CA1045974A - Creme pharmaceutique sans huile - Google Patents

Creme pharmaceutique sans huile

Info

Publication number: CA1045974A
Authority: CA; Canada
Prior art keywords: composition; alpha; beta; water; total weight
Prior art date: 1973-04-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA196,544A

Other languages

English (en)

Inventor

Michael J. Busse

Michael H. Franks

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Glaxo Laboratories Ltd

Original Assignee

Glaxo Laboratories Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1973-04-02

Filing date

1974-04-01

Publication date

1979-01-09

1974-04-01 Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd

1979-01-09 Application granted granted Critical

1979-01-09 Publication of CA1045974A publication Critical patent/CA1045974A/fr

Status Expired legal-status Critical Current

Links

239000008250 pharmaceutical cream Substances 0.000 title claims abstract description 6
239000000203 mixture Substances 0.000 claims abstract description 82
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 25
239000002904 solvent Substances 0.000 claims abstract description 19
239000006185 dispersion Substances 0.000 claims abstract description 7
239000002260 anti-inflammatory agent Substances 0.000 claims abstract description 6
239000008346 aqueous phase Substances 0.000 claims abstract description 6
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 21
239000004094 surface-active agent Substances 0.000 claims description 15
150000003431 steroids Chemical class 0.000 claims description 10
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 9
239000003981 vehicle Substances 0.000 claims description 7
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 5
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 5
229960002537 betamethasone Drugs 0.000 claims description 4
239000003795 chemical substances by application Substances 0.000 claims description 4
229920001223 polyethylene glycol Polymers 0.000 claims description 4
ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims description 4
150000002191 fatty alcohols Chemical class 0.000 claims description 3
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
125000000129 anionic group Chemical group 0.000 claims description 2
UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 claims description 2
229960000870 betamethasone benzoate Drugs 0.000 claims description 2
SOQJPQZCPBDOMF-YCUXZELOSA-N betamethasone benzoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(F)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@@H]1C)C(=O)CO)C(=O)C1=CC=CC=C1 SOQJPQZCPBDOMF-YCUXZELOSA-N 0.000 claims description 2
SNHRLVCMMWUAJD-SUYDQAKGSA-N betamethasone valerate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(OC(=O)CCCC)[C@@]1(C)C[C@@H]2O SNHRLVCMMWUAJD-SUYDQAKGSA-N 0.000 claims description 2
230000002209 hydrophobic effect Effects 0.000 claims description 2
239000007788 liquid Substances 0.000 claims description 2
229960004584 methylprednisolone Drugs 0.000 claims description 2
150000004671 saturated fatty acids Chemical class 0.000 claims description 2
239000002202 Polyethylene glycol Substances 0.000 claims 2
KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 claims 1
ZAQGQQMIBBCIRM-RDEWRQEPSA-N [(8s,9r,10s,11s,13s,14s,16s,17r)-17-acetyl-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(C)=O)(OC(=O)CC)[C@@]1(C)C[C@@H]2O ZAQGQQMIBBCIRM-RDEWRQEPSA-N 0.000 claims 1
230000000875 corresponding effect Effects 0.000 claims 1
SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims 1
150000004668 long chain fatty acids Chemical class 0.000 claims 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 1
239000003814 drug Substances 0.000 abstract description 22
229940079593 drug Drugs 0.000 abstract description 22
239000006071 cream Substances 0.000 abstract description 20
239000003921 oil Substances 0.000 abstract description 6
230000000699 topical effect Effects 0.000 abstract description 4
239000001993 wax Substances 0.000 description 16
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
-1 saturated fatty acid esters Chemical class 0.000 description 8
235000011187 glycerol Nutrition 0.000 description 7
GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 7
229960004063 propylene glycol Drugs 0.000 description 7
235000013772 propylene glycol Nutrition 0.000 description 7
DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 6
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 6
CFKMVGJGLGKFKI-UHFFFAOYSA-N 4-chloro-m-cresol Chemical compound CC1=CC(O)=CC=C1Cl CFKMVGJGLGKFKI-UHFFFAOYSA-N 0.000 description 6
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
239000000243 solution Substances 0.000 description 6
229940082500 cetostearyl alcohol Drugs 0.000 description 5
239000004615 ingredient Substances 0.000 description 5
238000000034 method Methods 0.000 description 5
239000012071 phase Substances 0.000 description 5
OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 5
230000000694 effects Effects 0.000 description 4
238000009472 formulation Methods 0.000 description 4
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 4
238000003756 stirring Methods 0.000 description 4
IQXJCCZJOIKIAD-UHFFFAOYSA-N 1-(2-methoxyethoxy)hexadecane Chemical compound CCCCCCCCCCCCCCCCOCCOC IQXJCCZJOIKIAD-UHFFFAOYSA-N 0.000 description 3
QIEPWCSVQYUPIY-LEKSSAKUSA-N Delta(1)-progesterone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 QIEPWCSVQYUPIY-LEKSSAKUSA-N 0.000 description 3
239000004166 Lanolin Substances 0.000 description 3
229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
235000013871 bee wax Nutrition 0.000 description 3
239000012166 beeswax Substances 0.000 description 3
229950009789 cetomacrogol 1000 Drugs 0.000 description 3
229960002242 chlorocresol Drugs 0.000 description 3
150000002334 glycols Chemical class 0.000 description 3
235000019388 lanolin Nutrition 0.000 description 3
229940039717 lanolin Drugs 0.000 description 3
238000004519 manufacturing process Methods 0.000 description 3
239000011734 sodium Substances 0.000 description 3
229910052708 sodium Inorganic materials 0.000 description 3
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
235000021355 Stearic acid Nutrition 0.000 description 2
239000013543 active substance Substances 0.000 description 2
150000001298 alcohols Chemical class 0.000 description 2
229940088710 antibiotic agent Drugs 0.000 description 2
239000003125 aqueous solvent Substances 0.000 description 2
125000004432 carbon atom Chemical group C* 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
150000002500 ions Chemical class 0.000 description 2
239000000314 lubricant Substances 0.000 description 2
239000000463 material Substances 0.000 description 2
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 2
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 2
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
239000003381 stabilizer Substances 0.000 description 2
239000008117 stearic acid Substances 0.000 description 2
239000000126 substance Substances 0.000 description 2
DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 description 1
YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 1
FDCJDKXCCYFOCV-UHFFFAOYSA-N 1-hexadecoxyhexadecane Chemical compound CCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCC FDCJDKXCCYFOCV-UHFFFAOYSA-N 0.000 description 1
KMZHZAAOEWVPSE-UHFFFAOYSA-N 2,3-dihydroxypropyl acetate Chemical compound CC(=O)OCC(O)CO KMZHZAAOEWVPSE-UHFFFAOYSA-N 0.000 description 1
HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
ZHMASVAJFJFFLS-UHFFFAOYSA-N 5-chloropyridin-3-amine Chemical compound NC1=CN=CC(Cl)=C1 ZHMASVAJFJFFLS-UHFFFAOYSA-N 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
DUFKCOQISQKSAV-UHFFFAOYSA-N Polypropylene glycol (m w 1,200-3,000) Chemical class CC(O)COC(C)CO DUFKCOQISQKSAV-UHFFFAOYSA-N 0.000 description 1
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
239000004141 Sodium laurylsulphate Substances 0.000 description 1
ITYMTTQVNYAJAA-XGQKBEPLSA-N [(8s,9r,10s,11s,13s,14s,16s,17r)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(OC(=O)CC)[C@@]1(C)C[C@@H]2O ITYMTTQVNYAJAA-XGQKBEPLSA-N 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
239000002253 acid Substances 0.000 description 1
239000000654 additive Substances 0.000 description 1
239000003470 adrenal cortex hormone Substances 0.000 description 1
230000002411 adverse Effects 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
230000000844 anti-bacterial effect Effects 0.000 description 1
230000003110 anti-inflammatory effect Effects 0.000 description 1
229940121375 antifungal agent Drugs 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 description 1
229940092705 beclomethasone Drugs 0.000 description 1
125000002511 behenyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000004359 castor oil Substances 0.000 description 1
235000019438 castor oil Nutrition 0.000 description 1
229960000541 cetyl alcohol Drugs 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
238000001816 cooling Methods 0.000 description 1
RKHQGWMMUURILY-UHRZLXHJSA-N cortivazol Chemical compound C([C@H]1[C@@H]2C[C@H]([C@]([C@@]2(C)C[C@H](O)[C@@H]1[C@@]1(C)C2)(O)C(=O)COC(C)=O)C)=C(C)C1=CC1=C2C=NN1C1=CC=CC=C1 RKHQGWMMUURILY-UHRZLXHJSA-N 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
239000002270 dispersing agent Substances 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
229960001484 edetic acid Drugs 0.000 description 1
238000004945 emulsification Methods 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
150000002170 ethers Chemical class 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
229960001347 fluocinolone acetonide Drugs 0.000 description 1
FEBLZLNTKCEFIT-VSXGLTOVSA-N fluocinolone acetonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O FEBLZLNTKCEFIT-VSXGLTOVSA-N 0.000 description 1
YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 1
SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
150000002314 glycerols Chemical class 0.000 description 1
125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
229940075507 glyceryl monostearate Drugs 0.000 description 1
125000003827 glycol group Chemical group 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
239000003906 humectant Substances 0.000 description 1
230000004968 inflammatory condition Effects 0.000 description 1
229940057995 liquid paraffin Drugs 0.000 description 1
229960005015 local anesthetics Drugs 0.000 description 1
150000002731 mercury compounds Chemical class 0.000 description 1
239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
229960002216 methylparaben Drugs 0.000 description 1
238000002156 mixing Methods 0.000 description 1
XONPDZSGENTBNJ-UHFFFAOYSA-N molecular hydrogen;sodium Chemical compound [Na].[H][H] XONPDZSGENTBNJ-UHFFFAOYSA-N 0.000 description 1
239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
238000005192 partition Methods 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
229940113116 polyethylene glycol 1000 Drugs 0.000 description 1
229920000166 polytrimethylene carbonate Polymers 0.000 description 1
229960005205 prednisolone Drugs 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
229960003415 propylparaben Drugs 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
235000003441 saturated fatty acids Nutrition 0.000 description 1
229920002545 silicone oil Polymers 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
239000004296 sodium metabisulphite Substances 0.000 description 1
235000010262 sodium metabisulphite Nutrition 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
229940012831 stearyl alcohol Drugs 0.000 description 1
239000000725 suspension Substances 0.000 description 1
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
229960004906 thiomersal Drugs 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
238000009736 wetting Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

CA196,544A 1973-04-02 1974-04-01 Creme pharmaceutique sans huile Expired CA1045974A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB1575873A GB1478009A (en)	1973-04-02	1973-04-02	Pharmaceutical compositions

Publications (1)

Publication Number	Publication Date
CA1045974A true CA1045974A (fr)	1979-01-09

Family

ID=10064952

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA196,544A Expired CA1045974A (fr)	1973-04-02	1974-04-01	Creme pharmaceutique sans huile

Country Status (11)

Country	Link
JP (1)	JPS589081B2 (fr)
BE (1)	BE813153A (fr)
CA (1)	CA1045974A (fr)
DE (1)	DE2347243A1 (fr)
DK (1)	DK144358C (fr)
FR (1)	FR2222998B1 (fr)
GB (1)	GB1478009A (fr)
IE (1)	IE39113B1 (fr)
LU (1)	LU69751A1 (fr)
NL (1)	NL7404378A (fr)
ZA (1)	ZA742064B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE8004580L (sv) *	1980-06-19	1981-12-20	Draco Ab	Farmaceutisk beredning
KR830005852A (ko) *	1980-07-18	1983-09-14	미첼 페터 잭슨	피부와 점막의 비루스 감염치료에 적합한 국소치료제의 제조방법
GB2080106B (en) *	1980-07-18	1984-03-07	Weelcome Foundation Ltd	Acyclovin preparations
DE3225848A1 (de) *	1982-07-07	1984-01-19	Schering AG, 1000 Berlin und 4709 Bergkamen	Kortikoidhaltige zubereitung zur topischen applikation
US4868169A (en) *	1987-11-13	1989-09-19	E. R. Squibb & Sons, Inc.	Steroid cream formulation
LU87457A1 (fr) *	1989-02-24	1990-09-19	Oreal	Utilisation,comme composition cosmetique pour cheveux,d'une microdispersion de cire,et procede de traitement des cheveux avec une telle composition
US8491875B2 (en) *	2010-08-18	2013-07-23	Kao Corporation	Hair volumizing compositions

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GB765600A (en) *	1954-01-15	1957-01-09	Drug Houses Of Australia Ltd	Salves for veterinary use
GB903407A (en) *	1958-07-25	1962-08-15	Upjohn Co	Improvements in or relating to antibacterial antiperspirant compositions
DE1198011B (de) *	1962-08-04	1965-08-05	Iwao Kawakami	Hautpflegemittel
BR6789910D0 (pt) *	1966-10-17	1973-05-17	Fmc Corp	Processo para preparar comestiveis contendo colagenio microcristalino

1973
- 1973-04-02 GB GB1575873A patent/GB1478009A/en not_active Expired
- 1973-09-19 DE DE19732347243 patent/DE2347243A1/de active Pending
1974
- 1974-04-01 ZA ZA00742064A patent/ZA742064B/xx unknown
- 1974-04-01 NL NL7404378A patent/NL7404378A/xx unknown
- 1974-04-01 DK DK179474A patent/DK144358C/da not_active IP Right Cessation
- 1974-04-01 LU LU69751A patent/LU69751A1/xx unknown
- 1974-04-01 FR FR7411572A patent/FR2222998B1/fr not_active Expired
- 1974-04-01 BE BE142726A patent/BE813153A/fr not_active IP Right Cessation
- 1974-04-01 CA CA196,544A patent/CA1045974A/fr not_active Expired
- 1974-04-01 IE IE00703/74A patent/IE39113B1/xx unknown
- 1974-04-01 JP JP49035716A patent/JPS589081B2/ja not_active Expired

Also Published As

Publication number	Publication date
DE2347243A1 (de)	1974-10-10
LU69751A1 (fr)	1974-07-17
GB1478009A (en)	1977-06-29
AU6724674A (en)	1975-10-02
IE39113B1 (en)	1978-08-02
JPS589081B2 (ja)	1983-02-18
NL7404378A (fr)	1974-10-04
FR2222998A1 (fr)	1974-10-25
DK144358B (da)	1982-03-01
JPS5058218A (fr)	1975-05-21
FR2222998B1 (fr)	1977-11-04
IE39113L (en)	1974-10-02
DK144358C (da)	1984-04-09
ZA742064B (en)	1975-03-26
BE813153A (fr)	1974-10-01

Publication	Publication Date	Title
US4305936A (en)	1981-12-15	Topical corticosteroid formulations
US4918065A (en)	1990-04-17	Corticoid-containing preparation for topical application
US4363806A (en)	1982-12-14	Pharmaceutical composition
AU774600B2 (en)	2004-07-01	Pharmaceutical composition
US7078058B2 (en)	2006-07-18	Corticosteroid-containing pharmaceutical composition
US4083974A (en)	1978-04-11	Topical steroidal anti-inflammatory preparations containing polyoxypropylene 15 stearyl ether
WO1991008733A1 (fr)	1991-06-27	Bases stables de creme et de lotion pour medicaments lipophiles
CA1085725A (fr)	1980-09-16	Steroide pour applications locales
CA1139665A (fr)	1983-01-18	Corticosteroide dans un excipient de sebacate
DE2309202A1 (de)	1974-08-29	Arzneiformen mit mikroverkapseltem arzneimittelwirkstoff
CA1182048A (fr)	1985-02-05	Compose pharmaceutique a usage local contenant des steroides anti-inflammatoires
JPH06128159A (ja)	1994-05-10	外用剤
JPH0459292B2 (fr)	1992-09-21
CA1045974A (fr)	1979-01-09	Creme pharmaceutique sans huile
JP2004506023A (ja)	2004-02-26	皮膚科用製剤
IT9067434A1 (it)	1991-12-14	Procedimento per migliorare l'efficacia terapeutica di corticosteroidi liposolubili e composizione per l'attuazione di tale procedimento
RU2157214C2 (ru)	2000-10-10	Противовоспалительное и антимикробное лекарственное средство для местного применения
JPH0676327B2 (ja)	1994-09-28	ステロイド軟膏製剤
JPH0676328B2 (ja)	1994-09-28	ステロイドクリ−ム製剤
EP0146065B1 (fr)	1989-07-12	Crème de bêtaméthazone dipropionate
JP3150021B2 (ja)	2001-03-26	皮膚外用クリーム剤
US6300326B1 (en)	2001-10-09	Composition and method for control and treatment of cutaneous inflammation
CA1146863A (fr)	1983-05-24	Onguent a usage local
DE4344697A1 (de)	1995-06-29	Corticosteroide enthaltende W/O-Lotion
JP3776466B2 (ja)	2006-05-17	非水系油性軟膏基剤