BRPI9908557B8 - processo para separação enanciomérica enzimática de 3(r)-hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahidro-piridina e 3-(s)- hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahidro-piridina e os ésteres de ácido carboxílico - Google Patents
processo para separação enanciomérica enzimática de 3(r)-hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahidro-piridina e 3-(s)- hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahidro-piridina e os ésteres de ácido carboxílicoInfo
- Publication number
- BRPI9908557B8 BRPI9908557B8 BRPI9908557A BRPI9908557A BRPI9908557B8 BR PI9908557 B8 BRPI9908557 B8 BR PI9908557B8 BR PI9908557 A BRPI9908557 A BR PI9908557A BR PI9908557 A BRPI9908557 A BR PI9908557A BR PI9908557 B8 BRPI9908557 B8 BR PI9908557B8
- Authority
- BR
- Brazil
- Prior art keywords
- trimethoxyphenyl
- hydroxy
- methyl
- tetrahydro
- pyridine
- Prior art date
Links
- 150000001733 carboxylic acid esters Chemical class 0.000 title abstract 3
- 230000002255 enzymatic effect Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000000926 separation method Methods 0.000 title abstract 2
- RUOBYKJSLYFVNY-GFCCVEGCSA-N (3s)-1-methyl-4-(2,4,6-trimethoxyphenyl)-3,6-dihydro-2h-pyridin-3-ol Chemical compound COC1=CC(OC)=CC(OC)=C1C1=CCN(C)C[C@H]1O RUOBYKJSLYFVNY-GFCCVEGCSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/001—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by metabolizing one of the enantiomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/814—Enzyme separation or purification
- Y10S435/816—Enzyme separation or purification by solubility
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyridine Compounds (AREA)
Abstract
patente de invenção: <b>"processo para separação enanciomérica enzimática de 3(r)-hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahidro-piridina e 3-(s)- hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahidro-piridina e os ésteres de ácido carboxílico"<d>. é descrito um processo para preparação de compostos oticamente puros de 3(r)-hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahidro-piridina ou 3(s)-hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahidropiridina e, dos ésteres de ácido carboxílico, por conversão estereodiferenciada das misturas enancioméricas com auxílio de uma enzima.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19809649A DE19809649A1 (de) | 1998-03-06 | 1998-03-06 | Verfahren zur enzymatischen Enantiomeren-Trennung von 3(R)- und 3(S)-Hydroxy-1-methyl-4-(2,4,6-trimethoxyphenyl)-1,2,3,6-tetrahydro-pyridin bzw. der Carbonsäureester |
| PCT/EP1999/001113 WO1999045133A1 (de) | 1998-03-06 | 1999-02-20 | Verfarhen zur enzymatischen enantiomeren-trennung von 3(r)- und 3(s)-hydroxy-1- methyl-4-(2,4, 6-trimethoxyphenyl)-1, 2,3,6- tetrahydro-pyridin bzw. der carbonsäureester |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI9908557B1 BRPI9908557B1 (pt) | 2018-09-18 |
| BRPI9908557B8 true BRPI9908557B8 (pt) | 2021-05-25 |
Family
ID=7859957
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9908557A BRPI9908557B8 (pt) | 1998-03-06 | 1999-02-20 | processo para separação enanciomérica enzimática de 3(r)-hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahidro-piridina e 3-(s)- hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahidro-piridina e os ésteres de ácido carboxílico |
| BR9908557-7A BR9908557A (pt) | 1998-03-06 | 1999-02-20 | Processo para separação enanciomérica enzimática de 3(r)-hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetr ahidro-piridina e 3-(s)- hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahid ro-piridina e os ésteres de ácido carboxìlico |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9908557-7A BR9908557A (pt) | 1998-03-06 | 1999-02-20 | Processo para separação enanciomérica enzimática de 3(r)-hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetr ahidro-piridina e 3-(s)- hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahid ro-piridina e os ésteres de ácido carboxìlico |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6406912B1 (pt) |
| EP (1) | EP1071807B1 (pt) |
| JP (1) | JP4344089B2 (pt) |
| KR (1) | KR100779864B1 (pt) |
| CN (1) | CN1230554C (pt) |
| AR (1) | AR018574A1 (pt) |
| AT (1) | ATE474061T1 (pt) |
| AU (1) | AU758106B2 (pt) |
| BR (2) | BRPI9908557B8 (pt) |
| CA (1) | CA2322842C (pt) |
| CY (1) | CY1110919T1 (pt) |
| CZ (1) | CZ301944B6 (pt) |
| DE (2) | DE19809649A1 (pt) |
| DK (1) | DK1071807T3 (pt) |
| ES (1) | ES2348394T3 (pt) |
| HU (1) | HU227994B1 (pt) |
| ID (1) | ID27000A (pt) |
| PL (1) | PL195006B1 (pt) |
| PT (1) | PT1071807E (pt) |
| RU (1) | RU2241040C2 (pt) |
| TR (1) | TR200002576T2 (pt) |
| WO (1) | WO1999045133A1 (pt) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002544367A (ja) | 1999-05-13 | 2002-12-24 | シエル・インターナシヨネイル・リサーチ・マーチヤツピイ・ベー・ウイ | 炭化水素変換法 |
| PT1412514E (pt) * | 2001-05-15 | 2010-04-27 | Novartis Ag | Processo enzimático para a preparação de ésteres carboxílicos substituídos |
| CN104232700A (zh) * | 2014-10-01 | 2014-12-24 | 青岛科技大学 | 一种生物法生产(2r,3s)羟基丙酸甲酯的方法 |
| CN104278061A (zh) * | 2014-10-01 | 2015-01-14 | 青岛科技大学 | 一种生产氟苯基甲基丙酸甲酯的产朊酵母还原法 |
| AU2016252609B2 (en) | 2015-04-20 | 2022-06-30 | Sumitomo Pharma Oncology, Inc. | Predicting response to alvocidib by mitochondrial profiling |
| HUE045585T2 (hu) | 2015-05-18 | 2020-01-28 | Tolero Pharmaceuticals Inc | Megnövelt biológiai hozzáférhetõséggel rendelkezõ Alvocidib gyógyszer-elõanyagok |
| AU2016301315C1 (en) | 2015-08-03 | 2022-07-07 | Sumitomo Pharma Oncology, Inc. | Combination therapies for treatment of cancer |
| WO2018094275A1 (en) | 2016-11-18 | 2018-05-24 | Tolero Pharmaceuticals, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
| CA3047557A1 (en) | 2016-12-19 | 2018-06-28 | Tolero Pharmaceuticals, Inc. | Profiling peptides and methods for sensitivity profiling |
| JP7196160B2 (ja) | 2017-09-12 | 2022-12-26 | スミトモ ファーマ オンコロジー， インコーポレイテッド | Ｍｃｌ－１阻害剤アルボシジブを用いた、ｂｃｌ－２阻害剤に対して非感受性である癌の治療レジメン |
| US11034710B2 (en) | 2018-12-04 | 2021-06-15 | Sumitomo Dainippon Pharma Oncology, Inc. | CDK9 inhibitors and polymorphs thereof for use as agents for treatment of cancer |
| JP2022525149A (ja) | 2019-03-20 | 2022-05-11 | スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド | ベネトクラクスが失敗した急性骨髄性白血病（ａｍｌ）の処置 |
| CN110577974B (zh) * | 2019-09-10 | 2021-07-20 | 杭州澳赛诺生物科技有限公司 | 手性3-羟基-1,2,3,6-四氢吡啶的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2691986B2 (ja) * | 1987-08-28 | 1997-12-17 | チッソ株式会社 | ピリジン骨格を有する光学活性化合物の製造法 |
| DE3743824C2 (de) * | 1987-12-23 | 1997-03-06 | Hoechst Ag | Verfahren zur enzymatischen Racematspaltung von racemischen Alkoholen mit/in Vinylestern durch Umesterung |
| JPH0641075A (ja) * | 1990-09-01 | 1994-02-15 | Kazuo Achinami | 新規な１，４−ジヒドロピリジン化合物及びその製造方法 |
| JPH05192145A (ja) * | 1991-04-02 | 1993-08-03 | Hoechst Ag | 固定化生体触媒、その製造およびカラムリアクター中でのエステル合成におけるその使用 |
| JPH0690790A (ja) | 1992-09-08 | 1994-04-05 | Mercian Corp | 光学活性１，４−ジヒドロピリジン−３，５−ジカルボン酸・モノエステル誘導体の製造方法 |
| DE19802449A1 (de) * | 1998-01-23 | 1999-07-29 | Hoechst Marion Roussel De Gmbh | Verfahren zur Herstellung von (-)cis-3-Hydroxy-1-methyl-4-(2,4,6-trimethoxypyhenyl)-piperidin |
-
1998
- 1998-03-06 DE DE19809649A patent/DE19809649A1/de not_active Withdrawn
-
1999
- 1999-02-20 EP EP99910248A patent/EP1071807B1/de not_active Expired - Lifetime
- 1999-02-20 BR BRPI9908557A patent/BRPI9908557B8/pt unknown
- 1999-02-20 CA CA2322842A patent/CA2322842C/en not_active Expired - Lifetime
- 1999-02-20 JP JP2000534664A patent/JP4344089B2/ja not_active Expired - Lifetime
- 1999-02-20 PL PL342877A patent/PL195006B1/pl unknown
- 1999-02-20 RU RU2000125273/13A patent/RU2241040C2/ru active
- 1999-02-20 ID IDW20001691A patent/ID27000A/id unknown
- 1999-02-20 DE DE59915183T patent/DE59915183D1/de not_active Expired - Lifetime
- 1999-02-20 CN CNB998035955A patent/CN1230554C/zh not_active Expired - Lifetime
- 1999-02-20 CZ CZ20003223A patent/CZ301944B6/cs not_active IP Right Cessation
- 1999-02-20 TR TR2000/02576T patent/TR200002576T2/xx unknown
- 1999-02-20 WO PCT/EP1999/001113 patent/WO1999045133A1/de not_active Ceased
- 1999-02-20 AU AU29275/99A patent/AU758106B2/en not_active Expired
- 1999-02-20 BR BR9908557-7A patent/BR9908557A/pt not_active IP Right Cessation
- 1999-02-20 AT AT99910248T patent/ATE474061T1/de active
- 1999-02-20 US US09/623,563 patent/US6406912B1/en not_active Expired - Lifetime
- 1999-02-20 PT PT99910248T patent/PT1071807E/pt unknown
- 1999-02-20 ES ES99910248T patent/ES2348394T3/es not_active Expired - Lifetime
- 1999-02-20 KR KR1020007009843A patent/KR100779864B1/ko not_active Expired - Lifetime
- 1999-02-20 HU HU0101795A patent/HU227994B1/hu unknown
- 1999-02-20 DK DK99910248.6T patent/DK1071807T3/da active
- 1999-03-04 AR ARP990100907A patent/AR018574A1/es active IP Right Grant
-
2010
- 2010-09-22 CY CY20101100850T patent/CY1110919T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9908557A (pt) | Processo para separação enanciomérica enzimática de 3(r)-hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetr ahidro-piridina e 3-(s)- hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahid ro-piridina e os ésteres de ácido carboxìlico | |
| DE69435232D1 (de) | DNS Polymerasen | |
| PT923554E (pt) | N-benzilpiperidina e derivados tetrahidropiridina | |
| IE861900L (en) | INTERMEDIATES FOR ß-LACTAM ANTIBIOTICS | |
| FI881315L (fi) | Menetelmä 2-(kroman- tai tiokroman-6-yyli)etynyylipyridiinikarboksyylihappojohdannaisten valmistamiseksi, joilla on retiinihapon kaltaista aktiivisuutta | |
| ID810B (id) | KRISTAL BENTUK ε DARI 2-(4-(2-FUROIL)-(2-PIPERAZIN)-1-IL)-4-AMINO-6,7-DIMETOKSIQUINAZOLIN HIDROKLORIDA ANHIDRAT DAN PROSES UNTUK PEMBUATANNYA | |
| BR9710911A (pt) | Um processo para a formação de um perácido e uma composição compreendendo o perácido referido. | |
| FI894022A0 (fi) | Menetelmä (2R,3S)-3-(4-metoksifenyyli)glysidiinihapon alemman alkyyliesterin valmistamiseksi | |
| AU2856589A (en) | Intermediates for the preparation of 11-substituted 5H, 11H-pyrrole (2,1-c) (1,4) benzoxazepines, and a method for their preparation | |
| BR9809687A (pt) | Processo novo | |
| EP0855446A3 (en) | Process for producing optically active azetidine-2-carboxylic acid derivative | |
| DE3851865D1 (de) | Verfahren zur Umwandlung des niedrigschmelzenden Polymorphs von Buspirone hydrochlorid in das höherschmelzende. | |
| BR0012481A (pt) | Processo para desacilação de lipodepsipeptìdeos | |
| BR9803289A (pt) | Processo para a preparação de ácido 4-(4-(4-(hridroxidifenil)-1-piperidinil)-1hidroxibutil)- alfa,alfa-dimetifenilacético e derivados fosforilados. | |
| BR0004965A (pt) | Processo para preparação de compostos de cromano esterificados | |
| AU585703B2 (en) | Process for the enzymatic resolution of racemic 2-amino- 1-alkanols | |
| EP0974670A3 (en) | Process for producing optically active N-substituted azetidine-2-carboxylic acid compound | |
| BR9811579A (pt) | Processo para preparação de ácidos 3-ciano-2,4-dialógeno-5-fluorobenzóicos | |
| FR2708603B1 (fr) | Procédé de préparation d'hydroperoxyde de cumène. | |
| EP1283200A3 (en) | Optically pure paroxetine precursors | |
| AU590450B2 (en) | Process for the preparation of dibenzothiepin derivative | |
| ATE105860T1 (de) | Gen und genprodukt zur herstellung von beta- lactamverbindungen. | |
| AU5390094A (en) | Chiral lactic acid derivatives | |
| DE3563963D1 (de) | Azetidine derivatives | |
| WO2001030991A3 (en) | Human narcolepsy gene |