CA1185602A - Imidazodiazepines - Google Patents
ImidazodiazepinesInfo
- Publication number
- CA1185602A CA1185602A CA000394685A CA394685A CA1185602A CA 1185602 A CA1185602 A CA 1185602A CA 000394685 A CA000394685 A CA 000394685A CA 394685 A CA394685 A CA 394685A CA 1185602 A CA1185602 A CA 1185602A
- Authority
- CA
- Canada
- Prior art keywords
- signifies
- group
- butyl
- halogen
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
- C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH133981 | 1981-02-27 | ||
| CH134181 | 1981-02-27 | ||
| CH1338/81 | 1981-02-27 | ||
| CH1341/81 | 1981-02-27 | ||
| CH1342/81 | 1981-02-27 | ||
| CH134281 | 1981-02-27 | ||
| CH133881 | 1981-02-27 | ||
| CH1339/81 | 1981-02-27 | ||
| CH367581 | 1981-06-04 | ||
| CH3675/81 | 1981-06-04 | ||
| CH793481 | 1981-12-11 | ||
| CH7934/81 | 1981-12-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1185602A true CA1185602A (en) | 1985-04-16 |
Family
ID=27543637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000394685A Expired CA1185602A (en) | 1981-02-27 | 1982-01-21 | Imidazodiazepines |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4353827A (cs) |
| EP (1) | EP0059391B1 (cs) |
| KR (1) | KR890002624B1 (cs) |
| AU (1) | AU551891B2 (cs) |
| BR (1) | BR8201024A (cs) |
| CA (1) | CA1185602A (cs) |
| CS (1) | CS247064B2 (cs) |
| DE (1) | DE3263633D1 (cs) |
| DK (1) | DK168073B1 (cs) |
| FI (1) | FI73430C (cs) |
| HK (1) | HK23288A (cs) |
| IE (1) | IE52543B1 (cs) |
| IL (1) | IL65056A0 (cs) |
| MC (1) | MC1442A1 (cs) |
| NO (1) | NO157620C (cs) |
| NZ (1) | NZ199793A (cs) |
| PH (1) | PH19881A (cs) |
| PT (1) | PT74504B (cs) |
| YU (1) | YU45860B (cs) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MC1528A1 (fr) * | 1982-07-21 | 1984-04-13 | Hoffmann La Roche | Imidazobenzodiazepines |
| FI850191A7 (fi) * | 1984-01-19 | 1985-07-20 | Hoffmann La Roche | Imidatsodiatsepiini-johdannaisia. |
| DK174086D0 (da) * | 1986-04-16 | 1986-04-16 | Ferrosan As | Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme |
| CA1327008C (en) * | 1988-01-15 | 1994-02-15 | Walter Merz | Anti-psychotic imidazobenzodiazepine |
| CA1312825C (en) * | 1988-01-27 | 1993-01-19 | F. Hoffmann-La Roche Ag | Prevention or interruption of panic states with an imidazobenzodiazepine |
| CA2015336A1 (en) * | 1989-05-19 | 1990-11-19 | F. Hoffmann-La Roche Ag | Imidazodiazepines for the treatment of neurological symptoms |
| CA2055308A1 (en) * | 1990-11-29 | 1992-05-30 | F. Hoffmann-La Roche Ag | Imidazobenzodiazepine for the treatment of sleep disorders |
| JO2259B1 (en) * | 1999-05-12 | 2004-10-07 | اف. هوفمان- لاروش أيه جي | Method for the manufacture of diazapine derivatives |
| US7678818B2 (en) * | 2006-02-07 | 2010-03-16 | Hoffmann-La Roche Inc. | Anthranilamide and 2-amino-heteroarene-carboxamide compounds |
| US20090054412A1 (en) * | 2007-08-20 | 2009-02-26 | John Alan Kemp | Treatment of Sleep Disorders |
| WO2009024325A2 (en) * | 2007-08-20 | 2009-02-26 | Evotec Neurosciences Gmbh | Treatment of sleep disorders |
| US8697688B2 (en) | 2010-04-15 | 2014-04-15 | Seattle Genetics Inc. | Pyrrolobenzodiazepines used to treat proliferative diseases |
| MX391454B (es) | 2010-04-15 | 2025-03-05 | Seagen Inc | Compuesto de engarce-fármaco para conjugación a una unidad de ligando. |
| JP6170494B2 (ja) | 2011-09-20 | 2017-07-26 | メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ | ピロロベンゾジアゼピン |
| CN103998449A (zh) | 2011-10-14 | 2014-08-20 | 斯皮罗根有限公司 | 吡咯并苯并二氮杂卓 |
| ES2945932T3 (es) | 2011-10-14 | 2023-07-10 | Seagen Inc | Pirrolobenzodiazepinas y conjugados dirigidos |
| CA2850103C (en) | 2011-10-14 | 2019-09-10 | Spirogen Sarl | Pyrrolobenzodiazepines |
| WO2013055993A1 (en) | 2011-10-14 | 2013-04-18 | Seattle Genetics, Inc. | Pyrrolobenzodiazepines and targeted conjugates |
| CN103374000B (zh) * | 2012-04-13 | 2015-11-11 | 中国科学院广州生物医药与健康研究院 | 嘧啶并二氮杂卓类化合物及其药用组合物和应用 |
| EP2906249B1 (en) | 2012-10-12 | 2018-06-27 | MedImmune Limited | Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation |
| AU2013328674B2 (en) | 2012-10-12 | 2017-06-22 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
| AU2013328625B2 (en) | 2012-10-12 | 2016-12-15 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
| EP2906250B1 (en) | 2012-10-12 | 2018-05-30 | ADC Therapeutics SA | Pyrrolobenzodiazepine-anti-psma antibody conjugates |
| CN104837502B (zh) | 2012-10-12 | 2018-08-10 | 麦迪穆有限责任公司 | 吡咯并苯并二氮杂卓及其结合物 |
| DK2906298T3 (en) | 2012-10-12 | 2018-12-17 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
| US10695433B2 (en) | 2012-10-12 | 2020-06-30 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| US10751346B2 (en) | 2012-10-12 | 2020-08-25 | Medimmune Limited | Pyrrolobenzodiazepine—anti-PSMA antibody conjugates |
| ES2649990T3 (es) | 2012-10-12 | 2018-01-16 | Medimmune Limited | Conjugados de anticuerpos anti-CD22-pirrolobenzodiazepinas |
| EP3054986B1 (en) | 2013-10-11 | 2019-03-20 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| EP3054985B1 (en) | 2013-10-11 | 2018-12-26 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| US10010624B2 (en) | 2013-10-11 | 2018-07-03 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| GB201317981D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| GB201317982D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| AU2015352545B2 (en) | 2014-11-25 | 2020-10-15 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
| GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
| GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
| GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
| GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
| GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
| MX375569B (es) | 2017-02-08 | 2025-03-04 | Adc Therapeutics Sa | Conjugados de pirrolobenzodiazepinas y anticuerpos |
| PT3612537T (pt) | 2017-04-18 | 2022-08-29 | Medimmune Ltd | Conjugados de pirrolobenzodiazepina |
| ES2977788T3 (es) | 2017-04-20 | 2024-08-30 | Adc Therapeutics Sa | Terapia combinada con un conjugado de anticuerpo anti-AXL y fármaco |
| MX2019015042A (es) | 2017-06-14 | 2020-08-06 | Adc Therapeutics Sa | Regimen de dosificacion. |
| DK3668874T3 (da) | 2017-08-18 | 2022-02-14 | Medimmune Ltd | Pyrrolobenzodiazepin-konjugater |
| GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
| GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| KR102890251B1 (ko) | 2019-03-15 | 2025-11-25 | 메드임뮨 리미티드 | 암의 치료에 사용하기 위한 아제티도벤조디아제핀 이량체 및 이를 포함하는 컨쥬게이트 |
| EP4069369A4 (en) * | 2019-12-06 | 2024-02-14 | Schrödinger, Inc. | CYCLIC COMPOUNDS AND METHODS OF USE |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3933794A (en) * | 1971-08-04 | 1976-01-20 | The Upjohn Company | 2-(2-Alkynylamino)-3H-1,4-benzodiazepines |
| GB1600600A (en) * | 1977-03-10 | 1981-10-21 | Diamond Shamrock Chem | Plasticiser compositions for use with synthetic resin polymers |
| US4118386A (en) * | 1977-04-04 | 1978-10-03 | Hoffmann-La Roche Inc. | Synthesis of imidazo[1,5-a]diazepine-3-carboxylates |
| CA1143728A (en) * | 1979-10-04 | 1983-03-29 | Max Gerecke | Imidazodiazepine derivatives |
-
1982
- 1982-01-21 CA CA000394685A patent/CA1185602A/en not_active Expired
- 1982-02-10 PH PH26851A patent/PH19881A/en unknown
- 1982-02-17 CS CS821081A patent/CS247064B2/cs unknown
- 1982-02-18 US US06/349,801 patent/US4353827A/en not_active Expired - Lifetime
- 1982-02-19 DE DE8282101273T patent/DE3263633D1/de not_active Expired
- 1982-02-19 DK DK074282A patent/DK168073B1/da not_active IP Right Cessation
- 1982-02-19 EP EP82101273A patent/EP0059391B1/de not_active Expired
- 1982-02-19 IL IL65056A patent/IL65056A0/xx not_active IP Right Cessation
- 1982-02-22 AU AU80669/82A patent/AU551891B2/en not_active Expired
- 1982-02-22 NZ NZ199793A patent/NZ199793A/en unknown
- 1982-02-25 MC MC821577A patent/MC1442A1/fr unknown
- 1982-02-25 FI FI820647A patent/FI73430C/fi not_active IP Right Cessation
- 1982-02-26 BR BR8201024A patent/BR8201024A/pt unknown
- 1982-02-26 IE IE421/82A patent/IE52543B1/en not_active IP Right Cessation
- 1982-02-26 KR KR8200862A patent/KR890002624B1/ko not_active Expired
- 1982-02-26 NO NO820622A patent/NO157620C/no unknown
- 1982-02-26 PT PT74504A patent/PT74504B/pt unknown
- 1982-02-26 YU YU43682A patent/YU45860B/sh unknown
-
1988
- 1988-03-30 HK HK232/88A patent/HK23288A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FI73430B (fi) | 1987-06-30 |
| CS247064B2 (en) | 1986-11-13 |
| IE820421L (en) | 1982-08-27 |
| HK23288A (en) | 1988-04-08 |
| EP0059391B1 (de) | 1985-05-08 |
| YU43682A (en) | 1988-08-31 |
| FI73430C (fi) | 1987-10-09 |
| AU551891B2 (en) | 1986-05-15 |
| NO820622L (no) | 1982-08-30 |
| PT74504B (en) | 1984-11-26 |
| BR8201024A (pt) | 1983-01-04 |
| PH19881A (en) | 1986-08-13 |
| KR890002624B1 (ko) | 1989-07-20 |
| DE3263633D1 (en) | 1985-06-13 |
| PT74504A (en) | 1982-03-01 |
| AU8066982A (en) | 1982-09-02 |
| DK74282A (da) | 1982-08-28 |
| MC1442A1 (fr) | 1982-12-06 |
| IE52543B1 (en) | 1987-12-09 |
| IL65056A0 (en) | 1982-04-30 |
| KR830009105A (ko) | 1983-12-17 |
| NZ199793A (en) | 1985-08-30 |
| FI820647L (fi) | 1982-08-28 |
| YU45860B (sh) | 1992-09-07 |
| NO157620C (no) | 1988-04-20 |
| NO157620B (no) | 1988-01-11 |
| DK168073B1 (da) | 1994-01-31 |
| US4353827A (en) | 1982-10-12 |
| EP0059391A1 (de) | 1982-09-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |