BRPI1013493A2 - composto de pirimidina - Google Patents

composto de pirimidina

Info

Publication number
BRPI1013493A2
BRPI1013493A2 BRPI1013493A BRPI1013493A BRPI1013493A2 BR PI1013493 A2 BRPI1013493 A2 BR PI1013493A2 BR PI1013493 A BRPI1013493 A BR PI1013493A BR PI1013493 A BRPI1013493 A BR PI1013493A BR PI1013493 A2 BRPI1013493 A2 BR PI1013493A2
Authority
BR
Brazil
Prior art keywords
pyrimidine compound
pyrimidine
compound
Prior art date
Application number
BRPI1013493A
Other languages
English (en)
Inventor
Fusako Nishigaki
Hirokazu Kubota
Hisao Hamaguchi
Takeshi Hondo
Yoshinori Okamoto
Yuji Matsushima
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of BRPI1013493A2 publication Critical patent/BRPI1013493A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011085389A1 (en) 2010-01-11 2011-07-14 Astraea Therapeutics, Llc Nicotinic acetylcholine receptor modulators
AR081626A1 (es) 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
EP2560488B1 (en) 2010-04-23 2015-10-28 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081331A1 (es) * 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
KR101566091B1 (ko) * 2010-11-10 2015-11-04 에프. 호프만-라 로슈 아게 Lrrk2 조절제로서 피라졸 아미노피리미딘 유도체
CN102283845B (zh) * 2011-07-07 2012-10-03 济南环肽医药科技有限公司 1,4,5,6-四氢-2-甲基-4-嘧啶羧酸及1,4,5,6-四氢-2-甲基-5-羟基-4-嘧啶羧酸在制备肺结核治疗药物中的应用
CN104470515B (zh) 2012-05-03 2016-12-07 圣路易斯药学院 用于增加神经营养肽的组合物和方法
KR102284944B1 (ko) * 2013-11-27 2021-08-03 선샤인 레이크 파르마 컴퍼니 리미티드 다이하이드로피리미딘 유도체 및 이의 중간산물의 제조 방법
GB201511382D0 (en) 2015-06-29 2015-08-12 Imp Innovations Ltd Novel compounds and their use in therapy
US10906888B2 (en) * 2016-07-14 2021-02-02 Pfizer Inc. Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme
WO2020228436A1 (zh) * 2019-05-10 2020-11-19 浙江海正药业股份有限公司 芳环或杂芳环类衍生物及其制备方法和用途
US20240124479A1 (en) * 2020-12-17 2024-04-18 Shanghai Meiyue Biotech Development Co. Ltd Pyrimidine carboxamide compound and use thereof
WO2022140677A1 (en) 2020-12-23 2022-06-30 The Broad Institute, Inc. Compositions and methods related to di-substituted bicyclo[2.2.1] heptanamine-containing compounds
EP4267548A4 (en) * 2020-12-23 2025-05-21 The Broad Institute Inc. COMPOSITIONS AND METHODS RELATED TO BICYCLO[2.2.1]HEPTANAMINE-CONTAINING COMPOUNDS
CN119997982A (zh) 2022-09-09 2025-05-13 迈里克斯制药有限公司 包含nmt抑制剂的抗体药物偶联物及其用途
WO2025143096A1 (ja) * 2023-12-29 2025-07-03 キッセイ薬品工業株式会社 含窒素縮環化合物

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0087326B1 (en) * 1982-02-24 1987-05-13 Nycomed As Substituted pyrimidin-2-ones and the salts thereof
HUT63941A (en) * 1992-05-15 1993-11-29 Hoechst Ag Process for producing 4-alkyl-substituted pyrimidine-5-carboxanilide derivatives, and fungicidal compositions comprising same
US5532237A (en) 1995-02-15 1996-07-02 Merck Frosst Canada, Inc. Indole derivatives with affinity for the cannabinoid receptor
AU726058B2 (en) * 1995-09-01 2000-10-26 Signal Pharmaceuticals, Inc. Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions
US5935966A (en) 1995-09-01 1999-08-10 Signal Pharmaceuticals, Inc. Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions
US5811428A (en) 1995-12-18 1998-09-22 Signal Pharmaceuticals, Inc. Pyrimidine carboxamides and related compounds and methods for treating inflammatory conditions
JPH11512399A (ja) 1995-09-01 1999-10-26 シグナル ファーマシューティカルズ，インコーポレイテッド ピリミジンカルボキサミドおよび関連化合物ならびに炎症状態を処置するための方法
DE60008550T2 (de) * 1999-09-09 2004-08-05 Kumiai Chemical Industry Co., Ltd. Pyrimidinderivate und herbizide welche diese enthalten
CZ2002961A3 (cs) 1999-09-17 2002-08-14 Millennium Pharmaceuticals, Inc. Benzamidy a příbuzné sloučeniny pro inhibici faktoru Xa
WO2004009027A2 (en) 2002-07-19 2004-01-29 Myriad Genetics, Inc Method and composition for treating and preventing herpesvirus infection
UY27939A1 (es) * 2002-08-21 2004-03-31 Glaxo Group Ltd Compuestos
JP2005539036A (ja) 2002-08-21 2005-12-22 グラクソ　グループ　リミテッド ピリミジン化合物
GB0222493D0 (en) 2002-09-27 2002-11-06 Glaxo Group Ltd Compounds
GB0222495D0 (en) 2002-09-27 2002-11-06 Glaxo Group Ltd Compounds
AU2003275242B2 (en) 2002-09-27 2010-03-04 Merck Sharp & Dohme Corp. Substituted pyrimidines
TW200505902A (en) 2003-03-20 2005-02-16 Schering Corp Cannabinoid receptor ligands
GB0402357D0 (en) 2004-02-03 2004-03-10 Glaxo Group Ltd Novel compounds
GB0402356D0 (en) 2004-02-03 2004-03-10 Glaxo Group Ltd Novel compounds
WO2005080350A1 (en) * 2004-02-23 2005-09-01 Glaxo Group Limited Pyrimidine derivatives as cannabinoid receptor modulators
ES2313304T3 (es) 2004-02-24 2009-03-01 Glaxo Group Limited Derivados de piridina y su uso como moduladores del receptor cb2.
GB0404105D0 (en) 2004-02-24 2004-03-31 Glaxo Group Ltd Novel compounds
DK1753764T3 (da) 2004-06-09 2009-02-16 Glaxo Group Ltd Pyrrolopyridin-derivater
EP1802293A4 (en) 2004-10-22 2009-04-29 Pharmos Corp ORNAMENTALLY EFFECTIVE CANNABINOID ANALOGUES
EP1809290A2 (en) 2004-11-03 2007-07-25 Vertex Pharmaceuticals Incorporated Pyrimidine derivatives as ion channel modulators and methods of use
GB0516379D0 (en) 2005-08-09 2005-09-14 Glaxo Group Ltd Compounds
BRPI0614272A2 (pt) 2005-08-09 2011-03-22 Glaxo Group Ltd derivados de imidazopiridinas como ligantes de receptores canabinóides
GB0602042D0 (en) 2006-02-01 2006-03-15 Glaxo Group Ltd Compounds
UY30284A1 (es) 2006-04-14 2007-11-30 Abbott Gmbh & Amp Compuestos de ariloxietilamina apropiados para tratar trastornos que responden a la modulacion del receptor de dopamina d3
US7563797B2 (en) 2006-08-28 2009-07-21 Forest Laboratories Holding Limited Substituted imidazo(1,2-A)pyrimidines and imidazo(1,2-A) pyridines as cannabinoid receptor ligands
GB0705803D0 (en) 2007-03-28 2007-05-02 Glaxo Group Ltd Novel compounds
WO2009137081A2 (en) 2008-05-07 2009-11-12 Massachusetts Institute Of Technology Small molecule inhibitors of plasmodium falciparum dihydroorotate dehydrogenase
ES2551557T3 (es) * 2008-12-19 2015-11-19 Boehringer Ingelheim International Gmbh Pirimidin-4-carboxamidas cíclicas como antagonistas del receptor CCR2 para el tratamiento de inflamaciones, asma y EPOC

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