CA1052697A - Compose therapeutique contre la mastite chez les mammiferes - Google Patents

Compose therapeutique contre la mastite chez les mammiferes

Info

Publication number: CA1052697A
Authority: CA; Canada
Prior art keywords: fatty acid; composition; oil; group; mastitis
Prior art date: 1974-03-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA221,421A

Other languages

English (en)

Inventor

Jack T. Bryan

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pharmacia and Upjohn Co

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-03-29

Filing date

1975-03-06

Publication date

1979-04-17

1975-03-06 Application filed by Upjohn Co filed Critical Upjohn Co

1979-04-17 Application granted granted Critical

1979-04-17 Publication of CA1052697A publication Critical patent/CA1052697A/fr

Status Expired legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims abstract description 30
208000004396 mastitis Diseases 0.000 title claims abstract description 28
241001465754 Metazoa Species 0.000 title claims abstract description 10
235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 24
239000000194 fatty acid Substances 0.000 claims abstract description 24
229930195729 fatty acid Natural products 0.000 claims abstract description 24
-1 fatty acid ester Chemical class 0.000 claims abstract description 19
239000003814 drug Substances 0.000 claims abstract description 16
238000001802 infusion Methods 0.000 claims abstract description 14
235000013336 milk Nutrition 0.000 claims abstract description 10
239000008267 milk Substances 0.000 claims abstract description 10
210000004080 milk Anatomy 0.000 claims abstract description 10
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical group CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 20
239000003921 oil Substances 0.000 claims description 19
235000019198 oils Nutrition 0.000 claims description 19
235000015112 vegetable and seed oil Nutrition 0.000 claims description 14
239000008158 vegetable oil Substances 0.000 claims description 14
235000019483 Peanut oil Nutrition 0.000 claims description 12
238000001035 drying Methods 0.000 claims description 12
239000000312 peanut oil Substances 0.000 claims description 12
239000003981 vehicle Substances 0.000 claims description 11
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 10
125000004432 carbon atom Chemical group C* 0.000 claims description 9
YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 claims description 8
SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 claims description 8
150000004665 fatty acids Chemical class 0.000 claims description 7
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
150000002763 monocarboxylic acids Chemical class 0.000 claims description 6
229920006395 saturated elastomer Polymers 0.000 claims description 6
229940114930 potassium stearate Drugs 0.000 claims description 5
ANBFRLKBEIFNQU-UHFFFAOYSA-M potassium;octadecanoate Chemical group [K+].CCCCCCCCCCCCCCCCCC([O-])=O ANBFRLKBEIFNQU-UHFFFAOYSA-M 0.000 claims description 5
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
235000011187 glycerol Nutrition 0.000 claims description 4
229910052708 sodium Inorganic materials 0.000 claims description 4
239000011734 sodium Substances 0.000 claims description 4
WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims description 3
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 3
229910052744 lithium Inorganic materials 0.000 claims description 3
229910052700 potassium Inorganic materials 0.000 claims description 3
239000011591 potassium Substances 0.000 claims description 3
150000001298 alcohols Chemical class 0.000 claims description 2
150000002148 esters Chemical class 0.000 claims description 2
229920001223 polyethylene glycol Polymers 0.000 claims description 2
238000000034 method Methods 0.000 abstract description 7
238000011282 treatment Methods 0.000 description 7
239000002480 mineral oil Substances 0.000 description 6
235000010446 mineral oil Nutrition 0.000 description 6
229940114926 stearate Drugs 0.000 description 5
235000017060 Arachis glabrata Nutrition 0.000 description 4
244000105624 Arachis hypogaea Species 0.000 description 4
235000010777 Arachis hypogaea Nutrition 0.000 description 4
235000018262 Arachis monticola Nutrition 0.000 description 4
201000006747 infectious mononucleosis Diseases 0.000 description 4
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 4
235000020232 peanut Nutrition 0.000 description 4
238000003756 stirring Methods 0.000 description 4
HSRJKNPTNIJEKV-UHFFFAOYSA-N Guaifenesin Chemical compound COC1=CC=CC=C1OCC(O)CO HSRJKNPTNIJEKV-UHFFFAOYSA-N 0.000 description 3
210000005075 mammary gland Anatomy 0.000 description 3
238000004519 manufacturing process Methods 0.000 description 3
KZDCMKVLEYCGQX-UDPGNSCCSA-N 2-(diethylamino)ethyl 4-aminobenzoate;(2s,5r,6r)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;hydrate Chemical compound O.CCN(CC)CCOC(=O)C1=CC=C(N)C=C1.N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 KZDCMKVLEYCGQX-UDPGNSCCSA-N 0.000 description 2
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 2
241000283690 Bos taurus Species 0.000 description 2
208000031462 Bovine Mastitis Diseases 0.000 description 2
244000020518 Carthamus tinctorius Species 0.000 description 2
235000003255 Carthamus tinctorius Nutrition 0.000 description 2
YJQPYGGHQPGBLI-UHFFFAOYSA-N Novobiocin Natural products O1C(C)(C)C(OC)C(OC(N)=O)C(O)C1OC1=CC=C(C(O)=C(NC(=O)C=2C=C(CC=C(C)C)C(O)=CC=2)C(=O)O2)C2=C1C YJQPYGGHQPGBLI-UHFFFAOYSA-N 0.000 description 2
241000194017 Streptococcus Species 0.000 description 2
210000000481 breast Anatomy 0.000 description 2
239000000084 colloidal system Substances 0.000 description 2
125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 2
229940075507 glyceryl monostearate Drugs 0.000 description 2
239000011630 iodine Substances 0.000 description 2
229910052740 iodine Inorganic materials 0.000 description 2
229940057995 liquid paraffin Drugs 0.000 description 2
239000001788 mono and diglycerides of fatty acids Substances 0.000 description 2
YJQPYGGHQPGBLI-KGSXXDOSSA-N novobiocin Chemical compound O1C(C)(C)[C@H](OC)[C@@H](OC(N)=O)[C@@H](O)[C@@H]1OC1=CC=C(C(O)=C(NC(=O)C=2C=C(CC=C(C)C)C(O)=CC=2)C(=O)O2)C2=C1C YJQPYGGHQPGBLI-KGSXXDOSSA-N 0.000 description 2
229960002950 novobiocin Drugs 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
239000008159 sesame oil Substances 0.000 description 2
235000011803 sesame oil Nutrition 0.000 description 2
239000003549 soybean oil Substances 0.000 description 2
235000012424 soybean oil Nutrition 0.000 description 2
UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
210000001519 tissue Anatomy 0.000 description 2
235000013311 vegetables Nutrition 0.000 description 2
229930186147 Cephalosporin Natural products 0.000 description 1
239000004099 Chlortetracycline Substances 0.000 description 1
241000186216 Corynebacterium Species 0.000 description 1
241000588724 Escherichia coli Species 0.000 description 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
206010061218 Inflammation Diseases 0.000 description 1
OJMMVQQUTAEWLP-UHFFFAOYSA-N Lincomycin Natural products CN1CC(CCC)CC1C(=O)NC(C(C)O)C1C(O)C(O)C(O)C(SC)O1 OJMMVQQUTAEWLP-UHFFFAOYSA-N 0.000 description 1
229930193140 Neomycin Natural products 0.000 description 1
WWPRGAYLRGSOSU-RNROJPEYSA-M Novobiocin sodium Chemical compound [Na+].O1C(C)(C)[C@H](OC)[C@@H](OC(N)=O)[C@@H](O)[C@@H]1OC1=CC=C(C([O-])=C(NC(=O)C=2C=C(CC=C(C)C)C(O)=CC=2)C(=O)O2)C2=C1C WWPRGAYLRGSOSU-RNROJPEYSA-M 0.000 description 1
229930182555 Penicillin Natural products 0.000 description 1
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
108010040201 Polymyxins Proteins 0.000 description 1
241000589516 Pseudomonas Species 0.000 description 1
241001354013 Salmonella enterica subsp. enterica serovar Enteritidis Species 0.000 description 1
239000004098 Tetracycline Substances 0.000 description 1
240000008042 Zea mays Species 0.000 description 1
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
235000002017 Zea mays subsp mays Nutrition 0.000 description 1
LPQOADBMXVRBNX-UHFFFAOYSA-N ac1ldcw0 Chemical compound Cl.C1CN(C)CCN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN3CCSC1=C32 LPQOADBMXVRBNX-UHFFFAOYSA-N 0.000 description 1
239000002253 acid Substances 0.000 description 1
230000000845 anti-microbial effect Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
229940124587 cephalosporin Drugs 0.000 description 1
150000001780 cephalosporins Chemical class 0.000 description 1
235000013351 cheese Nutrition 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
CYDMQBQPVICBEU-UHFFFAOYSA-N chlorotetracycline Natural products C1=CC(Cl)=C2C(O)(C)C3CC4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-UHFFFAOYSA-N 0.000 description 1
229960004475 chlortetracycline Drugs 0.000 description 1
CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 description 1
235000019365 chlortetracycline Nutrition 0.000 description 1
229960002227 clindamycin Drugs 0.000 description 1
KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 description 1
238000001816 cooling Methods 0.000 description 1
235000005822 corn Nutrition 0.000 description 1
235000005687 corn oil Nutrition 0.000 description 1
239000002285 corn oil Substances 0.000 description 1
235000012343 cottonseed oil Nutrition 0.000 description 1
239000002385 cottonseed oil Substances 0.000 description 1
235000020247 cow milk Nutrition 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
238000003745 diagnosis Methods 0.000 description 1
150000002334 glycols Chemical class 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
229930195733 hydrocarbon Natural products 0.000 description 1
150000002430 hydrocarbons Chemical class 0.000 description 1
POUMFISTNHIPTI-BOMBIWCESA-N hydron;(2s,4r)-n-[(1r,2r)-2-hydroxy-1-[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;chloride Chemical compound Cl.CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@@H](C)O)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 POUMFISTNHIPTI-BOMBIWCESA-N 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
230000004968 inflammatory condition Effects 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
OJMMVQQUTAEWLP-KIDUDLJLSA-N lincomycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@@H](C)O)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 OJMMVQQUTAEWLP-KIDUDLJLSA-N 0.000 description 1
229960005287 lincomycin Drugs 0.000 description 1
229960001595 lincomycin hydrochloride Drugs 0.000 description 1
239000000944 linseed oil Substances 0.000 description 1
235000021388 linseed oil Nutrition 0.000 description 1
239000007788 liquid Substances 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
244000005700 microbiome Species 0.000 description 1
239000011707 mineral Substances 0.000 description 1
229960004927 neomycin Drugs 0.000 description 1
239000004006 olive oil Substances 0.000 description 1
235000008390 olive oil Nutrition 0.000 description 1
229940049954 penicillin Drugs 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
231100000241 scar Toxicity 0.000 description 1
241000894007 species Species 0.000 description 1
229960005322 streptomycin Drugs 0.000 description 1
229960002180 tetracycline Drugs 0.000 description 1
229930101283 tetracycline Natural products 0.000 description 1
235000019364 tetracycline Nutrition 0.000 description 1
150000003522 tetracyclines Chemical class 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
150000004670 unsaturated fatty acids Chemical class 0.000 description 1
235000021122 unsaturated fatty acids Nutrition 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0041—Mammary glands, e.g. breasts, udder; Intramammary administration

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA221,421A 1974-03-29 1975-03-06 Compose therapeutique contre la mastite chez les mammiferes Expired CA1052697A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US45603074A	1974-03-29	1974-03-29

Publications (1)

Publication Number	Publication Date
CA1052697A true CA1052697A (fr)	1979-04-17

Family

ID=23811160

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA221,421A Expired CA1052697A (fr)	1974-03-29	1975-03-06	Compose therapeutique contre la mastite chez les mammiferes

Country Status (8)

Country	Link
BE (1)	BE827361A (fr)
CA (1)	CA1052697A (fr)
DE (1)	DE2512391C2 (fr)
DK (1)	DK143438C (fr)
FR (1)	FR2265408B1 (fr)
GB (1)	GB1456349A (fr)
NL (1)	NL7502808A (fr)
ZA (1)	ZA751451B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1547164A (en) *	1975-08-14	1979-06-06	Beecham Group Ltd	Veterinary compositions
IT1190445B (it) *	1985-11-08	1988-02-16	Fatro Spa	Composizioni veterinarie a base di agenti antimicrobici e loro impiego
SE457693B (sv) *	1986-07-01	1989-01-23	Drilletten Ab	Komposition med reglerad frigoering vari ett biologiskt material aer loest eller dispergerat i en l2-fas
DK16290D0 (da) *	1990-01-19	1990-01-19	Spindel & Spinnfluegelfab Veb	Pattebehandlingsmiddel navnlig til bekaempelse af mastitis
DK0673239T3 (da) *	1992-12-08	1999-03-22	Bimeda Res Dev Ltd	Vandig antibiotisk sammensætning til veterinær anvendelse
EP0926954A1 (fr) *	1996-09-06	1999-07-07	Minnesota Mining And Manufacturing Company	Compositions antimicrobiennes
ATE223201T1 (de)	1996-12-18	2002-09-15	Bimeda Res & Dev Ltd	Infektionsfreie intramammäre tierarzneimittelzusammenstellung
FR2833500A1 (fr) *	2001-12-17	2003-06-20	Veyron Et Froment Lab	Gel huileux anhydre stabilise
NZ519112A (en) *	2002-05-22	2004-12-24	Interag	Drug delivery device for administration of active agent to mammary gland cavity
US7842791B2 (en)	2002-12-19	2010-11-30	Nancy Jean Britten	Dispersible pharmaceutical compositions
US20040197422A1 (en) *	2002-12-20	2004-10-07	Pfizer Inc	Veterinary compositions for treating mastitis
GB0229642D0 (en) *	2002-12-20	2003-01-22	Pfizer Ltd	Veterinary compositions for treating mastitis
CA2824121C (fr)	2004-02-02	2016-11-22	Zoetis Broomhill Ip Limited	Procede et dispositif de traitement du canal du trayon d'un animal
AR054639A1 (es)	2004-02-02	2007-07-11	Bimeda Res & Dev Ltd	Un metodo y dispositivo
EP2450045A1 (fr)	2006-10-10	2012-05-09	Wisconsin Alumni Research Foundation	Formule d'étanchéité de tétine intra-mammaire et son procédé d'utilisation pour réduire ou supprimer les défauts visuels chez les fromages vieillis
NZ595229A (en) *	2009-04-08	2012-08-31	Wisconsin Alumni Res Found	Intra-mammary teat sealant formulation and method of using same to reduce or eliminate visual defects in aged cheeses

1975
- 1975-03-06 CA CA221,421A patent/CA1052697A/fr not_active Expired
- 1975-03-10 NL NL7502808A patent/NL7502808A/xx not_active Application Discontinuation
- 1975-03-10 ZA ZA00751451A patent/ZA751451B/xx unknown
- 1975-03-14 DK DK106175A patent/DK143438C/da not_active IP Right Cessation
- 1975-03-21 DE DE2512391A patent/DE2512391C2/de not_active Expired
- 1975-03-28 BE BE154927A patent/BE827361A/fr not_active IP Right Cessation
- 1975-03-28 FR FR7509948A patent/FR2265408B1/fr not_active Expired
- 1975-04-01 GB GB1331075A patent/GB1456349A/en not_active Expired

Also Published As

Publication number	Publication date
NL7502808A (nl)	1975-10-01
FR2265408A1 (fr)	1975-10-24
FR2265408B1 (fr)	1978-08-04
BE827361A (fr)	1975-09-29
GB1456349A (en)	1976-11-24
ZA751451B (en)	1976-02-25
AU7909675A (en)	1976-09-16
DE2512391C2 (de)	1986-10-09
DK143438C (da)	1981-12-21
DK106175A (fr)	1975-09-30
DE2512391A1 (de)	1975-10-02
DK143438B (da)	1981-08-24

Publication	Publication Date	Title
CA1052697A (fr)	1979-04-17	Compose therapeutique contre la mastite chez les mammiferes
EP0022289B1 (fr)	1983-06-22	Compositions polymères microbicides et leur utilisation dans des dispositifs médicaux
US4479795A (en)	1984-10-30	Antimicrobial polymer compositions
JP2632842B2 (ja)	1997-07-23	抗菌保存組成物
Iba et al.	1995	Studies on the use of a formic acid‐propionic acid mixture (Bio‐add™) to control experimental Salmonella infection in broiler chickens
CA2366793C (fr)	2009-06-02	Formulations du propofol presentant des caracteristiques microbiologiques renforcees
TWI504418B (zh)	2015-10-21	包含奧澤沙星之醫藥局部組成物及其用途
DE69715259T3 (de)	2015-08-20	Intramammäre tierarzneimittel ohne antiinfektiöse wirkstoffe
US4034099A (en)	1977-07-05	Compositions and method for treating mastitis in milk animals
CN107432834A (zh)	2017-12-05	一种具有抑菌效果的无防腐成分组合物及其制备方法和应用
CA2264286A1 (fr)	1998-03-12	Compositions antimicrobiennes
KR20110101138A (ko)	2011-09-15	에멀젼계 치료학적 국소 제형용 보존 시스템
DD255667A5 (de)	1988-04-13	Koeder fuer tiere
JP7090714B2 (ja)	2022-06-24	生体適合性材料
US4067967A (en)	1978-01-10	Composition for topical application to humans and animals
CN111249168A (zh)	2020-06-09	一种预防蚊虫叮咬的组合物及其制备方法
KR20220043794A (ko)	2022-04-05	소독용 겔 조성물 및 이의 제조 방법
ES2824477T3 (es)	2021-05-12	Composición emoliente
JP4398187B2 (ja)	2010-01-13	保湿性手袋およびその製造法
CH641351A5 (de)	1984-02-29	Rektal verabreichbares pharmazeutisches mittel.
ZA200300611B (en)	2004-04-22	Pharmaceutical composition having specific water activity.
DE651541C (de)	1937-11-11	Verfahren zum Aufbewahren saeurebildender Bakterienkulturen, insbesondere von Milchsaeurebakterien
RU2605631C1 (ru)	2016-12-27	Средство для профилактики мастита у крупного рогатого скота
EP2564861A1 (fr)	2013-03-06	Formule pharmaceutique de traitement de la mastite chez les mammifères
KR960030934A (ko)	1996-09-17	탈모방지, 발모촉진, 여드름치료 및 안드로겐성 피부질환 치료를 위한 조성물 및 그 제조방법