BRPI9508825B8 - processo de transferência de moléculas para o citosol de células, composição e kit - Google Patents

processo de transferência de moléculas para o citosol de células, composição e kit

Info

Publication number
BRPI9508825B8
BRPI9508825B8 BRPI9508825A BRPI9508825A BRPI9508825B8 BR PI9508825 B8 BRPI9508825 B8 BR PI9508825B8 BR PI9508825 A BRPI9508825 A BR PI9508825A BR PI9508825 A BRPI9508825 A BR PI9508825A BR PI9508825 B8 BRPI9508825 B8 BR PI9508825B8
Authority
BR
Brazil
Prior art keywords
cells
cytosol
kit
composition
molecules
Prior art date
Application number
BRPI9508825A
Other languages
English (en)
Inventor
Moan Johan
Sandvig Kirsten
Berg Kristian
Original Assignee
Photocure As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Photocure As filed Critical Photocure As
Publication of BR9508825A publication Critical patent/BR9508825A/pt
Publication of BRPI9508825B1 publication Critical patent/BRPI9508825B1/pt
Publication of BRPI9508825B8 publication Critical patent/BRPI9508825B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Catalysts (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

processo de transferência de moléculas para o citosol de células, composição e kit. a presente invenção descreve um método para liberar moléculas no citosol de células sem matar a maioria das células, permitindo que as moléculas sejam absorvidas em endossomos, lisossomas ou outros compartimentos celulares e usando a ativação de luz de compostos fotossensibilizadores para romper as membranas dos endossomos, lisossomas ou outros compartimentos celulares.
BRPI9508825A 1994-09-08 1995-09-04 processo de transferência de moléculas para o citosol de células, composição e kit BRPI9508825B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NO943327A NO180167C (no) 1994-09-08 1994-09-08 Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol
NO943327 1994-09-08
PCT/NO1995/000149 WO1996007432A1 (en) 1994-09-08 1995-09-04 Transfer of molecules into the cytosol of cells

Publications (3)

Publication Number Publication Date
BR9508825A BR9508825A (pt) 1998-01-06
BRPI9508825B1 BRPI9508825B1 (pt) 2020-12-22
BRPI9508825B8 true BRPI9508825B8 (pt) 2021-07-06

Family

ID=19897382

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9508825A BRPI9508825B8 (pt) 1994-09-08 1995-09-04 processo de transferência de moléculas para o citosol de células, composição e kit

Country Status (19)

Country Link
US (3) US5876989A (pt)
EP (1) EP0783323B1 (pt)
JP (1) JP4148328B2 (pt)
KR (2) KR100529967B1 (pt)
CN (1) CN1222309C (pt)
AT (1) ATE209507T1 (pt)
AU (1) AU700797B2 (pt)
BR (1) BRPI9508825B8 (pt)
CA (1) CA2199290C (pt)
CZ (1) CZ65897A3 (pt)
DE (1) DE69524238T2 (pt)
ES (1) ES2163527T3 (pt)
FI (1) FI121328B (pt)
HU (1) HU222984B1 (pt)
MX (1) MX9701676A (pt)
NO (1) NO180167C (pt)
NZ (2) NZ509519A (pt)
PT (1) PT783323E (pt)
WO (1) WO1996007432A1 (pt)

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Also Published As

Publication number Publication date
CN1222309C (zh) 2005-10-12
HU222984B1 (hu) 2004-01-28
AU700797B2 (en) 1999-01-14
DE69524238T2 (de) 2002-07-18
ES2163527T3 (es) 2002-02-01
NO943327D0 (no) 1994-09-08
JP4148328B2 (ja) 2008-09-10
BRPI9508825B1 (pt) 2020-12-22
AU3534795A (en) 1996-03-27
CN1164829A (zh) 1997-11-12
NO943327L (no) 1996-03-11
CZ65897A3 (en) 1997-10-15
KR20040004402A (ko) 2004-01-13
FI121328B (fi) 2010-10-15
KR100395615B1 (ko) 2003-12-31
CA2199290A1 (en) 1996-03-14
US20020155099A1 (en) 2002-10-24
ATE209507T1 (de) 2001-12-15
NZ293008A (en) 2001-04-27
US5876989A (en) 1999-03-02
EP0783323B1 (en) 2001-11-28
KR100529967B1 (ko) 2005-11-22
US6680301B2 (en) 2004-01-20
EP0783323A1 (en) 1997-07-16
CA2199290C (en) 2010-10-26
WO1996007432A1 (en) 1996-03-14
BR9508825A (pt) 1998-01-06
KR970705415A (ko) 1997-10-09
US20030134813A1 (en) 2003-07-17
MX9701676A (es) 1998-04-30
FI970983L (fi) 1997-03-07
HUT77469A (hu) 1998-05-28
FI970983A0 (fi) 1997-03-07
JPH10508295A (ja) 1998-08-18
NZ509519A (en) 2004-10-29
NO180167C (no) 1997-02-26
DE69524238D1 (de) 2002-01-10
NO180167B (no) 1996-11-18
PT783323E (pt) 2002-03-28
HK1004110A1 (en) 1998-11-20

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