BRPI9507227B8 - formulação farmacêutica para administração subcutânea, intramuscular ou intradérmica - Google Patents

formulação farmacêutica para administração subcutânea, intramuscular ou intradérmica

Info

Publication number
BRPI9507227B8
BRPI9507227B8 BRPI9507227A BR9507227A BRPI9507227B8 BR PI9507227 B8 BRPI9507227 B8 BR PI9507227B8 BR PI9507227 A BRPI9507227 A BR PI9507227A BR 9507227 A BR9507227 A BR 9507227A BR PI9507227 B8 BRPI9507227 B8 BR PI9507227B8
Authority
BR
Brazil
Prior art keywords
subcutaneous
factor viii
intramuscular
factor
intradermal administration
Prior art date
Application number
BRPI9507227A
Other languages
English (en)
Other versions
BR9507227A (pt
Inventor
Brita Sjöström
Jack Spira
Lars Widlund
Marianne Mikaelsson
Thomas Österberg
Original Assignee
Biovitrum Ab
Pharmacia & Upjohn Ab
Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26662019&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI9507227(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from SE9401105A external-priority patent/SE9401105D0/
Priority claimed from SE9500036A external-priority patent/SE9500036D0/xx
Application filed by Biovitrum Ab, Pharmacia & Upjohn Ab, Pharmacia Ab filed Critical Biovitrum Ab
Publication of BR9507227A publication Critical patent/BR9507227A/pt
Publication of BRPI9507227B8 publication Critical patent/BRPI9507227B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

patente de invenção "formulação farmacêutica para administração sbcutânea, intramuscular ou intradérmica, uso da mesma e de um derivado de extinção de um fator recombinante viii e processo para o tratamento de hemofilia". a presente invenção se refere a uma formulação farmacêutica para administração subcut[anea, intramuscular ou intradérmica, que compreende fator de coagulação viii ou fator ix, e seu uso para fabricação de um medicamento para tratar hemofilia a ou b. a formulação compreende um fator de coagulação viii ou fator ix, com uma atividade de pelo menos 200 ui por ml, e um aditivo de aumento da bio-disponibilidade de fator viii ou fator ix. os testes com fator viii dão um nível terapêutico de fator ativo viii na corrente sanguínea, por um tempo surpreendentemente longo, após a administração subcutânea, intramuscular ou intradérmica. o fator viii é adequadamente um fator viii de recombinante altamente purificado e, de preferência, um seu derivado que pode ser usado na fabricação de um medicamento para administração subcutânea.
BRPI9507227A 1994-03-31 1995-03-31 formulação farmacêutica para administração subcutânea, intramuscular ou intradérmica BRPI9507227B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9401105A SE9401105D0 (sv) 1993-07-05 1994-03-31 Formulation
SE9500036A SE9500036D0 (sv) 1995-01-05 1995-01-05 Formulation
PCT/SE1995/000348 WO1995026750A1 (en) 1994-03-31 1995-03-31 Pharmaceutical formulation for subcutaneous, intramuscular or intradermal administration of factor viii or factor ix

Publications (2)

Publication Number Publication Date
BR9507227A BR9507227A (pt) 1997-09-09
BRPI9507227B8 true BRPI9507227B8 (pt) 2015-12-08

Family

ID=26662019

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9507227A BRPI9507227B8 (pt) 1994-03-31 1995-03-31 formulação farmacêutica para administração subcutânea, intramuscular ou intradérmica

Country Status (19)

Country Link
US (1) US5925739A (pt)
EP (1) EP0772452B1 (pt)
JP (1) JP3939750B2 (pt)
AT (1) ATE222770T1 (pt)
AU (1) AU690666B2 (pt)
BR (1) BRPI9507227B8 (pt)
CA (1) CA2186126C (pt)
DE (1) DE69527966T2 (pt)
DK (1) DK0772452T3 (pt)
ES (1) ES2182899T3 (pt)
FI (1) FI118171B (pt)
HU (1) HU223314B1 (pt)
IL (2) IL113010A0 (pt)
NO (1) NO321139B1 (pt)
NZ (1) NZ283499A (pt)
PL (1) PL180282B1 (pt)
PT (1) PT772452E (pt)
TW (1) TW400234B (pt)
WO (1) WO1995026750A1 (pt)

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SE9502285D0 (sv) * 1995-06-22 1995-06-22 Pharmacia Ab Improvements related to injections
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US20050032690A1 (en) * 1997-09-10 2005-02-10 Rojkjaer Lisa Payne Factor VII polypeptides for preventing formation of inhibitors in subjects with haemophilia
US7786070B2 (en) * 1997-09-10 2010-08-31 Novo Nordisk Healthcare A/G Subcutaneous administration of coagulation factor VII
EP1820516B1 (en) 1999-02-22 2013-07-24 University of Connecticut Novel albumin-free factor VIII formulations
US20020156453A1 (en) * 1999-10-14 2002-10-24 Pettis Ronald J. Method and device for reducing therapeutic dosage
US8465468B1 (en) 2000-06-29 2013-06-18 Becton, Dickinson And Company Intradermal delivery of substances
JP4663837B2 (ja) * 1999-12-24 2011-04-06 一般財団法人化学及血清療法研究所 第▲ｖｉｉｉ▼因子を主成分とする血小板減少に伴う出血疾患の予防・治療用医薬組成物
US20020123093A1 (en) 2000-04-06 2002-09-05 Zannis Vassilis I. Compounds and methods for lowering cholesterol levels without inducing hypertrigylceridemia
JP5090605B2 (ja) 2000-05-03 2012-12-05 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 凝固因子ｖｉｉの皮下投与
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US20040009918A1 (en) * 2002-05-03 2004-01-15 Hanne Nedergaard Stabilised solid compositions of modified factor VII
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Also Published As

Publication number Publication date
IL113010A (en) 1999-10-28
DK0772452T3 (da) 2003-01-06
ATE222770T1 (de) 2002-09-15
MX9604455A (es) 1997-07-31
IL113010A0 (en) 1995-10-31
AU2156095A (en) 1995-10-23
FI963871A0 (fi) 1996-09-27
HU223314B1 (hu) 2004-05-28
HU9602693D0 (en) 1996-11-28
DE69527966D1 (de) 2002-10-02
FI963871L (fi) 1996-09-27
NO321139B1 (no) 2006-03-27
JPH10501522A (ja) 1998-02-10
ES2182899T3 (es) 2003-03-16
TW400234B (en) 2000-08-01
PT772452E (pt) 2003-01-31
FI118171B (fi) 2007-08-15
HUT74918A (en) 1997-03-28
PL316618A1 (en) 1997-01-20
PL180282B1 (pl) 2001-01-31
CA2186126C (en) 2007-11-20
CA2186126A1 (en) 1995-10-12
JP3939750B2 (ja) 2007-07-04
NO964081D0 (no) 1996-09-27
AU690666B2 (en) 1998-04-30
DE69527966T2 (de) 2003-05-28
EP0772452A1 (en) 1997-05-14
EP0772452B1 (en) 2002-08-28
BR9507227A (pt) 1997-09-09
WO1995026750A1 (en) 1995-10-12
NZ283499A (en) 1997-08-22
US5925739A (en) 1999-07-20
NO964081L (no) 1996-11-29

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