CA1270253A - R(-)-10,11-alkylenedioxy-n-alkylnorapomorphine - Google Patents

R(-)-10,11-alkylenedioxy-n-alkylnorapomorphine

Info

Publication number
CA1270253A
CA1270253A CA000405440A CA405440A CA1270253A CA 1270253 A CA1270253 A CA 1270253A CA 000405440 A CA000405440 A CA 000405440A CA 405440 A CA405440 A CA 405440A CA 1270253 A CA1270253 A CA 1270253A
Authority
CA
Canada
Prior art keywords
lower alkyl
npa
phenyl
acid
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000405440A
Other languages
English (en)
Inventor
John L. Neumeyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Northeastern University Boston
Original Assignee
Northeastern University Boston
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/379,557 external-priority patent/US4543256A/en
Application filed by Northeastern University Boston filed Critical Northeastern University Boston
Application granted granted Critical
Publication of CA1270253A publication Critical patent/CA1270253A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA000405440A 1981-06-18 1982-06-17 R(-)-10,11-alkylenedioxy-n-alkylnorapomorphine Expired CA1270253A (fr)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US27477281A 1981-06-18 1981-06-18
US274,772 1981-06-18
US346,841 1982-02-02
US34684182A 1982-02-08 1982-02-08
US35891782A 1982-03-17 1982-03-17
US35891882A 1982-03-17 1982-03-17
US358,918 1982-03-17
US06/379,557 US4543256A (en) 1982-03-17 1982-05-18 (-)-10,1L Methylenedioxy-N-N-propylnoraporphine and methods employing it for inhibiting the effects of epileptic seizures and for prevention and treatment of duodenal ulcers
US379,557 1982-05-18
US358,917 1989-05-26

Publications (1)

Publication Number Publication Date
CA1270253A true CA1270253A (fr) 1990-06-12

Family

ID=27540584

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000405440A Expired CA1270253A (fr) 1981-06-18 1982-06-17 R(-)-10,11-alkylenedioxy-n-alkylnorapomorphine

Country Status (8)

Country Link
CA (1) CA1270253A (fr)
DE (1) DE3222840A1 (fr)
DK (1) DK272182A (fr)
FR (1) FR2508043B1 (fr)
GB (1) GB2105323B (fr)
IE (1) IE53161B1 (fr)
IT (1) IT1191200B (fr)
NL (1) NL8202467A (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990012574A1 (fr) * 1989-04-25 1990-11-01 Northeastern University Composes agonistes de la dopamine
AU4536599A (en) 1999-06-21 2001-01-09 Geochemistry Research Limited Metal-rich silica products from geothermal and synthetic aqueous systems nen wie
US9359303B2 (en) 2009-04-21 2016-06-07 Purdue Research Foundation Octahydrobenzoisoquinoline modulators of dopamine receptors and uses therefor
WO2020070099A1 (fr) 2018-10-02 2020-04-09 H. Lundbeck A/S Administration de promédicaments de catécholamine en combinaison avec un antagoniste de 5-ht2b

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3717643A (en) * 1967-05-04 1973-02-20 Sterling Drug Inc N-substituted-norapomorphines
US3810987A (en) * 1972-06-12 1974-05-14 Merck & Co Inc Blood pressure lowering method using an aporphine

Also Published As

Publication number Publication date
GB2105323A (en) 1983-03-23
IT8267776A0 (it) 1982-06-17
DK272182A (da) 1982-12-19
IT1191200B (it) 1988-02-24
FR2508043B1 (fr) 1987-04-30
IE821441L (en) 1982-12-18
GB2105323B (en) 1985-12-11
IT8267776A1 (it) 1984-06-09
IE53161B1 (en) 1988-08-03
DE3222840A1 (de) 1983-05-05
NL8202467A (nl) 1983-01-17
FR2508043A1 (fr) 1982-12-24

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Legal Events

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