BRPI1014123A2 - produção de isopreno melhorada usando o caminho dxp e mva. - Google Patents

produção de isopreno melhorada usando o caminho dxp e mva.

Info

Publication number
BRPI1014123A2
BRPI1014123A2 BRPI1014123A BRPI1014123A BRPI1014123A2 BR PI1014123 A2 BRPI1014123 A2 BR PI1014123A2 BR PI1014123 A BRPI1014123 A BR PI1014123A BR PI1014123 A BRPI1014123 A BR PI1014123A BR PI1014123 A2 BRPI1014123 A2 BR PI1014123A2
Authority
BR
Brazil
Prior art keywords
path
dxp
mva
isoprene production
improved isoprene
Prior art date
Application number
BRPI1014123A
Other languages
English (en)
Inventor
T Nielsen Alex
M Peres Caroline
H Wells Derek
V Vaviline Dmitrii
K Chotani Gopal
C Mcauliffe Joseph
Charles Miller Michael
Erin Muir Rachel
Weyler Walter
Quinn Beck Zachary
Original Assignee
Danisco Us Inc
Goodyear Tire & Rubber
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Danisco Us Inc, Goodyear Tire & Rubber filed Critical Danisco Us Inc
Publication of BRPI1014123A2 publication Critical patent/BRPI1014123A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

produção de isopreno melhorada usando o caminho dxp e mva a presente invenção refere-se a métodos de produção de isopreno a partir de células cultivadas, com o uso de vários componentes do caminho dxp e caminho mva, ou componentes associados ao caminho dxp e ao caminho mva, polipeptídeos redox de interação por agrupamento ferro-enxofre e isopreno sintase. a invenção também fornece composições que incluem estas células cultivadas.
BRPI1014123A 2009-06-17 2010-06-16 produção de isopreno melhorada usando o caminho dxp e mva. BRPI1014123A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US18794109P 2009-06-17 2009-06-17
US18793009P 2009-06-17 2009-06-17
US31497910P 2010-03-17 2010-03-17
US31498510P 2010-03-17 2010-03-17
PCT/US2010/038904 WO2010148150A1 (en) 2009-06-17 2010-06-16 Improved isoprene production using the dxp and mva pathway

Publications (1)

Publication Number Publication Date
BRPI1014123A2 true BRPI1014123A2 (pt) 2019-07-02

Family

ID=43356749

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1014123A BRPI1014123A2 (pt) 2009-06-17 2010-06-16 produção de isopreno melhorada usando o caminho dxp e mva.

Country Status (10)

Country Link
US (2) US8507235B2 (pt)
EP (1) EP2443244A4 (pt)
CN (1) CN102753697A (pt)
AR (1) AR077115A1 (pt)
BR (1) BRPI1014123A2 (pt)
CA (1) CA2765805A1 (pt)
MY (1) MY158160A (pt)
SG (2) SG176936A1 (pt)
TW (2) TWI427149B (pt)
WO (1) WO2010148150A1 (pt)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009240505B2 (en) 2008-04-23 2013-09-05 Danisco Us Inc. Isoprene synthase variants for improved microbial production of isoprene
CA2737158A1 (en) 2008-09-15 2010-03-18 Danisco Us Inc. Increased isoprene production using the archaeal lower mevalonate pathway
ZA201102111B (en) * 2008-09-15 2013-10-30 Danisco Us Inc Reduction of carbon dioxide emission during isoprene production by fermentation
EP2337845A1 (en) * 2008-09-15 2011-06-29 Danisco US Inc. Increased isoprene production using mevalonate kinase and isoprene synthase
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
AU2010238770A1 (en) 2009-04-23 2011-11-03 Danisco Us Inc. Three-dimensional structure of isoprene synthase and its use thereof for generating variants
TWI427149B (zh) 2009-06-17 2014-02-21 Danisco Us Inc 使用ｄｘｐ及ｍｖａ途徑之改良之異戊二烯製造
US20110039323A1 (en) * 2009-08-14 2011-02-17 Eric Lawrence Singsaas Isoprene Production
CA2783976A1 (en) * 2009-12-18 2011-06-23 Danisco Us Inc. Purification of isoprene from renewable resources
EP2516657A1 (en) * 2009-12-22 2012-10-31 Danisco US Inc. Membrane bioreactor for increased production of isoprene gas
CN103025688A (zh) 2010-06-17 2013-04-03 丹尼斯科美国公司 包含异戊二烯衍生物的燃料组合物
WO2012019169A1 (en) 2010-08-06 2012-02-09 Danisco Us Inc. Production of isoprene under neutral ph conditions
CA2816306A1 (en) 2010-10-27 2012-05-03 Danisco Us Inc. Isoprene synthase variants for improved production of isoprene
BR112013018316A2 (pt) 2010-12-22 2018-09-11 Danisco Us Inc composições e métodos para produção aprimorada de isopreno usando dois tipos de enzimas ispg
US8691541B2 (en) 2010-12-22 2014-04-08 Danisco Us Inc. Biological production of pentose sugars using recombinant cells
WO2012135591A2 (en) * 2011-03-30 2012-10-04 Amyris, Inc. Microbial isoprenoid production using a heterologous dxp pathway
SG194691A1 (en) 2011-04-29 2013-12-30 Danisco Us Inc Production of mevalonate, isoprene, and isoprenoids using genes encodingpolypeptides having thiolase, hmg-coa synthase and hmg-coa reductase enzymatic activities
BR112013027555A2 (pt) 2011-04-29 2021-08-10 Danisco Us Inc. células recombinantes capazes de maior produção de isopreno, mevalonato e isoprenoides e método para produzir isopreno, mevalonato e isoprenoides
JP2014528705A (ja) 2011-08-04 2014-10-30 ダニスコ・ユーエス・インク アセトアセチルＣｏＡシンターゼを用いるイソプレン、イソプレノイド前駆体、及びイソプレノイドの生産
US8951764B2 (en) 2011-08-05 2015-02-10 Danisco Us Inc. Production of isoprenoids under neutral pH conditions
PL222067B1 (pl) * 2011-08-11 2016-06-30 Inst Biotechnologii I Antybiotyków Kaseta ekspresyjna, zastosowanie kasety ekspresyjnej, wektor ekspresyjny, komórka prokariotycznego gospodarza zawierająca wektor ekspresyjny, szczep bakteryjny oraz sposób wytwarzania polipeptydu
WO2013066568A1 (en) * 2011-10-07 2013-05-10 Danisco Us Inc. Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene
JP6101275B2 (ja) 2011-10-27 2017-03-22 ダニスコ・ユーエス・インク イソプレン産生時の溶解度が向上されたイソプレン合成酵素変異体
JP2015510392A (ja) 2011-12-23 2015-04-09 ダニスコ・ユーエス・インク 低減したｉｓｐａ活性を有する宿主細胞を用いるイソプレン産生増強法
WO2013096863A1 (en) * 2011-12-23 2013-06-27 The Regents Of The University Of California Constructs and methods for improved isoprene biosynthesis
WO2013096917A1 (en) 2011-12-23 2013-06-27 Danisco Us Inc. Production of isoprene under reduced oxygen inlet levels
US9315831B2 (en) 2012-03-30 2016-04-19 Danisco Us Inc. Direct starch to fermentable sugar as feedstock for the production of isoprene, isoprenoid precursor molecules, and/or isoprenoids
US9163263B2 (en) 2012-05-02 2015-10-20 The Goodyear Tire & Rubber Company Identification of isoprene synthase variants with improved properties for the production of isoprene
US8895277B2 (en) 2012-05-02 2014-11-25 Danisco Us Inc. Legume isoprene synthase for production of isoprene
WO2013181647A2 (en) 2012-06-01 2013-12-05 Danisco Us Inc. Compositions and methods of producing isoprene and/or industrrial bio-products using anaerobic microorganisms
US20130323820A1 (en) * 2012-06-01 2013-12-05 Lanzatech New Zealand Limited Recombinant microorganisms and uses therefor
US10030221B2 (en) 2012-09-20 2018-07-24 Danisco Us Inc. Microtiter plates for controlled release of culture components to cell cultures
WO2014066892A1 (en) * 2012-10-26 2014-05-01 Coelho Pedro S De novo metabolic pathways for isoprene biosynthesis
JP2016511630A (ja) 2012-12-21 2016-04-21 ダニスコ・ユーエス・インク 代案の下流メバロン酸経路を使用するイソプレン、イソプレノイド、およびイソプレノイド前駆体の生成
JP2016508737A (ja) * 2013-03-07 2016-03-24 キャリスタ， インコーポレイテッド イソプレンの生物学的産生のための組成物および方法
US9850512B2 (en) 2013-03-15 2017-12-26 The Research Foundation For The State University Of New York Hydrolysis of cellulosic fines in primary clarified sludge of paper mills and the addition of a surfactant to increase the yield
ES2735331T3 (es) 2013-04-10 2019-12-18 Goodyear Tire & Rubber Fosfocetolasas para mejorar la producción de metabolitos derivados de acetil-coenzima A, isopreno, precursores de isoprenoides e isoprenoides
WO2014205355A2 (en) 2013-06-21 2014-12-24 Danisco Us Inc. Compositions and methods for clostridial transformation
CN103602626B (zh) * 2013-10-12 2016-02-10 中国科学院青岛生物能源与过程研究所 一种以油脂为原料生产甲羟戊酸的方法及其构建的基因工程菌
CN103667153B (zh) * 2013-12-19 2015-05-13 中国石油大学(华东) 一株产聚3-羟基丁酸酯的嗜热菌
US10648004B2 (en) 2014-02-20 2020-05-12 Danisco Us Inc. Recombinant microorganisms for the enhanced production of mevalonate, isoprene, isoprenoid precursors, isoprenoids, and acetyl-CoA-derived products
US9951363B2 (en) 2014-03-14 2018-04-24 The Research Foundation for the State University of New York College of Environmental Science and Forestry Enzymatic hydrolysis of old corrugated cardboard (OCC) fines from recycled linerboard mill waste rejects
WO2016015021A1 (en) 2014-07-24 2016-01-28 The Regents Of The University Of California Oxidative starch degradation by a new family of pmos
US9850070B2 (en) 2014-09-17 2017-12-26 WCCO Belting, Inc. Environmentally friendly rubber composition
CN104372017B (zh) * 2014-11-05 2017-06-30 中国科学院青岛生物能源与过程研究所 一种提高基因工程菌异戊二烯及其衍生物产量的方法及应用
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
WO2018140778A1 (en) 2017-01-26 2018-08-02 Manus Bio, Inc. Metabolic engineering for microbial production of terpenoid products
KR20190139202A (ko) 2017-02-03 2019-12-17 마누스 바이오, 인크. 터페노이드 산물의 미생물 생산을 위한 대사 조작
CN110468090B (zh) * 2018-05-09 2023-07-04 深圳艾格鑫科技有限公司 微生物及其用途
CN110468091B (zh) * 2018-05-09 2023-07-11 深圳艾格鑫科技有限公司 微生物及其用途
CN108715825B (zh) * 2018-06-01 2021-03-09 天津大学 基因过表达及获得的菌株、应用
US20200239796A1 (en) * 2018-09-28 2020-07-30 The Regents Of The University Of California Host cells and methods for producing tricyclic sesquiterpenes, aviation and missile fuel precursors
CN109609424B (zh) * 2018-12-26 2020-07-31 浙江医药股份有限公司 用于生产法尼烯的大肠杆菌
WO2020150340A1 (en) * 2019-01-15 2020-07-23 North Carolina State University Isoprenoids and methods of making thereof
EP3683227A1 (en) * 2019-01-16 2020-07-22 Biosyntia ApS Cell factories for improved production of compounds and proteins dependent on iron sulfur clusters
KR102129038B1 (ko) * 2019-10-29 2020-07-01 천현수 질소 함유 천연물의 발효를 통한 산화질소 대사체의 고정화 및 안정화 방법
JP7754406B2 (ja) * 2021-03-26 2025-10-15 三菱ケミカル株式会社 イソプレン産生能を有する遺伝子改変微生物およびこれを用いたイソプレン製造方法
JP7742602B2 (ja) * 2021-03-26 2025-09-22 国立研究開発法人産業技術総合研究所 イソプレノイド類産生能を有する遺伝子改変微生物およびこれを用いたイソプレノイド類製造方法
WO2025111429A1 (en) 2023-11-22 2025-05-30 Bp Corporation North America Inc. Recombinant microorganisms with increased accumulation and/or flux of cytidine triphosphate (ctp)
WO2026010860A1 (en) 2024-07-02 2026-01-08 Bp Corporation North America Inc. Recombinant microorganisms for isoprene production

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8407828D0 (en) * 1984-03-27 1984-05-02 Ontario Research Foundation In situ preparation
US4570029A (en) * 1985-03-04 1986-02-11 Uop Inc. Process for separating isoprene
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
DE3650202T3 (de) 1985-08-29 2004-06-03 Genencor International, Inc., South San Francisco Expression von heterologen Polypeptiden in filamentösen Pilzen, Verfahren zu deren Herstellung und Vektoren zu deren Herstellung.
DK122686D0 (da) 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
ES2322032T3 (es) * 1990-12-10 2009-06-16 Genencor Int Sacrificacion mejorada de celulosa por clonacion y amplificacion del gen de beta-glucosidasa de trichoderma reesei.
WO1995004134A1 (en) 1993-08-02 1995-02-09 Genencor International, Inc. Method of reducing complex carbohydrates in fermentation products
US5861271A (en) * 1993-12-17 1999-01-19 Fowler; Timothy Cellulase enzymes and systems for their expressions
US5686276A (en) 1995-05-12 1997-11-11 E. I. Du Pont De Nemours And Company Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism
US5849970A (en) 1995-06-23 1998-12-15 The Regents Of The University Of Colorado Materials and methods for the bacterial production of isoprene
DE19629568C1 (de) 1996-07-15 1998-01-08 Fraunhofer Ges Forschung Verfahren zur Herstellung von Isopren
US6176176B1 (en) * 1998-04-30 2001-01-23 Board Of Trustees Operating Michigan State University Apparatus for treating cellulosic materials
US6268328B1 (en) * 1998-12-18 2001-07-31 Genencor International, Inc. Variant EGIII-like cellulase compositions
US6316695B1 (en) * 1999-04-22 2001-11-13 Korea Kumho Petrochemical Co., Ltd. Isopentenyl diphosphate isomerase from Hevea brasiliensis and rubber producing method using the same
AU2001278098A1 (en) * 2000-07-31 2002-02-13 Frederick M. Hahn Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
WO2002081631A2 (en) * 2001-04-04 2002-10-17 Genencor International, Inc. Uncoupled productive and catabolic host cell pathways
US6998471B2 (en) * 2001-07-25 2006-02-14 E.I. Du Pont De Nemours And Company Polynucleotides encoding an acetyl-CoA acetyltransferase from Hevea brasiliensis, related products, and methods
EP2374879A3 (en) * 2002-04-22 2012-01-11 E. I. du Pont de Nemours and Company Promoter and plasmid system for genetic engineering
US20050079617A1 (en) * 2003-10-03 2005-04-14 Cervin Marguerite A. Glucose transport mutants for production of biomaterial
WO2004033646A2 (en) 2002-10-04 2004-04-22 E.I. Du Pont De Nemours And Company Process for the biological production of 1,3-propanediol with high yield
EP1627049B1 (en) 2003-05-29 2010-02-17 Genencor International, Inc. Novel trichoderma genes
SI1685244T1 (sl) * 2003-11-21 2012-06-29 Danisco Us Inc Ekspresija encimov, ki hidrolizirajo zrnat škrob, v Trichodermi in postopek za proizvajanje glukoze iz zrnatih škrobnih substratov
US20050287625A1 (en) * 2004-03-05 2005-12-29 Miller Edward S Jr Process for expression of foreign genes in methylotrophic bacteria through chromosomal integration
SG172646A1 (en) * 2006-05-26 2011-07-28 Amyris Biotechnologies Inc Production of isoprenoids
US7947478B2 (en) 2006-06-29 2011-05-24 The Regents Of The University Of California Short chain volatile hydrocarbon production using genetically engineered microalgae, cyanobacteria or bacteria
WO2008128159A1 (en) 2007-04-16 2008-10-23 Amyris Biotechnologies, Inc. Production of isoprenoids
JP2010539902A (ja) * 2007-09-20 2010-12-24 アミリス バイオテクノロジーズ，インコーポレイティド イソプレノイドの生産
JP5262044B2 (ja) 2007-09-27 2013-08-14 凸版印刷株式会社 太陽電池裏面封止用シート及びこれを用いた太陽電池モジュール
AU2008334945C1 (en) * 2007-12-13 2013-09-05 Danisco Us Inc. Compositions and methods for producing isoprene
US20090153993A1 (en) 2007-12-18 2009-06-18 Teradyne, Inc. Disk Drive Testing
US20110045563A1 (en) * 2008-02-06 2011-02-24 The Regents Of The University Of California Short chain volatile isoprene hydrocarbon production using the mevalonic acid pathway in genetically engineered yeast and fungi
AU2009240505B2 (en) 2008-04-23 2013-09-05 Danisco Us Inc. Isoprene synthase variants for improved microbial production of isoprene
US7632995B2 (en) * 2008-05-09 2009-12-15 Monsanto Technology Llc Plants and seeds of hybrid corn variety CH852179
MX318543B (es) 2008-07-02 2014-03-18 Danisco Us Inc Composiciones y metodos para producir isopreno libre de hidrocarburos de c5 bajo condicion de desacoplamiento y/o intervalos de operacion seguros.
EP2337845A1 (en) 2008-09-15 2011-06-29 Danisco US Inc. Increased isoprene production using mevalonate kinase and isoprene synthase
CA2737158A1 (en) 2008-09-15 2010-03-18 Danisco Us Inc. Increased isoprene production using the archaeal lower mevalonate pathway
ZA201102111B (en) 2008-09-15 2013-10-30 Danisco Us Inc Reduction of carbon dioxide emission during isoprene production by fermentation
CA2737195A1 (en) 2008-09-15 2010-03-18 The Goodyear Tire & Rubber Company Conversion of prenyl derivatives to isoprene
SG169641A1 (en) 2008-09-15 2011-04-29 Danisco Us Inc Systems using cell culture for production of isoprene
SG172806A1 (en) * 2008-12-30 2011-08-29 Danisco Us Inc Methods of producing isoprene and a co-product
US20100297749A1 (en) * 2009-04-21 2010-11-25 Sapphire Energy, Inc. Methods and systems for biofuel production
AU2010238770A1 (en) 2009-04-23 2011-11-03 Danisco Us Inc. Three-dimensional structure of isoprene synthase and its use thereof for generating variants
TWI434921B (zh) * 2009-06-17 2014-04-21 Danisco Us Inc 從生物異戊二烯組合物製造燃料成分之方法及系統
TWI427149B (zh) * 2009-06-17 2014-02-21 Danisco Us Inc 使用ｄｘｐ及ｍｖａ途徑之改良之異戊二烯製造
SG179157A1 (en) 2009-09-15 2012-05-30 Sapphire Energy Inc A system for transformation of the chloroplast genome of scenedesmus sp. and dunaliella sp.
CA2783976A1 (en) * 2009-12-18 2011-06-23 Danisco Us Inc. Purification of isoprene from renewable resources
CA2816306A1 (en) 2010-10-27 2012-05-03 Danisco Us Inc. Isoprene synthase variants for improved production of isoprene
US8691541B2 (en) * 2010-12-22 2014-04-08 Danisco Us Inc. Biological production of pentose sugars using recombinant cells
BR112013018316A2 (pt) * 2010-12-22 2018-09-11 Danisco Us Inc composições e métodos para produção aprimorada de isopreno usando dois tipos de enzimas ispg

Also Published As

Publication number Publication date
SG176936A1 (en) 2012-02-28
TWI427149B (zh) 2014-02-21
EP2443244A1 (en) 2012-04-25
TW201111512A (en) 2011-04-01
TW201412988A (zh) 2014-04-01
CA2765805A1 (en) 2010-12-23
MY158160A (en) 2016-09-15
EP2443244A4 (en) 2014-11-26
US20110014672A1 (en) 2011-01-20
CN102753697A (zh) 2012-10-24
WO2010148150A1 (en) 2010-12-23
SG10201403297UA (en) 2014-10-30
US8507235B2 (en) 2013-08-13
AR077115A1 (es) 2011-08-03
US20140162337A1 (en) 2014-06-12

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