ATE513036T1 - Entkoppelte anabole und katabole stoffwechselwege in wirtszellen - Google Patents

Entkoppelte anabole und katabole stoffwechselwege in wirtszellen

Info

Publication number: ATE513036T1
Authority: AT; Austria
Prior art keywords: host cells; uncoupled; anabolic; nucleic acid; metabolic pathways
Prior art date: 2001-04-04

Application number

AT08020730T

Other languages

English (en)

Inventor

Timothy Dodge

Fernando Valle

Original Assignee

Danisco Us Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-04

Filing date

2002-04-04

Publication date

2011-07-15

2002-04-04 Application filed by Danisco Us Inc filed Critical Danisco Us Inc

2011-07-15 Application granted granted Critical

2011-07-15 Publication of ATE513036T1 publication Critical patent/ATE513036T1/de

Links

230000001195 anabolic effect Effects 0.000 title 1
230000001925 catabolic effect Effects 0.000 title 1
230000037353 metabolic pathway Effects 0.000 title 1
150000007523 nucleic acids Chemical class 0.000 abstract 3
102000039446 nucleic acids Human genes 0.000 abstract 3
108020004707 nucleic acids Proteins 0.000 abstract 3
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
229910052799 carbon Inorganic materials 0.000 abstract 2
230000002255 enzymatic effect Effects 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
230000004048 modification Effects 0.000 abstract 2
238000012986 modification Methods 0.000 abstract 2
RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 abstract 1
108010021582 Glucokinase Proteins 0.000 abstract 1
102000030595 Glucokinase Human genes 0.000 abstract 1
108010021382 Gluconokinase Proteins 0.000 abstract 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
125000003275 alpha amino acid group Chemical group 0.000 abstract 1
229960005070 ascorbic acid Drugs 0.000 abstract 1
235000010323 ascorbic acid Nutrition 0.000 abstract 1
239000011668 ascorbic acid Substances 0.000 abstract 1
230000006652 catabolic pathway Effects 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/02—Monosaccharides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P25/00—Preparation of compounds containing alloxazine or isoalloxazine nucleus, e.g. riboflavin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/58—Aldonic, ketoaldonic or saccharic acids
- C12P7/60—2-Ketogulonic acid

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT08020730T 2001-04-04 2002-04-04 Entkoppelte anabole und katabole stoffwechselwege in wirtszellen ATE513036T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US28161801P	2001-04-04	2001-04-04
US28225901P	2001-04-05	2001-04-05

Publications (1)

Publication Number	Publication Date
ATE513036T1 true ATE513036T1 (de)	2011-07-15

Family

ID=26960977

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT08020730T ATE513036T1 (de)	2001-04-04	2002-04-04	Entkoppelte anabole und katabole stoffwechselwege in wirtszellen
AT02763934T ATE421577T1 (de)	2001-04-04	2002-04-04	Entkoppelte anabole und katabole stoffwechselwege in wirtszellen

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT02763934T ATE421577T1 (de)	2001-04-04	2002-04-04	Entkoppelte anabole und katabole stoffwechselwege in wirtszellen

Country Status (9)

Country	Link
US (2)	US7241587B2 (de)
EP (2)	EP2055773B1 (de)
JP (2)	JP4430869B2 (de)
AT (2)	ATE513036T1 (de)
AU (1)	AU2002338340A1 (de)
CA (1)	CA2443145C (de)
DE (1)	DE60230971D1 (de)
DK (1)	DK1373480T3 (de)
WO (1)	WO2002081631A2 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK1383903T3 (da) *	2001-04-04	2009-03-23	Genencor Int	Fremgangsmåder til fremstilling af askorbinsyre-intermediater i vært-celler
US20080038787A1 (en) *	2003-12-18	2008-02-14	Basf Aktiengesellschaft	Methods for the Preparation of a Fine Chemical by Fermentation
EP1937807B1 (de) *	2005-09-09	2013-11-06	DSM IP Assets B.V.	Neues gen gms 08
US8222223B2 (en) *	2005-09-20	2012-07-17	Battelle Memorial Institute	Method of treating biocells
US7790427B1 (en) *	2005-09-20	2010-09-07	Battelle Memorial Institute	Method of treating biocells
AT505263B1 (de) *	2007-06-01	2009-08-15	Vogelbusch Gmbh	Verfahren zum herstellen von ascorbinsäure
JP6049982B2 (ja)	2007-12-13	2016-12-21	ダニスコ・ユーエス・インク	イソプレンを産出する組成物及び方法
JP2011518564A (ja)	2008-04-23	2011-06-30	ダニスコ・ユーエス・インク	改良された微生物によるイソプレン産出用のイソプレンシンターゼ変異体
SG167485A1 (en)	2008-06-30	2011-01-28	Danisco Us Inc	Polymers of isoprene from renewable resources
EP3406722A1 (de)	2008-07-02	2018-11-28	Danisco US Inc.	Zusammensetzungen und verfahren zur herstellung von c5-freiem isopren unter entkoppelungsbedingungen und/oder sicheren betriebsbereichen
WO2010031062A1 (en)	2008-09-15	2010-03-18	Danisco Us Inc.	Increased isoprene production using the archaeal lower mevalonate pathway
WO2010031068A1 (en) *	2008-09-15	2010-03-18	Danisco Us Inc.	Reduction of carbon dioxide emission during isoprene production by fermentation
US20100184178A1 (en) *	2008-09-15	2010-07-22	Zachary Quinn Beck	Increased isoprene production using mevalonate kinase and isoprene synthase
ZA201102109B (en)	2008-09-15	2013-10-30	Goodyear Tire & Rubber	Conversion of prenyl derivatives to isoprene
EP2344629B1 (de)	2008-09-15	2018-01-24	Danisco US Inc.	Systeme mit verwendung von zellkultur zur isoprenherstellung
MY171270A (en)	2008-12-30	2019-10-07	Goodyear Tire & Rubber	Methods of producing isoprene and a co-product
WO2010092924A1 (ja) *	2009-02-10	2010-08-19	国立大学法人宮崎大学	ペントース資化性エタノール生産組換え大腸菌及びこれを用いるエタノールの製造方法
CA2759700A1 (en)	2009-04-23	2010-10-28	Danisco Us Inc.	Three-dimensional structure of isoprene synthase and its use thereof for generating variants
TWI434921B (zh) *	2009-06-17	2014-04-21	Danisco Us Inc	從生物異戊二烯組合物製造燃料成分之方法及系統
TWI427149B (zh) *	2009-06-17	2014-02-21	Danisco Us Inc	使用ｄｘｐ及ｍｖａ途徑之改良之異戊二烯製造
WO2011160081A1 (en)	2010-06-17	2011-12-22	Danisco Us Inc.	Fuel compositions comprising isoprene derivatives
PH12013500068A1 (en) *	2010-07-12	2016-11-16	Inbiose Nv	Metabolically engineered organisms for the production of added value bio-products
BR112013010551A8 (pt)	2010-10-27	2018-07-03	Danisco Us Inc	variantes de isopreno sintase para produção aprimorada de isopreno
US8288137B2 (en) *	2010-11-15	2012-10-16	E I Du Pont De Nemours And Company	Recombinant Escherichia coli having enhanced acetyl-coenzyme a synthetase activity for producing glyerol and glycerol-derived products
CN103476926A (zh)	2010-12-22	2013-12-25	丹尼斯科美国公司	使用两种类型的ispg酶改善异戊二烯产量的组合物和方法
US8691541B2 (en)	2010-12-22	2014-04-08	Danisco Us Inc.	Biological production of pentose sugars using recombinant cells
US9163263B2 (en)	2012-05-02	2015-10-20	The Goodyear Tire & Rubber Company	Identification of isoprene synthase variants with improved properties for the production of isoprene

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4760025A (en)	1984-05-29	1988-07-26	Genencor, Inc.	Modified enzymes and methods for making same
US5004690A (en)	1983-06-28	1991-04-02	Genetech, Inc.	Ascorbic acid intermediates and process enzymes
US4757012A (en)	1983-06-28	1988-07-12	Genentech, Inc.	Ascorbic acid intermediates and process enzymes
US4758514A (en)	1983-06-28	1988-07-19	Genentech, Inc.	Ascorbic acid intermediates and process enzymes
US5008193A (en)	1984-06-14	1991-04-16	Genentech, Inc.	Ascorbic acid intermediates and process enzymes
US4757870A (en) *	1985-02-20	1988-07-19	Nissan Motor Co., Ltd.	Four wheel drive system having driving force distribution control responsive to front and rear wheel speed difference
DE3621781A1 (de)	1985-07-05	1987-01-15	Takeda Chemical Industries Ltd	Verfahren zur reinigung von l-ascorbinsaeure
US5032514A (en)	1988-08-08	1991-07-16	Genentech, Inc.	Metabolic pathway engineering to increase production of ascorbic acid intermediates
GB8826429D0 (en)	1988-11-11	1988-12-14	Univ Leeds Ind Service Ltd	Enzyme stabilisation systems
JP2779073B2 (ja)	1991-02-22	1998-07-23	キッコーマン株式会社	選択発酵法
WO1992018637A1 (en) *	1991-04-16	1992-10-29	F.Hoffmann-La Roche Ag	Method for the production of d-gluconic acid
US5272073A (en)	1992-06-30	1993-12-21	Purdue Research Foundation	Biocatalytic synthesis of catechol from glucose
US5376544A (en)	1992-09-08	1994-12-27	Rutgers The State University Of New Jersey	Enzymes for the production of 2-keto-L-gulonic acid
CN1048282C (zh)	1993-07-09	2000-01-12	武田药品工业株式会社	生产2－酮－l－古洛糖酸的方法
US5672509A (en)	1993-08-25	1997-09-30	Pfizer Inc.	hPDE IV-C: a human phosphodiesterase IV isozyme
US5985617A (en)	1997-02-18	1999-11-16	Liao; James C.	Microorganisms and methods for overproduction of DAHP by cloned PPS gene
US5686276A (en)	1995-05-12	1997-11-11	E. I. Du Pont De Nemours And Company	Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism
US5795761A (en)	1996-01-11	1998-08-18	Rutgers, The State University Of New Jersey	Mutants of 2,5-diketo-D-gluconic acid (2,5-DKG) reductase A
US5939307A (en)	1996-07-30	1999-08-17	The Archer-Daniels-Midland Company	Strains of Escherichia coli, methods of preparing the same and use thereof in fermentation processes for l-threonine production
CA2625060A1 (en)	1996-11-13	1998-05-22	E.I. Du Pont De Nemours And Company	Method for the production of glycerol by recombinant organisms
US6916646B1 (en)	1997-06-23	2005-07-12	Genencor International, Inc.	Enterobacteriaceae fermentation strains
CA2311601C (en)	1997-12-02	2008-07-08	E.I. Du Pont De Nemours And Company	Method for the production of glycerol by recombinant organisms
AU746542B2 (en)	1998-03-18	2002-05-02	Ajinomoto Co., Inc.	L-glutamic acid-producing bacterium and method for producing L-glutamic acid
DE19818541C2 (de)	1998-04-24	2003-04-10	Forschungszentrum Juelich Gmbh	Mikrobielle Herstellung von Substanzen aus dem aromatischen Stoffwechsel / III
DE19823834A1 (de)	1998-05-28	1999-12-02	Basf Ag	Genetisches Verfahren zur Herstellung von Riboflavin
US6599722B2 (en) *	1998-12-22	2003-07-29	Genencor International, Inc.	Method for producing ascorbic acid intermediates
ATE335823T1 (de)	1999-08-18	2006-09-15	Du Pont	Verfahren zur biologischen herstellung von 1,3- propandiol
US6586214B1 (en)	1999-09-15	2003-07-01	Degussa Ag	Method for increasing the metabolic flux through the pentose phosphate cycle in coryneform bacteria by regulation of the phosphoglucose isomerase (pgi gene)
DK1383903T3 (da) *	2001-04-04	2009-03-23	Genencor Int	Fremgangsmåder til fremstilling af askorbinsyre-intermediater i vært-celler

2002
- 2002-04-04 DK DK02763934T patent/DK1373480T3/da active
- 2002-04-04 AT AT08020730T patent/ATE513036T1/de not_active IP Right Cessation
- 2002-04-04 WO PCT/US2002/010575 patent/WO2002081631A2/en not_active Ceased
- 2002-04-04 EP EP08020730A patent/EP2055773B1/de not_active Expired - Lifetime
- 2002-04-04 AU AU2002338340A patent/AU2002338340A1/en not_active Abandoned
- 2002-04-04 AT AT02763934T patent/ATE421577T1/de not_active IP Right Cessation
- 2002-04-04 JP JP2002579995A patent/JP4430869B2/ja not_active Expired - Fee Related
- 2002-04-04 CA CA2443145A patent/CA2443145C/en not_active Expired - Fee Related
- 2002-04-04 DE DE60230971T patent/DE60230971D1/de not_active Expired - Lifetime
- 2002-04-04 EP EP02763934A patent/EP1373480B1/de not_active Expired - Lifetime
- 2002-04-04 US US10/117,283 patent/US7241587B2/en not_active Expired - Fee Related
2006
- 2006-11-13 US US11/598,375 patent/US7407780B2/en not_active Expired - Fee Related
2009
- 2009-10-30 JP JP2009250085A patent/JP5328038B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1373480A2 (de)	2004-01-02
US7241587B2 (en)	2007-07-10
DK1373480T3 (da)	2009-05-11
WO2002081631A3 (en)	2002-11-28
US7407780B2 (en)	2008-08-05
US20070059811A1 (en)	2007-03-15
CA2443145A1 (en)	2002-10-17
US20030073200A1 (en)	2003-04-17
WO2002081631A2 (en)	2002-10-17
JP5328038B2 (ja)	2013-10-30
DE60230971D1 (de)	2009-03-12
ATE421577T1 (de)	2009-02-15
AU2002338340A1 (en)	2002-10-21
EP1373480A4 (de)	2005-02-02
CA2443145C (en)	2013-01-22
JP4430869B2 (ja)	2010-03-10
JP2005503769A (ja)	2005-02-10
EP2055773A1 (de)	2009-05-06
JP2010057499A (ja)	2010-03-18
EP1373480B1 (de)	2009-01-21
EP2055773B1 (de)	2011-06-15

Legal Events

Date	Code	Title	Description
2011-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE513036T1 (de)	2011-07-15	Entkoppelte anabole und katabole stoffwechselwege in wirtszellen
DK1383903T3 (da)	2009-03-23	Fremgangsmåder til fremstilling af askorbinsyre-intermediater i vært-celler
ATE471370T1 (de)	2010-07-15	Varianten von beta-glukosidasen
EP1516053A4 (de)	2006-07-12	Xylanasen, diese codierende nukleinsäuren sowie verfahren zur herstellung und verwendung davon
WO2006073839A3 (en)	2006-11-23	Acid fungal proteases
EP2302042A3 (de)	2011-08-10	Polypeptide mit Lipase-Aktivität und diese kodierende Polynukleotide
NZ595499A (en)	2013-05-31	Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them
AU2001242299A1 (en)	2001-09-24	Fungal transcriptional activator useful in methods for producing polypeptides
WO2005033094A3 (de)	2005-11-24	Verfahren zur herstellung von 3-methylamino-1-(thien-2-yl)-propan-1-ol
WO2005058945A3 (de)	2005-10-20	Genvarianten die für proteine aus dem stoffwechselweg von feinchemikalien kodieren
DK1157100T3 (da)	2006-05-29	Oxaloacetathydrolase-defekte svampeværtsceller
DE60330579D1 (de)	2010-01-28	Mikrobielle trypsinvarianten mit chymotrypsinaktivität und diese codierende nukleinsäuren
EP1699469A4 (de)	2007-01-24	Rekombinanter faktor viii mit erhöhter spezifischer aktivität
TW200510460A (en)	2005-03-16	Antimicrobial polypeptides
TW200502253A (en)	2005-01-16	Antimicrobial polypeptides
DK1226236T3 (da)	2006-06-19	Polypeptider, der har glucanotransferase-aktivitet, og nucleinsyrer, som koder disse
EP1551976A4 (de)	2007-06-27	Neue n-acetylgalactosamin-transferasen und diese codierende nukleinsäuren
EA200700287A1 (ru)	2007-08-31	Улучшенные ферменты
ATE495245T1 (de)	2011-01-15	Verbesserte proteinexpression in bacillus subtilis
WO2002077009A3 (en)	2003-01-09	Polypeptides having gamma-glutamyl transpeptidase activity and nucleic acids encoding same
WO1999035274A3 (en)	1999-09-16	Nucleic acids encoding thermostable pullulanases
WO2000031241A3 (en)	2001-04-12	Polypeptides having choline oxidase activity and nucleic acids encoding same