BRPI9913097B8 - derivado heterocíclico de carboxamida contendo nitrogênio ou um sal do mesmo - Google Patents
derivado heterocíclico de carboxamida contendo nitrogênio ou um sal do mesmoInfo
- Publication number
- BRPI9913097B8 BRPI9913097B8 BRPI9913097A BR9913097A BRPI9913097B8 BR PI9913097 B8 BRPI9913097 B8 BR PI9913097B8 BR PI9913097 A BRPI9913097 A BR PI9913097A BR 9913097 A BR9913097 A BR 9913097A BR PI9913097 B8 BRPI9913097 B8 BR PI9913097B8
- Authority
- BR
- Brazil
- Prior art keywords
- salt
- carboxamide derivative
- containing nitrogen
- derivative containing
- heterocyclic carboxamide
- Prior art date
Links
- -1 heterocyclic carboxamide Chemical class 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title 2
- 229910052757 nitrogen Inorganic materials 0.000 title 1
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical class C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 abstract 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 abstract 1
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Natural products C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 abstract 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 229940053202 antiepileptics carboxamide derivative Drugs 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 125000005242 carbamoyl alkyl group Chemical group 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 150000003216 pyrazines Chemical class 0.000 abstract 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical class C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 241000712461 unidentified influenza virus Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/18—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Cosmetics (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25044198 | 1998-08-20 | ||
| JP14592299 | 1999-05-26 | ||
| PCT/JP1999/004429 WO2000010569A1 (en) | 1998-08-20 | 1999-08-18 | Nitrogenous heterocyclic carboxamide derivatives or salts thereof and antiviral agents containing both |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR9913097A BR9913097A (pt) | 2001-09-25 |
| BR9913097B1 BR9913097B1 (pt) | 2013-11-12 |
| BRPI9913097B8 true BRPI9913097B8 (pt) | 2021-05-25 |
Family
ID=26476908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9913097A BRPI9913097B8 (pt) | 1998-08-20 | 1999-08-18 | derivado heterocíclico de carboxamida contendo nitrogênio ou um sal do mesmo |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US6787544B2 (id) |
| EP (1) | EP1112743B1 (id) |
| JP (1) | JP3453362B2 (id) |
| KR (1) | KR100585240B1 (id) |
| CN (2) | CN1275947C (id) |
| AT (1) | ATE376418T1 (id) |
| AU (1) | AU756635B2 (id) |
| BR (1) | BRPI9913097B8 (id) |
| CA (1) | CA2339272C (id) |
| CY (1) | CY1107001T1 (id) |
| CZ (1) | CZ301763B6 (id) |
| DE (1) | DE69937405T2 (id) |
| DK (1) | DK1112743T3 (id) |
| ES (1) | ES2296399T3 (id) |
| HU (1) | HU227475B1 (id) |
| ID (1) | ID28806A (id) |
| IL (1) | IL141150A (id) |
| MX (1) | MXPA01001843A (id) |
| NO (1) | NO321026B1 (id) |
| NZ (1) | NZ509748A (id) |
| PL (1) | PL200955B1 (id) |
| PT (1) | PT1112743E (id) |
| RU (1) | RU2224520C2 (id) |
| TR (1) | TR200100574T2 (id) |
| WO (1) | WO2000010569A1 (id) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA02007890A (es) | 2000-02-16 | 2002-10-31 | Toyama Chemical Co Ltd | Derivados innovadores de piracina o sales para la misma, composicion farmaceutica que contiene la misma, y produccion de intermediarios para la misma. |
| BR0211900A (pt) * | 2001-08-14 | 2004-08-24 | Toyama Chemical Co Ltd | Método para inibição do desenvolvimento de vìrus e/ou virucida, análogos de nucleotìdeo de pirazina e de nucleosìdeo de pirazina, precursor do inibidor da polimerase de rna, inibidor da polimerase de rna, método para tratar pacientes infectados por vìrus, e, usos de um análogo de nucleotìdeo de pirazina ou um sal deste e de um análogo de nucleosìdeo de pirazina ou um sal deste |
| NZ533057A (en) | 2001-10-26 | 2005-11-25 | Angeletti P Ist Richerche Bio | N-substituted hydroxypyrimidinone carboxamide inhibitors of HIV integrase |
| EP1441734B1 (en) | 2001-10-26 | 2007-02-28 | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. | Dihydroxypyrimidine carboxamide inhibitors of hiv integrase |
| JP4200758B2 (ja) * | 2002-12-26 | 2008-12-24 | 株式会社日立ハイテクノロジーズ | パネルの樹脂塗布方法、ディスプレイ用パネルの製造方法及び樹脂塗布装置 |
| WO2005049111A2 (en) * | 2003-11-13 | 2005-06-02 | Symphony Medical, Inc. | Control of cardiac arrhythmias by modification of neuronal conduction within fat pads of the heart |
| TWI355894B (en) * | 2003-12-19 | 2012-01-11 | Du Pont | Herbicidal pyrimidines |
| CN1560035A (zh) * | 2004-03-12 | 2005-01-05 | 沈阳药科大学 | 5－羟基吲哚－3－羧酸脂类衍生物 |
| KR100700676B1 (ko) * | 2005-06-24 | 2007-03-28 | (주) 비엔씨바이오팜 | 6―（4―치환된―아닐리노）피리미딘 유도체, 그 제조방법및 이를 포함하는 항바이러스용 약학적 조성물 |
| CA2653933C (en) * | 2006-05-31 | 2013-10-08 | Toyama Chemical Co., Ltd. | Anti-foot-and-mouth disease virus agent for animal belonging to family suidae or sheep, and method for prevention or treatment of foot-and-mouth disease in animal belonging to family suidae or sheep |
| BRPI0807597B8 (pt) * | 2007-02-16 | 2021-05-25 | Fujifilm Toyama Chemical Co Ltd | composição farmacêutica, e, uso de um derivado de pirazina ou um sal do mesmo e um ou mais inibidor(es) de neuraminidase em combinação |
| CN101289455B (zh) * | 2007-04-17 | 2010-11-10 | 靳广毅 | 一种抗流感病毒前体药及其应用 |
| US8513261B2 (en) | 2009-03-13 | 2013-08-20 | Toyama Chemical Co., Ltd. | Tablet and granulated powder containing 6-fluoro-3-hydroxy-2-pyrazinecarboxamide |
| JP5739618B2 (ja) * | 2009-03-18 | 2015-06-24 | 富山化学工業株式会社 | ３−ヒドロキシ−２−ピラジンカルボキサミドの製造法 |
| TWI507397B (zh) * | 2010-09-30 | 2015-11-11 | Toyama Chemical Co Ltd | ６－氟－３－羥－２－吡羧醯胺之美洛明鹽 |
| SG189161A1 (en) * | 2010-09-30 | 2013-05-31 | Toyama Chemical Co Ltd | Sodium salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide |
| JP5787727B2 (ja) * | 2010-11-12 | 2015-09-30 | 富士フイルム株式会社 | ピラジノ〔２，３−ｄ〕イソオキサゾール誘導体 |
| CN102617491B (zh) * | 2011-07-01 | 2015-05-06 | 中国人民解放军军事医学科学院毒物药物研究所 | 3-氧代-3,4-二氢-2-吡嗪甲酰氨类衍生物、其药物组合物、其制备方法及用途 |
| CN102846617B (zh) * | 2011-07-01 | 2016-01-13 | 中国人民解放军军事医学科学院毒物药物研究所 | 3－(丁基氧基)－2－吡嗪甲酰氨的制备方法和用途 |
| WO2013004141A1 (zh) * | 2011-07-01 | 2013-01-10 | 中国人民解放军军事医学科学院毒物药物研究所 | 3－烷氧基取代－2－吡嗪甲酰氨类化合物及其用途 |
| WO2013004092A1 (zh) * | 2011-07-01 | 2013-01-10 | 中国人民解放军军事医学科学院毒物药物研究所 | 3-氧代-3，4-二氢-2-吡嗪甲酰氨类衍生物、其药物组合物、其制备方法及用途 |
| CN102603658B (zh) * | 2011-10-18 | 2014-04-30 | 山东齐都药业有限公司 | 6-氟-3-羟基-2-吡嗪酰胺的制备方法 |
| CN102603657B (zh) * | 2011-10-18 | 2015-02-04 | 山东齐都药业有限公司 | 6-溴-3-羟基-2-吡嗪酰胺的制备方法 |
| TW201348214A (zh) * | 2012-04-26 | 2013-12-01 | Toyama Chemical Co Ltd | 氘化含氮雜環羧醯胺衍生物 |
| WO2013180149A1 (ja) * | 2012-05-30 | 2013-12-05 | 富山化学工業株式会社 | 重水素化含窒素複素環カルボキサミド誘導体またはその塩 |
| FR3000490B1 (fr) * | 2012-12-27 | 2015-03-13 | Anaconda Pharma | Procede de synthese d'une hydrazine utile dans le traitement du virus du papillome |
| JP2018505183A (ja) | 2015-01-28 | 2018-02-22 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | エボラウイルス疾患の処置のための方法及び医薬組成物 |
| CN106588786B (zh) * | 2015-10-14 | 2019-03-08 | 山东省药学科学院 | 一种高纯度法匹拉韦杂质的制备方法 |
| CN105687152B (zh) * | 2016-03-22 | 2020-04-07 | 山东齐都药业有限公司 | 一种法匹拉韦快速释放药物制剂及制备方法 |
| CN106083745B (zh) * | 2016-08-15 | 2018-08-21 | 山东百诺医药股份有限公司 | 6-氟-3-羟基-2-吡嗪酰胺的合成方法 |
| CN107226794A (zh) * | 2017-07-17 | 2017-10-03 | 郑州大学 | 一种法匹拉韦的合成方法 |
| EP3733182A4 (en) | 2017-12-28 | 2021-09-01 | FUJIFILM Toyama Chemical Co., Ltd. | PROCESS FOR PREPARING A FREEZE-DRIED FORMULATION |
| US20220096468A1 (en) | 2018-12-25 | 2022-03-31 | Fujifilm Toyama Chemical Co., Ltd. | Therapeutic agent for RNA viral infection comprising a combination of pyrazine derivative and compound which increases amount of pyrazine derivative ribose triphosphate in cell |
| CN111265528A (zh) | 2020-01-21 | 2020-06-12 | 中国人民解放军军事科学院军事医学研究院 | 法匹拉韦在治疗冠状病毒感染方面的应用 |
| EP4129291A4 (en) | 2020-03-30 | 2024-04-10 | FUJIFILM Toyama Chemical Co., Ltd. | CORONAVIRUS INFECTION TREATMENT MEDICATION |
| US20230218644A1 (en) | 2020-04-16 | 2023-07-13 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
| CN112300083B (zh) * | 2020-04-20 | 2021-08-03 | 常州制药厂有限公司 | 一种法匹拉韦的制备方法 |
| CN113563273B (zh) * | 2020-04-28 | 2023-12-26 | 中国人民解放军军事科学院军事医学研究院 | 一种抗病毒的吡嗪酰胺衍生物及其制备方法 |
| US20230210848A1 (en) | 2020-04-30 | 2023-07-06 | Fujifilm Toyama Chemical Co., Ltd. | Coronavirus infection therapeutic agent formed through combination of pyrazine derivative and another coronavirus infection therapeutic drug |
| RU2744429C1 (ru) * | 2020-05-02 | 2021-03-09 | Андрей Александрович Иващенко | Противо-РНК вирусное, в том числе противокоронавирусное средство - замещенный хиноксалин, фармацевтическая композиция и применения |
| RU2731932C1 (ru) | 2020-05-07 | 2020-09-09 | Общество с ограниченной ответственностью "Кромис" (ООО "Кромис") | Противо-COVID-19 (SARS-CoV-2) вирусная фармацевтическая композиция |
| EP4159215A4 (en) | 2020-05-27 | 2023-11-22 | FUJIFILM Toyama Chemical Co., Ltd. | THERAPEUTIC AGENT FOR RNA VIRAL INFECTION OBTAINED BY COMBINATION OF A PYRAZINE DERIVATIVE AND A THIOPURINE DERIVATIVE |
| CN111704582B (zh) * | 2020-06-23 | 2021-06-11 | 杭州煌森生物科技有限公司 | 一种法匹拉韦及其衍生物的制备方法 |
| WO2022125006A1 (en) | 2020-12-08 | 2022-06-16 | Santa Farma Ilac Sanayii A.S. | High drug load compositions of favipiravir |
| CN116761591A (zh) | 2020-12-18 | 2023-09-15 | 富士胶片富山化学株式会社 | 药物组合物 |
| US20240041867A1 (en) | 2020-12-18 | 2024-02-08 | Fujifilm Toyama Chemical Co., Ltd. | Pharmaceutical composition |
| EP4321163A4 (en) | 2021-04-08 | 2025-03-12 | FUJIFILM Toyama Chemical Co., Ltd. | Therapeutic agent for coronavirus infection |
| US20240245679A1 (en) | 2021-05-14 | 2024-07-25 | Fujifilm Toyama Chemical Co., Ltd. | Agent for treating infectious diseases against mutant viruses of novel coronavirus |
| US20240325386A1 (en) | 2021-07-30 | 2024-10-03 | Fujifilm Toyama Chemical Co., Ltd. | Therapeutic agent for covid-19 |
| CN117164528B (zh) * | 2023-08-14 | 2025-11-18 | 山东大学 | 一种法匹拉韦水合物晶体及其制备方法和应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3472848A (en) * | 1966-11-17 | 1969-10-14 | Merck & Co Inc | 3-hydroxy and 3-mercapto-pyrazinoyl-guanidines,corresponding ethers and thioethers and processes for their preparation |
| US3631036A (en) * | 1969-11-04 | 1971-12-28 | American Home Prod | 5-amino-2 6-substituted-7h-pyrrolo(2 3-d) pyrimidines and related compounds |
| US3745161A (en) * | 1970-04-20 | 1973-07-10 | Merck & Co Inc | Phenyl-hydroxy-pyrazine carboxylic acids and derivatives |
| US4661145A (en) * | 1977-03-10 | 1987-04-28 | Rohm And Haas Company | Plant growth regulating 1-aryl-1,4-dihydro-4-oxo(thio)-pyridazines |
| JPS5620576A (en) * | 1979-07-27 | 1981-02-26 | Nippon Soda Co Ltd | Pyrimidine derivative and selective herbicide |
| CA1138872A (en) * | 1979-07-30 | 1983-01-04 | Rohm And Haas Company | Process for the preparation of 1-aryl-1,4- dihydro-4-oxopyridazine-3-carboxamides |
| US4545810A (en) * | 1980-08-07 | 1985-10-08 | Sds Biotech Corporation | Herbicidal and plant growth regulant diphenylpyridazinones |
| US4404203A (en) * | 1981-05-14 | 1983-09-13 | Warner-Lambert Company | Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents |
| US4565814A (en) * | 1983-01-28 | 1986-01-21 | Sanofi | Pyridazine derivatives having a psychotropic action and compositions |
| US5268389A (en) * | 1989-10-16 | 1993-12-07 | Uniroyal Chemical Company, Inc. | Thiocarboxylate ester compounds compositions containing the same |
| MX9202022A (es) * | 1991-05-01 | 1992-11-01 | Otsuka Pharma Co Ltd | Derivados de pirazina y proceso para su preparacion. |
| FR2705344B1 (fr) | 1993-05-17 | 1995-06-30 | Synthelabo | Dérivés de 2-aminopyrazine-5-carboxamide, leur préparation et leur application en thérapeutique. |
| US5597823A (en) * | 1995-01-27 | 1997-01-28 | Abbott Laboratories | Tricyclic substituted hexahydrobenz [e]isoindole alpha-1 adrenergic antagonists |
| JPH09216883A (ja) * | 1996-02-09 | 1997-08-19 | Fujisawa Pharmaceut Co Ltd | ピラゾロピリジン化合物および該化合物を含有する医薬 |
| US6159980A (en) * | 1996-09-16 | 2000-12-12 | Dupont Pharmaceuticals Company | Pyrazinones and triazinones and their derivatives thereof |
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1999
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- 1999-08-18 CN CNB2004100325508A patent/CN1275947C/zh not_active Expired - Lifetime
- 1999-08-18 DE DE69937405T patent/DE69937405T2/de not_active Expired - Lifetime
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- 1999-08-18 AT AT99938504T patent/ATE376418T1/de active
- 1999-08-18 RU RU2001104536/15A patent/RU2224520C2/ru active
- 1999-08-18 EP EP99938504A patent/EP1112743B1/en not_active Expired - Lifetime
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- 1999-08-18 WO PCT/JP1999/004429 patent/WO2000010569A1/ja not_active Ceased
- 1999-08-18 DK DK99938504T patent/DK1112743T3/da active
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- 1999-08-18 AU AU53004/99A patent/AU756635B2/en not_active Expired
- 1999-08-18 KR KR1020017001690A patent/KR100585240B1/ko not_active Expired - Lifetime
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2001
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