BRPI1013177A2 - construto de ligação de antígeno, polipeptídeo isolado, e, método para tratar doença cardíaca - Google Patents

construto de ligação de antígeno, polipeptídeo isolado, e, método para tratar doença cardíaca

Info

Publication number: BRPI1013177A2
Authority: BR; Brazil
Prior art keywords: antigen binding; heart disease; isolated polypeptide; binding construct; treating heart
Prior art date: 2009-05-28

Application number

BRPI1013177A

Other languages

English (en)

Inventor

Carolyn Enever

Edward Coulstock

Elena De Angelis

Jay Edelberg

Lahra Jawad-Alami

Stevie Holmes

Thil Dinuk Batuwangala

Victoria Ballard

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-05-28

Filing date

2010-05-26

Publication date

2016-04-12

2010-05-26 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2016-04-12 Publication of BRPI1013177A2 publication Critical patent/BRPI1013177A2/pt

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1858—Platelet-derived growth factor [PDGF]
- A61K38/1866—Vascular endothelial growth factor [VEGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/195—Chemokines, e.g. RANTES
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Vascular Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Cell Biology (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

BRPI1013177A 2009-05-28 2010-05-26 construto de ligação de antígeno, polipeptídeo isolado, e, método para tratar doença cardíaca BRPI1013177A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US18181409P	2009-05-28	2009-05-28
PCT/EP2010/057283 WO2010136508A2 (en)	2009-05-28	2010-05-26	Stem cell targeting

Publications (1)

Publication Number	Publication Date
BRPI1013177A2 true BRPI1013177A2 (pt)	2016-04-12

Family

ID=42752167

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI1013177A BRPI1013177A2 (pt)	2009-05-28	2010-05-26	construto de ligação de antígeno, polipeptídeo isolado, e, método para tratar doença cardíaca

Country Status (7)

Country	Link
US (1)	US20120253017A1 (pt)
EP (1)	EP2435067A2 (pt)
JP (1)	JP2012528117A (pt)
CN (1)	CN102481340A (pt)
BR (1)	BRPI1013177A2 (pt)
CA (1)	CA2763446A1 (pt)
WO (1)	WO2010136508A2 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP3763740A1 (en)	2011-01-26	2021-01-13	Celldex Therapeutics, Inc.	Anti-kit antibodies and uses thereof
EP2843051B1 (en) *	2012-04-23	2018-06-06	GeneFrontier Corporation	Anti-human cd69 antibody, and use thereof for medical purposes
CN104812775B (zh)	2012-07-25	2019-05-03	塞尔德克斯医疗公司	抗kit抗体及其用途
CN105378078B (zh) *	2013-02-04	2019-03-01	罗杰威廉姆斯医疗中心	用于治疗胃肠道间质瘤(gist)的方法和组合物
EP3145543A4 (en)	2014-05-23	2017-12-13	Celldex Therapeutics, Inc.	Treatment of eosinophil or mast cell related disorders
ES2715413T3 (es) *	2014-07-29	2019-06-04	Cellectis	Receptores de antígeno quiméricos específicos para ROR1 (NTRKR1) para inmunoterapia contra el cáncer
KR20170066546A (ko) *	2014-10-03	2017-06-14	노파르티스 아게	조합 요법
CN105567719A (zh) *	2016-01-06	2016-05-11	北京嘉万生物技术有限公司	cTnⅠ主要表位区的重组表达及其抗体的制备方法
CN107326065B (zh) *	2016-04-29	2022-07-29	博尔诚（北京）科技有限公司	一种基因标识物的筛选方法及其应用
MX2018015684A (es) *	2016-06-17	2019-08-29	Magenta Therapeutics Inc	Composiciones y metodos para el agotamiento de celulas cd117.
SG11201907422RA (en)	2017-02-17	2019-09-27	Denali Therapeutics Inc	Anti-tau antibodies and methods of use thereof
WO2018175319A1 (en) *	2017-03-20	2018-09-27	Allergan, Inc.	Heavy chain only antibodies to vegf
AU2019265019B2 (en)	2018-05-11	2025-11-06	Beam Therapeutics Inc.	Methods of substituting pathogenic amino acids using programmable base editor systems
KR102716514B1 (ko) *	2018-10-10	2024-10-15	주식회사 노벨티노빌리티	신규 항-c-KIT 항체
AU2019386976B2 (en)	2018-11-26	2024-05-30	Forty Seven, LLC	Humanized antibodies against c-Kit
JP2025527411A (ja) *	2022-08-15	2025-08-22	ジャスパー・セラピューティクス・インコーポレイテッド	キメラｃ－ｋｉｔタンパク質を発現するトランスジェニック動物
EP4669669A1 (en) *	2023-02-21	2025-12-31	Teneobio, Inc.	C-KIT BINDING PROTEINS, CHIMERIC ANTIGENIC RECEPTORS AND THEIR USES

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2003241313A1 (en) *	2002-04-23	2003-11-10	Roger Williams Hospital	Compositions and methods for stem cell delivery
US20050003403A1 (en) *	2003-04-22	2005-01-06	Rossi Edmund A.	Polyvalent protein complex
EP2222709B1 (en) *	2007-11-30	2016-11-23	Glaxo Group Limited	Antigen-binding constructs

2010
- 2010-05-26 US US13/322,030 patent/US20120253017A1/en not_active Abandoned
- 2010-05-26 EP EP10726023A patent/EP2435067A2/en not_active Withdrawn
- 2010-05-26 CA CA2763446A patent/CA2763446A1/en not_active Abandoned
- 2010-05-26 CN CN2010800250083A patent/CN102481340A/zh active Pending
- 2010-05-26 WO PCT/EP2010/057283 patent/WO2010136508A2/en not_active Ceased
- 2010-05-26 BR BRPI1013177A patent/BRPI1013177A2/pt not_active IP Right Cessation
- 2010-05-26 JP JP2012512368A patent/JP2012528117A/ja active Pending

Also Published As

Publication number	Publication date
EP2435067A2 (en)	2012-04-04
US20120253017A1 (en)	2012-10-04
JP2012528117A (ja)	2012-11-12
WO2010136508A3 (en)	2011-02-24
WO2010136508A2 (en)	2010-12-02
CN102481340A (zh)	2012-05-30
CA2763446A1 (en)	2010-12-02

Legal Events

Date	Code	Title	Description
2016-05-17	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE A 5A E 6A ANUIDADES
2016-09-06	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2367 DE 17-05-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

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