회사 종근당 키토산 및 액상결정 형성 물질을 포함하는 유전자 전달용 조성물
CN105142614A (zh) * 2013-03-14 2015-12-09 迪克纳制药公司 用于配制阴离子试剂的方法
WO2015009544A1 (en) * 2013-07-11 2015-01-22 Texas Heart Institute Rna interference of fabp4 for the treatment of atherosclerosis
CN103599549A (zh) * 2013-11-22 2014-02-26 大连民族学院 一种siRNA/抗癌药物联合转运复合载体及其制备方法和应用
CN104258416B (zh) * 2014-09-25 2018-05-25 山东大学 基于寡聚核苷酸共递送药物和基因的纳米载体及制备方法
EP3265063A4 (en) 2015-03-03 2018-11-07 Cureport, Inc. Dual loaded liposomal pharmaceutical formulations
US9895313B2 (en) 2015-03-03 2018-02-20 Cureport, Inc. Combination liposomal pharmaceutical formulations
CN107746857B (zh) * 2017-08-07 2021-02-05 中国农业大学 一种抑制基因表达的rna干扰方法
CN109419773B (zh) * 2017-08-23 2022-06-17 上海交通大学医学院附属仁济医院 复合纳米脂质给药系统及其对妇科肿瘤的治疗作用
HRP20240586T1 (hr) 2018-10-09 2024-07-19 The University Of British Columbia Sastavi i sustavi koji sadrže transfekcijske sposobne vezikle bez organskih otapala i deterdženta i s njim povezanim postupcima
CN112870373B (zh) * 2021-04-02 2022-12-30 四川大学 用于mRNA递送的多肽聚合物复合纳米颗粒及其制备方法和用途
CN113908288B (zh) * 2021-09-29 2023-10-13 深圳市人民医院 一种mRNA递送系统及其制备方法和应用
WO2023229023A1 (ja) * 2022-05-25 2023-11-30 学校法人 名城大学 粉末剤及びその製造方法
WO2024049164A1 (ko) * 2022-08-30 2024-03-07 한양대학교 산학협력단 세포막 유래 핵산 전달용 나노소낭 및 이의 제조 방법

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DE4402867C1 (de) * 1994-01-31 1995-06-14 Rentschler Arzneimittel Liposomen enthaltend darin verkapselte Proteine, Verfahren zu ihrer Herstellung sowie diese Liposomen enthaltende pharmazeutische und kosmetische Zubereitungen
CA2227989A1 (en) * 1995-08-01 1997-02-13 Karen Ophelia Hamilton Liposomal oligonucleotide compositions
US6302838B1 (en) * 1998-02-25 2001-10-16 Novartis Ag Cancer treatment with epothilones
AU6142700A (en) * 1999-07-07 2001-01-30 Her Majesty The Queen As Represented By The Minister Of National Defence Of Her Majesty's Canadian Government Delivery of liposomal-encapsulated antioxidants and applications thereof
GB9918429D0 (en) * 1999-08-04 1999-10-06 Novartis Ag Organic compounds
EP1530465B2 (en) * 2002-06-26 2015-12-16 MediGene AG Method of producing a cationic liposomal preparation comprising a lipophilic compound
AU2003268087A1 (en) * 2002-08-23 2004-03-11 Ian Ma Liposomal gemcitabine compositions for better drug delivery
DE602005010424D1 (de) * 2004-06-03 2008-11-27 Bracco Research Sa Liposomale anordnung für die therapeutische und/oder diagnostische anwendung
MX2007005234A (es) * 2004-10-29 2008-03-10 Neopharm Inc Proceso de fabricacion para preparaciones liposomales.
CA2605068A1 (en) * 2005-04-15 2006-10-26 The Board Of Regents Of The University Of Texas System Delivery of sirna by neutral lipid compositions
CA2665783C (en) * 2006-10-13 2015-12-15 Novosom Ag Improvements in or relating to amphoteric liposomes, a method of formulating an amphoteric liposome and a method of loading an amphoteric liposome
TW200819137A (en) * 2006-10-31 2008-05-01 Iner Aec Executive Yuan Method for preparation of lipid-spacer radical- reactions of functional group-peptide
AU2007337897A1 (en) * 2006-12-22 2008-07-03 Imuthes Limited Lipids and their use as non-viral delivery vehicle
US20100104623A1 (en) * 2007-02-28 2010-04-29 National University Corporation Hokkaido University Kyoto University And Shionogi & Co Ltd Agent for enhancing the resistance of liposome against biological component, and liposome modified with the agent
WO2008109432A2 (en) 2007-03-02 2008-09-12 The Board Of Regents Of The University Of Texas System Therapeutic targeting of interleukins using sirna in neutral liposomes
US20080311040A1 (en) * 2007-03-06 2008-12-18 Flagship Ventures METHODS AND COMPOSITIONS FOR IMPROVED THERAPEUTIC EFFECTS WITH siRNA
EP3494964B1 (en) * 2007-05-14 2021-04-07 Konica Minolta Holdings, Inc. Liposome and method for producing liposome
CA2710983A1 (en) * 2007-12-27 2009-10-01 The Ohio State University Research Foundation Lipid nanoparticle compositions and methods of making and using the same
ES2535419T3 (es) * 2007-12-27 2015-05-11 Protiva Biotherapeutics Inc. Silenciamiento de expresión de quinasa tipo polo usando ARN interferente
US20100129430A1 (en) * 2008-11-24 2010-05-27 Stavroula Sofou Liposome drug carriers with ph-sensitivity

Also Published As

Publication number Publication date
CA2756499A1 (en) 2010-09-30
KR20120013336A (ko) 2012-02-14
MX2011010045A (es) 2011-10-11
WO2010108934A1 (en) 2010-09-30
RU2011142620A (ru) 2013-04-27
JP2012521389A (ja) 2012-09-13
CN102361631A (zh) 2012-02-22
US20120015026A1 (en) 2012-01-19
EP2410988A1 (en) 2012-02-01
AU2010227549B2 (en) 2014-02-27
AU2010227549A1 (en) 2011-09-22

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.