AR018574A1 - Procedimiento para la separacion enzimatica de enantiomeros de 3 (r)- y 3 (s) - hidroxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahidro-piridina o bien de los esteres de acido carboxilico - Google Patents
Procedimiento para la separacion enzimatica de enantiomeros de 3 (r)- y 3 (s) - hidroxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahidro-piridina o bien de los esteres de acido carboxilicoInfo
- Publication number
- AR018574A1 AR018574A1 ARP990100907A ARP990100907A AR018574A1 AR 018574 A1 AR018574 A1 AR 018574A1 AR P990100907 A ARP990100907 A AR P990100907A AR P990100907 A ARP990100907 A AR P990100907A AR 018574 A1 AR018574 A1 AR 018574A1
- Authority
- AR
- Argentina
- Prior art keywords
- enantiomers
- tetrahydro
- pyridine
- methyl
- trimetoxifenil
- Prior art date
Links
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical compound C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 230000002255 enzymatic effect Effects 0.000 title 1
- 238000000926 separation method Methods 0.000 title 1
- 125000005808 2,4,6-trimethoxyphenyl group Chemical group [H][#6]-1=[#6](-[#8]C([H])([H])[H])-[#6](-*)=[#6](-[#8]C([H])([H])[H])-[#6]([H])=[#6]-1-[#8]C([H])([H])[H] 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 150000001733 carboxylic acid esters Chemical class 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/001—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by metabolizing one of the enantiomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/814—Enzyme separation or purification
- Y10S435/816—Enzyme separation or purification by solubility
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyridine Compounds (AREA)
Abstract
Se describe un procedimiento para la preparacion de compuestos opticamente puros de 3(R)- y 3(S)-hidroxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahidro-piridina o bien de los ésteres de ácido carboxílico por conversion estereodiferenciadora del a mezcla de enantiomeros por medio de unaenzima.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19809649A DE19809649A1 (de) | 1998-03-06 | 1998-03-06 | Verfahren zur enzymatischen Enantiomeren-Trennung von 3(R)- und 3(S)-Hydroxy-1-methyl-4-(2,4,6-trimethoxyphenyl)-1,2,3,6-tetrahydro-pyridin bzw. der Carbonsäureester |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR018574A1 true AR018574A1 (es) | 2001-11-28 |
Family
ID=7859957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990100907A AR018574A1 (es) | 1998-03-06 | 1999-03-04 | Procedimiento para la separacion enzimatica de enantiomeros de 3 (r)- y 3 (s) - hidroxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahidro-piridina o bien de los esteres de acido carboxilico |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6406912B1 (es) |
| EP (1) | EP1071807B1 (es) |
| JP (1) | JP4344089B2 (es) |
| KR (1) | KR100779864B1 (es) |
| CN (1) | CN1230554C (es) |
| AR (1) | AR018574A1 (es) |
| AT (1) | ATE474061T1 (es) |
| AU (1) | AU758106B2 (es) |
| BR (2) | BR9908557A (es) |
| CA (1) | CA2322842C (es) |
| CY (1) | CY1110919T1 (es) |
| CZ (1) | CZ301944B6 (es) |
| DE (2) | DE19809649A1 (es) |
| DK (1) | DK1071807T3 (es) |
| ES (1) | ES2348394T3 (es) |
| HU (1) | HU227994B1 (es) |
| ID (1) | ID27000A (es) |
| PL (1) | PL195006B1 (es) |
| PT (1) | PT1071807E (es) |
| RU (1) | RU2241040C2 (es) |
| TR (1) | TR200002576T2 (es) |
| WO (1) | WO1999045133A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA01011497A (es) | 1999-05-13 | 2002-07-30 | Shell Int Research | Metodo de conversion de hidrocarburo. |
| DE60235374D1 (de) | 2001-05-15 | 2010-04-01 | Novartis Ag | Verfahren zur herstellung von substituierten carbonsäureestern mittels enzymatischer hydrolyse |
| CN104278061A (zh) * | 2014-10-01 | 2015-01-14 | 青岛科技大学 | 一种生产氟苯基甲基丙酸甲酯的产朊酵母还原法 |
| CN104232700A (zh) * | 2014-10-01 | 2014-12-24 | 青岛科技大学 | 一种生物法生产(2r,3s)羟基丙酸甲酯的方法 |
| EP3611506B1 (en) | 2015-04-20 | 2021-11-17 | Sumitomo Dainippon Pharma Oncology, Inc. | Predicting response to alvocidib by mitochondrial profiling |
| PL3298021T3 (pl) | 2015-05-18 | 2019-11-29 | Tolero Pharmaceuticals Inc | Proleki alvocidibu o zwiększonej biodostępności |
| WO2017024073A1 (en) | 2015-08-03 | 2017-02-09 | Tolero Pharmaceuticals, Inc. | Combination therapies for treatment of cancer |
| WO2018094275A1 (en) | 2016-11-18 | 2018-05-24 | Tolero Pharmaceuticals, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
| KR20190099260A (ko) | 2016-12-19 | 2019-08-26 | 톨레로 파마수티컬스, 인크. | 프로파일링 펩티드 및 감도 프로파일링을 위한 방법 |
| WO2019055579A1 (en) | 2017-09-12 | 2019-03-21 | Tolero Pharmaceuticals, Inc. | TREATMENT REGIME FOR CANCERS THAT ARE INSENSITIVE TO BCL-2 INHIBITORS USING THE MCL-1 ALVOCIDIB INHIBITOR |
| JP2022511029A (ja) | 2018-12-04 | 2022-01-28 | スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド | がんの処置のための薬剤としての使用のためのｃｄｋ９インヒビターおよびその多形 |
| JP2022525149A (ja) | 2019-03-20 | 2022-05-11 | スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド | ベネトクラクスが失敗した急性骨髄性白血病（ａｍｌ）の処置 |
| CN110577974B (zh) * | 2019-09-10 | 2021-07-20 | 杭州澳赛诺生物科技有限公司 | 手性3-羟基-1,2,3,6-四氢吡啶的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2691986B2 (ja) * | 1987-08-28 | 1997-12-17 | チッソ株式会社 | ピリジン骨格を有する光学活性化合物の製造法 |
| DE3743824C2 (de) * | 1987-12-23 | 1997-03-06 | Hoechst Ag | Verfahren zur enzymatischen Racematspaltung von racemischen Alkoholen mit/in Vinylestern durch Umesterung |
| JPH0641075A (ja) * | 1990-09-01 | 1994-02-15 | Kazuo Achinami | 新規な１，４−ジヒドロピリジン化合物及びその製造方法 |
| AU647603B2 (en) | 1991-04-02 | 1994-03-24 | Hoechst Aktiengesellschaft | An immobilized biocatalyst, its preparation and use for ester synthesis in a column reactor |
| JPH0690790A (ja) * | 1992-09-08 | 1994-04-05 | Mercian Corp | 光学活性１，４−ジヒドロピリジン−３，５−ジカルボン酸・モノエステル誘導体の製造方法 |
| DE19802449A1 (de) * | 1998-01-23 | 1999-07-29 | Hoechst Marion Roussel De Gmbh | Verfahren zur Herstellung von (-)cis-3-Hydroxy-1-methyl-4-(2,4,6-trimethoxypyhenyl)-piperidin |
-
1998
- 1998-03-06 DE DE19809649A patent/DE19809649A1/de not_active Withdrawn
-
1999
- 1999-02-20 KR KR1020007009843A patent/KR100779864B1/ko not_active Expired - Lifetime
- 1999-02-20 CZ CZ20003223A patent/CZ301944B6/cs not_active IP Right Cessation
- 1999-02-20 AT AT99910248T patent/ATE474061T1/de active
- 1999-02-20 WO PCT/EP1999/001113 patent/WO1999045133A1/de not_active Ceased
- 1999-02-20 TR TR2000/02576T patent/TR200002576T2/xx unknown
- 1999-02-20 US US09/623,563 patent/US6406912B1/en not_active Expired - Lifetime
- 1999-02-20 CA CA2322842A patent/CA2322842C/en not_active Expired - Lifetime
- 1999-02-20 CN CNB998035955A patent/CN1230554C/zh not_active Expired - Lifetime
- 1999-02-20 DK DK99910248.6T patent/DK1071807T3/da active
- 1999-02-20 JP JP2000534664A patent/JP4344089B2/ja not_active Expired - Lifetime
- 1999-02-20 BR BR9908557-7A patent/BR9908557A/pt not_active IP Right Cessation
- 1999-02-20 RU RU2000125273/13A patent/RU2241040C2/ru active
- 1999-02-20 PT PT99910248T patent/PT1071807E/pt unknown
- 1999-02-20 HU HU0101795A patent/HU227994B1/hu unknown
- 1999-02-20 PL PL342877A patent/PL195006B1/pl unknown
- 1999-02-20 AU AU29275/99A patent/AU758106B2/en not_active Expired
- 1999-02-20 DE DE59915183T patent/DE59915183D1/de not_active Expired - Lifetime
- 1999-02-20 EP EP99910248A patent/EP1071807B1/de not_active Expired - Lifetime
- 1999-02-20 ES ES99910248T patent/ES2348394T3/es not_active Expired - Lifetime
- 1999-02-20 ID IDW20001691A patent/ID27000A/id unknown
- 1999-02-20 BR BRPI9908557A patent/BRPI9908557B8/pt unknown
- 1999-03-04 AR ARP990100907A patent/AR018574A1/es active IP Right Grant
-
2010
- 2010-09-22 CY CY20101100850T patent/CY1110919T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1110919T1 (el) | Μεθοδος για τον ενζυματικο διαχωρισμο εναντιομερων της 3(r)- kai 3(s)-υδροξυ-1-μεθυλο-4-(2,4,6-τριμεθοξυφαινυλο)-1,2,3,6-τετραϋδρο-πυριδινης ή των εστερων καρβοξυλικου οξεος αυτης. | |
| ATE514786T1 (de) | Biokatalytische synthese von shikiminsäure | |
| NO178969C (no) | Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte kinazolinoner | |
| HUT52162A (en) | New process for producing optically active | |
| DE69517832D1 (de) | Ein Verfahren zur Herstellung von Tetrazolyl-Verbindungen | |
| DK0885191T3 (da) | Opspaltning af threo-methylphenidat | |
| DK1200386T3 (da) | Fremgangsmåde til fremstilling af nitroxyalkylestere af naproxen | |
| MX9403286A (es) | Acido valerico substituido. | |
| DK125387D0 (da) | Fremgangsmaade til fremstilling af macrolidforbindelser | |
| DK0625137T3 (da) | Fremgangsmåde til racematadskillelse af verapamil | |
| IE851204L (en) | Beta-carbolines | |
| DK1097130T3 (da) | Fremgangsmåde til fremstilling af hydroxymethylthiosmörsyre | |
| ES2083407T3 (es) | Procedimiento de preparacion de esteres del acido 3-fenilglicidico opticamente activos. | |
| RU2000125273A (ru) | Способ ферментативного разделения энантиомеров 3 (r) - или 3 (s)-гидрокси-1-метил-4-(2,4,6-триметоксифенил)-1,2,3,6-тетрагидропиридина или сложных эфиров карбоновой кислоты | |
| ES2038665T3 (es) | Procedimiento de sintesis de penems. | |
| EP0602740B1 (en) | Process for the enzymatic preparation of optically active transglycidic acid esters | |
| DK163503C (da) | Fremgangsmaade til fremstilling af estere af aryloxyphenoxypropansyre | |
| TWI255812B (en) | A process for the preparation of r-(+)-6-carboxamido-3-n-methylamino-1,2,3,4-tetrahydrocarbazole | |
| ES2042409B1 (es) | Procedimiento para la preparacion de d-aminoacidos o derivados de d-aminoacidos. | |
| ES2051767T3 (es) | Cetorreduccion estereoespecifica de esteres de acido carboxilico-biciclooctanodiona por microorganismos. | |
| DK0834574T3 (da) | Fremgangsmåde til oprensning af K-252a | |
| EA200100241A1 (ru) | Способ синтеза экзохелинов (варианты) | |
| ATE165347T1 (de) | Verfahren zur herstellung pyridin-2,3- dicarboxylicsäure | |
| DE50213141D1 (de) | Verfahren zur Herstellung von Glycinderivaten | |
| DK0627007T3 (da) | Fremgangsmåde til enzymatisk oxidation af (D)-mælkesyre til pyrodruesyre |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |